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AP2014007793A0 - Novel morpholinyl derivatives useful as mogat-2 inhibitors - Google Patents

Novel morpholinyl derivatives useful as mogat-2 inhibitors

Info

Publication number
AP2014007793A0
AP2014007793A0 AP2014007793A AP2014007793A AP2014007793A0 AP 2014007793 A0 AP2014007793 A0 AP 2014007793A0 AP 2014007793 A AP2014007793 A AP 2014007793A AP 2014007793 A AP2014007793 A AP 2014007793A AP 2014007793 A0 AP2014007793 A0 AP 2014007793A0
Authority
AP
ARIPO
Prior art keywords
mogat
inhibitors
derivatives useful
novel
morpholinyl derivatives
Prior art date
Application number
AP2014007793A
Other languages
English (en)
Inventor
Maria Rosario Gonzalez-Garcia
Maria Carmen Fernandez
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48905712&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AP2014007793(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of AP2014007793A0 publication Critical patent/AP2014007793A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C07C57/145—Maleic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AP2014007793A 2012-01-31 2013-01-24 Novel morpholinyl derivatives useful as mogat-2 inhibitors AP2014007793A0 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP12382037 2012-01-31
US201261617093P 2012-03-29 2012-03-29
EP12382433 2012-11-06
PCT/US2013/022828 WO2013116065A1 (fr) 2012-01-31 2013-01-24 Nouveaux dérivés morpholynyle utiles comme inhibiteurs de mogat-2

Publications (1)

Publication Number Publication Date
AP2014007793A0 true AP2014007793A0 (en) 2014-07-31

Family

ID=48905712

Family Applications (1)

Application Number Title Priority Date Filing Date
AP2014007793A AP2014007793A0 (en) 2012-01-31 2013-01-24 Novel morpholinyl derivatives useful as mogat-2 inhibitors

Country Status (23)

Country Link
US (1) US8993568B2 (fr)
EP (1) EP2809661B1 (fr)
JP (1) JP5852269B2 (fr)
KR (1) KR20140107641A (fr)
CN (1) CN104080777B (fr)
AP (1) AP2014007793A0 (fr)
AU (1) AU2013215549B2 (fr)
BR (1) BR112014018712A8 (fr)
CA (1) CA2859992A1 (fr)
CL (1) CL2014001862A1 (fr)
CO (1) CO7020914A2 (fr)
CR (1) CR20140325A (fr)
DO (1) DOP2014000177A (fr)
EA (1) EA024182B1 (fr)
ES (1) ES2571577T3 (fr)
GT (1) GT201400169A (fr)
IL (1) IL233542A0 (fr)
MX (1) MX2014008604A (fr)
PE (1) PE20141789A1 (fr)
PH (1) PH12014501712A1 (fr)
SG (1) SG11201404508XA (fr)
WO (1) WO2013116065A1 (fr)
ZA (1) ZA201405227B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2807147A1 (fr) 2012-01-23 2014-12-03 Eli Lilly and Company Dérivés de phényle méthanesulfonamide utilisés comme inhibiteurs mgat - 2
TW201343629A (zh) 2012-01-31 2013-11-01 Lilly Co Eli 可作為ｍｏｇａｔ－２抑制劑之新穎芐磺醯胺衍生物
US8993568B2 (en) 2012-01-31 2015-03-31 Eli Lilly And Company Morpholinyl derivatives useful as MOGAT-2 inhibitors
EA201590696A1 (ru) 2012-11-06 2015-08-31 Эли Лилли Энд Компани Новые бензилсульфонамидные соединения, подходящие в качестве ингибиторов mogat-2
EP3395798A4 (fr) 2015-12-21 2019-07-17 Shionogi & Co., Ltd Dérivé hétérocyclique non-aromatique présentant une activité inhibitrice de mgat2
TWI782056B (zh) 2017-07-14 2022-11-01 日商鹽野義製藥股份有限公司 具有ｍｇａｔ２抑制活性的縮合環衍生物
KR20210114001A (ko) 2019-01-11 2021-09-17 시오노기 앤드 컴파니, 리미티드 Mgat2 저해 활성을 갖는 다이하이드로피라졸로피라지논 유도체

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5889006A (en) 1995-02-23 1999-03-30 Schering Corporation Muscarinic antagonists
GB9702194D0 (en) 1997-02-04 1997-03-26 Lilly Co Eli Sulphonide derivatives
AU5233999A (en) 1998-07-31 2000-02-21 Eli Lilly And Company Alkenyl sulphonamide derivatives
WO2000006083A2 (fr) 1998-07-31 2000-02-10 Eli Lilly And Company Derives de sulfonamide
GB0408777D0 (en) 2004-04-20 2004-05-26 Glaxo Group Ltd Compounds
EP1655283A1 (fr) 2004-11-08 2006-05-10 Evotec OAI AG Inhibiteurs de 11béta-HSD1
EP1659113A1 (fr) 2004-11-08 2006-05-24 Evotec AG Inhibiteurs de 11 beta hydroxy stéroid dehydrogenase type 1 (11beta-HSD1)
WO2008038768A1 (fr) 2006-09-28 2008-04-03 Dainippon Sumitomo Pharma Co., Ltd. Composé ayant une structure de pyrimidine bicyclique et composition pharmaceutique comprenant le composé
TW200831092A (en) * 2006-12-21 2008-08-01 Astrazeneca Ab Therapeutic agents
KR20100097701A (ko) * 2007-12-05 2010-09-03 아스트라제네카 아베 비만 치료제로서의 모르폴린 유도체
CA2709784A1 (fr) 2007-12-21 2009-07-09 University Of Rochester Procede permettant de modifier la duree de vie d'organismes eucaryotes
CN101981025A (zh) 2008-03-28 2011-02-23 万有制药株式会社 具有黑色素浓缩激素受体拮抗作用的二芳基甲基酰胺衍生物
AU2009254547A1 (en) 2008-06-04 2009-12-10 Astrazeneca Ab (Publ) New compounds V
WO2010095767A1 (fr) 2009-02-23 2010-08-26 Banyu Pharmaceutical Co.,Ltd. Dérivés de pyrimidin-4(3h)-one
JP2014051434A (ja) 2010-12-28 2014-03-20 Dainippon Sumitomo Pharma Co Ltd 二環性ピリミジン誘導体
EP2807147A1 (fr) 2012-01-23 2014-12-03 Eli Lilly and Company Dérivés de phényle méthanesulfonamide utilisés comme inhibiteurs mgat - 2
US8993568B2 (en) 2012-01-31 2015-03-31 Eli Lilly And Company Morpholinyl derivatives useful as MOGAT-2 inhibitors
TW201343629A (zh) 2012-01-31 2013-11-01 Lilly Co Eli 可作為ｍｏｇａｔ－２抑制劑之新穎芐磺醯胺衍生物
EA201590696A1 (ru) 2012-11-06 2015-08-31 Эли Лилли Энд Компани Новые бензилсульфонамидные соединения, подходящие в качестве ингибиторов mogat-2

Also Published As

Publication number Publication date
AU2013215549A1 (en) 2014-07-17
MX2014008604A (es) 2014-08-22
KR20140107641A (ko) 2014-09-04
CO7020914A2 (es) 2014-08-11
US20150005305A1 (en) 2015-01-01
BR112014018712A8 (pt) 2017-07-11
EA024182B1 (ru) 2016-08-31
JP5852269B2 (ja) 2016-02-03
CA2859992A1 (fr) 2013-08-08
CL2014001862A1 (es) 2014-11-14
BR112014018712A2 (fr) 2017-06-20
US8993568B2 (en) 2015-03-31
HK1199024A1 (zh) 2015-06-19
CN104080777A (zh) 2014-10-01
PH12014501712B1 (en) 2014-10-13
DOP2014000177A (es) 2014-08-31
ES2571577T3 (es) 2016-05-26
IL233542A0 (en) 2014-08-31
PH12014501712A1 (en) 2014-10-13
ZA201405227B (en) 2016-05-25
EA201491227A1 (ru) 2015-01-30
CR20140325A (es) 2014-08-25
CN104080777B (zh) 2015-12-09
GT201400169A (es) 2015-08-27
JP2015504917A (ja) 2015-02-16
PE20141789A1 (es) 2014-11-19
EP2809661A1 (fr) 2014-12-10
EP2809661B1 (fr) 2016-04-06
AU2013215549B2 (en) 2015-09-03
WO2013116065A1 (fr) 2013-08-08
SG11201404508XA (en) 2014-10-30

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