AR016212A1 - Uso de compuestos farmaceuticos que tienen una actividad antagonista de nmda para preparar un medicamento para el tratamiento del sindrome de intestino irritable (ibs), y composiciones farmaceuticas - Google Patents
Uso de compuestos farmaceuticos que tienen una actividad antagonista de nmda para preparar un medicamento para el tratamiento del sindrome de intestino irritable (ibs), y composiciones farmaceuticasInfo
- Publication number
- AR016212A1 AR016212A1 ARP990101817A ARP990101817A AR016212A1 AR 016212 A1 AR016212 A1 AR 016212A1 AR P990101817 A ARP990101817 A AR P990101817A AR P990101817 A ARP990101817 A AR P990101817A AR 016212 A1 AR016212 A1 AR 016212A1
- Authority
- AR
- Argentina
- Prior art keywords
- ibs
- prepare
- treatment
- nmda
- compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 210000000936 intestine Anatomy 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 208000011580 syndromic disease Diseases 0.000 title 1
- 208000002551 irritable bowel syndrome Diseases 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
- 230000003042 antagnostic effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 239000012458 free base Substances 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract 1
- 239000002207 metabolite Substances 0.000 abstract 1
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Uso de compuestos farmacéuticos que tienen una actividad antagonista NMDA para preparar un medicamento, donde compuestos especialmente adecuados tienen laformula (I) donde R1 y R2 son independientemente fenilo o 4-fluosofenilo; R3 es hidrogeno,alqui lo C1-6 o metoxicarbonilo; R4 es hidrogeno o metilo; ymetabolitos y sus isomeros ambos como base libre y sus sales farmacéuticament aceptables, util para tratar ciertas condiciones en el tracto gastrointestinal,como por ejemplo los trastornosgastroi ntestinales funcionales, y en particular,el síndrome de intestino irritable (IBS); composiciones farmacéuticas para usaren el tratamiento del IBS que comprenden a compuestos y un portador farmacéuticamente aceptable.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9801494A SE9801494D0 (sv) | 1998-04-28 | 1998-04-28 | Novel use |
| SE9803954A SE9803954D0 (sv) | 1998-11-18 | 1998-11-18 | Novel use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR016212A1 true AR016212A1 (es) | 2001-06-20 |
Family
ID=26663287
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990101817A AR016212A1 (es) | 1998-04-28 | 1999-04-20 | Uso de compuestos farmaceuticos que tienen una actividad antagonista de nmda para preparar un medicamento para el tratamiento del sindrome de intestino irritable (ibs), y composiciones farmaceuticas |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP1073431B1 (es) |
| JP (1) | JP2002512956A (es) |
| KR (1) | KR100569777B1 (es) |
| CN (1) | CN1200702C (es) |
| AR (1) | AR016212A1 (es) |
| AT (1) | ATE270545T1 (es) |
| AU (1) | AU760783B2 (es) |
| BR (1) | BR9909971A (es) |
| CA (1) | CA2329328A1 (es) |
| DE (1) | DE69918541T2 (es) |
| DK (1) | DK1073431T3 (es) |
| ES (1) | ES2221753T3 (es) |
| IL (1) | IL138919A0 (es) |
| MY (1) | MY121063A (es) |
| NO (1) | NO20005386D0 (es) |
| NZ (1) | NZ507436A (es) |
| PT (1) | PT1073431E (es) |
| SA (1) | SA99200482B1 (es) |
| TW (1) | TW570793B (es) |
| WO (1) | WO1999055323A1 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU3582101A (en) * | 2000-03-01 | 2001-09-12 | Euro-Celtique S.A. | The treatment of functional gastrointestinal disorders |
| TW593223B (en) * | 2000-06-20 | 2004-06-21 | Merz Pharma Gmbh & Co Kgaa | 1-amino-alkylcyclohexanes as 5-HT3 and neuronal nicotinic receptor antagonists |
| JP2003081872A (ja) * | 2001-09-13 | 2003-03-19 | Nippon Oruganon Kk | 掻痒治療薬 |
| CA2518385A1 (en) * | 2003-03-14 | 2004-09-23 | Agi Therapeutics Ltd. | Treatment of intestinal conditions with n-2,3,3-tetramethylbicyclo[2.2.1]heptan-2-amine |
| WO2004084889A1 (en) * | 2003-03-28 | 2004-10-07 | Pfizer Inc. | Use of protein kinase c inhibitor for suppressing sustained slow postsynaptic excitation (sspe) of enteric neurons |
| FR2865133B1 (fr) * | 2004-01-19 | 2008-01-18 | Rytek | Compositions pour le traitement de pathologies digestives |
| CA3105834A1 (en) * | 2018-07-06 | 2020-01-09 | Algernon Pharmaceuticals Inc. | Compounds for treatment of inflammatory bowel disease and methods thereof |
| KR102211282B1 (ko) | 2019-11-20 | 2021-02-03 | (주)파이브텍 | 데이터 라우팅 방법 및 이를 지원하는 스위치 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL84305A (en) * | 1987-02-06 | 1992-01-15 | Fisons Corp | 2-aminoacetamide derivatives |
| GB9518027D0 (en) * | 1995-09-05 | 1995-11-08 | Wellcome Found | Pharmacologically active compound |
| AUPN605795A0 (en) * | 1995-10-19 | 1995-11-09 | F.H. Faulding & Co. Limited | Analgesic pharmaceutical composition |
-
1999
- 1999-04-20 AR ARP990101817A patent/AR016212A1/es unknown
- 1999-04-27 MY MYPI99001635A patent/MY121063A/en unknown
- 1999-04-28 EP EP99947024A patent/EP1073431B1/en not_active Expired - Lifetime
- 1999-04-28 CA CA002329328A patent/CA2329328A1/en not_active Abandoned
- 1999-04-28 CN CNB998078182A patent/CN1200702C/zh not_active Expired - Fee Related
- 1999-04-28 ES ES99947024T patent/ES2221753T3/es not_active Expired - Lifetime
- 1999-04-28 WO PCT/SE1999/000702 patent/WO1999055323A1/en not_active Ceased
- 1999-04-28 AU AU43024/99A patent/AU760783B2/en not_active Ceased
- 1999-04-28 DE DE69918541T patent/DE69918541T2/de not_active Expired - Fee Related
- 1999-04-28 BR BR9909971-3A patent/BR9909971A/pt not_active Application Discontinuation
- 1999-04-28 JP JP2000545522A patent/JP2002512956A/ja active Pending
- 1999-04-28 IL IL13891999A patent/IL138919A0/xx not_active IP Right Cessation
- 1999-04-28 KR KR1020007011958A patent/KR100569777B1/ko not_active Expired - Fee Related
- 1999-04-28 PT PT99947024T patent/PT1073431E/pt unknown
- 1999-04-28 DK DK99947024T patent/DK1073431T3/da active
- 1999-04-28 NZ NZ507436A patent/NZ507436A/en unknown
- 1999-04-28 AT AT99947024T patent/ATE270545T1/de not_active IP Right Cessation
- 1999-08-13 TW TW088113888A patent/TW570793B/zh active
- 1999-08-17 SA SA99200482A patent/SA99200482B1/ar unknown
-
2000
- 2000-10-26 NO NO20005386A patent/NO20005386D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1073431B1 (en) | 2004-07-07 |
| JP2002512956A (ja) | 2002-05-08 |
| CA2329328A1 (en) | 1999-11-04 |
| PT1073431E (pt) | 2004-10-29 |
| KR20010043077A (ko) | 2001-05-25 |
| WO1999055323A1 (en) | 1999-11-04 |
| NZ507436A (en) | 2003-09-26 |
| TW570793B (en) | 2004-01-11 |
| CN1200702C (zh) | 2005-05-11 |
| DE69918541D1 (de) | 2004-08-12 |
| CN1307471A (zh) | 2001-08-08 |
| ES2221753T3 (es) | 2005-01-01 |
| DE69918541T2 (de) | 2005-08-18 |
| ATE270545T1 (de) | 2004-07-15 |
| NO20005386L (no) | 2000-10-26 |
| KR100569777B1 (ko) | 2006-04-11 |
| AU760783B2 (en) | 2003-05-22 |
| HK1033876A1 (en) | 2001-09-28 |
| EP1073431A1 (en) | 2001-02-07 |
| NO20005386D0 (no) | 2000-10-26 |
| IL138919A0 (en) | 2001-11-25 |
| BR9909971A (pt) | 2000-12-26 |
| AU4302499A (en) | 1999-11-16 |
| DK1073431T3 (da) | 2004-10-04 |
| SA99200482B1 (ar) | 2006-06-27 |
| MY121063A (en) | 2005-12-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |