PT891362E - Derivados de pirrolopirrolona como inibidores da elastase dos neutrofilos - Google Patents

Derivados de pirrolopirrolona como inibidores da elastase dos neutrofilos

Info

Publication number: PT891362E
Authority: PT; Portugal
Prior art keywords: pirrolopyrolone; neutrophyls; derivatives; elastase inhibitors; elastase
Prior art date: 1996-03-28

Application number

PT97915439T

Other languages

English (en)

Inventor

Michael Dennis Dowle

Harry Finch

Lee Andrew Harrison

Graham George Adam Inglis

Martin Redpath Johnson

Simon John Fawcett Macdonald

Pritom Shah

Robin Andrew Smith

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-03-28

Filing date

1997-03-26

Publication date

2004-08-31

1996-03-28 Priority claimed from GBGB9606508.1A external-priority patent/GB9606508D0/en

1996-11-05 Priority claimed from GBGB9623001.6A external-priority patent/GB9623001D0/en

1997-03-26 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

2004-08-31 Publication of PT891362E publication Critical patent/PT891362E/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/14—Nitrogen atoms not forming part of a nitro radical

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Urology & Nephrology (AREA)
Dermatology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Vascular Medicine (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyrrole Compounds (AREA)

PT97915439T 1996-03-28 1997-03-26 Derivados de pirrolopirrolona como inibidores da elastase dos neutrofilos PT891362E (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9606508.1A GB9606508D0 (en)	1996-03-28	1996-03-28	Chemical componds
GBGB9623001.6A GB9623001D0 (en)	1996-11-05	1996-11-05	Chemical compounds

Publications (1)

Publication Number	Publication Date
PT891362E true PT891362E (pt)	2004-08-31

Family

ID=26309008

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT97915439T PT891362E (pt)	1996-03-28	1997-03-26	Derivados de pirrolopirrolona como inibidores da elastase dos neutrofilos

Country Status (30)

Country	Link
US (3)	US5994344A (pt)
EP (1)	EP0891362B1 (pt)
JP (1)	JP4118337B2 (pt)
KR (1)	KR20000005039A (pt)
CN (1)	CN1067075C (pt)
AP (1)	AP823A (pt)
AR (1)	AR006401A1 (pt)
AT (1)	ATE261969T1 (pt)
AU (1)	AU726649B2 (pt)
BR (1)	BR9708449A (pt)
CA (1)	CA2250209A1 (pt)
CO (1)	CO4790152A1 (pt)
CZ (1)	CZ309798A3 (pt)
DE (1)	DE69728139T2 (pt)
DK (1)	DK0891362T3 (pt)
EA (1)	EA001437B1 (pt)
EE (1)	EE9800335A (pt)
ES (1)	ES2217404T3 (pt)
HU (1)	HUP9900567A3 (pt)
IL (1)	IL125859A0 (pt)
IS (1)	IS4837A (pt)
NO (1)	NO984470L (pt)
NZ (1)	NZ331490A (pt)
PE (1)	PE55298A1 (pt)
PL (1)	PL329153A1 (pt)
PT (1)	PT891362E (pt)
SK (1)	SK132498A3 (pt)
TR (1)	TR199801935T2 (pt)
WO (1)	WO1997036903A1 (pt)
YU (1)	YU41198A (pt)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9719189D0 (en) *	1997-09-09	1997-11-12	Glaxo Group Ltd	New therapeutic method
PE107899A1 (es) *	1997-09-09	1999-11-17	Glaxo Group Ltd	Derivados de pirrolopirrolona como inhibidores de elastasa leucocitaria
GB9719187D0 (en)	1997-09-09	1997-11-12	Glaxo Group Ltd	Compounds
GB9719172D0 (en) *	1997-09-09	1997-11-12	Glaxo Group Ltd	Compounds
GB9821199D0 (en) *	1998-09-30	1998-11-25	Glaxo Group Ltd	Chemical compounds
GB9905418D0 (en) *	1999-03-09	1999-05-05	Glaxo Group Ltd	Process
AU2003216707A1 (en) *	2003-03-10	2004-09-30	Hetero Drugs Limited	Amorphous clopidogrel hydrogen sulfate
CA2517888C (en)	2003-03-14	2012-05-01	Ono Pharmaceutical Co., Ltd.	Nitrogen-containing heterocyclic derivatives and drugs containing the same as the active ingredient
US8039504B2 (en) *	2003-06-20	2011-10-18	Siga Technologies, Inc.	Chemicals, compositions, and methods for treatment and prevention of orthopoxvirus infections and associated diseases
US8530509B2 (en)	2003-06-20	2013-09-10	Siga Technologies, Inc.	Compounds, compositions and methods for treatment and prevention of orthopoxvirus infections and associated diseases
GB2418427A (en)	2004-09-02	2006-03-29	Univ Cambridge Tech	Ligands for G-protein coupled receptors
US7692037B2 (en) *	2004-09-02	2010-04-06	Eastman Chemical Company	Optimized liquid-phase oxidation
JP4894518B2 (ja) *	2004-09-13	2012-03-14	小野薬品工業株式会社	含窒素複素環誘導体およびそれらを有効成分とする薬剤
GB0512238D0 (en) *	2005-06-15	2005-07-27	Univ Cambridge Tech	Anti-inflammatory agents
WO2007105637A1 (ja)	2006-03-10	2007-09-20	Ono Pharmaceutical Co., Ltd.	含窒素複素環誘導体およびそれらを有効成分とする薬剤
ES2552733T3 (es)	2007-11-16	2015-12-01	Rigel Pharmaceuticals, Inc.	Compuestos de carboxamida, sulfonamida y amina para trastornos metabólicos
WO2009076631A1 (en)	2007-12-12	2009-06-18	Rigel Pharmaceuticals, Inc.	Carboxamide, sulfonamide and amine compounds for metabolic disorders
EP2276761B1 (en)	2008-04-23	2015-07-29	Rigel Pharmaceuticals, Inc.	Carboxamide compounds for the treatment of metabolic disorders
TWI675837B (zh) *	2012-12-18	2019-11-01	義大利商吉斯藥品公司	作為人類嗜中性細胞彈性蛋白酶抑制劑之嘧啶酮化合物
BR112022004861A2 (pt)	2019-09-17	2022-06-07	Univ Duke	Alvelestat para uso no tratamento de rejeição de transplante, síndrome de bronquiolite obliterante e doença de transplante versus hospedeiro
US20230190723A1 (en)	2020-04-16	2023-06-22	Mereo Biopharma 4 Limited	Methods involving neutrophil elastase inhibitor alvelestat for treating respiratory disease mediated by alpha-1 antitrypsin deficiency
AU2022373971A1 (en)	2021-10-20	2024-04-04	Mereo Biopharma 4 Limited	Neutrophil elastase inhibitors for use in the treatment of fibrosis

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2932650A (en) *	1957-11-19	1960-04-12	Arthur C Cope	2-6-diazabicyclo (3. 3. 0) octanes
US4997950A (en) *	1989-04-20	1991-03-05	Richard Finbar Murphy	Novel C-terminal gastrin antagonists
GB9211783D0 (en) *	1992-06-04	1992-07-15	Ici Plc	Amide derivatives
GB9402680D0 (en) *	1994-02-11	1994-04-06	Zeneca Ltd	Pyrrolidine derivatives
US5610296A (en) *	1994-12-05	1997-03-11	G. D. Searle & Co.	Process for the preparation of amidino phenyl pyrrolidine beta-alanine urea analogs

1997
- 1997-03-26 AP APAP/P/1998/001351A patent/AP823A/en active
- 1997-03-26 TR TR1998/01935T patent/TR199801935T2/xx unknown
- 1997-03-26 AR ARP970101212A patent/AR006401A1/es not_active Application Discontinuation
- 1997-03-26 AU AU22917/97A patent/AU726649B2/en not_active Ceased
- 1997-03-26 BR BR9708449A patent/BR9708449A/pt unknown
- 1997-03-26 JP JP53490797A patent/JP4118337B2/ja not_active Expired - Fee Related
- 1997-03-26 PE PE1997000244A patent/PE55298A1/es not_active Application Discontinuation
- 1997-03-26 HU HU9900567A patent/HUP9900567A3/hu unknown
- 1997-03-26 AT AT97915439T patent/ATE261969T1/de not_active IP Right Cessation
- 1997-03-26 US US09/155,323 patent/US5994344A/en not_active Expired - Fee Related
- 1997-03-26 DK DK97915439T patent/DK0891362T3/da active
- 1997-03-26 PL PL97329153A patent/PL329153A1/xx unknown
- 1997-03-26 WO PCT/EP1997/001530 patent/WO1997036903A1/en not_active Ceased
- 1997-03-26 KR KR1019980707664A patent/KR20000005039A/ko not_active Withdrawn
- 1997-03-26 EE EE9800335A patent/EE9800335A/xx unknown
- 1997-03-26 CN CN97194959A patent/CN1067075C/zh not_active Expired - Lifetime
- 1997-03-26 ES ES97915439T patent/ES2217404T3/es not_active Expired - Lifetime
- 1997-03-26 EP EP97915439A patent/EP0891362B1/en not_active Expired - Lifetime
- 1997-03-26 CZ CZ983097A patent/CZ309798A3/cs unknown
- 1997-03-26 SK SK1324-98A patent/SK132498A3/sk unknown
- 1997-03-26 IL IL12585997A patent/IL125859A0/xx unknown
- 1997-03-26 PT PT97915439T patent/PT891362E/pt unknown
- 1997-03-26 DE DE69728139T patent/DE69728139T2/de not_active Expired - Fee Related
- 1997-03-26 CA CA002250209A patent/CA2250209A1/en not_active Abandoned
- 1997-03-26 NZ NZ331490A patent/NZ331490A/en unknown
- 1997-03-26 EA EA199800773A patent/EA001437B1/ru not_active IP Right Cessation
- 1997-03-31 CO CO97015902A patent/CO4790152A1/es unknown
1998
- 1998-08-28 IS IS4837A patent/IS4837A/is unknown
- 1998-09-23 YU YU41198A patent/YU41198A/sh unknown
- 1998-09-25 NO NO984470A patent/NO984470L/no not_active Application Discontinuation
1999
- 1999-10-15 US US09/418,644 patent/US6057457A/en not_active Expired - Fee Related
2000
- 2000-03-03 US US09/517,963 patent/US6215002B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE69728139D1 (de)	2004-04-22
NO984470D0 (no)	1998-09-25
ATE261969T1 (de)	2004-04-15
US6215002B1 (en)	2001-04-10
EE9800335A (et)	1999-04-15
EA001437B1 (ru)	2001-02-26
EP0891362A1 (en)	1999-01-20
JP4118337B2 (ja)	2008-07-16
CN1067075C (zh)	2001-06-13
US5994344A (en)	1999-11-30
ES2217404T3 (es)	2004-11-01
HUP9900567A3 (en)	2001-02-28
CA2250209A1 (en)	1997-10-09
TR199801935T2 (xx)	1999-03-22
US6057457A (en)	2000-05-02
JP2000507950A (ja)	2000-06-27
AU2291797A (en)	1997-10-22
CN1219935A (zh)	1999-06-16
AP9801351A0 (en)	1998-09-30
DE69728139T2 (de)	2004-10-21
DK0891362T3 (da)	2004-07-12
CZ309798A3 (cs)	1999-02-17
WO1997036903A1 (en)	1997-10-09
BR9708449A (pt)	1999-08-03
IS4837A (is)	1998-08-28
AR006401A1 (es)	1999-08-25
EA199800773A1 (ru)	1999-06-24
PL329153A1 (en)	1999-03-15
NZ331490A (en)	2000-06-23
AP823A (en)	2000-04-25
SK132498A3 (en)	1999-08-06
HUP9900567A2 (hu)	1999-06-28
EP0891362B1 (en)	2004-03-17
YU41198A (sh)	1999-09-27
IL125859A0 (en)	1999-04-11
PE55298A1 (es)	1998-09-19
KR20000005039A (ko)	2000-01-25
CO4790152A1 (es)	1999-05-31
AU726649B2 (en)	2000-11-16
NO984470L (no)	1998-11-25

Publication	Publication Date	Title
PT891362E (pt)	2004-08-31	Derivados de pirrolopirrolona como inibidores da elastase dos neutrofilos
PT946512E (pt)	2004-01-30	Derivados de 6-fenilpiridil-2-amina uteis como inibidores de nos
PT934320E (pt)	2003-07-31	Derivados de naftiridina
BR9708386A (pt)	1999-08-03	Derivados de 6-fenilpiridil-2-amina
PT818448E (pt)	2004-04-30	Cicloalcano-piridinas como inibidores da cetp
DK0901474T3 (da)	2006-07-31	Arylpyrimidinderivater
DK0915088T3 (da)	2003-01-27	D-prolinderivater
PT858452E (pt)	2002-07-31	Derivado tiazol como inibidor da proteina-quinase c
PT1097127E (pt)	2003-07-31	Derivados de diacil-hidrazina como inibidores da integrina
PT1097139E (pt)	2003-04-30	Derivados da quinolina
PT956294E (pt)	2004-10-29	Inibidores da trombina
EE200000140A (et)	2001-02-15	Asendatud kromaani derivaadid
DE69732576D1 (de)	2005-03-31	Tetrahydrobenzindolon-derivate
BR9709065A (pt)	1999-08-03	Derivados de alquilaminobenzotiazole e-benzoxazol
PT934280E (pt)	2003-08-29	Derivados 2-cianoiminoimidazolo inibidores da pde iv
PT1023268E (pt)	2003-09-30	Isoquinolinas como inibidores de uroquinase
EE200000144A (et)	2001-02-15	Asendatud kromaani derivaadid
DE69700887D1 (de)	2000-01-13	Isoprenderivate
DE69733263D1 (de)	2005-06-16	Markierte elastase-inhibitoren
EE9900182A (et)	1999-12-15	2-metoksüfenüülpiperasiini derivaadid
NO307708B1 (no)	2000-05-15	Ferrocenderivater
PT906279E (pt)	2003-02-28	Derivados de pirrol
PT948483E (pt)	2002-08-30	Inibidores da farnesil-transferase
PT931087E (pt)	2002-09-30	Novos derivados de piranosido
PT1066284E (pt)	2005-11-30	Derivados de benzo [c] quinolizina e sua utilizacao como inibidores de 5-alfa-redutases