NO984217L - Nitrogenholdige tricykliske forbindelser og medikamenter omfattende disse - Google Patents
Nitrogenholdige tricykliske forbindelser og medikamenter omfattende disseInfo
- Publication number
- NO984217L NO984217L NO984217A NO984217A NO984217L NO 984217 L NO984217 L NO 984217L NO 984217 A NO984217 A NO 984217A NO 984217 A NO984217 A NO 984217A NO 984217 L NO984217 L NO 984217L
- Authority
- NO
- Norway
- Prior art keywords
- optionally substituted
- acridone
- halogeno
- leukotriene
- hydrazone
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 title 1
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 abstract 4
- DZBUGLKDJFMEHC-UHFFFAOYSA-N acridine Chemical compound C1=CC=CC2=CC3=CC=CC=C3N=C21 DZBUGLKDJFMEHC-UHFFFAOYSA-N 0.000 abstract 4
- 125000005843 halogen group Chemical group 0.000 abstract 3
- WJFKNYWRSNBZNX-UHFFFAOYSA-N 10H-phenothiazine Chemical compound C1=CC=C2NC3=CC=CC=C3SC2=C1 WJFKNYWRSNBZNX-UHFFFAOYSA-N 0.000 abstract 2
- SVANEUDZNISLJD-UHFFFAOYSA-N acridin-9-ylhydrazine Chemical compound C1=CC=C2C(NN)=C(C=CC=C3)C3=NC2=C1 SVANEUDZNISLJD-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000008533 dibenzodiazepines Chemical class 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 229960001340 histamine Drugs 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
- 150000002617 leukotrienes Chemical class 0.000 abstract 2
- MTTDBNNPWUCQNW-UHFFFAOYSA-N n-acridin-9-ylhydroxylamine Chemical compound C1=CC=C2C(=NO)C3=CC=CC=C3NC2=C1 MTTDBNNPWUCQNW-UHFFFAOYSA-N 0.000 abstract 2
- 229950000688 phenothiazine Drugs 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 208000035285 Allergic Seasonal Rhinitis Diseases 0.000 abstract 1
- 206010012438 Dermatitis atopic Diseases 0.000 abstract 1
- 206010020751 Hypersensitivity Diseases 0.000 abstract 1
- 206010039085 Rhinitis allergic Diseases 0.000 abstract 1
- 208000024780 Urticaria Diseases 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 208000026935 allergic disease Diseases 0.000 abstract 1
- 201000010105 allergic rhinitis Diseases 0.000 abstract 1
- 230000007815 allergy Effects 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 201000008937 atopic dermatitis Diseases 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 230000037213 diet Effects 0.000 abstract 1
- 235000005911 diet Nutrition 0.000 abstract 1
- 201000005298 gastrointestinal allergy Diseases 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000004446 heteroarylalkyl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/18—[b, e]-condensed with two six-membered rings
- C07D279/22—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/18—[b, e]-condensed with two six-membered rings
- C07D279/22—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom
- C07D279/24—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom with hydrocarbon radicals, substituted by amino radicals, attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B21/00—Thiazine dyes
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B57/00—Other synthetic dyes of known constitution
- C09B57/08—Naphthalimide dyes; Phthalimide dyes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5562896 | 1996-03-13 | ||
| PCT/JP1997/000789 WO1997033871A1 (en) | 1996-03-13 | 1997-03-13 | Nitrogenous tricyclic compounds and drugs comprising the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO984217D0 NO984217D0 (no) | 1998-09-11 |
| NO984217L true NO984217L (no) | 1998-11-12 |
Family
ID=13004054
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO984217A NO984217L (no) | 1996-03-13 | 1998-09-11 | Nitrogenholdige tricykliske forbindelser og medikamenter omfattende disse |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US6333322B1 (ja) |
| EP (1) | EP0889037A1 (ja) |
| CN (1) | CN1216982A (ja) |
| AU (1) | AU1939997A (ja) |
| CA (1) | CA2248820A1 (ja) |
| HU (1) | HUP9902342A3 (ja) |
| NO (1) | NO984217L (ja) |
| WO (1) | WO1997033871A1 (ja) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6583138B1 (en) | 1998-02-27 | 2003-06-24 | Eisai Co., Ltd. | Heterocyclic-ring condensed benzothiazine compound |
| AU4653299A (en) * | 1998-07-17 | 2000-02-07 | Daiichi Fine Chemical Co., Ltd. | Therapeutic agents for allergic diseases |
| US20040072825A1 (en) * | 2000-12-19 | 2004-04-15 | Yves Lamberty | 2-(2-(4-((2r)-2-methyl-3-(10h-phenothiazin-10-yl)propyl)-1-piperazinyl)-ethoxy) ethanol, process for the preparation thereof, pharmaceutical compositions containing said compound and therapeutic uses thereof |
| US7655646B2 (en) | 2003-01-21 | 2010-02-02 | Thallion Pharmaceuticals, Inc. | Dibenzodiazepinone analogues, processes for their production and their use as pharmaceuticals |
| US7358241B2 (en) | 2003-01-21 | 2008-04-15 | Thallion Pharmaceuticals, Inc. | Compositions and methods comprising farnesyl dibenzodiazepinones for treating neoplastic cells and conditions |
| EP1585814B1 (en) | 2003-01-21 | 2014-05-07 | Thallion Pharmaceuticals Inc. | Farnesyl dibenzodiazepinones, processes for their production and their use as pharmaceuticals |
| US7186713B2 (en) | 2003-01-21 | 2007-03-06 | Ecopia Biosciences, Inc. | Farnesyl dibenzodiazepinones and methods of treating cancer using same |
| WO2005020913A2 (en) * | 2003-08-25 | 2005-03-10 | Combinatorx, Incorporated | Formulations, conjugates, and combinations of drugs for the treatment of neoplasms |
| CN101146800A (zh) * | 2005-01-27 | 2008-03-19 | 生物工程大学精神物质实验室 | 用于治疗阿尔茨海默病的有机化合物，它们的用途和制备方法 |
| US20070299093A1 (en) * | 2005-01-27 | 2007-12-27 | Alma Mater Studiorum-Universitá Di Bologna | Organic Compounds Useful for the Treatment of Alzheimer's Disease, Their Use and Method of Preparation |
| US7763604B2 (en) | 2005-05-16 | 2010-07-27 | Thallion Pharma Ceuticals, Inc. | Methods for administration of a farnesyl dibenzodiazepinone |
| US7829578B1 (en) | 2005-12-12 | 2010-11-09 | Oregon Health & Science University | Aromatic ketones and uses thereof |
| PL2004155T3 (pl) | 2006-03-29 | 2018-08-31 | Wista Laboratories Ltd. | Inhibitory agregacji białek |
| KR100983301B1 (ko) | 2006-03-29 | 2010-09-20 | 위스타 레보레이토리스 리미티드 | ３,７―다이아미노―１０ｈ―페노티아진염 및 이의 용도 |
| CA2662215A1 (en) * | 2006-09-01 | 2008-03-06 | Immune Control, Inc. | Novel compositions and methods for treatment of diseases related to activated lymphocytes |
| US8592447B2 (en) * | 2006-11-13 | 2013-11-26 | Oregon Health & Science University | Acridone compounds |
| EP2247293A2 (en) * | 2008-02-29 | 2010-11-10 | Immune Control, Inc. | Novel compositions and methods for treatment of diseases related to activated lymphocytes |
| WO2010056979A1 (en) * | 2008-11-14 | 2010-05-20 | Immune Control, Inc. | Phenothiazine derivatives for treatment of asthma |
| US8598354B2 (en) | 2008-12-05 | 2013-12-03 | University Of South Florida | Compounds having antiparasitic or anti-infectious activity |
| SG186885A1 (en) | 2010-06-04 | 2013-02-28 | Albany Molecular Res Inc | Glycine transporter-1 inhibitors, methods of making them, and uses thereof |
| JP5898701B2 (ja) | 2011-02-11 | 2016-04-13 | ウィスタ ラボラトリーズ リミテッド | フェノチアジンジアミニウム塩およびそれらの使用 |
| CN103781481B (zh) | 2011-08-02 | 2018-12-14 | 亥姆霍兹慕尼黑中心-德国环境健康研究中心 (Gmbh) | 吩噻嗪衍生物对malt1蛋白酶的选择性抑制 |
| WO2013043744A2 (en) | 2011-09-21 | 2013-03-28 | Inception 1, Inc. | Tricyclic compounds useful as neurogenic and neuroprotective agents |
| SG11201506450RA (en) * | 2013-02-19 | 2015-09-29 | Icahn School Med Mount Sinai | Tricyclic heterocycles as anticancer agents |
| WO2015138496A1 (en) | 2014-03-11 | 2015-09-17 | Icahn School Of Medicine At Mount Sinai | Constrained tricyclic sulfonamides |
| WO2015138500A1 (en) | 2014-03-11 | 2015-09-17 | Icahn School Of Medicine At Mount Sinai | Sulfonamides derived from tricyclyl-2-aminocycloalkanols as anticancer agents |
| JP6955485B2 (ja) | 2015-09-09 | 2021-10-27 | アイカーン スクール オブ メディスン アット マウント サイナイＩｃａｈｎ Ｓｃｈｏｏｌ ｏｆ Ｍｅｄｉｃｉｎｅ ａｔ Ｍｔ． Ｓｉｎａｉ | 抗がん剤としての複素環式の限定された三環系スルホンアミド |
| JP6966425B2 (ja) | 2015-09-09 | 2021-11-17 | アイカーン スクール オブ メディスン アット マウント サイナイIcahn School of Medicine at Mt. Sinai | 抗がん剤としての複素環式の限定された三環系スルホンアミド |
| CN107068881B (zh) * | 2016-04-25 | 2019-12-03 | 中节能万润股份有限公司 | 一种含有吖啶酮类化合物的有机电致发光器件及其应用 |
| WO2019018741A1 (en) | 2017-07-20 | 2019-01-24 | Board Of Trustees Of Michigan State University | REDOX FLOW BATTERY |
| US11414387B2 (en) | 2017-11-20 | 2022-08-16 | Stingthera, Inc. | Oxoacridinyl acetic acid derivatives and methods of use |
| AU2018368789B2 (en) * | 2017-11-20 | 2022-06-02 | Stingthera, Inc. | Oxoacridinyl acetic acid derivatives and methods of use |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3449334A (en) | 1967-10-26 | 1969-06-10 | Smithkline Corp | 9-(2-(2-piperidinyl)ethyl) and 9-(2-(2-pyrrolidinyl)ethyl)acridanes |
| GB1258005A (ja) * | 1969-03-27 | 1971-12-22 | ||
| JPS502513A (ja) | 1973-05-07 | 1975-01-11 | ||
| GB2132194A (en) | 1982-12-02 | 1984-07-04 | Wellcome Found | Phenothiazines |
| DD213922A5 (de) | 1982-12-02 | 1984-09-26 | Wellcome Found | Verfahren zur herstellung von phenothiazinverbindungen |
| EP0138481B1 (en) | 1983-10-05 | 1991-06-26 | Merck Frosst Canada Inc. | Leukotriene biosynthesis inhibitors |
| US4711889A (en) | 1983-11-15 | 1987-12-08 | Hoffman-La Roche Inc. | Schistosomicidal acridanone hydrazones |
| GB8413915D0 (en) | 1984-05-31 | 1984-07-04 | Wellcome Found | Phenothiazine compounds |
| DE3531682A1 (de) * | 1985-09-05 | 1987-03-12 | Thomae Gmbh Dr K | (+)-6-chlor-5,10-dihydro-5-((1-methyl-4- piperidinyl)acetyl)-11h-dibenzo(b,e)(1,4) diazepin-11-on, seine isolierung und verwendung als arzneimittel |
| IT8721978A0 (it) * | 1987-09-21 | 1987-09-21 | Angeli Inst Spa | Nuovi derivati ammidinici triciclici. |
| JPH05163256A (ja) | 1991-12-13 | 1993-06-29 | Hokuriku Seiyaku Co Ltd | フェノチアジン誘導体 |
-
1997
- 1997-03-12 US US09/125,451 patent/US6333322B1/en not_active Expired - Fee Related
- 1997-03-13 CN CN97194202A patent/CN1216982A/zh active Pending
- 1997-03-13 CA CA002248820A patent/CA2248820A1/en not_active Abandoned
- 1997-03-13 AU AU19399/97A patent/AU1939997A/en not_active Abandoned
- 1997-03-13 WO PCT/JP1997/000789 patent/WO1997033871A1/ja not_active Ceased
- 1997-03-13 EP EP97907297A patent/EP0889037A1/en not_active Withdrawn
- 1997-03-13 HU HU9902342A patent/HUP9902342A3/hu unknown
-
1998
- 1998-09-11 NO NO984217A patent/NO984217L/no unknown
-
2001
- 2001-11-02 US US09/985,416 patent/US6489336B2/en not_active Expired - Fee Related
-
2002
- 2002-07-25 US US10/201,952 patent/US6703388B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20020103189A1 (en) | 2002-08-01 |
| US6333322B1 (en) | 2001-12-25 |
| CA2248820A1 (en) | 1997-09-18 |
| WO1997033871A1 (en) | 1997-09-18 |
| EP0889037A1 (en) | 1999-01-07 |
| AU1939997A (en) | 1997-10-01 |
| US6489336B2 (en) | 2002-12-03 |
| NO984217D0 (no) | 1998-09-11 |
| CN1216982A (zh) | 1999-05-19 |
| HUP9902342A2 (hu) | 2000-08-28 |
| HUP9902342A3 (en) | 2000-09-28 |
| US6703388B2 (en) | 2004-03-09 |
| US20030171367A1 (en) | 2003-09-11 |
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