AR008238A1 - Derivados de heterociclilmetilamino de ciclobuteno-3, 4-dionas, una composicion farmaceutica que los contienen y el uso de los mismos para prepararmedicamentos - Google Patents
Derivados de heterociclilmetilamino de ciclobuteno-3, 4-dionas, una composicion farmaceutica que los contienen y el uso de los mismos para prepararmedicamentosInfo
- Publication number
- AR008238A1 AR008238A1 ARP970102616A ARP970102616A AR008238A1 AR 008238 A1 AR008238 A1 AR 008238A1 AR P970102616 A ARP970102616 A AR P970102616A AR P970102616 A ARP970102616 A AR P970102616A AR 008238 A1 AR008238 A1 AR 008238A1
- Authority
- AR
- Argentina
- Prior art keywords
- carbon atoms
- alkyl
- cyclobuteno
- dionas
- pharmaceutical composition
- Prior art date
Links
- BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical class NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000004432 carbon atom Chemical group C* 0.000 abstract 5
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000004391 aryl sulfonyl group Chemical group 0.000 abstract 2
- 125000001589 carboacyl group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 abstract 1
- 229920001774 Perfluoroether Polymers 0.000 abstract 1
- 150000004703 alkoxides Chemical class 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000005431 alkyl carboxamide group Chemical group 0.000 abstract 1
- 125000005422 alkyl sulfonamido group Chemical group 0.000 abstract 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 1
- 125000005140 aralkylsulfonyl group Chemical group 0.000 abstract 1
- 125000003435 aroyl group Chemical group 0.000 abstract 1
- 125000005018 aryl alkenyl group Chemical group 0.000 abstract 1
- 125000005533 aryl carboxamido group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004421 aryl sulphonamide group Chemical group 0.000 abstract 1
- 150000001602 bicycloalkyls Chemical group 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- RGBVWCQARBEPPW-UHFFFAOYSA-N cyclobut-3-ene-1,2-dione Chemical class O=C1C=CC1=O RGBVWCQARBEPPW-UHFFFAOYSA-N 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000003187 heptyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Furan Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Derivados de heterociclilmetilamino de ciclobuteno-3, 4-dionas de fórmula (I) donde R1 y R2 son, independientemente, hidrógeno, alquilo de cadena rectade 1 a 10 a 10 átomos de carbono, alquilo de cadena ramificada de 3 a 10 átomos de carbono,ciclo alquilo de 3 a 8 átomos de carbono, bicicloalquilo de 4 a 10átomos de carbono o aralquilo de 7 a 20 átomos de carbono, donde la porción aromática del grupo aralquilo puede estar opcionalmente substituida con uno atres grupos alquilo decadena rec ta de 1 a 10 átomos de carbono, alquilo de cadena ramificada de 1 a 10 átomos de carbono, halógeno, nitro ciano, alcoxide 1 a 6 átomos de carbono, alcoxicarbonilo de 2 a 7 átomos de carbono, trifluormetilo o trifluormetoxi; R3es hidrógen o, formilo, alcanoilo de 2 a 7átomos de carbono, alquenoilo de 3 a 7 átomos de carbono, alquilo sulfonilo de 1 a 7 átomos de carbono, aroilo de 7 a 12 átomos de carbono, arilalquenoilo de9 a 20 átomos de carbono, arilsulfonilo de 6 a 12átomos de ca rbono, arilalcanoilo de 8 a 12 átomos de carbono o arilalquilsulfonilo de 7 a 12átomos de carbono; A esta seleccionado del grupo que consiste en fórmulas (I), donde n es 0 a 1; R4, R5 y R6 son, independientemente, ciano,nitro, aminoalqui lo de 1 a 6 átomos de carbono, perfluoralquilo de 1 a 6 átomos de carbono, alcoxi, de 1 a 6 átomos de carbono, perfluoralcoxi de 1 a 6 átomos de carbono,alquilamino de 1 a 6 átomos de carbono, dialquilamino de 2 a 12 átomos de carbono, sulfamil o, alquilsulfonamido de 1 a 6 átomos de carbono,arilsulfonamido de 6 a 12 átomos de carbono, alquil carboxamido de 2 a 7 átomos de carbono, arilcarboxamido de 7 a 13 átomos de carbono, alcanoilo de 2a 6 átomos de carbono,alquilsulfonilo de 1 a 6 átomos de carbono, perfluoralquilsulfonilo de 1 a 6 átomos de carbono, arilsulfonilo de 6 a 12
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66458396A | 1996-06-17 | 1996-06-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR008238A1 true AR008238A1 (es) | 1999-12-29 |
Family
ID=24666578
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970102616A AR008238A1 (es) | 1996-06-17 | 1997-06-13 | Derivados de heterociclilmetilamino de ciclobuteno-3, 4-dionas, una composicion farmaceutica que los contienen y el uso de los mismos para prepararmedicamentos |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0906282A1 (es) |
| JP (1) | JP2000512655A (es) |
| KR (1) | KR20000016815A (es) |
| CN (1) | CN1227543A (es) |
| AR (1) | AR008238A1 (es) |
| AU (1) | AU727217B2 (es) |
| BR (1) | BR9709905A (es) |
| CA (1) | CA2258536A1 (es) |
| IL (1) | IL127261A0 (es) |
| NZ (1) | NZ332859A (es) |
| TW (1) | TW442473B (es) |
| WO (1) | WO1997048682A1 (es) |
| ZA (1) | ZA975287B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL359416A1 (en) * | 2000-07-18 | 2004-08-23 | Yamanouchi Pharmaceutical Co, Ltd. | Medicine comprising dicyanopyridine derivative |
| US6495576B2 (en) | 2001-02-07 | 2002-12-17 | Abbott Laboratories | Aminal diones as potassium channel openers |
| EP2655362A1 (en) | 2010-12-22 | 2013-10-30 | Abbvie Inc. | Hepatitis c inhibitors and uses thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2222083A (en) * | 1982-12-14 | 1984-06-21 | Smith Kline & French Laboratories Limited | Pyridine derivatives |
| JPS60255756A (ja) * | 1984-06-01 | 1985-12-17 | Ikeda Mohandou:Kk | アミノアルキルフエノキシ誘導体 |
| JPH0692915A (ja) * | 1992-07-28 | 1994-04-05 | Sumitomo Metal Ind Ltd | １，２−ジアミノシクロブテン−３，４−ジオン誘導体及びその用途 |
| US5354763A (en) * | 1993-11-17 | 1994-10-11 | American Home Products Corporation | Substituted N-heteroaryl and N-aryl-1,2-diaminocyclobutene-3,4-diones |
| US5466712A (en) * | 1994-11-04 | 1995-11-14 | American Home Products Corporation | Substituted n-aryl-1,2-diaminocyclobutene-3,4-diones |
| US5464867A (en) * | 1994-11-16 | 1995-11-07 | American Home Products Corporation | Diaminocyclobutene-3,4-diones |
-
1997
- 1997-06-10 JP JP10503051A patent/JP2000512655A/ja active Pending
- 1997-06-10 IL IL12726197A patent/IL127261A0/xx unknown
- 1997-06-10 CN CN97197139A patent/CN1227543A/zh active Pending
- 1997-06-10 WO PCT/US1997/009744 patent/WO1997048682A1/en not_active Ceased
- 1997-06-10 NZ NZ332859A patent/NZ332859A/en unknown
- 1997-06-10 EP EP97928856A patent/EP0906282A1/en not_active Withdrawn
- 1997-06-10 BR BR9709905A patent/BR9709905A/pt unknown
- 1997-06-10 CA CA002258536A patent/CA2258536A1/en not_active Abandoned
- 1997-06-10 KR KR1019980710500A patent/KR20000016815A/ko not_active Withdrawn
- 1997-06-10 AU AU33017/97A patent/AU727217B2/en not_active Ceased
- 1997-06-11 TW TW086108282A patent/TW442473B/zh active
- 1997-06-13 ZA ZA975287A patent/ZA975287B/xx unknown
- 1997-06-13 AR ARP970102616A patent/AR008238A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2258536A1 (en) | 1997-12-24 |
| CN1227543A (zh) | 1999-09-01 |
| ZA975287B (en) | 1998-12-14 |
| AU727217B2 (en) | 2000-12-07 |
| KR20000016815A (ko) | 2000-03-25 |
| TW442473B (en) | 2001-06-23 |
| IL127261A0 (en) | 1999-09-22 |
| NZ332859A (en) | 2000-06-23 |
| BR9709905A (pt) | 1999-08-10 |
| WO1997048682A1 (en) | 1997-12-24 |
| EP0906282A1 (en) | 1999-04-07 |
| JP2000512655A (ja) | 2000-09-26 |
| AU3301797A (en) | 1998-01-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |