AR012032A1 - Compuestos derivados 3'-n-oxido, 3'-n-dimetilamina, 9-oxima eritromicina a y un proceso para su preparacion - Google Patents
Compuestos derivados 3'-n-oxido, 3'-n-dimetilamina, 9-oxima eritromicina a y un proceso para su preparacionInfo
- Publication number
- AR012032A1 AR012032A1 ARP980100584A ARP980100584A AR012032A1 AR 012032 A1 AR012032 A1 AR 012032A1 AR P980100584 A ARP980100584 A AR P980100584A AR P980100584 A ARP980100584 A AR P980100584A AR 012032 A1 AR012032 A1 AR 012032A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- lower alkyl
- atoms
- attached
- taken together
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 title abstract 2
- 229930006677 Erythromycin A Natural products 0.000 title abstract 2
- 229960003276 erythromycin Drugs 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 8
- 125000004429 atom Chemical group 0.000 abstract 6
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- 125000002877 alkyl aryl group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 150000002923 oximes Chemical class 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004849 alkoxymethyl group Chemical group 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- -1 hydroxy, hydroxy Chemical group 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Un compuesto derivado de 3-N-oxido, 3-dimetilamina, 9-oxima eritromicina A, que tiene la formula (I): en donde R1 y R2 son independientemente hidrogenoo un grupo protector de hidroxi; R3 es un grupo alquilo inferior; Y es seleccionado del g rupoque consiste de: (a) una oxima que tiene la formula:N-O-R4, en donde R4 es seleccinado del grupo que consiste de: un grupo alquenilo inferior; un grupo alquilarilo; un grupo alquilarilo sustituido; ungrupo aril (alquilo inferior), o un grupo aril(alquilo inferior) sustituido; o (b) una oxima que tiene la formula (II) en donde R5 es seleccionado del grupoque consiste de: un grupo alquilo inferior; un grupo cicloalquilo, un grupo fenilo, un grupo aril (alquilo inferior), o R5 y R6, o R5 y R7y los átomos delos cuales están unidos se toman juntos para formar un anillo de 5 a 7 miembros conteniendo un átomo de oxígeno; R6 es seleccionado del grupo que consite de:un grupo alquilo inferior, un grupo alcoximetilo inferior; o R6 y R5 y losátomos a los cuales están unidos se toman juntos para formar un grupocicloalquilo de 5 a 7 miembros; y R7 es seleccionado del grupo que consiste de: un átomo de hidrogeno, un grupo alquilo inferior, un grupo fenilo, un grupoaril (alqu ilo inferior);o R7 y R5 y los átomos a los cuales están unidos se toman juntos para formar un anillo de 5 a 7 miembros conteniendo un átomo deoxígeno; o R7 y R6 y los átomos a los cuales están unidos se toman juntos para formar un grupo cicloalq uilo de 5 a 7miembros; con el requisito de que solo unpar de sustituyentes (R5 y R6), (R5 y R7), o (R6 y R7) pueden ser formados junto con los átomos a los cuales están unidos para formar un anillo como sedefine con anterioridad; y Z es hidroge no, hidroxi, ohidroxi protegido y un proceso para su preparacion. Los compuestos anteriormente descriptos se usan en
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/800,009 US5864023A (en) | 1997-02-13 | 1997-02-13 | 3'-N'oxide, 3'-n-dimethylamine, 9-oxime erythromycin a derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR012032A1 true AR012032A1 (es) | 2000-09-27 |
Family
ID=25177295
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980100584A AR012032A1 (es) | 1997-02-13 | 1998-02-10 | Compuestos derivados 3'-n-oxido, 3'-n-dimetilamina, 9-oxima eritromicina a y un proceso para su preparacion |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US5864023A (es) |
| EP (1) | EP0966477B1 (es) |
| JP (1) | JP2001512456A (es) |
| KR (1) | KR100561326B1 (es) |
| CN (1) | CN1326865C (es) |
| AR (1) | AR012032A1 (es) |
| AT (1) | ATE252108T1 (es) |
| AU (1) | AU725274B2 (es) |
| BG (1) | BG64099B1 (es) |
| BR (1) | BR9807349A (es) |
| CA (1) | CA2279932C (es) |
| CZ (1) | CZ294481B6 (es) |
| DE (1) | DE69818977T2 (es) |
| DK (1) | DK0966477T3 (es) |
| ES (1) | ES2212266T3 (es) |
| HU (1) | HUP0001330A3 (es) |
| IL (1) | IL130697A0 (es) |
| NO (1) | NO993876L (es) |
| NZ (1) | NZ336482A (es) |
| PL (1) | PL187357B1 (es) |
| PT (1) | PT966477E (es) |
| SK (1) | SK284157B6 (es) |
| TR (1) | TR199901874T2 (es) |
| WO (1) | WO1998035976A1 (es) |
| ZA (1) | ZA98986B (es) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100317907B1 (ko) * | 1998-11-24 | 2001-12-24 | 김 완 주 | 신규한 중간체, 이를 이용한 마크로라이드계 항생제의제조방법 |
| US6437106B1 (en) | 1999-06-24 | 2002-08-20 | Abbott Laboratories | Process for preparing 6-o-substituted erythromycin derivatives |
| KR20010008496A (ko) * | 1999-07-01 | 2001-02-05 | 유충식 | 6-오-메틸 에리트로마이신의 제조방법 |
| KR100336447B1 (ko) * | 1999-11-24 | 2002-05-15 | 민경윤 | 클라리스로마이신의 개선된 제조방법 |
| AU783055B2 (en) | 1999-12-16 | 2005-09-22 | Teva Pharmaceutical Industries Ltd. | Processes for preparing clarithromycin polymorphs and novel polymorph IV |
| RU2002118308A (ru) | 2000-01-11 | 2004-02-20 | Тева Фамэситикл Индастрис Лтд. (Il) | Способы получения полиморфных модификаций кларитромицина |
| US6565882B2 (en) * | 2000-02-24 | 2003-05-20 | Advancis Pharmaceutical Corp | Antibiotic composition with inhibitor |
| US6544555B2 (en) * | 2000-02-24 | 2003-04-08 | Advancis Pharmaceutical Corp. | Antibiotic product, use and formulation thereof |
| US6617436B2 (en) | 2000-02-29 | 2003-09-09 | Teva Pharmaceutical Industries Ltd. | Processes for preparing clarithromycin and clarithromycin intermediate, essentially oxime-free clarithromycin, and pharmaceutical composition comprising the same |
| WO2001068662A1 (en) * | 2000-03-15 | 2001-09-20 | Hanmi Pharm. Co., Ltd. | Method of preparing clarithromycin of form ii crystals |
| KR20000037126A (ko) * | 2000-04-08 | 2000-07-05 | 김용규 | 6-메틸 에리스로마이신 ａ의 제조방법 |
| US6541014B2 (en) * | 2000-10-13 | 2003-04-01 | Advancis Pharmaceutical Corp. | Antiviral product, use and formulation thereof |
| US20020068078A1 (en) * | 2000-10-13 | 2002-06-06 | Rudnic Edward M. | Antifungal product, use and formulation thereof |
| US20020197314A1 (en) * | 2001-02-23 | 2002-12-26 | Rudnic Edward M. | Anti-fungal composition |
| WO2005009365A2 (en) * | 2003-07-21 | 2005-02-03 | Advancis Pharmaceutical Corporation | Antibiotic product, use and formulation thereof |
| CA2533292C (en) * | 2003-07-21 | 2013-12-31 | Advancis Pharmaceutical Corporation | Antibiotic product, use and formulation thereof |
| US8425936B2 (en) * | 2003-07-21 | 2013-04-23 | Shionogi Inc. | Antibiotic product, use and formulation thereof |
| WO2005016311A1 (en) * | 2003-08-11 | 2005-02-24 | Advancis Pharmaceutical Corporation | Robust pellet |
| CA2535398C (en) * | 2003-08-12 | 2013-11-12 | Advancis Pharmaceuticals Corporation | Antibiotic product, use and formulation thereof |
| AU2004270170B2 (en) * | 2003-08-29 | 2011-01-27 | Shionogi, Inc. | Antibiotic product, use and formulation thereof |
| US8460710B2 (en) * | 2003-09-15 | 2013-06-11 | Shionogi, Inc. | Antibiotic product, use and formulation thereof |
| JP2007517039A (ja) * | 2003-12-24 | 2007-06-28 | アドバンシス ファーマスーティカル コーポレイション | 変性放出製剤の吸収増強 |
| US8715727B2 (en) * | 2004-07-02 | 2014-05-06 | Shionogi Inc. | Tablet for pulsed delivery |
| US7694523B2 (en) * | 2004-07-19 | 2010-04-13 | Earthrenew, Inc. | Control system for gas turbine in material treatment unit |
| US8357394B2 (en) | 2005-12-08 | 2013-01-22 | Shionogi Inc. | Compositions and methods for improved efficacy of penicillin-type antibiotics |
| US8778924B2 (en) * | 2006-12-04 | 2014-07-15 | Shionogi Inc. | Modified release amoxicillin products |
| US8299052B2 (en) | 2006-05-05 | 2012-10-30 | Shionogi Inc. | Pharmaceutical compositions and methods for improved bacterial eradication |
| US20090054634A1 (en) * | 2007-08-09 | 2009-02-26 | Vinod Kumar Kansal | Process for the preparation of clarithromycin |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4331803A (en) * | 1980-06-04 | 1982-05-25 | Taisho Pharmaceutical Co., Ltd. | Novel erythromycin compounds |
| JPS60214796A (ja) * | 1984-04-06 | 1985-10-28 | Taisho Pharmaceut Co Ltd | ６−０−メチルエリスロマイシン類の製法 |
| JPS61103890A (ja) * | 1984-10-26 | 1986-05-22 | Taisho Pharmaceut Co Ltd | ６−０−メチルエリスロマイシンａ誘導体 |
| US4670549A (en) * | 1985-03-18 | 1987-06-02 | Taisho Pharmaceutical Co., Ltd. | Method for selective methylation of erythromycin a derivatives |
| JPS61229895A (ja) * | 1985-04-03 | 1986-10-14 | Nippon Zeon Co Ltd | 保護化デス−ｎ−メチルエリスロマイシン誘導体 |
| EP0254534A3 (en) * | 1986-07-24 | 1991-04-17 | William S. Robinson | Erythromycin derivatives and compositions and use for inhibiting virus replication and disease |
| DE3782994T2 (de) * | 1986-09-18 | 1993-04-08 | Taisho Pharma Co Ltd | Erythromycin-a-derivate und verfahren zu ihrer herstellung. |
| KR960000434B1 (ko) * | 1986-12-17 | 1996-01-06 | 다이쇼 세이야꾸 가부시끼가이샤 | 에리스로마이신 a유도체 및 그의 제조 방법 |
| JP2751385B2 (ja) * | 1988-05-19 | 1998-05-18 | 大正製薬株式会社 | エリスロマイシンａオキシム及びその塩の製造方法 |
-
1997
- 1997-02-13 US US08/800,009 patent/US5864023A/en not_active Expired - Lifetime
-
1998
- 1998-02-03 PT PT98904822T patent/PT966477E/pt unknown
- 1998-02-03 AU AU62608/98A patent/AU725274B2/en not_active Ceased
- 1998-02-03 WO PCT/US1998/001929 patent/WO1998035976A1/en not_active Ceased
- 1998-02-03 HU HU0001330A patent/HUP0001330A3/hu unknown
- 1998-02-03 ES ES98904822T patent/ES2212266T3/es not_active Expired - Lifetime
- 1998-02-03 SK SK974-99A patent/SK284157B6/sk not_active IP Right Cessation
- 1998-02-03 NZ NZ336482A patent/NZ336482A/en unknown
- 1998-02-03 JP JP53578098A patent/JP2001512456A/ja not_active Ceased
- 1998-02-03 PL PL98335301A patent/PL187357B1/pl not_active IP Right Cessation
- 1998-02-03 IL IL13069798A patent/IL130697A0/xx unknown
- 1998-02-03 KR KR1019997007251A patent/KR100561326B1/ko not_active Expired - Fee Related
- 1998-02-03 CA CA002279932A patent/CA2279932C/en not_active Expired - Fee Related
- 1998-02-03 CZ CZ19992704A patent/CZ294481B6/cs not_active IP Right Cessation
- 1998-02-03 TR TR1999/01874T patent/TR199901874T2/xx unknown
- 1998-02-03 EP EP98904822A patent/EP0966477B1/en not_active Expired - Lifetime
- 1998-02-03 BR BR9807349-4A patent/BR9807349A/pt not_active Application Discontinuation
- 1998-02-03 CN CNB988023784A patent/CN1326865C/zh not_active Expired - Fee Related
- 1998-02-03 DE DE69818977T patent/DE69818977T2/de not_active Expired - Fee Related
- 1998-02-03 AT AT98904822T patent/ATE252108T1/de not_active IP Right Cessation
- 1998-02-03 DK DK98904822T patent/DK0966477T3/da active
- 1998-02-06 ZA ZA98986A patent/ZA98986B/xx unknown
- 1998-02-10 AR ARP980100584A patent/AR012032A1/es active IP Right Grant
-
1999
- 1999-08-11 NO NO993876A patent/NO993876L/no not_active Application Discontinuation
- 1999-08-20 BG BG103673A patent/BG64099B1/bg unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |