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IT1266582B1 - (DI) AZACYLO-HEXANIC AND DIAZACYLO-HEPTANIC DERIVATIVES - Google Patents

(DI) AZACYLO-HEXANIC AND DIAZACYLO-HEPTANIC DERIVATIVES

Info

Publication number
IT1266582B1
IT1266582B1 IT93MI001717A ITMI931717A IT1266582B1 IT 1266582 B1 IT1266582 B1 IT 1266582B1 IT 93MI001717 A IT93MI001717 A IT 93MI001717A IT MI931717 A ITMI931717 A IT MI931717A IT 1266582 B1 IT1266582 B1 IT 1266582B1
Authority
IT
Italy
Prior art keywords
diazacylo
azacylo
hexanic
heptanic
derivatives
Prior art date
Application number
IT93MI001717A
Other languages
Italian (it)
Inventor
Amedeo Leonardi
Gianni Motta
Carlo Riva
Rodolfo Testa
Original Assignee
Recordati Chem Pharm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Recordati Chem Pharm filed Critical Recordati Chem Pharm
Publication of ITMI931717A0 publication Critical patent/ITMI931717A0/en
Priority to IT93MI001717A priority Critical patent/IT1266582B1/en
Priority to IL11034894A priority patent/IL110348A0/en
Priority to AU75323/94A priority patent/AU680037B2/en
Priority to CA002168443A priority patent/CA2168443A1/en
Priority to PCT/EP1994/002437 priority patent/WO1995004049A1/en
Priority to KR1019960700460A priority patent/KR960703884A/en
Priority to SG1996002067A priority patent/SG46281A1/en
Priority to CN94193622A priority patent/CN1132508A/en
Priority to EP94925382A priority patent/EP0711288A1/en
Priority to JP7505546A priority patent/JPH09500883A/en
Priority to NZ271634A priority patent/NZ271634A/en
Priority to ZA945625A priority patent/ZA945625B/en
Priority to MXPA94005805A priority patent/MXPA94005805A/en
Publication of ITMI931717A1 publication Critical patent/ITMI931717A1/en
Priority to NO960371A priority patent/NO960371L/en
Application granted granted Critical
Publication of IT1266582B1 publication Critical patent/IT1266582B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/650952—Six-membered rings having the nitrogen atoms in the positions 1 and 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
IT93MI001717A 1993-07-30 1993-07-30 (DI) AZACYLO-HEXANIC AND DIAZACYLO-HEPTANIC DERIVATIVES IT1266582B1 (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
IT93MI001717A IT1266582B1 (en) 1993-07-30 1993-07-30 (DI) AZACYLO-HEXANIC AND DIAZACYLO-HEPTANIC DERIVATIVES
IL11034894A IL110348A0 (en) 1993-07-30 1994-07-18 Piperazine derivatives and pharmaceutical compositions containing them
SG1996002067A SG46281A1 (en) 1993-07-30 1994-07-22 Piperazine derivatives
JP7505546A JPH09500883A (en) 1993-07-30 1994-07-22 Piperazine derivatives as α1A-adrenoceptor antagonists
PCT/EP1994/002437 WO1995004049A1 (en) 1993-07-30 1994-07-22 PIPERAZINE DERIVATIVES AS α1A-ADRENERGIC RECEPTOR ANTAGONISTS
KR1019960700460A KR960703884A (en) 1993-07-30 1994-07-22 PIPERAZINE DERIVATIV ES AS α₁_A-ADRENERGIC RECEPTOR ANTAGONISTS as an α₁_A-adrenergic receptor antagonist
AU75323/94A AU680037B2 (en) 1993-07-30 1994-07-22 Piperazine derivatives as alpha1a-adrenergic receptor antagonists
CN94193622A CN1132508A (en) 1993-07-30 1994-07-22 Piperazine derivatives
EP94925382A EP0711288A1 (en) 1993-07-30 1994-07-22 Piperazine derivatives as alpha 1a-adrenergic receptor antagonists
CA002168443A CA2168443A1 (en) 1993-07-30 1994-07-22 Piperazine derivatives as .alpha.1a-adrenergic receptor antagonists
NZ271634A NZ271634A (en) 1993-07-30 1994-07-22 1-phenyl-4-(substituted alkyl)piperazine derivatives; pharmaceutical compositions
ZA945625A ZA945625B (en) 1993-07-30 1994-07-29 Piperazine derivatives
MXPA94005805A MXPA94005805A (en) 1993-07-30 1994-07-29 Piperazine derivatives.
NO960371A NO960371L (en) 1993-07-30 1996-01-29 Piperazine derivatives as ter

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT93MI001717A IT1266582B1 (en) 1993-07-30 1993-07-30 (DI) AZACYLO-HEXANIC AND DIAZACYLO-HEPTANIC DERIVATIVES

Publications (3)

Publication Number Publication Date
ITMI931717A0 ITMI931717A0 (en) 1993-07-30
ITMI931717A1 ITMI931717A1 (en) 1995-01-30
IT1266582B1 true IT1266582B1 (en) 1997-01-09

Family

ID=11366733

Family Applications (1)

Application Number Title Priority Date Filing Date
IT93MI001717A IT1266582B1 (en) 1993-07-30 1993-07-30 (DI) AZACYLO-HEXANIC AND DIAZACYLO-HEPTANIC DERIVATIVES

Country Status (14)

Country Link
EP (1) EP0711288A1 (en)
JP (1) JPH09500883A (en)
KR (1) KR960703884A (en)
CN (1) CN1132508A (en)
AU (1) AU680037B2 (en)
CA (1) CA2168443A1 (en)
IL (1) IL110348A0 (en)
IT (1) IT1266582B1 (en)
MX (1) MXPA94005805A (en)
NO (1) NO960371L (en)
NZ (1) NZ271634A (en)
SG (1) SG46281A1 (en)
WO (1) WO1995004049A1 (en)
ZA (1) ZA945625B (en)

Families Citing this family (32)

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US5620993A (en) * 1995-06-07 1997-04-15 Merck & Co., Inc. Alpha-1a adrenergic receptor antagonists
US5661163A (en) * 1995-06-07 1997-08-26 Merck & Co., Inc. Alpha-1a adrenergic receptor antagonists
US5659033A (en) * 1995-09-13 1997-08-19 Neurogen Corporation N-aminoalkylfluorenecarboxamides; a new class of dopamine receptor subtype specific ligands
US5807856A (en) * 1995-11-15 1998-09-15 Merck & Co., Inc. Alpha 1a adrenergic receptor antagonist
NZ321293A (en) * 1995-11-17 2001-04-27 Warner Lambert Co Sulfonamide inhibitors of matrix metalloproteinases
PT871619E (en) 1995-12-29 2003-03-31 Boehringer Ingelheim Pharma PHENYL-TIAZOL DERIVATIVES WITH HERPESC ANTI-VIRUS PROPERTIES
US6288091B1 (en) 1995-12-29 2001-09-11 Boehringer Ingelheim Ltd. Antiherpes virus compounds and methods for their preparation and use
AU2393997A (en) * 1996-04-05 1997-10-29 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Alpha1-adrenergic receptor antagonists
JP4150435B2 (en) * 1996-04-18 2008-09-17 株式会社資生堂 Alkylene diamine derivatives and anti-ulcer agents, antibacterial agents
EP0912562A1 (en) 1996-07-19 1999-05-06 Takeda Chemical Industries, Ltd. Heterocyclic compounds, their production and use
ATE250033T1 (en) * 1997-05-12 2003-10-15 Ortho Mcneil Pharm Inc ARYL SUBSTITUTED PIPERAZINES USEFUL IN THE TREATMENT OF BENICAENT PROSTATIC HYPERLASIA
AU2002300904B2 (en) * 1997-05-12 2004-12-23 Ortho-Mcneil Pharmaceutical, Inc. Arylsubstituted piperazines useful in the treatment of benign prostatic hyperplasia
US6271234B1 (en) 1997-08-01 2001-08-07 Recordati S.A., Chemical And Pharmaceutical Company 1,4-disubstituted piperazines
IT1293804B1 (en) 1997-08-01 1999-03-10 Recordati Chem Pharm DIARYLALKYL PIPERAZINS ACTIVE ON LOW URINARY TRACT
US6399614B1 (en) 1997-08-01 2002-06-04 Recordati S.A. Chemical And Pharmaceutical Company 1-(N-phenylaminoalkyl)piperazine derivatives substituted at position 2 of the phenyl ring
EP1000045A1 (en) * 1997-08-01 2000-05-17 RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY 1,4-disubstituted piperazines
IT1293807B1 (en) * 1997-08-01 1999-03-10 Recordati Chem Pharm 1- (N-PHENYLAMINOALKYL) PIPERAZINE DERIVATIVES SUBSTITUTED AT POSITION 2 OF THE PHENYL RING
US6218396B1 (en) * 1998-02-20 2001-04-17 Orth-Mcneil Pharmaceutical, Inc. Substituted pyridino arylpiperazines useful in the treatment of benign prostatic hyperplasia
JP2002522425A (en) 1998-08-07 2002-07-23 カイロン コーポレイション Substituted isoxazoles as estrogen receptor modulators
IT1314191B1 (en) * 1999-10-18 2002-12-06 Recordati Chem Pharm ISOSSAZOLCARBOSSAMIDIC DERIVATIVES
US6365591B1 (en) 1999-10-18 2002-04-02 Recordati, S.A., Chemical And Pharmacueticals Company Isoxazolecarboxamide derivatives
AR027133A1 (en) * 1999-12-30 2003-03-12 Lundbeck & Co As H DERIVATIVES OF HETEROARILO, ITS PREPARATION AND USE.
SE0004780D0 (en) 2000-12-22 2000-12-22 Jordanian Pharmaceutical Mfg & Novel compunds
JP3940290B2 (en) * 2000-12-22 2007-07-04 ザ・ヨルダニアン・フアーマシユーテイカル・エム・エフ・ジー・アンド・メデイカル・イクイツプメント・カンパニー・リミテツド New compounds
US20040077654A1 (en) * 2001-01-15 2004-04-22 Bouillot Anne Marie Jeanne Aryl piperidine and piperazine derivatives as inducers of ldl-receptor expression
US7153858B2 (en) * 2003-01-31 2006-12-26 Epix Delaware, Inc. Arylpiperazinyl compounds
JP5260627B2 (en) * 2007-03-30 2013-08-14 カウンスィル オブ サイエンティフィック アンド インダストリアル リサーチ Benzophenone compound and method for producing the same
CN102015606B (en) 2007-06-08 2015-02-04 满康德股份有限公司 IRE-1α inhibitor
WO2011156321A1 (en) 2010-06-07 2011-12-15 Novomedix, Llc Furanyl compounds and the use thereof
CA2858752C (en) * 2011-12-09 2019-12-31 Research Triangle Institute 1-substituted 4-arylpiperazines as kappa opioid receptor antagonists
BR102012000187A2 (en) * 2012-01-05 2018-04-10 Univ Rio De Janeiro N-phenylpiperazine derivatives a1a, a1d and 5-ht1a receptor antagonist antagonists in the treatment of benign prostatic hyperplasia, pharmaceutical compositions containing the same
WO2023044364A1 (en) 2021-09-15 2023-03-23 Enko Chem, Inc. Protoporphyrinogen oxidase inhibitors

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US2997472A (en) * 1961-08-22 Certificate of correction
FR1543944A (en) * 1967-03-10 1968-10-31 Bruneau & Cie Lab Salicylic acid amide derivatives and their preparation
FR6452M (en) * 1967-03-10 1968-11-12
US3557107A (en) * 1967-05-01 1971-01-19 Shulton Inc Phenylpiperazinylalkyl alkoxy anthranilates
FR1537901A (en) * 1967-07-19 1968-08-30 Bruneau & Cie Lab Amide derivatives of halogeno and nitro benzoic acids and their preparation
FR6924M (en) * 1967-10-18 1969-05-05
US3846430A (en) * 1968-01-12 1974-11-05 Bruneau & Cie Lab 1-(2-methoxy-phenyl)-4-{8 2-(4-fluoro-benzamido)-ethyl{9 -piperazine
NL8005133A (en) * 1980-09-12 1982-04-01 Duphar Int Res PHENYLPIPERAZINE DERIVATIVES WITH ANTIAGRESSIVE ACTION.
US4642291A (en) * 1982-09-01 1987-02-10 Sloan-Kettering Institute For Cancer Research Cell surface antigens of human astrocytoma
JPS5955878A (en) * 1982-09-24 1984-03-31 Chugai Pharmaceut Co Ltd Novel phenylpiperazine derivative
JPS60169467A (en) * 1984-02-10 1985-09-02 Chugai Pharmaceut Co Ltd Novel phenylpiperazine derivative
JP2556722B2 (en) * 1988-02-18 1996-11-20 興和株式会社 Novel sulfonamide compound
US4857644A (en) * 1988-06-09 1989-08-15 American Home Products Corporation Aryl sulfonopiperazines as anti-inflammatory agents
ES2027898A6 (en) * 1991-01-24 1992-06-16 Espanola Prod Quimicos 2-Methoxyphenylpiperazine derivatives.
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SE9201138D0 (en) * 1992-04-09 1992-04-09 Astra Ab NOVEL PHTHALIMIDOALKYL PIPERAZINES

Also Published As

Publication number Publication date
NO960371L (en) 1996-03-29
ITMI931717A0 (en) 1993-07-30
NO960371D0 (en) 1996-01-29
IL110348A0 (en) 1994-10-21
ITMI931717A1 (en) 1995-01-30
NZ271634A (en) 1996-09-25
KR960703884A (en) 1996-08-31
MXPA94005805A (en) 2004-08-20
ZA945625B (en) 1995-03-07
CN1132508A (en) 1996-10-02
JPH09500883A (en) 1997-01-28
CA2168443A1 (en) 1995-02-09
EP0711288A1 (en) 1996-05-15
AU7532394A (en) 1995-02-28
WO1995004049A1 (en) 1995-02-09
SG46281A1 (en) 1998-02-20
AU680037B2 (en) 1997-07-17

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Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970129