NO980171D0 - Anvendelse av 1,4-dihydropyridin-derivater ved forebyggelse av behandling av aterosklerotisk nedbrytning av arterie-vegger - Google Patents

Anvendelse av 1,4-dihydropyridin-derivater ved forebyggelse av behandling av aterosklerotisk nedbrytning av arterie-vegger

Info

Publication number: NO980171D0
Authority: NO; Norway
Prior art keywords: arterial walls; prevention; treatment; lercanidipine; atherosclerotic
Prior art date: 1995-07-14

Application number

NO980171A

Other languages

English (en)

Norwegian (no)

Other versions

NO980171L (no

Inventor

Abraham Sartani

Amedeo Leonardi

Rudolfo Testa

Original Assignee

Recordati Chem Pharm

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-07-14

Filing date

1998-01-14

Publication date

1998-01-14

1998-01-14 Application filed by Recordati Chem Pharm filed Critical Recordati Chem Pharm

1998-01-14 Publication of NO980171L publication Critical patent/NO980171L/no

1998-01-14 Publication of NO980171D0 publication Critical patent/NO980171D0/no

Links

YNGDWRXWKFWCJY-UHFFFAOYSA-N 1,4-Dihydropyridine Chemical class C1C=CNC=C1 YNGDWRXWKFWCJY-UHFFFAOYSA-N 0.000 title abstract 3
230000003143 atherosclerotic effect Effects 0.000 title abstract 3
230000015556 catabolic process Effects 0.000 title abstract 2
238000006731 degradation reaction Methods 0.000 title abstract 2
230000002265 prevention Effects 0.000 title 1
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
ZDXUKAKRHYTAKV-MGBGTMOVSA-N 5-o-[1-[3,3-diphenylpropyl(methyl)amino]-2-methylpropan-2-yl] 3-o-methyl (4r)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Chemical compound C1([C@H]2C(=C(C)NC(C)=C2C(=O)OC)C(=O)OC(C)(C)CN(C)CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)=CC=CC([N+]([O-])=O)=C1 ZDXUKAKRHYTAKV-MGBGTMOVSA-N 0.000 abstract 1
ZDXUKAKRHYTAKV-XIFFEERXSA-N 5-o-[1-[3,3-diphenylpropyl(methyl)amino]-2-methylpropan-2-yl] 3-o-methyl (4s)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Chemical compound C1([C@@H]2C(=C(C)NC(C)=C2C(=O)OC)C(=O)OC(C)(C)CN(C)CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)=CC=CC([N+]([O-])=O)=C1 ZDXUKAKRHYTAKV-XIFFEERXSA-N 0.000 abstract 1
102000007330 LDL Lipoproteins Human genes 0.000 abstract 1
108010007622 LDL Lipoproteins Proteins 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
ZDXUKAKRHYTAKV-UHFFFAOYSA-N lercanidipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)(C)CN(C)CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)C1C1=CC=CC([N+]([O-])=O)=C1 ZDXUKAKRHYTAKV-UHFFFAOYSA-N 0.000 abstract 1
229960004294 lercanidipine Drugs 0.000 abstract 1
210000002540 macrophage Anatomy 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
230000004060 metabolic process Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
238000013508 migration Methods 0.000 abstract 1
230000005012 migration Effects 0.000 abstract 1
238000012986 modification Methods 0.000 abstract 1
230000004048 modification Effects 0.000 abstract 1
210000000107 myocyte Anatomy 0.000 abstract 1
230000001590 oxidative effect Effects 0.000 abstract 1
230000035755 proliferation Effects 0.000 abstract 1
231100000216 vascular lesion Toxicity 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Urology & Nephrology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Cardiology (AREA)
General Chemical & Material Sciences (AREA)
Vascular Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)

NO980171A 1995-07-14 1998-01-14 Anvendelse av 1,4-dihydropyridin-derivater ved forebyggelse av behandling av aterosklerotisk nedbrytning av arterie-vegger NO980171D0 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
ITMI951513A IT1275532B (it)	1995-07-14	1995-07-14	Uso di derivati 1,4-diidropiridinici per la prevenzione e la terapia della degenerazione aterosclerotica della parete arteriosa
PCT/EP1996/002872 WO1997003669A1 (fr)	1995-07-14	1996-06-28	Utilisation de derives de 1,4 dihydropyridine dans la prevention et la therapie de la degradation atherosclereuse des parois arterielles

Publications (2)

Publication Number	Publication Date
NO980171L NO980171L (no)	1998-01-14
NO980171D0 true NO980171D0 (no)	1998-01-14

Family

ID=11371972

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO980171A NO980171D0 (no)	1995-07-14	1998-01-14	Anvendelse av 1,4-dihydropyridin-derivater ved forebyggelse av behandling av aterosklerotisk nedbrytning av arterie-vegger

Country Status (19)

Country	Link
EP (1)	EP0839036B1 (fr)
JP (1)	JPH11509214A (fr)
KR (1)	KR19990028741A (fr)
CN (1)	CN1190345A (fr)
AT (1)	ATE183644T1 (fr)
AU (1)	AU690471B2 (fr)
CA (1)	CA2219501A1 (fr)
CZ (1)	CZ11698A3 (fr)
DE (1)	DE69603968T2 (fr)
DK (1)	DK0839036T3 (fr)
ES (1)	ES2138359T3 (fr)
GR (1)	GR3031096T3 (fr)
HU (1)	HUP9802736A3 (fr)
IL (1)	IL122302A (fr)
IT (1)	IT1275532B (fr)
NO (1)	NO980171D0 (fr)
SK (1)	SK4198A3 (fr)
WO (1)	WO1997003669A1 (fr)
ZA (1)	ZA965924B (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6852737B2 (en)	2001-08-06	2005-02-08	Recordati Ireland Limited	Crude and crystalline forms of lercanidipine hydrochloride
ITMI20011726A1 (it) *	2001-08-06	2003-02-06	Recordati Ind Chimica E Farma	Forme polimorfe della lercanidipina cloridrato
TW200613275A (en)	2004-08-24	2006-05-01	Recordati Ireland Ltd	Lercanidipine salts
AR053023A1 (es) *	2005-02-25	2007-04-18	Recordati Ireland Ltd	Base libre de lercanidipina, metodos para su preparacion y composiciones farmaceuticas que las contienen
WO2011161223A2 (fr)	2010-06-23	2011-12-29	Krka, Tovarna Zdravil, D.D., Novo Mesto	Formes pharmaceutiques à usage oral comprenant de la lercanidipine et de l'énalapril et leurs sels pharmaceutiquement acceptables
DK2627173T4 (en)	2010-10-12	2018-10-22	Chiesi Farm Spa	CLEVIDIPINE EMULSUM FORMULATIONS CONTAINING ANTIMICROBIANTS
US8658676B2 (en)	2010-10-12	2014-02-25	The Medicines Company	Clevidipine emulsion formulations containing antimicrobial agents
WO2012085249A2 (fr)	2010-12-24	2012-06-28	Krka, D.D., Novo Mesto	Formes pharmaceutiques orales homogènes comprenant de la lercanidipine et de l'énalapril ou leurs sels pharmaceutiquement acceptables

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8403866D0 (en) *	1984-02-14	1984-03-21	Recordati Chem Pharm	Diphenylalkylaminoalkyl esters

1995
- 1995-07-14 IT ITMI951513A patent/IT1275532B/it active IP Right Grant
1996
- 1996-06-28 HU HU9802736A patent/HUP9802736A3/hu unknown
- 1996-06-28 CZ CZ98116A patent/CZ11698A3/cs unknown
- 1996-06-28 CN CN96195439A patent/CN1190345A/zh active Pending
- 1996-06-28 EP EP96924834A patent/EP0839036B1/fr not_active Expired - Lifetime
- 1996-06-28 AT AT96924834T patent/ATE183644T1/de not_active IP Right Cessation
- 1996-06-28 CA CA002219501A patent/CA2219501A1/fr not_active Abandoned
- 1996-06-28 DE DE69603968T patent/DE69603968T2/de not_active Expired - Fee Related
- 1996-06-28 IL IL12230296A patent/IL122302A/xx not_active IP Right Cessation
- 1996-06-28 SK SK41-98A patent/SK4198A3/sk unknown
- 1996-06-28 DK DK96924834T patent/DK0839036T3/da active
- 1996-06-28 JP JP9506222A patent/JPH11509214A/ja active Pending
- 1996-06-28 AU AU65164/96A patent/AU690471B2/en not_active Ceased
- 1996-06-28 ES ES96924834T patent/ES2138359T3/es not_active Expired - Lifetime
- 1996-06-28 KR KR1019980700039A patent/KR19990028741A/ko not_active Withdrawn
- 1996-06-28 WO PCT/EP1996/002872 patent/WO1997003669A1/fr not_active Ceased
- 1996-07-12 ZA ZA965924A patent/ZA965924B/xx unknown
1998
- 1998-01-14 NO NO980171A patent/NO980171D0/no not_active Application Discontinuation
1999
- 1999-08-26 GR GR990402179T patent/GR3031096T3/el unknown

Also Published As

Publication number	Publication date
ITMI951513A0 (it)	1995-07-14
DK0839036T3 (da)	2000-01-24
EP0839036A1 (fr)	1998-05-06
ES2138359T3 (es)	2000-01-01
AU6516496A (en)	1997-02-18
ZA965924B (en)	1997-01-30
ATE183644T1 (de)	1999-09-15
CZ11698A3 (cs)	1998-06-17
DE69603968D1 (de)	1999-09-30
HUP9802736A3 (en)	2000-03-28
CA2219501A1 (fr)	1997-02-06
AU690471B2 (en)	1998-04-23
CN1190345A (zh)	1998-08-12
IL122302A (en)	2000-08-13
NO980171L (no)	1998-01-14
IT1275532B (it)	1997-08-07
WO1997003669A1 (fr)	1997-02-06
KR19990028741A (ko)	1999-04-15
IL122302A0 (en)	1998-04-05
EP0839036B1 (fr)	1999-08-25
HUP9802736A2 (hu)	1999-03-29
JPH11509214A (ja)	1999-08-17
DE69603968T2 (de)	2000-04-06
ITMI951513A1 (it)	1997-01-14
GR3031096T3 (en)	1999-12-31
SK4198A3 (en)	1998-05-06

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Legal Events

Date	Code	Title	Description
2002-03-25	FC2A	Withdrawal, rejection or dismissal of laid open patent application