AP2014007598A0 - Estra-1,3,5(10),16-tetraene-3-carboxamide derivatives, process for preparation thereof, pharmaceutical preparations comprising them, and use thereof for production of medicaments - Google Patents

Estra-1,3,5(10),16-tetraene-3-carboxamide derivatives, process for preparation thereof, pharmaceutical preparations comprising them, and use thereof for production of medicaments

Info

Publication number: AP2014007598A0
Authority: AP; ARIPO
Prior art keywords: estra; tetraene; medicaments; preparation; production
Prior art date: 2011-09-29

Application number

AP2014007598A

Other languages

English (en)

Inventor

Ulrich Bothe

Naomi Barak

Ingo Hartung

Original Assignee

Bayer Ip Gmbh

Bayer Pharma AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2011-09-29

Filing date

2012-09-24

Publication date

2014-04-30

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46963705&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AP2014007598(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2012-09-24 Application filed by Bayer Ip Gmbh, Bayer Pharma AG filed Critical Bayer Ip Gmbh

2014-04-30 Publication of AP2014007598A0 publication Critical patent/AP2014007598A0/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Dermatology (AREA)
Reproductive Health (AREA)
Epidemiology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Child & Adolescent Psychology (AREA)
Hematology (AREA)
Obesity (AREA)
Neurosurgery (AREA)
Urology & Nephrology (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Neurology (AREA)
Pulmonology (AREA)
Biomedical Technology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AP2014007598A 2011-09-29 2012-09-24 Estra-1,3,5(10),16-tetraene-3-carboxamide derivatives, process for preparation thereof, pharmaceutical preparations comprising them, and use thereof for production of medicaments AP2014007598A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE102011083725A DE102011083725A1 (de)	2011-09-29	2011-09-29	Estra-1,3,5(10),16-tetraen-3-carboxamid-Derivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate die diese enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln
PCT/EP2012/068803 WO2013045407A1 (de)	2011-09-29	2012-09-24	Estra-1,3,5(10),16-tetraen-3-carboxamid-derivate, verfahren zu ihrer herstellung, pharmazeutische präparate, die diese enthalten, sowie deren verwendung zur herstellung von arzneimitteln

Publications (1)

Publication Number	Publication Date
AP2014007598A0 true AP2014007598A0 (en)	2014-04-30

Family

ID=46963705

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AP2014007598A AP2014007598A0 (en)	2011-09-29	2012-09-24	Estra-1,3,5(10),16-tetraene-3-carboxamide derivatives, process for preparation thereof, pharmaceutical preparations comprising them, and use thereof for production of medicaments

Country Status (42)

Country	Link
US (1)	US9487554B2 (pl)
EP (1)	EP2760878B1 (pl)
JP (1)	JP5791810B2 (pl)
KR (1)	KR20140069013A (pl)
CN (1)	CN103827133B (pl)
AP (1)	AP2014007598A0 (pl)
AR (1)	AR088180A1 (pl)
AU (1)	AU2012314627B2 (pl)
BR (1)	BR112014007223A2 (pl)
CA (1)	CA2850047C (pl)
CL (1)	CL2014000775A1 (pl)
CO (1)	CO6920294A2 (pl)
CR (1)	CR20140144A (pl)
CU (1)	CU20140037A7 (pl)
CY (1)	CY1117123T1 (pl)
DE (1)	DE102011083725A1 (pl)
DK (1)	DK2760878T3 (pl)
DO (1)	DOP2014000059A (pl)
EA (1)	EA025518B9 (pl)
EC (1)	ECSP14013275A (pl)
ES (1)	ES2560257T3 (pl)
GT (1)	GT201400059A (pl)
HR (1)	HRP20160050T1 (pl)
HU (1)	HUE026645T2 (pl)
IL (1)	IL231755A (pl)
JO (1)	JO3122B1 (pl)
MA (1)	MA35455B1 (pl)
MX (1)	MX2014003823A (pl)
MY (1)	MY175804A (pl)
PE (1)	PE20141554A1 (pl)
PH (1)	PH12014500674A1 (pl)
PL (1)	PL2760878T3 (pl)
PT (1)	PT2760878E (pl)
RS (1)	RS54521B1 (pl)
SG (1)	SG11201400144SA (pl)
SI (1)	SI2760878T1 (pl)
TN (1)	TN2014000131A1 (pl)
TW (1)	TWI537284B (pl)
UA (1)	UA107550C2 (pl)
UY (1)	UY34356A (pl)
WO (1)	WO2013045407A1 (pl)
ZA (1)	ZA201401568B (pl)

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PE20150353A1 (es)	2012-07-10	2015-03-28	Bayer Pharma AG	Derivados de estra-1,3,5(10),16-tetraeno 3-sustituidos, metodos para su preparacion, preparaciones farmaceuticas que los contienen, asi como su uso para la preparacion de medicamentos
CN105008382B (zh)	2013-02-21	2018-01-30	拜耳医药股份公司	用于抑制17β‑羟类固醇脱氢酶(AKR1 C3)的雌甾‑1,3,5(10),16‑四烯‑3‑羧酰胺
CA2960630A1 (en) *	2014-09-11	2016-03-17	Bayer Pharma Aktiengesellschaft	3-nitrogen or sulphur substituted oestra-1,3,5(10),16-tetraene akr1c3 inhibitors
US10167293B2 (en)	2016-05-26	2019-01-01	Bayer Pharma Aktiengesellschaft	[8-(phenylsulfonyl)-3,8-diazabicyclo[3.2.1]oct-3-yl](1H-1,2,3-triazol-4-yl)methanones
CZ307437B6 (cs)	2016-06-07	2018-08-22	Ăšstav organickĂ© chemie a biochemie AV ÄŚR, v.v.i.	15β-substituované deriváty estronu jako selektivní inhibitory 17β-hydroxysteoiddehydrogenáz
EP3269373A1 (en) *	2016-07-11	2018-01-17	Bayer Pharma Aktiengesellschaft	Low-dosed oral dosage form of an akr1c3 inhibitor for treatment of diseases
CA3047196A1 (en)	2016-12-19	2018-06-28	Bayer Pharma Aktiengesellschaft	[(phenylsulfonyl)octahydro-epiminoisoindol-yl](1h-1,2,3-triazol-5-yl)methanones
WO2018114672A1 (en)	2016-12-19	2018-06-28	Bayer Pharma Aktiengesellschaft	[4-(phenylsulfonyl)piperazin-1-yl](1h-1,2,3-triazol-4-yl)methanones
TW201825478A (zh)	2016-12-19	2018-07-16	德商拜耳製藥公司	［４－（苯基磺醯基）哌嗪－１－-基］（１ｈ－１，２，３－三唑－４-基）甲酮
EP3421483A1 (en)	2017-06-29	2019-01-02	Bayer Pharma Aktiengesellschaft	Novel steroidal 17-beta heteroaryl compounds as inhibitors of akr1c3
CN108503695B (zh) *	2018-03-09	2021-06-08	南方医科大学南方医院	基于GnRH多肽衍生物的示踪剂及其制备方法和应用
CN110693892A (zh) *	2018-07-09	2020-01-17	深圳艾欣达伟医药科技有限公司	化合物用于制备预防、治疗或改善疼痛的药物的用途
EP3935068B1 (en)	2019-03-06	2023-09-06	Propella Therapeutics, Inc.	Abiraterone prodrugs
CN113683648B (zh) *	2021-08-26	2025-03-07	上海皓鸿生物医药科技有限公司	一种2’-氟-2’-脱氧尿苷的合成方法及其中间体

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US4632003A (en)	1985-07-15	1986-12-30	Kopp William L	Musical instrument sound quality enhancement device
US5604213A (en)	1992-03-31	1997-02-18	British Technology Group Limited	17-substituted steroids useful in cancer treatment
WO1993020097A1 (en) *	1992-03-31	1993-10-14	British Technology Group Ltd.	17-substituted steroids useful in cancer treatment
RU2000125533A (ru)	1998-03-11	2002-10-20	Эндорешерш, Инк. (Ca)	Ингибиторы 17-бета-гидроксистероиддегидрогеназ 5 и 3 типа и способы их применения
US7498322B2 (en)	2004-03-12	2009-03-03	Entremed, Inc.	Antiangiogenic agents
CA2671075A1 (en) *	2006-11-30	2008-06-05	Solvay Pharmaceuticals Gmbh	Substituted estratrien derivatives as 17beta hsd inhibitors
WO2009120565A2 (en)	2008-03-25	2009-10-01	University Of Maryland, Baltimore	Novel prodrugs of c-17-heteroaryl steroidal cyp17 inhibitors/antiandrogens: synthesis, in vitro biological activities, pharmacokinetics and antitumor activity
EP2393827B1 (en)	2009-02-05	2015-10-07	Tokai Pharmaceuticals, Inc.	Novel prodrugs of steroidal cyp17 inhibitors/antiandrogens
MX2012012523A (es)	2010-04-27	2012-12-17	Pharma Mar Sa	Lactonas esteroideas anticancerigenas insaturadas en la posicion 7(8).

2011
- 2011-09-29 DE DE102011083725A patent/DE102011083725A1/de not_active Withdrawn
2012
- 2012-09-24 DK DK12766636.0T patent/DK2760878T3/en active
- 2012-09-24 UA UAA201404419A patent/UA107550C2/uk unknown
- 2012-09-24 RS RS20160023A patent/RS54521B1/sr unknown
- 2012-09-24 AP AP2014007598A patent/AP2014007598A0/xx unknown
- 2012-09-24 HU HUE12766636A patent/HUE026645T2/en unknown
- 2012-09-24 EA EA201490653A patent/EA025518B9/ru not_active IP Right Cessation
- 2012-09-24 ES ES12766636.0T patent/ES2560257T3/es active Active
- 2012-09-24 CA CA2850047A patent/CA2850047C/en not_active Expired - Fee Related
- 2012-09-24 MX MX2014003823A patent/MX2014003823A/es unknown
- 2012-09-24 MY MYPI2014700715A patent/MY175804A/en unknown
- 2012-09-24 PL PL12766636T patent/PL2760878T3/pl unknown
- 2012-09-24 HR HRP20160050TT patent/HRP20160050T1/hr unknown
- 2012-09-24 US US14/348,645 patent/US9487554B2/en not_active Expired - Fee Related
- 2012-09-24 PE PE2014000441A patent/PE20141554A1/es active IP Right Grant
- 2012-09-24 AU AU2012314627A patent/AU2012314627B2/en not_active Ceased
- 2012-09-24 SG SG11201400144SA patent/SG11201400144SA/en unknown
- 2012-09-24 CN CN201280047810.1A patent/CN103827133B/zh not_active Expired - Fee Related
- 2012-09-24 WO PCT/EP2012/068803 patent/WO2013045407A1/de not_active Ceased
- 2012-09-24 BR BR112014007223A patent/BR112014007223A2/pt not_active Application Discontinuation
- 2012-09-24 SI SI201230440T patent/SI2760878T1/sl unknown
- 2012-09-24 PT PT127666360T patent/PT2760878E/pt unknown
- 2012-09-24 EP EP12766636.0A patent/EP2760878B1/de active Active
- 2012-09-24 JP JP2014532337A patent/JP5791810B2/ja not_active Expired - Fee Related
- 2012-09-24 KR KR1020147007566A patent/KR20140069013A/ko not_active Abandoned
- 2012-09-24 PH PH1/2014/500674A patent/PH12014500674A1/en unknown
- 2012-09-27 JO JOP/2012/0285A patent/JO3122B1/ar active
- 2012-09-28 UY UY0001034356A patent/UY34356A/es not_active Application Discontinuation
- 2012-09-28 AR ARP120103610A patent/AR088180A1/es unknown
- 2012-09-28 TW TW101136042A patent/TWI537284B/zh not_active IP Right Cessation
2014
- 2014-02-28 ZA ZA2014/01568A patent/ZA201401568B/en unknown
- 2014-03-27 MA MA36857A patent/MA35455B1/fr unknown
- 2014-03-27 IL IL231755A patent/IL231755A/en active IP Right Grant
- 2014-03-28 EC ECSP14013275 patent/ECSP14013275A/es unknown
- 2014-03-28 CR CR20140144A patent/CR20140144A/es unknown
- 2014-03-28 CU CU2014000037A patent/CU20140037A7/es unknown
- 2014-03-28 DO DO2014000059A patent/DOP2014000059A/es unknown
- 2014-03-28 TN TNP2014000131A patent/TN2014000131A1/en unknown
- 2014-03-28 CL CL2014000775A patent/CL2014000775A1/es unknown
- 2014-03-28 GT GT201400059A patent/GT201400059A/es unknown
- 2014-03-28 CO CO14066898A patent/CO6920294A2/es unknown
2016
- 2016-01-18 CY CY20161100045T patent/CY1117123T1/el unknown

Also Published As

Publication number	Publication date
AU2012314627B2 (en)	2016-08-18
RS54521B1 (sr)	2016-06-30
MY175804A (en)	2020-07-09
AR088180A1 (es)	2014-05-14
UA107550C2 (uk)	2015-01-12
EA025518B9 (ru)	2017-10-31
PE20141554A1 (es)	2014-10-24
DOP2014000059A (es)	2014-06-15
CY1117123T1 (el)	2017-04-05
CN103827133B (zh)	2015-11-25
JP5791810B2 (ja)	2015-10-07
SG11201400144SA (en)	2014-05-29
ZA201401568B (en)	2016-11-30
NZ622081A (en)	2015-10-30
EA025518B1 (ru)	2016-12-30
MA35455B1 (fr)	2014-09-01
CO6920294A2 (es)	2014-04-10
JP2014527994A (ja)	2014-10-23
CN103827133A (zh)	2014-05-28
HUE026645T2 (en)	2016-07-28
UY34356A (es)	2013-04-30
US9487554B2 (en)	2016-11-08
ES2560257T3 (es)	2016-02-18
AU2012314627A1 (en)	2014-04-10
MX2014003823A (es)	2014-06-04
CL2014000775A1 (es)	2014-08-18
PH12014500674A1 (en)	2021-08-09
ECSP14013275A (es)	2014-04-30
IL231755A (en)	2016-06-30
HRP20160050T1 (hr)	2016-02-12
EP2760878A1 (de)	2014-08-06
CU20140037A7 (es)	2014-07-30
EP2760878B1 (de)	2015-10-28
GT201400059A (es)	2015-02-17
CA2850047C (en)	2016-03-29
TN2014000131A1 (en)	2015-07-01
CA2850047A1 (en)	2013-04-04
EA201490653A1 (ru)	2014-09-30
DE102011083725A1 (de)	2013-04-04
DK2760878T3 (en)	2016-01-25
BR112014007223A2 (pt)	2017-04-04
HK1197414A1 (zh)	2015-01-16
WO2013045407A1 (de)	2013-04-04
CR20140144A (es)	2014-05-16
PL2760878T3 (pl)	2016-04-29
TW201317253A (zh)	2013-05-01
KR20140069013A (ko)	2014-06-09
US20140249119A1 (en)	2014-09-04
JO3122B1 (ar)	2017-09-20
SI2760878T1 (sl)	2016-02-29
PT2760878E (pt)	2016-02-26
TWI537284B (zh)	2016-06-11

Publication	Publication Date	Title
ZA201401568B (en)	2016-11-30	Estra-1,3,5(10),16-tetraene-3-carboxamide derivatives, process for preparation thereof, pharmaceutical preparations comprising them, and use thereof for production of medicaments
IL223795A (en)	2015-11-30	History of Tetrahydro-Pyrido-Pyrimidine
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IL227594A (en)	2015-11-30	History of Aminobutyric Replaced as Nephrilicin Inhibitors, their Preparation, Pharmaceutical Preparations Containing Them and Their Use in Medication Preparation
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IL236581A0 (en)	2015-02-26	History of astra-5,3,1 (10), 16-tetrane modified in position 3, methods for their production, pharmaceutical preparations containing them, and their use for the production of drugs
IL223770A0 (en)	2013-03-05	6,7-dihydro-5h-benzo[7]annulene derivatives, methods of production thereof, pharmaceutical preparations containing them, and use thereof for the production of medicinal products
IL232771A0 (en)	2014-08-03	History of 7,6-dihydro-h5-benzo[7]anolane, methods for their production, pharmaceutical preparations containing these history of 7,6-dihydro-5h-benzo[7]anolane and their use for the production of drugs
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