PE20141789A1 - Nuevos derivados de morofolinilo utiles como inhibidores de mogat-2 - Google Patents
Nuevos derivados de morofolinilo utiles como inhibidores de mogat-2Info
- Publication number
- PE20141789A1 PE20141789A1 PE2014001194A PE2014001194A PE20141789A1 PE 20141789 A1 PE20141789 A1 PE 20141789A1 PE 2014001194 A PE2014001194 A PE 2014001194A PE 2014001194 A PE2014001194 A PE 2014001194A PE 20141789 A1 PE20141789 A1 PE 20141789A1
- Authority
- PE
- Peru
- Prior art keywords
- mogat
- morofolinyl
- inhibitors
- new
- derivatives useful
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 208000006575 hypertriglyceridemia Diseases 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- YUXQSZNZGIKWCP-APBUJDDRSA-N n-[(1s)-1-(4-bromophenyl)-2,2,2-trifluoroethyl]-2-methylpropane-2-sulfinamide Chemical compound CC(C)(C)[S@@](=O)N[C@H](C(F)(F)F)C1=CC=C(Br)C=C1 YUXQSZNZGIKWCP-APBUJDDRSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
- C07C57/13—Dicarboxylic acids
- C07C57/145—Maleic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
- C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA I O UNA SAL FARMACEUTICAMENTE ACEPTABLE DEL MISMO, DONDE: R1 ES -CH3 y -CF3; R2 ES H O -CH3; R3 ES H O -CH3; R4 ES H, HALOGENO; R5 ES H, -CF3, -OCH3 Y HALOGENO; R6 ES H Y HALOGENO. SON COMPUESTOS PREFERIDOS: (N-Z)-N-[(4-BROMOFENIL)METILEN]-(R)-2-METIL-PROPAN-2-SULFINAMIDA; N-[(1S)-1-(4-BROMOFENIL)-2,2,2-TRIFLUORO-ETIL]-(R)-2-METIL-PROPAN-2-SULFINAMIDA; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHO COMPUESTO ES UN INHIBIDOR DE MOGAT-2, UTIL EN EL TRATAMIENTO DE HIPERTRIGLICERIDEMIA.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12382037 | 2012-01-31 | ||
| US201261617093P | 2012-03-29 | 2012-03-29 | |
| EP12382433 | 2012-11-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20141789A1 true PE20141789A1 (es) | 2014-11-19 |
Family
ID=48905712
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2014001194A PE20141789A1 (es) | 2012-01-31 | 2013-01-24 | Nuevos derivados de morofolinilo utiles como inhibidores de mogat-2 |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US8993568B2 (es) |
| EP (1) | EP2809661B1 (es) |
| JP (1) | JP5852269B2 (es) |
| KR (1) | KR20140107641A (es) |
| CN (1) | CN104080777B (es) |
| AP (1) | AP2014007793A0 (es) |
| AU (1) | AU2013215549B2 (es) |
| BR (1) | BR112014018712A8 (es) |
| CA (1) | CA2859992A1 (es) |
| CL (1) | CL2014001862A1 (es) |
| CO (1) | CO7020914A2 (es) |
| CR (1) | CR20140325A (es) |
| DO (1) | DOP2014000177A (es) |
| EA (1) | EA024182B1 (es) |
| ES (1) | ES2571577T3 (es) |
| GT (1) | GT201400169A (es) |
| IL (1) | IL233542A0 (es) |
| MX (1) | MX2014008604A (es) |
| PE (1) | PE20141789A1 (es) |
| PH (1) | PH12014501712A1 (es) |
| SG (1) | SG11201404508XA (es) |
| WO (1) | WO2013116065A1 (es) |
| ZA (1) | ZA201405227B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2807147A1 (en) | 2012-01-23 | 2014-12-03 | Eli Lilly and Company | Phenyl methanesulfonamide derivatives useful as mgat - 2 inhibitors |
| TW201343629A (zh) | 2012-01-31 | 2013-11-01 | Lilly Co Eli | 可作為ｍｏｇａｔ－２抑制劑之新穎芐磺醯胺衍生物 |
| US8993568B2 (en) | 2012-01-31 | 2015-03-31 | Eli Lilly And Company | Morpholinyl derivatives useful as MOGAT-2 inhibitors |
| EA201590696A1 (ru) | 2012-11-06 | 2015-08-31 | Эли Лилли Энд Компани | Новые бензилсульфонамидные соединения, подходящие в качестве ингибиторов mogat-2 |
| EP3395798A4 (en) | 2015-12-21 | 2019-07-17 | Shionogi & Co., Ltd | NON-AROMATIC HETEROCYCLIC DERIVATIVE HAVING MGAT2 INHIBITORY ACTIVITY |
| TWI782056B (zh) | 2017-07-14 | 2022-11-01 | 日商鹽野義製藥股份有限公司 | 具有ｍｇａｔ２抑制活性的縮合環衍生物 |
| KR20210114001A (ko) | 2019-01-11 | 2021-09-17 | 시오노기 앤드 컴파니, 리미티드 | Mgat2 저해 활성을 갖는 다이하이드로피라졸로피라지논 유도체 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5889006A (en) | 1995-02-23 | 1999-03-30 | Schering Corporation | Muscarinic antagonists |
| GB9702194D0 (en) | 1997-02-04 | 1997-03-26 | Lilly Co Eli | Sulphonide derivatives |
| AU5233999A (en) | 1998-07-31 | 2000-02-21 | Eli Lilly And Company | Alkenyl sulphonamide derivatives |
| WO2000006083A2 (en) | 1998-07-31 | 2000-02-10 | Eli Lilly And Company | Sulfonamide derivatives |
| GB0408777D0 (en) | 2004-04-20 | 2004-05-26 | Glaxo Group Ltd | Compounds |
| EP1655283A1 (en) | 2004-11-08 | 2006-05-10 | Evotec OAI AG | 11beta-HSD1 Inhibitors |
| EP1659113A1 (en) | 2004-11-08 | 2006-05-24 | Evotec AG | Inhibitors of 11beta-hydroxy steroid dehydrogenase type 1 (11beta-HSD1) |
| WO2008038768A1 (en) | 2006-09-28 | 2008-04-03 | Dainippon Sumitomo Pharma Co., Ltd. | Compound having bicyclic pyrimidine structure and pharmaceutical composition comprising the compound |
| TW200831092A (en) * | 2006-12-21 | 2008-08-01 | Astrazeneca Ab | Therapeutic agents |
| KR20100097701A (ko) * | 2007-12-05 | 2010-09-03 | 아스트라제네카 아베 | 비만 치료제로서의 모르폴린 유도체 |
| CA2709784A1 (en) | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| CN101981025A (zh) | 2008-03-28 | 2011-02-23 | 万有制药株式会社 | 具有黑色素浓缩激素受体拮抗作用的二芳基甲基酰胺衍生物 |
| AU2009254547A1 (en) | 2008-06-04 | 2009-12-10 | Astrazeneca Ab (Publ) | New compounds V |
| WO2010095767A1 (en) | 2009-02-23 | 2010-08-26 | Banyu Pharmaceutical Co.,Ltd. | Pyrimidin-4(3h)-one derivatives |
| JP2014051434A (ja) | 2010-12-28 | 2014-03-20 | Dainippon Sumitomo Pharma Co Ltd | 二環性ピリミジン誘導体 |
| EP2807147A1 (en) | 2012-01-23 | 2014-12-03 | Eli Lilly and Company | Phenyl methanesulfonamide derivatives useful as mgat - 2 inhibitors |
| US8993568B2 (en) | 2012-01-31 | 2015-03-31 | Eli Lilly And Company | Morpholinyl derivatives useful as MOGAT-2 inhibitors |
| TW201343629A (zh) | 2012-01-31 | 2013-11-01 | Lilly Co Eli | 可作為ｍｏｇａｔ－２抑制劑之新穎芐磺醯胺衍生物 |
| EA201590696A1 (ru) | 2012-11-06 | 2015-08-31 | Эли Лилли Энд Компани | Новые бензилсульфонамидные соединения, подходящие в качестве ингибиторов mogat-2 |
-
2013
- 2013-01-24 US US14/372,833 patent/US8993568B2/en not_active Expired - Fee Related
- 2013-01-24 SG SG11201404508XA patent/SG11201404508XA/en unknown
- 2013-01-24 EP EP13702564.9A patent/EP2809661B1/en active Active
- 2013-01-24 MX MX2014008604A patent/MX2014008604A/es unknown
- 2013-01-24 ES ES13702564T patent/ES2571577T3/es active Active
- 2013-01-24 KR KR1020147021129A patent/KR20140107641A/ko not_active Abandoned
- 2013-01-24 CA CA2859992A patent/CA2859992A1/en not_active Abandoned
- 2013-01-24 PE PE2014001194A patent/PE20141789A1/es not_active Application Discontinuation
- 2013-01-24 CN CN201380007113.8A patent/CN104080777B/zh not_active Expired - Fee Related
- 2013-01-24 JP JP2014554806A patent/JP5852269B2/ja not_active Expired - Fee Related
- 2013-01-24 EA EA201491227A patent/EA024182B1/ru not_active IP Right Cessation
- 2013-01-24 AU AU2013215549A patent/AU2013215549B2/en not_active Ceased
- 2013-01-24 WO PCT/US2013/022828 patent/WO2013116065A1/en not_active Ceased
- 2013-01-24 AP AP2014007793A patent/AP2014007793A0/xx unknown
- 2013-01-24 BR BR112014018712A patent/BR112014018712A8/pt not_active IP Right Cessation
-
2014
- 2014-07-07 IL IL233542A patent/IL233542A0/en unknown
- 2014-07-08 CR CR20140325A patent/CR20140325A/es unknown
- 2014-07-15 CL CL2014001862A patent/CL2014001862A1/es unknown
- 2014-07-16 ZA ZA2014/05227A patent/ZA201405227B/en unknown
- 2014-07-24 CO CO14161421A patent/CO7020914A2/es unknown
- 2014-07-29 GT GT201400169A patent/GT201400169A/es unknown
- 2014-07-30 PH PH12014501712A patent/PH12014501712A1/en unknown
- 2014-07-30 DO DO2014000177A patent/DOP2014000177A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2013215549A1 (en) | 2014-07-17 |
| MX2014008604A (es) | 2014-08-22 |
| KR20140107641A (ko) | 2014-09-04 |
| CO7020914A2 (es) | 2014-08-11 |
| US20150005305A1 (en) | 2015-01-01 |
| BR112014018712A8 (pt) | 2017-07-11 |
| EA024182B1 (ru) | 2016-08-31 |
| JP5852269B2 (ja) | 2016-02-03 |
| CA2859992A1 (en) | 2013-08-08 |
| CL2014001862A1 (es) | 2014-11-14 |
| BR112014018712A2 (es) | 2017-06-20 |
| US8993568B2 (en) | 2015-03-31 |
| HK1199024A1 (zh) | 2015-06-19 |
| CN104080777A (zh) | 2014-10-01 |
| PH12014501712B1 (en) | 2014-10-13 |
| AP2014007793A0 (en) | 2014-07-31 |
| DOP2014000177A (es) | 2014-08-31 |
| ES2571577T3 (es) | 2016-05-26 |
| IL233542A0 (en) | 2014-08-31 |
| PH12014501712A1 (en) | 2014-10-13 |
| ZA201405227B (en) | 2016-05-25 |
| EA201491227A1 (ru) | 2015-01-30 |
| CR20140325A (es) | 2014-08-25 |
| CN104080777B (zh) | 2015-12-09 |
| GT201400169A (es) | 2015-08-27 |
| JP2015504917A (ja) | 2015-02-16 |
| EP2809661A1 (en) | 2014-12-10 |
| EP2809661B1 (en) | 2016-04-06 |
| AU2013215549B2 (en) | 2015-09-03 |
| WO2013116065A1 (en) | 2013-08-08 |
| SG11201404508XA (en) | 2014-10-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20210128A1 (es) | Inhibidores de la ectonucleotido pirofosfatasa-fosfodiesterasa 1 (enpp-1) y usos de los mismos | |
| PE20141682A1 (es) | Derivados de (4-fenilimidazol-2-il) etilamina utiles como moduladores de canal de sodio | |
| PE20141789A1 (es) | Nuevos derivados de morofolinilo utiles como inhibidores de mogat-2 | |
| PE20170705A1 (es) | Nuevos compuestos como inhibidores de ret (reorganizado durante la transfeccion) | |
| PE20121050A1 (es) | Compuestos de n-(1-(4-(1h-pirazol-5-il)ftalazin-1-il)piperidin-4-il)-benzamida sustituidos como antagonistas de la trayectoria hedgehog | |
| PE20170695A1 (es) | Compuestos de indol carboxamida utiles como inhibidores de cinasas | |
| PE20170666A1 (es) | 2-(morfolin-4-il)-1,7-naftiridinas | |
| EA201690223A1 (ru) | Ингибиторы фактора в комплемента на основе производных пиперидинилиндола и их применение | |
| MX383688B (es) | Derivados de piridona amida como agonistas de canales de sodio nav1. 8 y el uso de los mismos en el tratamiento de dolor. | |
| PE20161218A1 (es) | (2s)-n-[(1s)-1-ciano-2-feniletil]-1,4-oxazepan-2-carboxamidas como inhibidores de dipeptidil peptidasa 1 | |
| PE20150709A1 (es) | Benzamidas | |
| BR112016000825A8 (pt) | compostos moduladores de sulfonamidas dos canais de sódio, composição farmacêutica, e uso dos mesmos | |
| PE20161225A1 (es) | 2-amino-3,5,5-trifluoro-3,4,5,6-tetrahidropiridinas como inhibidores de bace1 para el tratamiento de la enfermedad de alzheimer | |
| PE20170331A1 (es) | Derivados quinolina como inhibidores smo | |
| PE20140302A1 (es) | Inhibidores del virus de la hepatitis c | |
| PE20142258A1 (es) | Compuesto heterociclico nitrogenado | |
| CR20150419A (es) | Derivados sustituidos del ácido bisfenil butanóico fosfónico como inhibidores de la nep | |
| EA201690888A1 (ru) | Новые гетероциклические соединения | |
| PE20141679A1 (es) | Derivados de bencil sulfonamida utiles como inhibidores de mogat-2 | |
| EA201400822A1 (ru) | Производные гетероциклических амидов в качестве антагонистов p2xрецептора | |
| EA201890906A1 (ru) | ПРОИЗВОДНЫЕ ХИНОКСАЛИНА И ПИРИДОПИРАЗИНА В КАЧЕСТВЕ ИНГИБИТОРОВ PI3Kβ | |
| PH12018500378B1 (en) | Novel annelated phenoxyacetamides | |
| EA201692300A1 (ru) | Производные карбоксамида | |
| PE20200848A1 (es) | Compuestos derivados de fenilpiridina con actividad dual anti-btk y anti-itk y composiciones farmaceuticas que los contienen | |
| PE20151782A1 (es) | Derivados de azaquinolin-carboxamida |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |