AR006301A1 - Derivados de oxazolidin-2-ona, procedimiento para prepararlos, medicamento constituido por dicho derivado y composicion farmaceutica que comprende a dicho derivado - Google Patents
Derivados de oxazolidin-2-ona, procedimiento para prepararlos, medicamento constituido por dicho derivado y composicion farmaceutica que comprende a dicho derivadoInfo
- Publication number
- AR006301A1 AR006301A1 ARP960102870A AR10287096A AR006301A1 AR 006301 A1 AR006301 A1 AR 006301A1 AR P960102870 A ARP960102870 A AR P960102870A AR 10287096 A AR10287096 A AR 10287096A AR 006301 A1 AR006301 A1 AR 006301A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- derivative
- derivatives
- hydrogen atom
- oxazolidin
- Prior art date
Links
- 229940079593 drug Drugs 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- -1 methylenedioxy group Chemical group 0.000 abstract 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- CSNIZNHTOVFARY-UHFFFAOYSA-N 1,2-benzothiazole Chemical class C1=CC=C2C=NSC2=C1 CSNIZNHTOVFARY-UHFFFAOYSA-N 0.000 abstract 1
- KTZQTRPPVKQPFO-UHFFFAOYSA-N 1,2-benzoxazole Chemical compound C1=CC=C2C=NOC2=C1 KTZQTRPPVKQPFO-UHFFFAOYSA-N 0.000 abstract 1
- BAXOFTOLAUCFNW-UHFFFAOYSA-N 1H-indazole Chemical compound C1=CC=C2C=NNC2=C1 BAXOFTOLAUCFNW-UHFFFAOYSA-N 0.000 abstract 1
- IZXIZTKNFFYFOF-UHFFFAOYSA-N 2-Oxazolidone Chemical group O=C1NCCO1 IZXIZTKNFFYFOF-UHFFFAOYSA-N 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Derivados de oxazolidin-2-ona substituidos en la posicion 3 por un núcleo indazol, bencisoxazol o bencisotiazol, que responden a la fórmulageneral (I), en la cual: X representa un átomo de oxígeno, un átomo de azufre o un grupo NR,siendo R un átomo de hidrógeno o una cadena alquiloEn C1-C4, lineal o ramificada, R1 es un átomo de hidrógeno o un grupo metilo y R2 es (i) un grupo R3O en el cual R3 representa ya sea un átomo dehidrógeno, un grupo bencilo eventualmentesustituid o por un átomo de halógeno o por un grupo nitro o metilendioxi o un grupo metoxietilo, butilo,4,4,4-trifluorobutilo, 4,4,4-trifluoro-3-hidroxibutilo o 4,4,4-trifluorobut- 2-enilo, o (ii) un grupo -CH=CH-R4 o -CH2-CH2-R4 y en el cualR4 es un áto mode hidrógeno o un grupo fenilo, 3,3,3-trifluoropropilo o 3,3,3-trifluoro -2-2hidroxipropilo, su procedimiento de preparación, medicamentos constituidospor dichos derivados y las composiciones farmaceuticas que los contienen.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9506563A FR2734820B1 (fr) | 1995-06-02 | 1995-06-02 | Derives de 3-(1,2-benzisoxazol-3-yl)oxazolidin-2-one, leur preparation et leur application en therapeutique |
| FR9506564A FR2734821B1 (fr) | 1995-06-02 | 1995-06-02 | Derives de 5-methoxymethyl-3-(1,2-benzisoxazol-3-yl) oxazolidin-2-one, leur preparation et leur application en therapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR006301A1 true AR006301A1 (es) | 1999-08-25 |
Family
ID=26232004
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP960102870A AR006301A1 (es) | 1995-06-02 | 1996-06-03 | Derivados de oxazolidin-2-ona, procedimiento para prepararlos, medicamento constituido por dicho derivado y composicion farmaceutica que comprende a dicho derivado |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US5843975A (es) |
| EP (1) | EP0835254B1 (es) |
| JP (1) | JP3856829B2 (es) |
| KR (1) | KR100457502B1 (es) |
| CN (1) | CN1075072C (es) |
| AR (1) | AR006301A1 (es) |
| AT (1) | ATE184005T1 (es) |
| AU (1) | AU699367B2 (es) |
| BR (1) | BR9608896A (es) |
| CA (1) | CA2223011C (es) |
| CO (1) | CO4700462A1 (es) |
| CZ (1) | CZ378497A3 (es) |
| DE (1) | DE69604071T2 (es) |
| DK (1) | DK0835254T3 (es) |
| ES (1) | ES2138346T3 (es) |
| GR (1) | GR3031710T3 (es) |
| HU (1) | HU224879B1 (es) |
| MX (1) | MX9709410A (es) |
| NO (1) | NO309091B1 (es) |
| NZ (1) | NZ310487A (es) |
| PL (1) | PL183919B1 (es) |
| RU (1) | RU2164226C2 (es) |
| SK (1) | SK281934B6 (es) |
| TW (1) | TW360654B (es) |
| WO (1) | WO1996038444A1 (es) |
| ZA (1) | ZA964563B (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1078632A1 (en) * | 1999-08-16 | 2001-02-28 | Sanofi-Synthelabo | Use of monoamine oxydase inhibitors for the manufacture of drugs intended for the treatment of obesity |
| KR20040041092A (ko) * | 2001-01-31 | 2004-05-13 | 시냅틱 파마세틱칼 코포레이션 | 우울증 및/또는 불안증의 치료를 위한 ｇａｌ3 수용체길항물질의 용도 및 상기와 같은 방법에 유용한 화합물 |
| TWI248438B (en) * | 2001-04-10 | 2006-02-01 | Sod Conseils Rech Applic | Derivatives of heterocycles with 5 members, their preparation and their use as medicaments |
| DE60238999D1 (de) * | 2001-09-26 | 2011-03-03 | Pfizer Italia Srl | Aminoindazolderivate mit kinaseinhibierender wirkung, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen |
| DE10334309A1 (de) * | 2003-07-28 | 2005-03-03 | Aventis Pharma Deutschland Gmbh | Substituierte Thiazol-Benzoisothiazoldioxidderivate, Verfahren zu deren Herstellung und deren Verwendung |
| US20090221655A1 (en) * | 2006-02-01 | 2009-09-03 | Pitzer, Inc. | Antibacterial agents |
| EP2141154A4 (en) * | 2007-03-30 | 2011-06-01 | Inst Med Molecular Design Inc | OXAZOLIDINONE DERIVATIVITY WITH HEMMETIC EFFECT ON TYPE I 11-HYDROXYSTEROIDDEHYDROGENASE |
| EP2123159A1 (de) * | 2008-05-21 | 2009-11-25 | Bayer CropScience AG | (1,2-Benzisothiazol-3-yl)(thio)carbamate und (1,2-Benzisothiazol-3-yl)(thio)oxamate und deren Oxidationsformen als Pestizide |
| WO2011075565A1 (en) * | 2009-12-18 | 2011-06-23 | Janssen Pharmaceutica Nv | SUBSTITUTED AMINOTHIAZOLONE INDAZOLES AS ESTROGEN RELATED RECEPTOR-Aα MODULATORS |
| CN102869660A (zh) * | 2010-02-17 | 2013-01-09 | 詹森药业有限公司 | 作为雌激素相关受体-α调节剂的氨基噻唑酮 |
| WO2016097355A1 (en) * | 2014-12-19 | 2016-06-23 | Ge Healthcare Limited | Labelled oxazolidinone derivatives |
| DE102015012050A1 (de) * | 2015-09-15 | 2017-03-16 | Merck Patent Gmbh | Verbindungen als ASIC-Inhibitoren und deren Verwendungen |
| RU2637643C1 (ru) * | 2016-09-05 | 2017-12-05 | Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт фундаментальной и клинической иммунологии" (НИИФКИ) | Иммунодепрессант |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2076253T3 (es) * | 1989-05-19 | 1995-11-01 | Hoechst Roussel Pharma | N-(ariloxialquil)-heteroarilpiperidinas y -heteroarilpiperazinas, un procedimiento para su preparacion y su uso como medicamentos. |
| US5196543A (en) * | 1989-10-17 | 1993-03-23 | Delalande S.A. | 3-aryloxazolidinone derivatives, process for their preparation and their use in therapy |
| FR2653017B1 (fr) * | 1989-10-17 | 1995-05-05 | Delalande Sa | Derives d'aryl-3 oxazolidinone-2, leur procede de preparation et leur application en therapeutique. |
| US5235063A (en) * | 1989-10-17 | 1993-08-10 | Delalande S.A. | Process of preparing by condensation certain |
| US5182296A (en) * | 1989-10-26 | 1993-01-26 | Tanabe Seiyaky Co., Ltd. | Naphthyloxazolidone derivatives |
| FR2671350A1 (fr) * | 1991-01-08 | 1992-07-10 | Adir | Nouveaux derives de benzisoxazole et de benzisothiazole, leur procede de preparation, et les compositions pharmaceutiques les renfermant. |
| WO1992014418A1 (en) * | 1991-02-20 | 1992-09-03 | Yusaku Koda | Articulator |
-
1996
- 1996-05-28 PL PL96323673A patent/PL183919B1/pl unknown
- 1996-05-28 AU AU61288/96A patent/AU699367B2/en not_active Expired
- 1996-05-28 WO PCT/FR1996/000792 patent/WO1996038444A1/fr not_active Ceased
- 1996-05-28 AT AT96918719T patent/ATE184005T1/de active
- 1996-05-28 HU HU9901349A patent/HU224879B1/hu unknown
- 1996-05-28 EP EP96918719A patent/EP0835254B1/fr not_active Expired - Lifetime
- 1996-05-28 DK DK96918719T patent/DK0835254T3/da active
- 1996-05-28 NZ NZ310487A patent/NZ310487A/xx not_active IP Right Cessation
- 1996-05-28 US US08/973,246 patent/US5843975A/en not_active Expired - Lifetime
- 1996-05-28 RU RU98100257/04A patent/RU2164226C2/ru active
- 1996-05-28 CZ CZ973784A patent/CZ378497A3/cs unknown
- 1996-05-28 JP JP53624596A patent/JP3856829B2/ja not_active Expired - Lifetime
- 1996-05-28 DE DE69604071T patent/DE69604071T2/de not_active Expired - Lifetime
- 1996-05-28 KR KR1019970708666A patent/KR100457502B1/ko not_active Expired - Lifetime
- 1996-05-28 CA CA002223011A patent/CA2223011C/en not_active Expired - Lifetime
- 1996-05-28 CN CN96195713A patent/CN1075072C/zh not_active Expired - Lifetime
- 1996-05-28 ES ES96918719T patent/ES2138346T3/es not_active Expired - Lifetime
- 1996-05-28 SK SK1614-97A patent/SK281934B6/sk not_active IP Right Cessation
- 1996-05-28 BR BR9608896A patent/BR9608896A/pt active IP Right Grant
- 1996-05-31 CO CO96028173A patent/CO4700462A1/es unknown
- 1996-06-01 TW TW085106564A patent/TW360654B/zh not_active IP Right Cessation
- 1996-06-03 AR ARP960102870A patent/AR006301A1/es active IP Right Grant
- 1996-06-03 ZA ZA964563A patent/ZA964563B/xx unknown
-
1997
- 1997-12-01 NO NO975530A patent/NO309091B1/no not_active IP Right Cessation
- 1997-12-02 MX MX9709410A patent/MX9709410A/es unknown
-
1999
- 1999-11-03 GR GR990402802T patent/GR3031710T3/el unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |