OA12532A - Salts of a isothiazole-4-carboxamide and their useas anti-hyperproliferation agents. - Google Patents

Salts of a isothiazole-4-carboxamide and their useas anti-hyperproliferation agents. Download PDF

Info

Publication number: OA12532A
Authority: OA; OAPI
Prior art keywords: sait; isothiazole; bromo; benzyloxy; ureido
Prior art date: 2000-11-28

Application number

OA1200300137A

Other languages

English (en)

Inventor

Thomas G Gant

Glenn Robert Williams

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-11-28

Filing date

2001-11-19

Publication date

2006-06-02

2001-11-19 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

2006-06-02 Publication of OA12532A publication Critical patent/OA12532A/en

Links

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Classifications

- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
- C07D275/03—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Dermatology (AREA)
Hematology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Rheumatology (AREA)
Oncology (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Obesity (AREA)
Pain & Pain Management (AREA)
Vascular Medicine (AREA)
Ophthalmology & Optometry (AREA)
Transplantation (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

OA1200300137A 2000-11-28 2001-11-19 Salts of a isothiazole-4-carboxamide and their useas anti-hyperproliferation agents. OA12532A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US25351300P	2000-11-28	2000-11-28

Publications (1)

Publication Number	Publication Date
OA12532A true OA12532A (en)	2006-06-02

Family

ID=22960587

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
OA1200300137A OA12532A (en)	2000-11-28	2001-11-19	Salts of a isothiazole-4-carboxamide and their useas anti-hyperproliferation agents.

Country Status (49)

Country	Link
US (1)	US6831091B2 (xx)
EP (1)	EP1337521B1 (xx)
JP (2)	JP2004514714A (xx)
KR (2)	KR20050116401A (xx)
CN (1)	CN1231474C (xx)
AP (1)	AP2001002358A0 (xx)
AR (1)	AR031512A1 (xx)
AT (1)	ATE340786T1 (xx)
AU (2)	AU2002214204B2 (xx)
BG (1)	BG107752A (xx)
BR (1)	BR0115621A (xx)
CA (1)	CA2430065C (xx)
CR (1)	CR6963A (xx)
CY (1)	CY1106240T1 (xx)
CZ (1)	CZ20031315A3 (xx)
DE (1)	DE60123461T2 (xx)
DK (1)	DK1337521T3 (xx)
DO (1)	DOP2001000288A (xx)
EA (1)	EA005859B1 (xx)
EC (1)	ECSP034628A (xx)
EE (1)	EE200300247A (xx)
ES (1)	ES2271086T3 (xx)
GE (1)	GEP20053652B (xx)
GT (1)	GT200100237A (xx)
HN (1)	HN2001000268A (xx)
HR (1)	HRP20030408A2 (xx)
HU (1)	HUP0302553A3 (xx)
IL (1)	IL155371A0 (xx)
IS (1)	IS6788A (xx)
MA (1)	MA26960A1 (xx)
MX (1)	MXPA03004714A (xx)
MY (1)	MY136686A (xx)
NO (1)	NO325187B1 (xx)
NZ (1)	NZ525788A (xx)
OA (1)	OA12532A (xx)
PA (1)	PA8533801A1 (xx)
PE (1)	PE20020591A1 (xx)
PL (1)	PL362079A1 (xx)
PT (1)	PT1337521E (xx)
SI (1)	SI1337521T1 (xx)
SK (1)	SK5862003A3 (xx)
SV (1)	SV2002000748A (xx)
TN (1)	TNSN01167A1 (xx)
TW (1)	TWI287542B (xx)
UA (1)	UA74221C2 (xx)
UY (1)	UY27039A1 (xx)
WO (1)	WO2002044158A1 (xx)
YU (1)	YU36403A (xx)
ZA (1)	ZA200303341B (xx)

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UA60365C2 (uk) *	1998-06-04	2003-10-15	Пфайзер Продактс Інк.	Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця
US7351834B1 (en)	1999-01-13	2008-04-01	Bayer Pharmaceuticals Corporation	ω-Carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
ATE556713T1 (de)	1999-01-13	2012-05-15	Bayer Healthcare Llc	Omega-carboxyarylsubstituierte-diphenyl- harnstoffe als p38-kinasehemmer
US8124630B2 (en)	1999-01-13	2012-02-28	Bayer Healthcare Llc	ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
AU2003209116A1 (en)	2002-02-11	2003-09-04	Bayer Pharmaceuticals Corporation	Aryl ureas with angiogenesis inhibiting activity
AU2003209119A1 (en)	2002-02-11	2003-09-04	Bayer Pharmaceuticals Corporation	Pyridine, quinoline, and isoquinoline n-oxides as kinase inhibitors
AU2003281664A1 (en) *	2002-07-25	2004-02-16	Pfizer Products Inc.	Isothiazole derivatives useful as anticancer agents
PL375713A1 (en) *	2002-08-19	2005-12-12	Pfizer Products Inc.	Combination therapy for hyperproliferative diseases
PT1636585E (pt)	2003-05-20	2008-03-27	Bayer Pharmaceuticals Corp	Diarilureias com actividade inibidora de cinase
NZ544920A (en)	2003-07-23	2009-11-27	Bayer Healthcare Llc	4{4-[3-(4-chloro-3-trifluoromethylphenyl)-ureido]-3-fluorophenoxy}-pyridine-2-carboxylic acid methylamide and metabolites for the treatment and prevention of diseases and conditions
BRPI0415836A (pt) *	2003-10-27	2007-01-02	Merck & Co Inc	composto, métodos para a modulação da atividade de receptor de quimocina em um mamìfero, e para o tratamento, a melhoria, o controle ou a redução do risco de uma doença ou distúrbio inflamatório e imunorregulatório, e de artrite reumatóide, composição farmacêutica
EP1694686A1 (en)	2003-12-19	2006-08-30	Takeda San Diego, Inc.	Kinase inhibitors
WO2005102327A1 (en) *	2004-04-20	2005-11-03	Pfizer Products Inc.	Dosage forms and methods of treatment using vegfr inhibitors
CA2564325A1 (en)	2004-04-30	2005-11-24	Bayer Pharmaceuticals Corporation	Substituted pyrazolyl urea derivatives useful in the treatment of cancer
TW200538104A (en) *	2004-05-17	2005-12-01	Pfizer Prod Inc	Phenyl derivatives for the treatment of abnormal cell growth
EP1778669A2 (en)	2004-08-18	2007-05-02	Takeda San Diego, Inc.	Kinase inhibitors
ATE479687T1 (de)	2004-10-15	2010-09-15	Takeda Pharmaceutical	Kinaseinhibitoren
US8119655B2 (en)	2005-10-07	2012-02-21	Takeda Pharmaceutical Company Limited	Kinase inhibitors
US8722684B2 (en)	2006-06-16	2014-05-13	H. Lundbeck A/S	1-[2-(2,4-dimethylphenylsulfanyl)-phenyl] piperazine as a compound with combined serotonin reuptake, 5-HT3 and 5-HT1A activity for the treatment of cognitive impairment
US7932390B2 (en)	2006-06-29	2011-04-26	Hoffman-La Roche Inc.	Substituted thieno[3,2-C]pyridine carboxylic acid derivatives
JP2010505962A (ja)	2006-10-09	2010-02-25	武田薬品工業株式会社	キナーゼ阻害剤
MX2010001636A (es)	2007-08-14	2010-03-15	Hoffmann La Roche	Derivados de pirazolo[3,4-d]-pirimidina como agentes antiproliferativos.
WO2011073521A1 (en)	2009-12-15	2011-06-23	Petri Salven	Methods for enriching adult-derived endothelial progenitor cells and uses thereof
US20130177500A1 (en)	2010-07-23	2013-07-11	Trustee Of Boston University	Anti-despr inhibitors as therapeutics for inhibition of pathological angiogenesis and tumor cell invasiveness and for molecular imaging and targeted delivery
CN105142686B (zh) *	2013-03-14	2020-04-10	帕恩欧普佳有限公司	给药于眼后段的眼用制剂
US9814702B2 (en) *	2014-09-17	2017-11-14	Panoptica, Inc.	Ocular formulations for drug-delivery and protection of the anterior segment of the eye
WO2024140850A1 (zh) *	2022-12-28	2024-07-04	苏州必扬医药科技有限公司	一种蛋白酪氨酸激酶抑制剂及其医药用途

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UA60365C2 (uk) *	1998-06-04	2003-10-15	Пфайзер Продактс Інк.	Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця

2001
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2003
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- 2003-05-13 MA MA27158A patent/MA26960A1/fr unknown
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- 2003-05-28 EC EC2003004628A patent/ECSP034628A/es unknown
2006
- 2006-11-13 CY CY20061101645T patent/CY1106240T1/el unknown
2007
- 2007-10-29 JP JP2007279951A patent/JP4971946B2/ja not_active Expired - Lifetime

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PE20020591A1 (es)	2002-07-06
BG107752A (bg)	2004-01-30
EP1337521B1 (en)	2006-09-27
AP2001002358A0 (en)	2001-12-31
IL155371A0 (en)	2003-11-23
GEP20053652B (en)	2005-11-10
US20020151573A1 (en)	2002-10-17
PL362079A1 (en)	2004-10-18
CZ20031315A3 (cs)	2004-04-14
EA005859B1 (ru)	2005-06-30
KR20050116401A (ko)	2005-12-12
SI1337521T1 (sl)	2006-12-31
CA2430065A1 (en)	2002-06-06
CR6963A (es)	2003-11-25
EE200300247A (et)	2003-10-15
TNSN01167A1 (fr)	2005-11-10
NO20032388L (no)	2003-07-18
MXPA03004714A (es)	2003-08-19
TWI287542B (en)	2007-10-01
MY136686A (en)	2008-11-28
HN2001000268A (es)	2002-01-30
US6831091B2 (en)	2004-12-14
NO325187B1 (no)	2008-02-11
HRP20030408A2 (en)	2003-08-31
EP1337521A1 (en)	2003-08-27
NO20032388D0 (no)	2003-05-27
ATE340786T1 (de)	2006-10-15
JP2004514714A (ja)	2004-05-20
SK5862003A3 (en)	2004-05-04
PT1337521E (pt)	2006-12-29
DOP2001000288A (es)	2002-12-15
KR20030059275A (ko)	2003-07-07
CN1231474C (zh)	2005-12-14
AR031512A1 (es)	2003-09-24
DE60123461D1 (de)	2006-11-09
UA74221C2 (uk)	2005-11-15
WO2002044158A1 (en)	2002-06-06
ECSP034628A (es)	2003-07-25
ZA200303341B (en)	2004-04-30
HK1059085A1 (en)	2004-06-18
ES2271086T3 (es)	2007-04-16
DE60123461T2 (de)	2007-02-15
IS6788A (is)	2003-04-14
AU1420402A (en)	2002-06-11
CY1106240T1 (el)	2011-06-08
AU2002214204B2 (en)	2007-05-24
YU36403A (sh)	2006-08-17
MA26960A1 (fr)	2004-12-20
JP4971946B2 (ja)	2012-07-11
JP2008056692A (ja)	2008-03-13
HUP0302553A2 (hu)	2003-11-28
GT200100237A (es)	2002-07-03
BR0115621A (pt)	2003-09-02
CN1476439A (zh)	2004-02-18
NZ525788A (en)	2004-11-26
EA200300424A1 (ru)	2003-10-30
UY27039A1 (es)	2002-07-31
DK1337521T3 (da)	2007-01-29
HUP0302553A3 (en)	2009-03-30
CA2430065C (en)	2008-05-20
SV2002000748A (es)	2002-12-02
PA8533801A1 (es)	2002-10-31

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