AP2008004470A0 - Spirocyclic quinazoline derivatives as pde7 inhibitors - Google Patents

Spirocyclic quinazoline derivatives as pde7 inhibitors

Info

Publication number: AP2008004470A0
Authority: AP; ARIPO
Prior art keywords: spirocyclic; quinazoline derivatives; pde7 inhibitors; pde7; inhibitors
Prior art date: 2005-12-02

Application number

AP2008004470A

Other languages

English (en)

Inventor

David James Rawson

Nigel Alan Swain

Original Assignee

Pfizer Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-12-02

Filing date

2006-11-23

Publication date

2008-06-30

2006-11-23 Application filed by Pfizer Ltd filed Critical Pfizer Ltd

2008-06-30 Publication of AP2008004470A0 publication Critical patent/AP2008004470A0/xx

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/80—Oxygen atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pulmonology (AREA)
Rheumatology (AREA)
Epidemiology (AREA)
Physical Education & Sports Medicine (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Virology (AREA)
Pain & Pain Management (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Molecular Biology (AREA)
Tropical Medicine & Parasitology (AREA)
AIDS & HIV (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AP2008004470A 2005-12-02 2006-11-23 Spirocyclic quinazoline derivatives as pde7 inhibitors AP2008004470A0 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US74185405P	2005-12-02	2005-12-02
US79118606P	2006-04-10	2006-04-10
PCT/IB2006/003388 WO2007063391A2 (en)	2005-12-02	2006-11-23	Spirocyclic quinazoline derivatives as pde7 inhibitors

Publications (1)

Publication Number	Publication Date
AP2008004470A0 true AP2008004470A0 (en)	2008-06-30

Family

ID=37882213

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AP2008004470A AP2008004470A0 (en)	2005-12-02	2006-11-23	Spirocyclic quinazoline derivatives as pde7 inhibitors

Country Status (22)

Country	Link
US (1)	US7507742B2 (es)
EP (1)	EP1957467A2 (es)
JP (1)	JP2009517453A (es)
KR (1)	KR101009554B1 (es)
AP (1)	AP2008004470A0 (es)
AR (1)	AR058266A1 (es)
AU (1)	AU2006321349A1 (es)
BR (1)	BRPI0619126A2 (es)
CA (1)	CA2631535C (es)
CR (1)	CR10039A (es)
EA (1)	EA200801145A1 (es)
EC (1)	ECSP088484A (es)
GT (1)	GT200600494A (es)
MA (1)	MA30014B1 (es)
ME (1)	MEP0408A (es)
NL (1)	NL2000336C2 (es)
NO (1)	NO20082077L (es)
PE (1)	PE20071087A1 (es)
RS (1)	RS20080233A (es)
TW (1)	TW200732307A (es)
UY (1)	UY29979A1 (es)
WO (1)	WO2007063391A2 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU714980B2 (en)	1996-07-24	2000-01-13	Warner-Lambert Company Llc	Isobutylgaba and its derivatives for the treatment of pain
BRPI0609879A2 (pt) *	2005-04-28	2010-05-11	Pfizer Ltd	derivados de aminoácidos
AU2008230710B2 (en) *	2007-03-27	2014-04-10	Omeros Corporation	The use of PDE7 inhibitors for the treatment of movement disorders
US8637528B2 (en)	2007-03-27	2014-01-28	Omeros Corporation	Use of PDE7 inhibitors for the treatment of movement disorders
US20100216823A1 (en) *	2007-05-24	2010-08-26	Pfizer Inc.	Spirocyclic Derivatives
JP2010043063A (ja)	2008-05-09	2010-02-25	Agency For Science Technology & Research	川崎病の診断及び治療
EP2433124B1 (en) *	2009-05-19	2017-03-01	Vivia Biotech S.L.	Methods for providing personalized medicine tests ex vivo for hematological neoplasms
US9220715B2 (en)	2010-11-08	2015-12-29	Omeros Corporation	Treatment of addiction and impulse-control disorders using PDE7 inhibitors
KR20220047894A (ko)	2010-11-08	2022-04-19	오메로스 코포레이션	Pde7 억제제를 사용한 중독 및 충동-조절 장애의 치료
CU24152B1 (es)	2010-12-20	2016-02-29	Irm Llc	1,2 oxazol-8-azabiciclo[3,2,1]octano 8 il como moduladores de fxr
EP3652180B1 (en) *	2017-07-12	2023-11-29	Dart NeuroScience, LLC	Substituted benzoxazole and benzofuran compounds as pde7 inhibitors
KR20250048344A (ko)	2022-08-18	2025-04-08	미토디큐어 게엠베하	만성 피로, 탈진 및/또는 운동 불내성과 연관된 질환의 치료 및 예방을 위한 포스포디에스테라제-7 억제 활성을 갖는 치료제의 용도

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20030138815A1 (en)	2000-04-28	2003-07-24	Franz-Werner Kluxen	Splice variant of camp phosphodiesterase type7(pde7a3)
AP1699A (en)	2001-03-21	2006-12-26	Warner Lambert Co	New spirotricyclic derivatives and their use as phosphodiesterase-7 inhibitors
EP1400244A1 (en)	2002-09-17	2004-03-24	Warner-Lambert Company LLC	New spirocondensed quinazolinones and their use as phosphodiesterase inhibitors
RU2007132865A (ru) *	2005-03-01	2009-03-10	Пфайзер Лимитед (GB)	Применение ингибиторов pde7 для лечения невропатической боли
WO2006092692A1 (en) *	2005-03-01	2006-09-08	Pfizer Limited	Use of combinations of pde7 inhibitors and alpha-2-delty ligands for the treatment of neuropathic pain

2006
- 2006-11-23 BR BRPI0619126-6A patent/BRPI0619126A2/pt not_active Application Discontinuation
- 2006-11-23 KR KR1020087013205A patent/KR101009554B1/ko not_active Expired - Fee Related
- 2006-11-23 WO PCT/IB2006/003388 patent/WO2007063391A2/en not_active Ceased
- 2006-11-23 EA EA200801145A patent/EA200801145A1/xx unknown
- 2006-11-23 ME MEP-04/08A patent/MEP0408A/xx unknown
- 2006-11-23 CA CA2631535A patent/CA2631535C/en not_active Expired - Fee Related
- 2006-11-23 RS RSP-2008/0233A patent/RS20080233A/sr unknown
- 2006-11-23 JP JP2008542855A patent/JP2009517453A/ja not_active Withdrawn
- 2006-11-23 AP AP2008004470A patent/AP2008004470A0/xx unknown
- 2006-11-23 EP EP06820991A patent/EP1957467A2/en not_active Withdrawn
- 2006-11-23 AU AU2006321349A patent/AU2006321349A1/en not_active Abandoned
- 2006-11-27 NL NL2000336A patent/NL2000336C2/nl not_active IP Right Cessation
- 2006-11-29 PE PE2006001519A patent/PE20071087A1/es not_active Application Discontinuation
- 2006-11-29 GT GT200600494A patent/GT200600494A/es unknown
- 2006-11-30 UY UY29979A patent/UY29979A1/es not_active Application Discontinuation
- 2006-12-01 US US11/565,953 patent/US7507742B2/en not_active Expired - Fee Related
- 2006-12-01 AR ARP060105332A patent/AR058266A1/es unknown
- 2006-12-01 TW TW095144665A patent/TW200732307A/zh unknown
2008
- 2008-05-02 NO NO20082077A patent/NO20082077L/no not_active Application Discontinuation
- 2008-05-29 EC EC2008008484A patent/ECSP088484A/es unknown
- 2008-05-30 CR CR10039A patent/CR10039A/es not_active Application Discontinuation
- 2008-06-02 MA MA30981A patent/MA30014B1/fr unknown

Also Published As

Publication number	Publication date
MEP0408A (xx)	2010-02-10
JP2009517453A (ja)	2009-04-30
GT200600494A (es)	2007-07-06
NO20082077L (no)	2008-06-04
EA200801145A1 (ru)	2008-10-30
WO2007063391A2 (en)	2007-06-07
EP1957467A2 (en)	2008-08-20
TW200732307A (en)	2007-09-01
PE20071087A1 (es)	2007-12-29
AR058266A1 (es)	2008-01-30
NL2000336C2 (nl)	2007-08-07
US7507742B2 (en)	2009-03-24
KR20080059338A (ko)	2008-06-26
AU2006321349A1 (en)	2007-06-07
KR101009554B1 (ko)	2011-01-18
WO2007063391A3 (en)	2007-09-13
BRPI0619126A2 (pt)	2011-09-13
NL2000336A1 (nl)	2007-06-05
UY29979A1 (es)	2007-06-29
ECSP088484A (es)	2008-06-30
US20070129388A1 (en)	2007-06-07
CR10039A (es)	2008-07-10
MA30014B1 (fr)	2008-12-01
CA2631535A1 (en)	2007-06-07
CA2631535C (en)	2010-07-27
RS20080233A (sr)	2009-07-15

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