AR053023A1 - Base libre de lercanidipina, metodos para su preparacion y composiciones farmaceuticas que las contienen - Google Patents
Base libre de lercanidipina, metodos para su preparacion y composiciones farmaceuticas que las contienenInfo
- Publication number
- AR053023A1 AR053023A1 ARP060100640A ARP060100640A AR053023A1 AR 053023 A1 AR053023 A1 AR 053023A1 AR P060100640 A ARP060100640 A AR P060100640A AR P060100640 A ARP060100640 A AR P060100640A AR 053023 A1 AR053023 A1 AR 053023A1
- Authority
- AR
- Argentina
- Prior art keywords
- free base
- lercanidipine
- solution
- lercanidipine free
- organic solvent
- Prior art date
Links
- ZDXUKAKRHYTAKV-UHFFFAOYSA-N lercanidipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)(C)CN(C)CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)C1C1=CC=CC([N+]([O-])=O)=C1 ZDXUKAKRHYTAKV-UHFFFAOYSA-N 0.000 title abstract 15
- 229960004294 lercanidipine Drugs 0.000 title abstract 13
- 239000012458 free base Substances 0.000 title abstract 12
- 238000000034 method Methods 0.000 title abstract 7
- 238000002360 preparation method Methods 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 239000003960 organic solvent Substances 0.000 abstract 5
- 239000000203 mixture Substances 0.000 abstract 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 3
- 239000012074 organic phase Substances 0.000 abstract 2
- 239000000725 suspension Substances 0.000 abstract 2
- 239000012736 aqueous medium Substances 0.000 abstract 1
- 239000008346 aqueous phase Substances 0.000 abstract 1
- 239000002585 base Substances 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 150000007529 inorganic bases Chemical class 0.000 abstract 1
- 239000002244 precipitate Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicinal Preparation (AREA)
- Pyridine Compounds (AREA)
Abstract
Base libre de lercanidipina sustancialmente pura, que tiene una pureza de pro lo menos 95%, preferentemente por lo menos aproximadamente 97 %, más preferentemente por lo menos aproximadamente 99%, y aun más preferentemente por lo menos aproximadamente 99,5%. La base libre de lercanidipina es formada como un solido amorfo que es fácilmente manipulado y particularmente adecuado para la formulacion de composiciones farmacéuticas. Reivindicacion 4: Un método para la preparacion de la base libre de lercanidipina, comprendiendo el método las etapas de: a) disolver una sal de lercanidipina en un solvente orgánico para formar una solucion; b) mezclar la solucion y un medio acuoso que tiene un pH de entre 9 y 14; y c) aislar la base libre de lercanidipina. Reivindicacion 12: Un método para la preparacion de la base libre de lercanidipina, comprendiendo el método las etapas de: a) mezclar una sal de lercanidipina en un solvente orgánico inmiscible en agua y agua para formar una suspension; b) mezclar la suspension y una base inorgánica; c) separar la fase orgánica de la fase acuosa; d) evaporar el solvente de la fase orgánica para producir la base libre de lercanidipina; e) disolver la base libre de lercanidipina en un solvente orgánico miscible en agua para formar una solucion; f) precipitar la base libre de lercanidipina de la solucion; y g) aislar la base libre de lercanidipina. Reivindicacion 19: Un método para la preparacion de la base libre de lercanidipina, comprendiendo el método las etapas de: a) disolver una sal de lercanidipina en un primer solvente orgánico para formar una solucion; b) mezclar la solucion de la etapa a) con una solucion de una base en un segundo solvente orgánico; c) mezclar la solucion de la etapa b) con agua; y d) aislar la base libre de lercanidipina.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65674105P | 2005-02-25 | 2005-02-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR053023A1 true AR053023A1 (es) | 2007-04-18 |
Family
ID=36587241
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060100640A AR053023A1 (es) | 2005-02-25 | 2006-02-22 | Base libre de lercanidipina, metodos para su preparacion y composiciones farmaceuticas que las contienen |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20060199849A1 (es) |
| EP (1) | EP1853562A1 (es) |
| JP (1) | JP2008531516A (es) |
| KR (1) | KR20070105978A (es) |
| CN (1) | CN101142186A (es) |
| AR (1) | AR053023A1 (es) |
| AU (1) | AU2006218027A1 (es) |
| BR (1) | BRPI0608136A2 (es) |
| CA (1) | CA2597992A1 (es) |
| EA (1) | EA200701686A1 (es) |
| IL (1) | IL184348A0 (es) |
| MX (1) | MX2007010362A (es) |
| NO (1) | NO20074873L (es) |
| PE (1) | PE20061393A1 (es) |
| TW (1) | TW200640860A (es) |
| UY (1) | UY29400A1 (es) |
| WO (1) | WO2006089788A1 (es) |
| ZA (1) | ZA200708126B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100651212B1 (ko) * | 2004-10-27 | 2006-12-01 | 제일약품주식회사 | 무정형 레르카니디핀의 제조방법 |
| WO2008040367A1 (en) * | 2006-08-01 | 2008-04-10 | Union Quimico-Farmaceutica S.A. | Lercanidipine hydrobromide, a process for its preparation, crystalline forms and compositions thereof |
| DE102010005124A1 (de) * | 2010-01-19 | 2012-03-01 | Stada Arzneimittel Ag | Feste pharmazeutische Zusammensetzung umfassend Lercanidipin |
| CN102531999B (zh) * | 2011-12-16 | 2014-02-26 | 华润赛科药业有限责任公司 | 无定形盐酸乐卡地平及其制备方法 |
| CN102558032B (zh) * | 2011-12-16 | 2014-02-26 | 华润赛科药业有限责任公司 | 一种无定形盐酸乐卡地平及其制备方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8403866D0 (en) * | 1984-02-14 | 1984-03-21 | Recordati Chem Pharm | Diphenylalkylaminoalkyl esters |
| US5696139A (en) * | 1995-05-12 | 1997-12-09 | Recordati S.A., Chemical And Pharmaceutical Company | Use of S-enantiomers of 1,4-dihydropyridine derivatives for treating heart failure |
| US5767136A (en) * | 1995-05-12 | 1998-06-16 | Recordati, S.A. Chemical And Pharmaceutical Company | 1,4-Dihydropyridines useful for prevention or reduction of atherosclerotic lesions on arterial walls |
| IT1275532B (it) * | 1995-07-14 | 1997-08-07 | Recordati Chem Pharm | Uso di derivati 1,4-diidropiridinici per la prevenzione e la terapia della degenerazione aterosclerotica della parete arteriosa |
| IT1298732B1 (it) * | 1998-03-13 | 2000-02-02 | Recordati Chem Pharm | Composizioni farmaceutiche orali assumibili senza liquidi,contenenti complessi di inclusione |
| US6852737B2 (en) * | 2001-08-06 | 2005-02-08 | Recordati Ireland Limited | Crude and crystalline forms of lercanidipine hydrochloride |
| US20030069285A1 (en) * | 2001-08-06 | 2003-04-10 | Recordati Ireland Limited | Novel solvate and crystalline forms of lercanidipine hydrochloride |
| US20030180355A1 (en) * | 2001-10-16 | 2003-09-25 | Amedeo Leonardi | Combination therapy for hypertension |
| WO2004035051A1 (en) * | 2002-10-16 | 2004-04-29 | Recordati Ireland Limited | Lisinopril/lercanidipine combination therapy |
| US20040147566A1 (en) * | 2002-10-16 | 2004-07-29 | Amedeo Leonardi | Lisinopril/lercanidipine combination therapy |
| US20040198789A1 (en) * | 2003-02-28 | 2004-10-07 | Recordati Ireland Limited | Lercanidipine/ARB/diuretic therapeutic combinations |
| WO2005053689A2 (en) * | 2003-12-01 | 2005-06-16 | Lifecycle Pharma A/S | Pharmaceutical compositions comprising lercanidipine |
| TW200613275A (en) * | 2004-08-24 | 2006-05-01 | Recordati Ireland Ltd | Lercanidipine salts |
| TW200616681A (en) * | 2004-10-05 | 2006-06-01 | Recordati Ireland Ltd | Lercanidipine capsules |
-
2006
- 2006-02-22 AR ARP060100640A patent/AR053023A1/es not_active Application Discontinuation
- 2006-02-24 WO PCT/EP2006/001783 patent/WO2006089788A1/en not_active Ceased
- 2006-02-24 PE PE2006000225A patent/PE20061393A1/es not_active Application Discontinuation
- 2006-02-24 KR KR1020077017757A patent/KR20070105978A/ko not_active Withdrawn
- 2006-02-24 TW TW095106335A patent/TW200640860A/zh unknown
- 2006-02-24 AU AU2006218027A patent/AU2006218027A1/en not_active Abandoned
- 2006-02-24 UY UY29400A patent/UY29400A1/es unknown
- 2006-02-24 MX MX2007010362A patent/MX2007010362A/es not_active Application Discontinuation
- 2006-02-24 BR BRPI0608136-3A patent/BRPI0608136A2/pt not_active Application Discontinuation
- 2006-02-24 CA CA002597992A patent/CA2597992A1/en not_active Abandoned
- 2006-02-24 EP EP06723129A patent/EP1853562A1/en not_active Withdrawn
- 2006-02-24 JP JP2007556566A patent/JP2008531516A/ja not_active Withdrawn
- 2006-02-24 EA EA200701686A patent/EA200701686A1/ru unknown
- 2006-02-24 CN CNA2006800055031A patent/CN101142186A/zh active Pending
- 2006-02-27 US US11/364,861 patent/US20060199849A1/en not_active Abandoned
-
2007
- 2007-07-02 IL IL184348A patent/IL184348A0/en unknown
- 2007-09-21 ZA ZA200708126A patent/ZA200708126B/xx unknown
- 2007-09-25 NO NO20074873A patent/NO20074873L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2006218027A1 (en) | 2006-08-31 |
| ZA200708126B (en) | 2008-11-26 |
| TW200640860A (en) | 2006-12-01 |
| KR20070105978A (ko) | 2007-10-31 |
| PE20061393A1 (es) | 2007-01-16 |
| CN101142186A (zh) | 2008-03-12 |
| UY29400A1 (es) | 2006-06-30 |
| NO20074873L (no) | 2007-11-22 |
| CA2597992A1 (en) | 2006-08-31 |
| WO2006089788A1 (en) | 2006-08-31 |
| EA200701686A1 (ru) | 2008-02-28 |
| IL184348A0 (en) | 2007-10-31 |
| EP1853562A1 (en) | 2007-11-14 |
| BRPI0608136A2 (pt) | 2009-11-17 |
| MX2007010362A (es) | 2007-10-17 |
| US20060199849A1 (en) | 2006-09-07 |
| JP2008531516A (ja) | 2008-08-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |