AP2011005717A0 - Uracyl cyclopropyl nucleotides. - Google Patents

Uracyl cyclopropyl nucleotides.

Info

Publication number: AP2011005717A0
Authority: AP; ARIPO
Prior art keywords: uracyl; cyclopropyl; nucleotides; uracyl cyclopropyl; cyclopropyl nucleotides
Prior art date: 2008-12-08

Application number

AP2011005717A

Other languages

English (en)

Inventor

Tim Hugo Maria Jonckers

Koen Vandyck

Steven Maurice Paula Van Hoof

Original Assignee

Centocor Ortho Biotech Products L P

Medivir Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-12-08

Filing date

2009-12-08

Publication date

2011-06-30

2009-12-08 Application filed by Centocor Ortho Biotech Products L P, Medivir Ab filed Critical Centocor Ortho Biotech Products L P

2011-06-30 Publication of AP2011005717A0 publication Critical patent/AP2011005717A0/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Virology (AREA)
Molecular Biology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AP2011005717A 2008-12-08 2009-12-08 Uracyl cyclopropyl nucleotides. AP2011005717A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP08171006		2008-12-08
PCT/EP2009/066562 WO2010066699A1 (en)	2008-12-08	2009-12-08	Uracyl cyclopropyl nucleotides

Publications (1)

Publication Number	Publication Date
AP2011005717A0 true AP2011005717A0 (en)	2011-06-30

Family

ID=40852521

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AP2011005717A AP2011005717A0 (en)	2008-12-08	2009-12-08	Uracyl cyclopropyl nucleotides.

Country Status (21)

Country	Link
US (1)	US8399429B2 (xx)
EP (1)	EP2373671B1 (xx)
JP (1)	JP5683480B2 (xx)
KR (1)	KR20110104000A (xx)
CN (1)	CN102256991B (xx)
AP (1)	AP2011005717A0 (xx)
AR (1)	AR074504A1 (xx)
AU (1)	AU2009326125B2 (xx)
BR (1)	BRPI0922681A2 (xx)
CA (1)	CA2745523C (xx)
CL (1)	CL2011001364A1 (xx)
EA (1)	EA020244B1 (xx)
ES (1)	ES2525007T3 (xx)
IL (1)	IL212897A (xx)
MX (1)	MX2011006023A (xx)
PA (1)	PA8852101A1 (xx)
SG (1)	SG171973A1 (xx)
TW (1)	TW201036989A (xx)
UY (1)	UY32308A (xx)
WO (1)	WO2010066699A1 (xx)
ZA (1)	ZA201104231B (xx)

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JO3027B1 (ar) *	2009-05-14	2016-09-05	Janssen Products Lp	نيوكليوسيدات يوراسيل سبيرواوكسيتان
ES2597757T3 (es)	2012-05-25	2017-01-20	Janssen Sciences Ireland Uc	Nucleósidos de uracilespirooxetano
ES2627195T3 (es) *	2012-11-16	2017-07-27	University College Cardiff Consultants Limited	Mezcla de RP/SP gemcitabina-[fenil-(bencloxi-l-alaninil)]-fosfato
CA2899763C (en) *	2013-03-08	2020-03-10	Nanjing Sanhome Pharmaceutical Co., Ltd.	Nucleoside phosphoramidate compound and use thereof
CN103848876B (zh) *	2013-03-25	2016-05-11	安徽贝克联合制药有限公司	一种核苷磷酰胺前药及其制备方法和其应用
RU2015148006A (ru)	2013-04-12	2017-05-18	Ачиллион Фармасютикалз, Инк.	Дейтерированные нуклеозидные пролекарства, применимые для лечения hcv
CN105348342B (zh) *	2014-09-30	2018-09-21	南京正大天晴制药有限公司	核苷氨基磷酸酯化合物及药物组合物和用途
WO2016073756A1 (en) *	2014-11-06	2016-05-12	Enanta Pharmaceuticals, Inc.	Deuterated nucleoside/tide derivatives
CN105801646B (zh) *	2014-12-31	2019-08-16	浙江大德药业集团有限公司	炔基取代的核苷氨基磷酸酯
WO2016134053A1 (en) *	2015-02-18	2016-08-25	Abbvie Inc.	Anti-viral compounds
WO2016144918A1 (en)	2015-03-06	2016-09-15	Atea Pharmaceuticals, Inc.	β-D-2'-DEOXY-2'α-FLUORO-2'-β-C-SUBSTITUTED-2-MODIFIED-N6-SUBSTITUTED PURINE NUCLEOTIDES FOR HCV TREATMENT
CA2997170A1 (en)	2015-09-02	2017-03-09	Abbvie Inc.	Anti-viral tetrahydrofurane derivatives
US10711029B2 (en)	2016-07-14	2020-07-14	Atea Pharmaceuticals, Inc.	Beta-d-2′-deoxy-2′-alpha-fluoro-2′-beta-c-substituted-4′fluoro-n6-substituted-6-amino-2-substituted purine nucleotides for the treatment of hepatitis c virus infection
SG11201901457TA (en)	2016-09-07	2019-03-28	Atea Pharmaceuticals Inc	2'-substituted-n6-substituted purine nucleotides for rna virus treatment
IL295609B2 (en)	2017-02-01	2023-11-01	Atea Pharmaceuticals Inc	Nucleotide hemisulfate salt for the treatment of hepatitis C virus
CN112351799A (zh)	2018-04-10	2021-02-09	阿堤亚制药公司	具有硬化的hcv感染患者的治疗
US10874687B1 (en)	2020-02-27	2020-12-29	Atea Pharmaceuticals, Inc.	Highly active compounds against COVID-19
JP2024525164A (ja)	2021-06-17	2024-07-10	アテアファーマシューティカルズ，インコーポレイテッド	有利な抗ｈｃｖ併用療法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4916122A (en) *	1987-01-28	1990-04-10	University Of Georgia Research Foundation, Inc.	3'-Azido-2',3'-dideoxyuridine anti-retroviral composition
EP1090914B1 (en)	1992-12-29	2003-01-02	Abbott Laboratories	Retroviral protease inhibiting compounds
US20010021509A1 (en) *	1997-10-23	2001-09-13	Sathe Ganesh Madhusudan	cDNA clone HNEAA81 that encodes a human 7-transmembrane receptor
PT1523489E (pt) *	2002-06-28	2014-06-24	Centre Nat Rech Scient	Profármacos de nucleósido modificado em 2' e 3' para tratamento de infecções por flaviridae
CA2514466C (en) *	2003-02-19	2015-05-26	Yale University	Anti-viral nucleoside analogs and methods for treating viral infections, especially hiv infections
CA2523083C (en) *	2003-04-25	2014-07-08	Gilead Sciences, Inc.	Antiviral phosphonate analogs
CA2600886A1 (en) *	2005-03-08	2006-09-14	Biota Scientific Management Pty Ltd.	Bicyclic nucleosides and nucleotides as therapeutic agents
NZ575889A (en)	2006-10-10	2011-09-30	Medivir Ab	Hcv nucleoside inhibitor

2009
- 2009-12-03 PA PA20098852101A patent/PA8852101A1/es unknown
- 2009-12-07 TW TW098141651A patent/TW201036989A/zh unknown
- 2009-12-07 AR ARP090104736A patent/AR074504A1/es not_active Application Discontinuation
- 2009-12-08 EA EA201170780A patent/EA020244B1/ru not_active IP Right Cessation
- 2009-12-08 ES ES09764845.5T patent/ES2525007T3/es active Active
- 2009-12-08 UY UY0001032308A patent/UY32308A/es unknown
- 2009-12-08 US US13/130,602 patent/US8399429B2/en not_active Expired - Fee Related
- 2009-12-08 JP JP2011539051A patent/JP5683480B2/ja not_active Expired - Fee Related
- 2009-12-08 KR KR1020117015453A patent/KR20110104000A/ko not_active Withdrawn
- 2009-12-08 BR BRPI0922681A patent/BRPI0922681A2/pt not_active Application Discontinuation
- 2009-12-08 MX MX2011006023A patent/MX2011006023A/es active IP Right Grant
- 2009-12-08 CN CN200980150162.0A patent/CN102256991B/zh not_active Expired - Fee Related
- 2009-12-08 EP EP09764845.5A patent/EP2373671B1/en not_active Not-in-force
- 2009-12-08 AP AP2011005717A patent/AP2011005717A0/xx unknown
- 2009-12-08 AU AU2009326125A patent/AU2009326125B2/en not_active Ceased
- 2009-12-08 WO PCT/EP2009/066562 patent/WO2010066699A1/en not_active Ceased
- 2009-12-08 CA CA2745523A patent/CA2745523C/en not_active Expired - Fee Related
- 2009-12-08 SG SG2011040979A patent/SG171973A1/en unknown
2011
- 2011-05-16 IL IL212897A patent/IL212897A/en not_active IP Right Cessation
- 2011-06-07 CL CL2011001364A patent/CL2011001364A1/es unknown
- 2011-06-07 ZA ZA2011/04231A patent/ZA201104231B/en unknown

Also Published As

Publication number	Publication date
ES2525007T3 (es)	2014-12-17
IL212897A0 (en)	2011-07-31
AR074504A1 (es)	2011-01-19
CN102256991B (zh)	2015-08-12
IL212897A (en)	2013-12-31
US8399429B2 (en)	2013-03-19
CN102256991A (zh)	2011-11-23
MX2011006023A (es)	2011-06-28
WO2010066699A1 (en)	2010-06-17
UY32308A (es)	2010-06-30
EA020244B1 (ru)	2014-09-30
ZA201104231B (en)	2012-11-28
SG171973A1 (en)	2011-07-28
CA2745523A1 (en)	2010-06-17
PA8852101A1 (es)	2010-07-27
EP2373671A1 (en)	2011-10-12
US20110230436A1 (en)	2011-09-22
JP2012510980A (ja)	2012-05-17
CA2745523C (en)	2017-07-04
CL2011001364A1 (es)	2011-09-23
AU2009326125B2 (en)	2015-03-12
TW201036989A (en)	2010-10-16
EA201170780A1 (ru)	2011-12-30
EP2373671B1 (en)	2014-09-10
BRPI0922681A2 (pt)	2016-01-05
KR20110104000A (ko)	2011-09-21
AU2009326125A1 (en)	2010-06-17
JP5683480B2 (ja)	2015-03-11

Publication	Publication Date	Title
AP2011005717A0 (en)	2011-06-30	Uracyl cyclopropyl nucleotides.
AP2011005958A0 (en)	2011-10-31	Uracyl spirooxetane nucleosides.
AP2011005929A0 (en)	2011-10-31	Substituted nucleoside and nucleotide analogs.
AP2011005987A0 (en)	2011-12-31	Antiviral compounds.
GB0919264D0 (en)	2009-12-16	Oligonucleotide primers
ZA201008829B (en)	2011-09-28	Nucleoside cyclicphosphates
AP2012006192A0 (en)	2012-04-30	PyrroloÄ2,3-DÜ pyrimidine compounds.
AP2010005505A0 (en)	2010-12-31	Cyclopropyl polymerase inhibitors.
AP2011005695A0 (en)	2011-06-30	Therapeutic antiviral poptides.
ZA201104286B (en)	2012-02-29	Reciprocally-cycled,externally-actuated weapon
GB2477477A9 (en)	2012-10-03	Hob.
AP2011005894A0 (en)	2011-10-31	5-alkynyl-pyridines.
EP2429778A4 (en)	2012-10-31	CHOPPED
AP2011005932A0 (en)	2011-10-31	Pyrazinoisoquinoline Compounds.
GB2476715B (en)	2012-05-02	Eco-F.E.W.L.
AP2011005899A0 (en)	2011-10-31	Plaswall.
GB0919942D0 (en)	2009-12-30	Group specific primers
GB0914855D0 (en)	2009-09-30	Nucleotide
GB0913073D0 (en)	2009-09-02	.
GB0903183D0 (en)	2009-04-08	.
GB0902615D0 (en)	2009-04-01	.
GB0918988D0 (en)	2009-12-16	.
GB0903558D0 (en)	2009-04-08	.
GB0907991D0 (en)	2009-06-24	.
GB0913633D0 (en)	2009-09-16	.