NO984470L - Pyrrolopyrrolon-derivater som inhibitorer for neutrofil elastase - Google Patents

Pyrrolopyrrolon-derivater som inhibitorer for neutrofil elastase

Info

Publication number: NO984470L
Authority: NO; Norway
Prior art keywords: inhibitors; neutrophil elastase; compounds; pyrrolopyrrolone; derivatives
Prior art date: 1996-03-28

Application number

NO984470A

Other languages

English (en)

Norwegian (no)

Other versions

NO984470D0 (no

Inventor

Michael Dennis Dowle

Harry Finch

Lee Andrew Harrison

Graham George Adam Inglis

Martin Redpath Johnson

Simon John Fawcett Macdonald

Pritom Shah

Robin Andrew Smith

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-03-28

Filing date

1998-09-25

Publication date

1998-11-25

1996-03-28 Priority claimed from GBGB9606508.1A external-priority patent/GB9606508D0/en

1996-11-05 Priority claimed from GBGB9623001.6A external-priority patent/GB9623001D0/en

1998-09-25 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

1998-09-25 Publication of NO984470D0 publication Critical patent/NO984470D0/no

1998-11-25 Publication of NO984470L publication Critical patent/NO984470L/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/14—Nitrogen atoms not forming part of a nitro radical

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Urology & Nephrology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Dermatology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Vascular Medicine (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyrrole Compounds (AREA)

NO984470A 1996-03-28 1998-09-25 Pyrrolopyrrolon-derivater som inhibitorer for neutrofil elastase NO984470L (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB9606508.1A GB9606508D0 (en)	1996-03-28	1996-03-28	Chemical componds
GBGB9623001.6A GB9623001D0 (en)	1996-11-05	1996-11-05	Chemical compounds
PCT/EP1997/001530 WO1997036903A1 (fr)	1996-03-28	1997-03-26	Derives du pyrrolopyrrolone utilises comme inhibiteurs de l'elastase de neutrophiles

Publications (2)

Publication Number	Publication Date
NO984470D0 NO984470D0 (no)	1998-09-25
NO984470L true NO984470L (no)	1998-11-25

Family

ID=26309008

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO984470A NO984470L (no)	1996-03-28	1998-09-25	Pyrrolopyrrolon-derivater som inhibitorer for neutrofil elastase

Country Status (30)

Country	Link
US (3)	US5994344A (fr)
EP (1)	EP0891362B1 (fr)
JP (1)	JP4118337B2 (fr)
KR (1)	KR20000005039A (fr)
CN (1)	CN1067075C (fr)
AP (1)	AP823A (fr)
AR (1)	AR006401A1 (fr)
AT (1)	ATE261969T1 (fr)
AU (1)	AU726649B2 (fr)
BR (1)	BR9708449A (fr)
CA (1)	CA2250209A1 (fr)
CO (1)	CO4790152A1 (fr)
CZ (1)	CZ309798A3 (fr)
DE (1)	DE69728139T2 (fr)
DK (1)	DK0891362T3 (fr)
EA (1)	EA001437B1 (fr)
EE (1)	EE9800335A (fr)
ES (1)	ES2217404T3 (fr)
HU (1)	HUP9900567A3 (fr)
IL (1)	IL125859A0 (fr)
IS (1)	IS4837A (fr)
NO (1)	NO984470L (fr)
NZ (1)	NZ331490A (fr)
PE (1)	PE55298A1 (fr)
PL (1)	PL329153A1 (fr)
PT (1)	PT891362E (fr)
SK (1)	SK132498A3 (fr)
TR (1)	TR199801935T2 (fr)
WO (1)	WO1997036903A1 (fr)
YU (1)	YU41198A (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9719189D0 (en) *	1997-09-09	1997-11-12	Glaxo Group Ltd	New therapeutic method
GB9719172D0 (en)	1997-09-09	1997-11-12	Glaxo Group Ltd	Compounds
GB9719187D0 (en)	1997-09-09	1997-11-12	Glaxo Group Ltd	Compounds
PE107899A1 (es) *	1997-09-09	1999-11-17	Glaxo Group Ltd	Derivados de pirrolopirrolona como inhibidores de elastasa leucocitaria
GB9821199D0 (en) *	1998-09-30	1998-11-25	Glaxo Group Ltd	Chemical compounds
GB9905418D0 (en) *	1999-03-09	1999-05-05	Glaxo Group Ltd	Process
US20060100231A1 (en) *	2003-03-10	2006-05-11	Hetero Drugs Limited	Amorphous clopidogrel hydrogen sulfate
TW201018661A (en)	2003-03-14	2010-05-16	Ono Pharmaceutical Co	Heterocyclic rinf having nitrogen atom derivatives and medicament containing the derivatives as active ingredient
US8530509B2 (en)	2003-06-20	2013-09-10	Siga Technologies, Inc.	Compounds, compositions and methods for treatment and prevention of orthopoxvirus infections and associated diseases
US7692037B2 (en) *	2004-09-02	2010-04-06	Eastman Chemical Company	Optimized liquid-phase oxidation
GB2418427A (en)	2004-09-02	2006-03-29	Univ Cambridge Tech	Ligands for G-protein coupled receptors
TWI400232B (zh)	2004-09-13	2013-07-01	Ono Pharmaceutical Co	含氮雜環衍生物及以該含氮雜環衍生物為有效成分之藥劑
GB0512238D0 (en) *	2005-06-15	2005-07-27	Univ Cambridge Tech	Anti-inflammatory agents
AU2007225836A1 (en)	2006-03-10	2007-09-20	Ono Pharmaceutical Co., Ltd.	Nitrogenated heterocyclic derivative, and pharmaceutical agent comprising the derivative as active ingredient
MX363189B (es) *	2007-04-23	2019-03-14	Siga Tech Inc	Productos químicos, composiciones y métodos para tratamiento y prevención de infecciones de virus orthopox y enfermedades asociadas.
ES2552733T3 (es)	2007-11-16	2015-12-01	Rigel Pharmaceuticals, Inc.	Compuestos de carboxamida, sulfonamida y amina para trastornos metabólicos
US8129390B2 (en)	2007-12-12	2012-03-06	Rigel Pharmaceuticals, Inc.	Carboxamide, sulfonamide and amine compounds and methods for using the same
BRPI0911681B8 (pt)	2008-04-23	2021-05-25	Rigel Pharmaceuticals Inc	composto, composição farmacêutica, e, método para ativar a via de proteína quinase ativada por 5'-amp em uma célula in vitro
AU2013363783B2 (en) *	2012-12-18	2018-02-08	Chiesi Farmaceutici S.P.A.	Novel compounds
US20220354833A1 (en)	2019-09-17	2022-11-10	Mereo Biopharma 4 Limited	Alvelestat for use in the treatment of graft rejection, bronchiolitis obliterans syndrome and graft versus host disease
DK4106757T3 (da)	2020-04-16	2023-10-23	Mereo Biopharma 4 Ltd	Fremgangsmåder der involverer neutrofil elastase-inhibitor alvelestat til behandling af luftvejssygdom medieret af alpha-1-antitrypsin-mangel
CN118265527A (zh)	2021-10-20	2024-06-28	美莱奥生物制药第四有限公司	用于治疗纤维化的中性粒细胞弹性蛋白酶抑制剂

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2932650A (en) *	1957-11-19	1960-04-12	Arthur C Cope	2-6-diazabicyclo (3. 3. 0) octanes
US4997950A (en) *	1989-04-20	1991-03-05	Richard Finbar Murphy	Novel C-terminal gastrin antagonists
GB9211783D0 (en) *	1992-06-04	1992-07-15	Ici Plc	Amide derivatives
GB9402680D0 (en) *	1994-02-11	1994-04-06	Zeneca Ltd	Pyrrolidine derivatives
US5610296A (en) *	1994-12-05	1997-03-11	G. D. Searle & Co.	Process for the preparation of amidino phenyl pyrrolidine beta-alanine urea analogs

1997
- 1997-03-26 AT AT97915439T patent/ATE261969T1/de not_active IP Right Cessation
- 1997-03-26 SK SK1324-98A patent/SK132498A3/sk unknown
- 1997-03-26 PE PE1997000244A patent/PE55298A1/es not_active Application Discontinuation
- 1997-03-26 CN CN97194959A patent/CN1067075C/zh not_active Expired - Lifetime
- 1997-03-26 JP JP53490797A patent/JP4118337B2/ja not_active Expired - Fee Related
- 1997-03-26 AR ARP970101212A patent/AR006401A1/es not_active Application Discontinuation
- 1997-03-26 PT PT97915439T patent/PT891362E/pt unknown
- 1997-03-26 EE EE9800335A patent/EE9800335A/xx unknown
- 1997-03-26 PL PL97329153A patent/PL329153A1/xx unknown
- 1997-03-26 CA CA002250209A patent/CA2250209A1/fr not_active Abandoned
- 1997-03-26 BR BR9708449A patent/BR9708449A/pt unknown
- 1997-03-26 WO PCT/EP1997/001530 patent/WO1997036903A1/fr not_active Ceased
- 1997-03-26 NZ NZ331490A patent/NZ331490A/en unknown
- 1997-03-26 AU AU22917/97A patent/AU726649B2/en not_active Ceased
- 1997-03-26 US US09/155,323 patent/US5994344A/en not_active Expired - Fee Related
- 1997-03-26 EA EA199800773A patent/EA001437B1/ru not_active IP Right Cessation
- 1997-03-26 AP APAP/P/1998/001351A patent/AP823A/en active
- 1997-03-26 KR KR1019980707664A patent/KR20000005039A/ko not_active Withdrawn
- 1997-03-26 ES ES97915439T patent/ES2217404T3/es not_active Expired - Lifetime
- 1997-03-26 CZ CZ983097A patent/CZ309798A3/cs unknown
- 1997-03-26 DE DE69728139T patent/DE69728139T2/de not_active Expired - Fee Related
- 1997-03-26 DK DK97915439T patent/DK0891362T3/da active
- 1997-03-26 HU HU9900567A patent/HUP9900567A3/hu unknown
- 1997-03-26 TR TR1998/01935T patent/TR199801935T2/xx unknown
- 1997-03-26 EP EP97915439A patent/EP0891362B1/fr not_active Expired - Lifetime
- 1997-03-26 IL IL12585997A patent/IL125859A0/xx unknown
- 1997-03-31 CO CO97015902A patent/CO4790152A1/es unknown
1998
- 1998-08-28 IS IS4837A patent/IS4837A/is unknown
- 1998-09-23 YU YU41198A patent/YU41198A/sh unknown
- 1998-09-25 NO NO984470A patent/NO984470L/no not_active Application Discontinuation
1999
- 1999-10-15 US US09/418,644 patent/US6057457A/en not_active Expired - Fee Related
2000
- 2000-03-03 US US09/517,963 patent/US6215002B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CA2250209A1 (fr)	1997-10-09
HUP9900567A3 (en)	2001-02-28
YU41198A (sh)	1999-09-27
BR9708449A (pt)	1999-08-03
CN1219935A (zh)	1999-06-16
ATE261969T1 (de)	2004-04-15
EA001437B1 (ru)	2001-02-26
SK132498A3 (en)	1999-08-06
JP4118337B2 (ja)	2008-07-16
AU2291797A (en)	1997-10-22
US6057457A (en)	2000-05-02
CO4790152A1 (es)	1999-05-31
US6215002B1 (en)	2001-04-10
US5994344A (en)	1999-11-30
AR006401A1 (es)	1999-08-25
IS4837A (is)	1998-08-28
AU726649B2 (en)	2000-11-16
PT891362E (pt)	2004-08-31
AP9801351A0 (en)	1998-09-30
DE69728139T2 (de)	2004-10-21
EP0891362B1 (fr)	2004-03-17
NO984470D0 (no)	1998-09-25
IL125859A0 (en)	1999-04-11
JP2000507950A (ja)	2000-06-27
CN1067075C (zh)	2001-06-13
EP0891362A1 (fr)	1999-01-20
KR20000005039A (ko)	2000-01-25
CZ309798A3 (cs)	1999-02-17
DE69728139D1 (de)	2004-04-22
TR199801935T2 (xx)	1999-03-22
EA199800773A1 (ru)	1999-06-24
NZ331490A (en)	2000-06-23
EE9800335A (et)	1999-04-15
WO1997036903A1 (fr)	1997-10-09
AP823A (en)	2000-04-25
DK0891362T3 (da)	2004-07-12
ES2217404T3 (es)	2004-11-01
PL329153A1 (en)	1999-03-15
PE55298A1 (es)	1998-09-19
HUP9900567A2 (hu)	1999-06-28

Publication	Publication Date	Title
NO984470L (no)	1998-11-25	Pyrrolopyrrolon-derivater som inhibitorer for neutrofil elastase
DE60204452D1 (de)	2005-07-07	Pyrazolo[1,5]pyridinderivate
BR0212042A (pt)	2004-08-17	Composto, composição farmacêutica, método de tratamento ou prevenção de doenças, e, uso de um composto
PL348451A1 (en)	2002-05-20	Glycopeptide derivatives and pharmaceutical compositions containing the same
MX9702382A (es)	1998-02-28	Nuevos derivados de pirimidona con actividad antifungica.
NO20025601L (no)	2003-01-06	Arylmetylaminderivater for anvendelse som tryptaseinhibitorer
DK41193D0 (da)	1993-04-07	Ionkanalaabnere
CA2343236A1 (fr)	2000-03-16	Derives de 4,4-biarylpiperidine
MX9702380A (es)	1998-02-28	Nuevas carboxamidas con actividad antifungica.
MXPA03010961A (es)	2004-02-27	Compuestos de tiazol utiles como inhibidores de proteinas cinasas.
AP9701041A0 (en)	1999-01-10	Pyridylpyrrole compounds.
CA2210258A1 (fr)	1996-07-18	Inhibiteurs de la calpaine et/ou de la cathepsine b derives d'oxazolidine substituee
NZ536750A (en)	2007-02-23	7-Aryl-3,9-diazabicyclo (3.3.1)non-6-ene derivatives and their use as renin inhibitors in the treatment of hypertension, cardiovascular or renal diseases
AU2002239348A1 (en)	2002-06-24	Pyrazolopyridine derivatives
IL163625A0 (en)	2005-12-18	Alkoxy-pyridine derivatives and pharmaceutical compositions containing the same
TR200101978T2 (tr)	2001-12-21	3,3-Biarilpiperidin ve 2,2-biarilmorfolin türevleri.
WO2003053971A8 (fr)	2004-01-29	Antiviraux a base de pyridoquinoxaline
AP2000001761A0 (en)	2000-03-31	Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase.
NO975681L (no)	1998-02-05	Benzisoxazol- og indazol-derivater som antipsykotiske midler
MXPA04001773A (es)	2004-05-31	Derivados de 6,7-dihidroxitetrahidroisquinolinas 3-sustituidas parta uso como agentes antibacterianos.
NO982072D0 (no)	1998-05-06	Amidin- og isotioureaderivater som inhibitorer av nitrogenoksydsyntase
AU2002357740A1 (en)	2003-06-23	Pyrazolo-pyridine derivatives as antiherpes agents
WO2003080631A3 (fr)	2004-04-15	Inhibiteurs de plasma carboxypeptidase b
CA2299036A1 (fr)	2000-08-22	Derives de 4-phenyl-4-heteroarylpiperidine
GEP20032975B (en)	2003-05-27	Echinocandin Derivatives, Preparation Method and Pharmaceutical Composition

Legal Events

Date	Code	Title	Description
2001-12-17	FC2A	Withdrawal, rejection or dismissal of laid open patent application