NO994105L - Hydroksymetylderivater av 2-amino-1,2,3,4-tetrahydronaftalen i form av kardiovaskulaere midler - Google Patents
Hydroksymetylderivater av 2-amino-1,2,3,4-tetrahydronaftalen i form av kardiovaskulaere midlerInfo
- Publication number
- NO994105L NO994105L NO994105A NO994105A NO994105L NO 994105 L NO994105 L NO 994105L NO 994105 A NO994105 A NO 994105A NO 994105 A NO994105 A NO 994105A NO 994105 L NO994105 L NO 994105L
- Authority
- NO
- Norway
- Prior art keywords
- single bond
- hydrogen atom
- alkyl group
- alkyl
- amino
- Prior art date
Links
- 229940125692 cardiovascular agent Drugs 0.000 title 1
- 239000002327 cardiovascular agent Substances 0.000 title 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 title 1
- IMCGHZIGRANKHV-AJNGGQMLSA-N tert-butyl (3s,5s)-2-oxo-5-[(2s,4s)-5-oxo-4-propan-2-yloxolan-2-yl]-3-propan-2-ylpyrrolidine-1-carboxylate Chemical compound O1C(=O)[C@H](C(C)C)C[C@H]1[C@H]1N(C(=O)OC(C)(C)C)C(=O)[C@H](C(C)C)C1 IMCGHZIGRANKHV-AJNGGQMLSA-N 0.000 title 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 abstract 2
- -1 NHCONH 2 Chemical group 0.000 abstract 2
- 125000004760 (C1-C4) alkylsulfonylamino group Chemical group 0.000 abstract 1
- 125000004750 (C1-C6) alkylaminosulfonyl group Chemical group 0.000 abstract 1
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 abstract 1
- 125000003830 C1- C4 alkylcarbonylamino group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001721 carbon Chemical group 0.000 abstract 1
- 229910002091 carbon monoxide Inorganic materials 0.000 abstract 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 1
- 229910052742 iron Inorganic materials 0.000 abstract 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/64—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Forbindelser med formel (II) CH2-CH2-CH3 N-(CH2)rNH-(CH2)s-A. (ID CH2OH hvori r er et helt tall utvalgt fra 5, 6 og 7; s er et helt tall utvalgt fra 2 og 3; A er O eller en enkeltbinding; R'4, R'5 og R'6, like eller forskjel-lige, er hydrogen, OH, halogen, nitro, Cj-C^-alkyl. C^-C,- alkoksy, C^-C^alkyltio, NH2, mono- eller di-C^-C^alkylamino, SH, C1-Ct- alkylsulfonyl, C^C^-alkoksykarbonyl, NHCHO, C,-C4-alkylkarbonylamino, NHCONH2, Ci-C^alkylsulfonylamino, C^C alkylamino-sulfonyl, SO2NH2, NHSO2NH2, COOH, SO3H, CONH2, CH2OH eller fenyl: eller R'4 og R'5/ i ortoposisjon i forhold til hverandre, danner til sammen en kjede på 3 eller 4 grupper utvalgt fra CT'T", CO, S, O og NT"' , hvori T' er et hydrogenatom eller en Cj-C^alkylgruppe, T" er et hydrogenatom, en Cj-C^-alkyl-gruppe eller en aminogruppe, og T"' er et hydrogenatom eller en Cj-C^-alkyl- gruppe; eller T' danner sammen med en naboliggende T" eller T"' en enkelt- binding, eller T"' danner sammen med en naboliggende T' eller T"' en enkelt- binding; Etjernen markerer et asymmetrisk karbonatom; og de farma- søytisk akseptable salter derav som er anvendbare innen det kardiovaskulære område, er beskrevet.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT97MI000415A IT1289980B1 (it) | 1997-02-26 | 1997-02-26 | Derivati idrossimetilici del 2-ammino-1,2,3,4-tetraidronaftalene attivi in campo cardiovascolare |
| PCT/EP1998/000588 WO1998038154A1 (en) | 1997-02-26 | 1998-02-04 | Hydroxymethyl derivatives of 2-amino-1,2,3,4-tetrahydronaphthalene as cardiovascular agent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO994105D0 NO994105D0 (no) | 1999-08-25 |
| NO994105L true NO994105L (no) | 1999-10-26 |
Family
ID=11376183
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO994105A NO994105L (no) | 1997-02-26 | 1999-08-25 | Hydroksymetylderivater av 2-amino-1,2,3,4-tetrahydronaftalen i form av kardiovaskulaere midler |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6232348B1 (no) |
| EP (1) | EP0966423A1 (no) |
| JP (1) | JP2001513090A (no) |
| KR (1) | KR20000075735A (no) |
| AU (1) | AU6394298A (no) |
| CA (1) | CA2282455A1 (no) |
| HU (1) | HUP0001075A3 (no) |
| IT (1) | IT1289980B1 (no) |
| NO (1) | NO994105L (no) |
| NZ (1) | NZ336681A (no) |
| WO (1) | WO1998038154A1 (no) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1289980B1 (it) | 1997-02-26 | 1998-10-19 | Zambon Spa | Derivati idrossimetilici del 2-ammino-1,2,3,4-tetraidronaftalene attivi in campo cardiovascolare |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1224405B (it) | 1987-12-23 | 1990-10-04 | Simes | Composti attivi sul sistema cardiovascolare |
| IT1254521B (it) | 1992-03-17 | 1995-09-25 | Zambon Spa | Derivati della 2-ammino-tetralina attivi sul sistema cardiovascolare |
| IT1271411B (it) | 1993-09-14 | 1997-05-28 | Zambon Spa | Derivati del 2-ammino-1,2,3,4-tetraidro-naftalene attivi sul sistema cardiovascolare |
| IT1271007B (it) | 1994-09-13 | 1997-05-26 | Zambon Spa | Derivati del 2-ammino-1,2,3,4-tetraidronaftalene attivi sul sistema cardiovascolare |
| IT1289980B1 (it) | 1997-02-26 | 1998-10-19 | Zambon Spa | Derivati idrossimetilici del 2-ammino-1,2,3,4-tetraidronaftalene attivi in campo cardiovascolare |
-
1997
- 1997-02-26 IT IT97MI000415A patent/IT1289980B1/it active IP Right Grant
-
1998
- 1998-02-04 HU HU0001075A patent/HUP0001075A3/hu unknown
- 1998-02-04 EP EP98909385A patent/EP0966423A1/en not_active Withdrawn
- 1998-02-04 KR KR1019997007804A patent/KR20000075735A/ko not_active Withdrawn
- 1998-02-04 AU AU63942/98A patent/AU6394298A/en not_active Abandoned
- 1998-02-04 US US09/367,358 patent/US6232348B1/en not_active Expired - Fee Related
- 1998-02-04 CA CA002282455A patent/CA2282455A1/en not_active Abandoned
- 1998-02-04 JP JP53721798A patent/JP2001513090A/ja active Pending
- 1998-02-04 NZ NZ336681A patent/NZ336681A/xx unknown
- 1998-02-04 WO PCT/EP1998/000588 patent/WO1998038154A1/en not_active Ceased
-
1999
- 1999-08-25 NO NO994105A patent/NO994105L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0966423A1 (en) | 1999-12-29 |
| JP2001513090A (ja) | 2001-08-28 |
| ITMI970415A1 (it) | 1998-08-26 |
| HUP0001075A2 (hu) | 2001-06-28 |
| WO1998038154A1 (en) | 1998-09-03 |
| CA2282455A1 (en) | 1998-09-03 |
| IT1289980B1 (it) | 1998-10-19 |
| NO994105D0 (no) | 1999-08-25 |
| AU6394298A (en) | 1998-09-18 |
| US6232348B1 (en) | 2001-05-15 |
| HUP0001075A3 (en) | 2001-07-30 |
| NZ336681A (en) | 2000-09-29 |
| KR20000075735A (ko) | 2000-12-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |