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NO943140L - Heterobicyclic Compounds - Google Patents

Heterobicyclic Compounds

Info

Publication number
NO943140L
NO943140L NO943140A NO943140A NO943140L NO 943140 L NO943140 L NO 943140L NO 943140 A NO943140 A NO 943140A NO 943140 A NO943140 A NO 943140A NO 943140 L NO943140 L NO 943140L
Authority
NO
Norway
Prior art keywords
compounds
meanings
treatment
group
so2nh
Prior art date
Application number
NO943140A
Other languages
Norwegian (no)
Other versions
NO943140D0 (en
Inventor
Amedeo Leonardi
Gianni Motta
Carlo Riva
Rodolfo Testa
Original Assignee
Recordati Chem Pharm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ITMI920408A external-priority patent/IT1254469B/en
Application filed by Recordati Chem Pharm filed Critical Recordati Chem Pharm
Publication of NO943140D0 publication Critical patent/NO943140D0/en
Publication of NO943140L publication Critical patent/NO943140L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/32—2,3-Dihydro derivatives, e.g. flavanones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/60—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

Det frembringes forbindelser med den generelle formel Y-Z-B Heteroatomet X er fortrinnsvis oksygen, men kan ha andre betydninger. Gruppen W er fortrinnsvis en karbonylgruppe, men kan ha andre betydninger. Den foretrukne heterocykliske ring er dermed en 4-okso- 4H-l-benzopyranring. Denne kan ha et vidt spektrum av R2-, R3-, R6- og R^substituenter. Y betyr en binden- de gruppe, valgt fra et vidt spektrum men innbefat- tende -COO-, -CONH-, -O-, -S02- og -SO2NH-. Z betyr en alkylenkjede, og B etyr et kompleksamin. Disse forbindelser og deres prodroger, enantiomerer, dia- stereoisomerer, N-oksyder og farmasøytisk akseptable salter er nyttige ved behandling av hypertensjon og lidelser i urinveiene forbundet med godartet prosta- tisk hypertrofi, og ved behandling av andre sykdommer.Compounds of the general formula Y-Z-B are produced. The hetero atom X is preferably oxygen, but may have other meanings. The group W is preferably a carbonyl group, but may have other meanings. Thus, the preferred heterocyclic ring is a 4-oxo-4H-1-benzopyran ring. This may have a wide range of R2, R3, R6 and R6 substituents. Y means a binding group selected from a wide spectrum but including -COO-, -CONH-, -O-, -SO2- and -SO2NH-. Z represents an alkylene chain and B represents a complex amine. These compounds and their prodrugs, enantiomers, diastereoisomers, N-oxides and pharmaceutically acceptable salts are useful in the treatment of hypertension and urinary disorders associated with benign prostatic hypertrophy, and in the treatment of other diseases.

NO943140A 1992-02-25 1994-08-25 Heterobicyclic Compounds NO943140L (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMI920408A IT1254469B (en) 1992-02-25 1992-02-25 BENZOPYRANIC AND BENZOTHIOPYRANIC DERIVATIVES
US07/888,775 US5403842A (en) 1992-02-25 1992-05-26 Benzopyran and benzothiopyran derivatives
PCT/EP1993/000420 WO1993017007A1 (en) 1992-02-25 1993-02-23 Heterobicyclic compounds

Publications (2)

Publication Number Publication Date
NO943140D0 NO943140D0 (en) 1994-08-25
NO943140L true NO943140L (en) 1994-08-25

Family

ID=26330842

Family Applications (1)

Application Number Title Priority Date Filing Date
NO943140A NO943140L (en) 1992-02-25 1994-08-25 Heterobicyclic Compounds

Country Status (25)

Country Link
EP (1) EP0558245A1 (en)
JP (1) JPH069606A (en)
AU (2) AU3629693A (en)
BG (1) BG61946B1 (en)
CA (1) CA2090156A1 (en)
CZ (1) CZ205994A3 (en)
DZ (1) DZ1666A1 (en)
EE (1) EE03177B1 (en)
EG (1) EG20333A (en)
FI (1) FI943876A0 (en)
HR (1) HRP930210A2 (en)
HU (1) HUT72448A (en)
IL (1) IL104824A (en)
LT (1) LT3038B (en)
LV (1) LV10099B (en)
MX (1) MX9300977A (en)
NO (1) NO943140L (en)
NZ (1) NZ245995A (en)
PL (1) PL175556B1 (en)
SG (1) SG65570A1 (en)
SI (1) SI9300094A (en)
SK (1) SK280143B6 (en)
TW (1) TW382628B (en)
WO (1) WO1993017007A1 (en)
ZA (1) ZA931278B (en)

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Also Published As

Publication number Publication date
BG61946B1 (en) 1998-10-30
TW382628B (en) 2000-02-21
BG98990A (en) 1995-05-31
DZ1666A1 (en) 2002-02-17
LV10099A (en) 1994-05-10
ZA931278B (en) 1993-11-18
CZ205994A3 (en) 1995-02-15
SK100794A3 (en) 1995-04-12
SG65570A1 (en) 1999-06-22
CA2090156A1 (en) 1993-08-26
FI943876A7 (en) 1994-08-23
HUT72448A (en) 1996-04-29
LV10099B (en) 1995-02-20
LTIP354A (en) 1994-04-25
LT3038B (en) 1994-09-25
SK280143B6 (en) 1999-09-10
EP0558245A1 (en) 1993-09-01
SI9300094A (en) 1993-09-30
EG20333A (en) 1998-10-31
AU660067B2 (en) 1995-06-08
AU3629693A (en) 1993-09-13
JPH069606A (en) 1994-01-18
HU9402443D0 (en) 1994-10-28
FI943876A0 (en) 1994-08-23
AU3377393A (en) 1993-08-26
MX9300977A (en) 1993-12-01
NO943140D0 (en) 1994-08-25
WO1993017007A1 (en) 1993-09-02
EE03177B1 (en) 1999-04-15
PL175556B1 (en) 1999-01-29
HRP930210A2 (en) 1995-06-30
NZ245995A (en) 1994-09-27
IL104824A0 (en) 1993-06-10
IL104824A (en) 1999-12-22

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