OA13115A - Beta-carbolines useful for treating inflammatory disease. - Google Patents

Beta-carbolines useful for treating inflammatory disease. Download PDF

Info

Publication number: OA13115A
Authority: OA; OAPI
Prior art keywords: hydrogen; aliphatic; halo; ring; amino
Prior art date: 2003-04-09

Application number

OA1200500279A

Other languages

English (en)

Inventor

Alfredo Castro

Paul E Fleming

Michael E Hepperle

Jeremy D Little

Julie Fields Liu

Hormoz Mazdiyasni

Robert S Murray

Raman Prakash

Dominic Reynolds

Francois Soucy

Yingchun Ye

Original Assignee

Millenium Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-04-09

Filing date

2004-04-09

Publication date

2006-11-10

2004-04-09 Application filed by Millenium Pharmaceuticals Inc filed Critical Millenium Pharmaceuticals Inc

2006-11-10 Publication of OA13115A publication Critical patent/OA13115A/en

Links

208000027866 inflammatory disease Diseases 0.000 title claims abstract description 11
AIFRHYZBTHREPW-UHFFFAOYSA-N β-carboline Chemical class N1=CC=C2C3=CC=CC=C3NC2=C1 AIFRHYZBTHREPW-UHFFFAOYSA-N 0.000 title abstract description 16
150000001875 compounds Chemical class 0.000 claims abstract description 171
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 40
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206010028980 Neoplasm Diseases 0.000 claims abstract description 13
201000011510 cancer Diseases 0.000 claims abstract description 13
239000003112 inhibitor Substances 0.000 claims abstract description 8
125000002757 morpholinyl group Chemical group 0.000 claims abstract description 7
125000004193 piperazinyl group Chemical group 0.000 claims abstract description 6
125000004076 pyridyl group Chemical group 0.000 claims abstract description 6
125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims abstract description 5
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201000006417 multiple sclerosis Diseases 0.000 claims description 88
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Classifications

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- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P17/06—Antipsoriatics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems

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Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
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Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
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Immunology (AREA)
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Neurosurgery (AREA)
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Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Hospice & Palliative Care (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

OA1200500279A 2003-04-09 2004-04-09 Beta-carbolines useful for treating inflammatory disease. OA13115A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US46146803P	2003-04-09	2003-04-09

Publications (1)

Publication Number	Publication Date
OA13115A true OA13115A (en)	2006-11-10

Family

ID=33299818

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
OA1200500279A OA13115A (en)	2003-04-09	2004-04-09	Beta-carbolines useful for treating inflammatory disease.

Country Status (22)

Country	Link
US (2)	US7727985B2 (fr)
EP (1)	EP1611134A1 (fr)
JP (1)	JP2006522824A (fr)
KR (1)	KR20060006031A (fr)
CN (1)	CN1802375A (fr)
AU (1)	AU2004230952A1 (fr)
BR (1)	BRPI0409263A (fr)
CA (1)	CA2521300A1 (fr)
CO (1)	CO5700746A2 (fr)
CR (1)	CR8042A (fr)
EA (1)	EA009121B1 (fr)
EC (1)	ECSP056145A (fr)
HR (1)	HRP20050926A2 (fr)
MA (1)	MA27837A1 (fr)
MX (1)	MXPA05010793A (fr)
NI (1)	NI200500174A (fr)
NO (1)	NO20054598L (fr)
OA (1)	OA13115A (fr)
RS (1)	RS20050832A (fr)
TN (1)	TNSN05257A1 (fr)
WO (1)	WO2004092167A1 (fr)
ZA (1)	ZA200508198B (fr)

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JP2007532582A (ja) *	2004-04-09	2007-11-15	ミレニアム・ファーマシューティカルズ・インコーポレイテッド	炎症性疾患の処置に有用なβ−カルボリン
US8119655B2 (en) *	2005-10-07	2012-02-21	Takeda Pharmaceutical Company Limited	Kinase inhibitors
EP1954290B1 (fr) *	2005-11-22	2012-07-25	Merck Sharp & Dohme Corp.	Composes tricycliques utilises comme inhibiteurs de kinases
US8426355B2 (en) *	2006-03-15	2013-04-23	Theralogics, Inc.	Methods of treating muscular wasting diseases using NF-κB activation inhibitors
WO2008002246A1 (fr) *	2006-06-28	2008-01-03	Astrazeneca Ab	Composition pharmaceutique comprenant un inhibiteur de la ikk2 et un second ingrédient actif
WO2008076265A1 (fr) *	2006-12-13	2008-06-26	Gilead Sciences, Inc.	MONOPHOSPHATES UTILISÉS COMME PROMÉDICAMENTS MUTUELS DE MODULATEURS DE LA TRANSDUCTION DU SIGNAL ANTI-INFLAMMATOIRES ET DE β-AGONISTES DANS LE TRAITEMENT DE L'INFLAMMATON PULMONAIRE ET DE LA BRONCHOCONSTRICTION
US20090137579A1 (en) *	2007-10-23	2009-05-28	Millennium Pharmaceuticals, Inc.	Mesylate salt of an IKK inhibitor
US20090131422A1 (en) *	2007-10-23	2009-05-21	Millennium Pharmaceuticals, Inc.	Salts of an IKK inhibitor
EP2297347B1 (fr)	2008-05-14	2017-03-08	Millennium Pharmaceuticals, Inc.	Méthodes et trousses pour surveiller les effets d'immunomodulateurs sur l'immunité adaptative
KR101323448B1 (ko)	2008-10-02	2013-11-27	아사히 가세이 파마 가부시키가이샤	８위 치환 이소퀴놀린 유도체 및 이의 용도
US8748428B2 (en)	2010-03-30	2014-06-10	Novartis Ag	Use of a PKC inhibitor
DK2691394T3 (en) *	2011-03-28	2017-08-28	Sjt Molecular Res S L	RELATIONSHIPS FOR TREATMENT OF METABOLIC SYNDROME
CN102416014B (zh) *	2011-09-13	2012-11-21	河南中医学院	一种生物碱类成分组合物在制备抗甲型h1n1流感病毒药物中的应用
CN102391323B (zh) *	2011-10-18	2013-09-25	首都医科大学	四氢-β-咔啉衍生物、其制备方法及其用途
KR101646916B1 (ko)	2015-07-13	2016-08-09	강원대학교산학협력단	베타-카르볼린 알칼로이드 화합물을 함유하는 염증성 질환의 예방 또는 치료용 조성물
WO2017067670A1 (fr)	2015-10-23	2017-04-27	Pharmathen S.A.	Nouveau procédé de préparation de tryptamines et de leurs dérivés
CN109593089B (zh) *	2019-01-24	2022-01-28	西南大学	二氮杂螺癸烷哌啶甲酰胺类化合物制备和应用
CN112824387B (zh) *	2019-11-21	2023-03-21	济南尚博生物科技有限公司	一种2-甲基烟酸酯及其制备方法和应用
CN117510494B (zh) *	2023-11-07	2024-04-19	桂林医学院附属医院	β-咔啉-沙利度胺偶联物及其在制备逆转ABT-199耐药的药物中的应用

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CA2402549A1 (fr)	2000-03-15	2001-09-20	Aventis Pharma Deutschland Gmbh	Beta-carbolines substituees ayant une activite inhibitrice de l'ikb-kinase
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ES2286275T3 (es)	2001-09-19	2007-12-01	Pharmacia Corporation	Compuestos de pirazolo sustituidos para el tratamiento de la inflamacion.
DE60217532T8 (de) *	2001-11-07	2008-02-07	Millennium Pharmaceuticals, Inc., Cambridge	Carboline derivate als ikb-inhibitoren zur behandlung des m ultiplen myelomas
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JP2006522824A (ja)	2003-04-09	2006-10-05	ミレニアム・ファーマシューティカルズ・インコーポレイテッド	炎症性疾患を処置するために有用なβ−カルボリン

2004
- 2004-04-09 JP JP2006509889A patent/JP2006522824A/ja active Pending
- 2004-04-09 EP EP04759390A patent/EP1611134A1/fr not_active Withdrawn
- 2004-04-09 OA OA1200500279A patent/OA13115A/en unknown
- 2004-04-09 KR KR1020057019268A patent/KR20060006031A/ko not_active Ceased
- 2004-04-09 CN CNA2004800160170A patent/CN1802375A/zh active Pending
- 2004-04-09 BR BRPI0409263-5A patent/BRPI0409263A/pt not_active IP Right Cessation
- 2004-04-09 RS YUP-2005/0832A patent/RS20050832A/sr unknown
- 2004-04-09 HR HR20050926A patent/HRP20050926A2/hr not_active Application Discontinuation
- 2004-04-09 CA CA002521300A patent/CA2521300A1/fr not_active Abandoned
- 2004-04-09 AU AU2004230952A patent/AU2004230952A1/en not_active Abandoned
- 2004-04-09 WO PCT/US2004/011080 patent/WO2004092167A1/fr not_active Ceased
- 2004-04-09 US US10/821,545 patent/US7727985B2/en not_active Expired - Lifetime
- 2004-04-09 MX MXPA05010793A patent/MXPA05010793A/es active IP Right Grant
- 2004-04-09 EA EA200501584A patent/EA009121B1/ru not_active IP Right Cessation
2005
- 2005-10-06 NO NO20054598A patent/NO20054598L/no not_active Application Discontinuation
- 2005-10-07 NI NI200500174A patent/NI200500174A/es unknown
- 2005-10-07 TN TNP2005000257A patent/TNSN05257A1/en unknown
- 2005-10-11 ZA ZA200508198A patent/ZA200508198B/xx unknown
- 2005-10-12 CR CR8042A patent/CR8042A/es not_active Application Discontinuation
- 2005-11-04 CO CO05113041A patent/CO5700746A2/es not_active Application Discontinuation
- 2005-11-07 EC EC2005006145A patent/ECSP056145A/es unknown
- 2005-11-09 MA MA28592A patent/MA27837A1/fr unknown
2009
- 2009-12-17 US US12/640,335 patent/US20100093713A1/en not_active Abandoned

Also Published As

Publication number	Publication date
NO20054598D0 (no)	2005-10-06
MXPA05010793A (es)	2005-12-05
CO5700746A2 (es)	2006-11-30
NO20054598L (no)	2005-10-27
MA27837A1 (fr)	2006-04-03
CA2521300A1 (fr)	2004-10-28
EA009121B1 (ru)	2007-10-26
HRP20050926A2 (en)	2006-06-30
AU2004230952A1 (en)	2004-10-28
CR8042A (es)	2006-05-30
NI200500174A (es)	2006-04-17
TNSN05257A1 (en)	2007-07-10
WO2004092167A1 (fr)	2004-10-28
BRPI0409263A (pt)	2006-03-28
EA200501584A1 (ru)	2006-06-30
JP2006522824A (ja)	2006-10-05
US20040235839A1 (en)	2004-11-25
US20100093713A1 (en)	2010-04-15
EP1611134A1 (fr)	2006-01-04
ECSP056145A (es)	2006-04-19
CN1802375A (zh)	2006-07-12
RS20050832A (sr)	2007-12-31
US7727985B2 (en)	2010-06-01
WO2004092167A8 (fr)	2006-01-05
KR20060006031A (ko)	2006-01-18
ZA200508198B (en)	2007-01-31

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US20100093713A1 (en)	2010-04-15	Beta-carbolines useful for treating inflammatory disease
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CA2693182C (fr)	2018-01-02	Composes de pyrimidine, procedes de synthese de ceux-ci et utilisation de ceux-ci dans le traitement des troubles medies par la kinase raf
KR20220102156A (ko)	2022-07-19	Bcl6 표적화 모이어티에 연결된 e3 유비퀴틴 리가아제 결합 모이어티를 함유하는 이기능성 분자
EP1735311B1 (fr)	2010-03-31	Utilisation de beta-carbolines pour le traitement de maladies inflammatoires
KR20210006356A (ko)	2021-01-18	단백질분해 조절제 및 연관된 사용 방법
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JP2023537062A (ja)	2023-08-30	Ｃ５ａＲ阻害剤としての化合物
EP1819332A2 (fr)	2007-08-22	Amides d'acide pyrrolopyridine-2-carboxylique
WO2005118583A1 (fr)	2005-12-15	Inhibiteurs de chk-1
KR20230000983A (ko)	2023-01-03	유비퀴틴 프로테오좀 경로를 통해 비티케이 분해작용을 가지는 신규한 이작용성 헤테로사이클릭 화합물과 이의 용도
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WO2009067233A1 (fr)	2009-05-28	Bêta-carbolines et leurs utilisations
WO2011125006A2 (fr)	2011-10-13	Nouveaux composés sultame
AU2014200030A1 (en)	2014-01-23	Pyrimidine Derivatives Useful as Raf Kinase Inhibitors