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AP9901544A0 - Polymorphs of a crystalline pyrazine-monohydrochloride and their pharmaceutical compositions. - Google Patents

Polymorphs of a crystalline pyrazine-monohydrochloride and their pharmaceutical compositions.

Info

Publication number
AP9901544A0
AP9901544A0 APAP/P/1999/001544A AP9901544A AP9901544A0 AP 9901544 A0 AP9901544 A0 AP 9901544A0 AP 9901544 A AP9901544 A AP 9901544A AP 9901544 A0 AP9901544 A0 AP 9901544A0
Authority
AP
ARIPO
Prior art keywords
monohydrochloride
polymorphs
pyrazine
crystalline
pharmaceutical compositions
Prior art date
Application number
APAP/P/1999/001544A
Inventor
Douglas John Meldrum Allen
Thomas Leonard Staigers
Gregory Randall Young
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of AP9901544A0 publication Critical patent/AP9901544A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Two crystalline polymorphic forms (7s,9as)-7-[3-cyanophenoxy]methyl-2-(5-fluoropyrimidin-2-yl)-2,3,4,6,78,9a-octahydro-1h pyrido [1,2-a]pyrazine-monochloride (the monohydrochloride)are form a and form b. The pharmaceutical composition containing at least one of these polymorphs has advantageous stability for formulation to treat anxiety, depression and psychotic diseases such as affective psychosis, schizophreia, and schizo-affective diorders. The administration of this pharmaceutical composition is oral by preferably by tablet or capsule. A method of making a and b forms is also disclosed.
APAP/P/1999/001544A 1998-05-22 1999-05-20 Polymorphs of a crystalline pyrazine-monohydrochloride and their pharmaceutical compositions. AP9901544A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8641298P 1998-05-22 1998-05-22

Publications (1)

Publication Number Publication Date
AP9901544A0 true AP9901544A0 (en) 1999-06-30

Family

ID=22198401

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/1999/001544A AP9901544A0 (en) 1998-05-22 1999-05-20 Polymorphs of a crystalline pyrazine-monohydrochloride and their pharmaceutical compositions.

Country Status (8)

Country Link
AP (1) AP9901544A0 (en)
AU (1) AU3529899A (en)
GT (1) GT199900060A (en)
MA (1) MA26632A1 (en)
PA (1) PA8470901A1 (en)
TN (1) TNSN99096A1 (en)
WO (1) WO1999061441A1 (en)
ZA (1) ZA993477B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3610890A1 (en) 2012-11-14 2020-02-19 The Johns Hopkins University Methods and compositions for treating schizophrenia

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0783503B1 (en) * 1994-09-30 2001-11-28 Pfizer Inc. 2,7-substituted octahydro-1h-pyrido[ 1,2-a]pyrazine derivatives

Also Published As

Publication number Publication date
AU3529899A (en) 1999-12-13
GT199900060A (en) 2000-10-14
WO1999061441A1 (en) 1999-12-02
PA8470901A1 (en) 2000-09-29
ZA993477B (en) 2000-11-21
MA26632A1 (en) 2004-12-20
TNSN99096A1 (en) 2005-11-10

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