OA12687A - Oral pharmaceutical composition of cefpodoxime proxetil. - Google Patents
Oral pharmaceutical composition of cefpodoxime proxetil. Download PDFInfo
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- OA12687A OA12687A OA1200300220A OA1200300220A OA12687A OA 12687 A OA12687 A OA 12687A OA 1200300220 A OA1200300220 A OA 1200300220A OA 1200300220 A OA1200300220 A OA 1200300220A OA 12687 A OA12687 A OA 12687A
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- Prior art keywords
- pharmaceutical composition
- composition according
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- daim
- gum
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- LTINZAODLRIQIX-FBXRGJNPSA-N cefpodoxime proxetil Chemical group N([C@H]1[C@@H]2N(C1=O)C(=C(CS2)COC)C(=O)OC(C)OC(=O)OC(C)C)C(=O)C(=N/OC)\C1=CSC(N)=N1 LTINZAODLRIQIX-FBXRGJNPSA-N 0.000 title abstract description 23
- 229960004797 cefpodoxime proxetil Drugs 0.000 title abstract description 23
- 239000008203 oral pharmaceutical composition Substances 0.000 title description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 43
- 239000000203 mixture Substances 0.000 claims description 40
- 239000002245 particle Substances 0.000 claims description 30
- 239000003795 chemical substances by application Substances 0.000 claims description 16
- 229960005090 cefpodoxime Drugs 0.000 claims description 13
- WYUSVOMTXWRGEK-HBWVYFAYSA-N cefpodoxime Chemical compound N([C@H]1[C@@H]2N(C1=O)C(=C(CS2)COC)C(O)=O)C(=O)C(=N/OC)\C1=CSC(N)=N1 WYUSVOMTXWRGEK-HBWVYFAYSA-N 0.000 claims description 13
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- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 7
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- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 5
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- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims description 4
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- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical class OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 claims description 2
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 2
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- SGPGESCZOCHFCL-UHFFFAOYSA-N Tilisolol hydrochloride Chemical compound [Cl-].C1=CC=C2C(=O)N(C)C=C(OCC(O)C[NH2+]C(C)(C)C)C2=C1 SGPGESCZOCHFCL-UHFFFAOYSA-N 0.000 claims 8
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- 229960000502 poloxamer Drugs 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 1
- 235000019814 powdered cellulose Nutrition 0.000 description 1
- 229920003124 powdered cellulose Polymers 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000000651 prodrug Substances 0.000 description 1
- 229940002612 prodrug Drugs 0.000 description 1
- 238000009877 rendering Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 238000004513 sizing Methods 0.000 description 1
- 235000011083 sodium citrates Nutrition 0.000 description 1
- 239000007892 solid unit dosage form Substances 0.000 description 1
- 239000008137 solubility enhancer Substances 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 229940035044 sorbitan monolaurate Drugs 0.000 description 1
- 235000011071 sorbitan monopalmitate Nutrition 0.000 description 1
- 239000001570 sorbitan monopalmitate Substances 0.000 description 1
- 229940031953 sorbitan monopalmitate Drugs 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 238000005550 wet granulation Methods 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 239000002132 β-lactam antibiotic Substances 0.000 description 1
- 229940124586 β-lactam antibiotics Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
- A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN190DE2001 | 2001-02-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| OA12687A true OA12687A (en) | 2006-06-21 |
Family
ID=11097036
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| OA1200300220A OA12687A (en) | 2001-02-27 | 2002-02-27 | Oral pharmaceutical composition of cefpodoxime proxetil. |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP1365764B1 (fr) |
| JP (1) | JP2004522782A (fr) |
| KR (1) | KR20030087009A (fr) |
| CN (1) | CN1505515A (fr) |
| AT (1) | ATE303149T1 (fr) |
| AU (1) | AU2002237462B2 (fr) |
| BR (1) | BR0207640A (fr) |
| DE (1) | DE60205870T2 (fr) |
| EA (1) | EA006974B1 (fr) |
| ES (1) | ES2248521T3 (fr) |
| MX (1) | MXPA03007678A (fr) |
| NZ (1) | NZ527867A (fr) |
| OA (1) | OA12687A (fr) |
| WO (1) | WO2002067943A1 (fr) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6766376B2 (en) | 2000-09-12 | 2004-07-20 | Sn Acquisition, L.L.C | Streaming media buffering system |
| DE60324944D1 (de) * | 2002-08-16 | 2009-01-08 | Orchid Chemicals & Pharm Ltd | Pharmazeutische zusammensetzung mit verzögerte freisetzung enthaltend einen cephalosporin-antibiotikum |
| AU2002321743A1 (en) * | 2002-08-19 | 2004-03-03 | Orchid Health Care | Sustained release pharmaceutical composition of a cephalosporin antibiotic |
| WO2004105728A2 (fr) * | 2003-05-27 | 2004-12-09 | Ranbaxy Laboratories Limited | Dispersions solides de cefpodoxime-proxetil et leurs procedes de preparation |
| EP1883393A2 (fr) * | 2005-05-05 | 2008-02-06 | Lupin Ltd. | Compositions pharmaceutiques stabilisees de cephalosporines |
| EP1915139A1 (fr) * | 2005-05-16 | 2008-04-30 | Elan Pharma International Limited | Compositions nanoparticulaires et à libération contrôlée comprenant une céphalosporine |
| US8900637B2 (en) * | 2005-12-02 | 2014-12-02 | Lupin Limited | Stable taste masked formulations of cephalosporins |
| WO2008057058A1 (fr) * | 2006-11-10 | 2008-05-15 | Nobel Ilac Sanayii Ve Ticaret As | Compositions pharmaceutiques orales |
| CN101278914B (zh) * | 2008-01-02 | 2010-06-02 | 海南三叶美好制药有限公司 | 头孢泊肟酯干混悬剂组合物及其制备方法 |
| TR201001417A1 (tr) * | 2010-02-25 | 2011-09-21 | Sanovel İlaç San. Ve Ti̇c. A. Ş. | Geliştirilmiş çözünme hızına sahip sefdinir formülasyonu |
| TR201002878A2 (tr) | 2010-04-13 | 2011-10-21 | Bi̇lgi̇ç Mahmut | Sefpodoksim proksetil içeren farmasötik bileşimler. |
| EP2575811B1 (fr) * | 2010-06-03 | 2020-08-12 | Mahmut Bilgic | Composition pharmaceutique comprenant cefpodoxime proxetil et acide clavulanique |
| TR201007106A1 (tr) * | 2010-08-25 | 2012-03-21 | Bi̇lgi̇ç Mahmut | Sefpodoksim proksetil formülasyonları. |
| TR201007107A1 (tr) * | 2010-08-25 | 2012-03-21 | B�Lg�� Mahmut | Tat düzenleyici ajan içeren sefpodoksim proksetil formülasyonları. |
| TR201009168A2 (tr) * | 2010-11-05 | 2012-05-21 | Bi̇lgi̇ç Mahmut | Suda dağılan sefpodoksim proksetil formülasyonları. |
| EP2647648B1 (fr) * | 2010-12-03 | 2017-08-09 | Nippon Soda Co., Ltd. | Forme galénique solide contenant de l'HYDROXYALKYLCELLULOSE a faible viscosité |
| JP6062422B2 (ja) * | 2012-03-29 | 2017-01-18 | 杏林製薬株式会社 | カプセル製剤 |
| US10166219B2 (en) | 2012-07-27 | 2019-01-01 | Redhill Bipharma Ltd. | Formulations and methods of manufacturing formulations for use in colonic evacuation |
| CN103142506B (zh) * | 2013-04-03 | 2015-02-25 | 天津医药集团津康制药有限公司 | 一种头孢泊肟酯颗粒剂及其制备方法 |
| JP5651812B1 (ja) | 2013-04-25 | 2015-01-14 | 杏林製薬株式会社 | 固形医薬組成物 |
| JP5700740B1 (ja) * | 2013-04-25 | 2015-04-15 | 杏林製薬株式会社 | 固形医薬組成物 |
| KR101509168B1 (ko) * | 2013-06-10 | 2015-04-06 | 한국화학연구원 | 세팔로스포린 항생제의 서방형 제제 및 이를 포함하는 서방형 약제학적 조성물 |
| CN103301075B (zh) * | 2013-06-28 | 2015-11-18 | 山东罗欣药业集团股份有限公司 | 一种头孢克肟组合物混悬颗粒剂及其制备方法 |
| JP6292788B2 (ja) * | 2013-07-30 | 2018-03-14 | ライオン株式会社 | 錠剤及び錠剤の製造方法 |
| JP2016204260A (ja) * | 2013-10-04 | 2016-12-08 | 日本曹達株式会社 | 錠剤の製造方法 |
| JP6018334B2 (ja) | 2014-10-23 | 2016-11-02 | 杏林製薬株式会社 | 固形医薬組成物 |
| CN104771368B (zh) * | 2015-04-08 | 2017-12-22 | 石家庄四药有限公司 | 头孢泊肟酯速释制剂及其制备方法 |
| CN113456599A (zh) * | 2020-03-30 | 2021-10-01 | 洛阳惠中兽药有限公司 | 一种头孢泊肟酯片的制备方法及其制备的头孢泊肟酯片 |
| CN113952313A (zh) * | 2021-08-26 | 2022-01-21 | 宁夏医科大学 | 一种头孢呋辛酯胶囊及其制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4486425A (en) * | 1980-09-30 | 1984-12-04 | Sankyo Company Limited | 7-[2-(2-Aminothiazol-4-yl)-2-(syn)-methoxyiminoacetamido]-3-methoxymethyl-3-cephem-4-carboxylates |
| US5929086A (en) * | 1996-05-10 | 1999-07-27 | Pharmacia & Upjohn Company | Topical administration of antimicrobial agents for the treatment of systemic bacterial diseases |
| AT500063A1 (de) * | 1999-11-23 | 2005-10-15 | Sandoz Ag | Beschichtete tablettenkerne |
| CA2413251C (fr) * | 2000-06-21 | 2012-06-12 | Cubist Pharmaceuticals, Inc. | Compositions et methodes visant a ameliorer l'absorption orale d'agents anti-microbiens |
-
2002
- 2002-02-27 KR KR10-2003-7011273A patent/KR20030087009A/ko not_active Withdrawn
- 2002-02-27 BR BR0207640-3A patent/BR0207640A/pt not_active Application Discontinuation
- 2002-02-27 ES ES02703777T patent/ES2248521T3/es not_active Expired - Lifetime
- 2002-02-27 DE DE60205870T patent/DE60205870T2/de not_active Expired - Fee Related
- 2002-02-27 MX MXPA03007678A patent/MXPA03007678A/es unknown
- 2002-02-27 EA EA200300937A patent/EA006974B1/ru not_active IP Right Cessation
- 2002-02-27 AT AT02703777T patent/ATE303149T1/de not_active IP Right Cessation
- 2002-02-27 OA OA1200300220A patent/OA12687A/en unknown
- 2002-02-27 JP JP2002567310A patent/JP2004522782A/ja active Pending
- 2002-02-27 WO PCT/IB2002/000602 patent/WO2002067943A1/fr not_active Ceased
- 2002-02-27 NZ NZ52786702A patent/NZ527867A/xx unknown
- 2002-02-27 AU AU2002237462A patent/AU2002237462B2/en not_active Ceased
- 2002-02-27 CN CNA028089766A patent/CN1505515A/zh active Pending
- 2002-02-27 EP EP02703777A patent/EP1365764B1/fr not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EA006974B1 (ru) | 2006-06-30 |
| MXPA03007678A (es) | 2004-03-16 |
| EP1365764A1 (fr) | 2003-12-03 |
| DE60205870T2 (de) | 2006-06-29 |
| KR20030087009A (ko) | 2003-11-12 |
| DE60205870D1 (de) | 2005-10-06 |
| AU2002237462B2 (en) | 2006-05-18 |
| WO2002067943A1 (fr) | 2002-09-06 |
| BR0207640A (pt) | 2004-07-27 |
| JP2004522782A (ja) | 2004-07-29 |
| EP1365764B1 (fr) | 2005-08-31 |
| EA200300937A1 (ru) | 2004-04-29 |
| EP1365764A4 (fr) | 2004-08-11 |
| CN1505515A (zh) | 2004-06-16 |
| ES2248521T3 (es) | 2006-03-16 |
| NZ527867A (en) | 2004-12-24 |
| ATE303149T1 (de) | 2005-09-15 |
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