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NO20032388L - Salter av et isotiazol-4-karboksamid og anvendelse derav som anti-hyperproliferasjonsmidler - Google Patents

Salter av et isotiazol-4-karboksamid og anvendelse derav som anti-hyperproliferasjonsmidler

Info

Publication number
NO20032388L
NO20032388L NO20032388A NO20032388A NO20032388L NO 20032388 L NO20032388 L NO 20032388L NO 20032388 A NO20032388 A NO 20032388A NO 20032388 A NO20032388 A NO 20032388A NO 20032388 L NO20032388 L NO 20032388L
Authority
NO
Norway
Prior art keywords
isothiazole
carboxamide
salts
hyperproliferative agents
hyperproliferative
Prior art date
Application number
NO20032388A
Other languages
English (en)
Other versions
NO20032388D0 (no
NO325187B1 (no
Inventor
Thomas G Gant
Glenn Robert Williams
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of NO20032388D0 publication Critical patent/NO20032388D0/no
Publication of NO20032388L publication Critical patent/NO20032388L/no
Publication of NO325187B1 publication Critical patent/NO325187B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
    • C07D275/03—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
NO20032388A 2000-11-28 2003-05-27 Hydrobromidsalt og hemisuksinatsalt av et isotiazol-4-karboksamid samt anvendelse og fremstilling derav, og farmasoytisk preparat NO325187B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25351300P 2000-11-28 2000-11-28
PCT/IB2001/002193 WO2002044158A1 (en) 2000-11-28 2001-11-19 Salts of a isothiazole-4-carboxamide and their use as anti-hyperproliferation agents

Publications (3)

Publication Number Publication Date
NO20032388D0 NO20032388D0 (no) 2003-05-27
NO20032388L true NO20032388L (no) 2003-07-18
NO325187B1 NO325187B1 (no) 2008-02-11

Family

ID=22960587

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20032388A NO325187B1 (no) 2000-11-28 2003-05-27 Hydrobromidsalt og hemisuksinatsalt av et isotiazol-4-karboksamid samt anvendelse og fremstilling derav, og farmasoytisk preparat

Country Status (49)

Country Link
US (1) US6831091B2 (no)
EP (1) EP1337521B1 (no)
JP (2) JP2004514714A (no)
KR (2) KR20050116401A (no)
CN (1) CN1231474C (no)
AP (1) AP2001002358A0 (no)
AR (1) AR031512A1 (no)
AT (1) ATE340786T1 (no)
AU (2) AU1420402A (no)
BG (1) BG107752A (no)
BR (1) BR0115621A (no)
CA (1) CA2430065C (no)
CR (1) CR6963A (no)
CY (1) CY1106240T1 (no)
CZ (1) CZ20031315A3 (no)
DE (1) DE60123461T2 (no)
DK (1) DK1337521T3 (no)
DO (1) DOP2001000288A (no)
EA (1) EA005859B1 (no)
EC (1) ECSP034628A (no)
EE (1) EE200300247A (no)
ES (1) ES2271086T3 (no)
GE (1) GEP20053652B (no)
GT (1) GT200100237A (no)
HN (1) HN2001000268A (no)
HR (1) HRP20030408A2 (no)
HU (1) HUP0302553A3 (no)
IL (1) IL155371A0 (no)
IS (1) IS6788A (no)
MA (1) MA26960A1 (no)
MX (1) MXPA03004714A (no)
MY (1) MY136686A (no)
NO (1) NO325187B1 (no)
NZ (1) NZ525788A (no)
OA (1) OA12532A (no)
PA (1) PA8533801A1 (no)
PE (1) PE20020591A1 (no)
PL (1) PL362079A1 (no)
PT (1) PT1337521E (no)
SI (1) SI1337521T1 (no)
SK (1) SK5862003A3 (no)
SV (1) SV2002000748A (no)
TN (1) TNSN01167A1 (no)
TW (1) TWI287542B (no)
UA (1) UA74221C2 (no)
UY (1) UY27039A1 (no)
WO (1) WO2002044158A1 (no)
YU (1) YU36403A (no)
ZA (1) ZA200303341B (no)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA60365C2 (uk) * 1998-06-04 2003-10-15 Пфайзер Продактс Інк. Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця
US8124630B2 (en) 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
US7351834B1 (en) 1999-01-13 2008-04-01 Bayer Pharmaceuticals Corporation ω-Carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
ATE538794T1 (de) 1999-01-13 2012-01-15 Bayer Healthcare Llc Gamma carboxyarylsubstituierte diphenylharnstoffverbindungen als p38 kinasehemmer
MXPA04007832A (es) 2002-02-11 2005-09-08 Bayer Pharmaceuticals Corp Aril-ureas con actividad inhibitoria de angiogenesis.
WO2003068229A1 (en) 2002-02-11 2003-08-21 Bayer Pharmaceuticals Corporation Pyridine, quinoline, and isoquinoline n-oxides as kinase inhibitors
AU2003281664A1 (en) * 2002-07-25 2004-02-16 Pfizer Products Inc. Isothiazole derivatives useful as anticancer agents
RS20050106A (sr) * 2002-08-19 2007-11-15 Pfizer Products Inc., Kombinovana terapija hiperproliferativnih bolesti
EP1636585B2 (en) 2003-05-20 2012-06-13 Bayer HealthCare LLC Diaryl ureas with kinase inhibiting activity
HRP20060073B1 (hr) 2003-07-23 2014-03-14 Bayer Healthcare Llc Fluoro supstituirana omega-karboksiaril difenil urea za lijeäśenje i prevenciju bolesti i stanja
UA81365C2 (en) * 2003-10-27 2007-12-25 Merck & Co Inc Ccr-2 antagonist salt, method for modulation of chemokine receptor activity, method for treating (variants) and pharmaceutical composition
EP1694686A1 (en) 2003-12-19 2006-08-30 Takeda San Diego, Inc. Kinase inhibitors
WO2005102327A1 (en) * 2004-04-20 2005-11-03 Pfizer Products Inc. Dosage forms and methods of treatment using vegfr inhibitors
CN101010315A (zh) 2004-04-30 2007-08-01 拜耳制药公司 用于治疗癌症的取代的吡唑基脲衍生物
TW200538104A (en) * 2004-05-17 2005-12-01 Pfizer Prod Inc Phenyl derivatives for the treatment of abnormal cell growth
JP2008510734A (ja) 2004-08-18 2008-04-10 タケダ サン ディエゴ インコーポレイテッド キナーゼ阻害剤
EP1812439B2 (en) 2004-10-15 2017-12-06 Takeda Pharmaceutical Company Limited Kinase inhibitors
US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
EP2439201B1 (en) 2006-06-16 2013-08-07 H. Lundbeck A/S Compounds with combined sert, 5-ht3 and 5-ht1a activity
US7932390B2 (en) 2006-06-29 2011-04-26 Hoffman-La Roche Inc. Substituted thieno[3,2-C]pyridine carboxylic acid derivatives
JP2010505962A (ja) 2006-10-09 2010-02-25 武田薬品工業株式会社 キナーゼ阻害剤
MX2010001636A (es) 2007-08-14 2010-03-15 Hoffmann La Roche Derivados de pirazolo[3,4-d]-pirimidina como agentes antiproliferativos.
WO2011073521A1 (en) 2009-12-15 2011-06-23 Petri Salven Methods for enriching adult-derived endothelial progenitor cells and uses thereof
ES2979168T3 (es) 2010-07-23 2024-09-24 Univ Boston Inhibidores anti-DEspR como productos terapéuticos para inhibición de angiogénesis patológica e invasividad de células tumorales y para imagenología molecular y administración dirigida
SG11201507316UA (en) * 2013-03-14 2015-10-29 Panoptica Inc Ocular formulations for drug-delivery to the posterior segment of the eye
MA56220A (fr) * 2014-09-17 2022-04-20 Panoptica Inc Formulations oculaires permettant l'administration de médicament et la protection du segment antérieur de l'oeil
WO2024140850A1 (zh) * 2022-12-28 2024-07-04 苏州必扬医药科技有限公司 一种蛋白酪氨酸激酶抑制剂及其医药用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA60365C2 (uk) * 1998-06-04 2003-10-15 Пфайзер Продактс Інк. Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця

Also Published As

Publication number Publication date
EP1337521A1 (en) 2003-08-27
ES2271086T3 (es) 2007-04-16
CA2430065A1 (en) 2002-06-06
PT1337521E (pt) 2006-12-29
CZ20031315A3 (cs) 2004-04-14
EP1337521B1 (en) 2006-09-27
KR20050116401A (ko) 2005-12-12
NZ525788A (en) 2004-11-26
TNSN01167A1 (fr) 2005-11-10
ATE340786T1 (de) 2006-10-15
BR0115621A (pt) 2003-09-02
HRP20030408A2 (en) 2003-08-31
US6831091B2 (en) 2004-12-14
HN2001000268A (es) 2002-01-30
JP2008056692A (ja) 2008-03-13
KR20030059275A (ko) 2003-07-07
EE200300247A (et) 2003-10-15
DK1337521T3 (da) 2007-01-29
PE20020591A1 (es) 2002-07-06
IS6788A (is) 2003-04-14
UA74221C2 (uk) 2005-11-15
US20020151573A1 (en) 2002-10-17
GEP20053652B (en) 2005-11-10
SV2002000748A (es) 2002-12-02
WO2002044158A1 (en) 2002-06-06
OA12532A (en) 2006-06-02
HUP0302553A2 (hu) 2003-11-28
NO20032388D0 (no) 2003-05-27
TWI287542B (en) 2007-10-01
DOP2001000288A (es) 2002-12-15
IL155371A0 (en) 2003-11-23
MA26960A1 (fr) 2004-12-20
CN1231474C (zh) 2005-12-14
EA200300424A1 (ru) 2003-10-30
MY136686A (en) 2008-11-28
GT200100237A (es) 2002-07-03
DE60123461T2 (de) 2007-02-15
HK1059085A1 (en) 2004-06-18
JP4971946B2 (ja) 2012-07-11
EA005859B1 (ru) 2005-06-30
CN1476439A (zh) 2004-02-18
BG107752A (bg) 2004-01-30
AU2002214204B2 (en) 2007-05-24
ECSP034628A (es) 2003-07-25
SK5862003A3 (en) 2004-05-04
AU1420402A (en) 2002-06-11
DE60123461D1 (de) 2006-11-09
HUP0302553A3 (en) 2009-03-30
PL362079A1 (en) 2004-10-18
JP2004514714A (ja) 2004-05-20
CR6963A (es) 2003-11-25
ZA200303341B (en) 2004-04-30
PA8533801A1 (es) 2002-10-31
MXPA03004714A (es) 2003-08-19
YU36403A (sh) 2006-08-17
SI1337521T1 (sl) 2006-12-31
CA2430065C (en) 2008-05-20
AR031512A1 (es) 2003-09-24
NO325187B1 (no) 2008-02-11
CY1106240T1 (el) 2011-06-08
UY27039A1 (es) 2002-07-31
AP2001002358A0 (en) 2001-12-31

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