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NO911938L - PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY ACTIVE INDOLD DERIVATIVES. - Google Patents

PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY ACTIVE INDOLD DERIVATIVES.

Info

Publication number
NO911938L
NO911938L NO91911938A NO911938A NO911938L NO 911938 L NO911938 L NO 911938L NO 91911938 A NO91911938 A NO 91911938A NO 911938 A NO911938 A NO 911938A NO 911938 L NO911938 L NO 911938L
Authority
NO
Norway
Prior art keywords
chem
alkyl
hydrogen
preparation
derivatives
Prior art date
Application number
NO91911938A
Other languages
Norwegian (no)
Other versions
NO175475C (en
NO175475B (en
NO911938D0 (en
Inventor
Satoshi Okada
Kozo Sawada
Natsuko Kayakiri
Yuki Saitoh
Hirokazu Tanaka
Masashi Hashimoto
Original Assignee
Fujisawa Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co
Publication of NO911938D0 publication Critical patent/NO911938D0/en
Publication of NO911938L publication Critical patent/NO911938L/en
Publication of NO175475B publication Critical patent/NO175475B/en
Publication of NO175475C publication Critical patent/NO175475C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The present invention relates to novel indole derivatives of the formula : <CHEM> wherein R<1> is carboxy or protected carboxy, R<2> is hydrogen, lower alkyl or halogen, R<3> is aryl or ar(lower)alkyl, each of which may have suitable substituent(s), or a group of the formula : <CHEM> A is lower alkylene which may be substituted by oxo or lower alkenylene, Q is carbonyl or lower alkylene, X is <CHEM> or <CHEM> in which R<4> is hydrogen or lower alkyl, and R<5> is hydrogen, lower alkyl or Y-Z-R<3>, Y is bond or lower alkylene, Z is lower alkylene, -O- or <CHEM> in which R<6> is hydrogen, lower alkyl, ar(lower)alkyl which may have suitable substituent(s) or amino protective group, and pharmaceutically acceptable salts thereof, which have pharmacological activities such as inhibitory activity on testosteron 5 alpha -reductase and the like, to process for preparation thereof, to a pharmaceutical composition comprising the same and to a use of the same for manufacturing a medicament.
NO911938A 1990-05-21 1991-05-16 Analogous Process for Preparation of Therapeutically Active Indole Derivatives NO175475C (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909011335A GB9011335D0 (en) 1990-05-21 1990-05-21 Indolebutyric acid derivatives and process for preparation thereof

Publications (4)

Publication Number Publication Date
NO911938D0 NO911938D0 (en) 1991-05-16
NO911938L true NO911938L (en) 1991-11-22
NO175475B NO175475B (en) 1994-07-11
NO175475C NO175475C (en) 1994-10-19

Family

ID=10676312

Family Applications (1)

Application Number Title Priority Date Filing Date
NO911938A NO175475C (en) 1990-05-21 1991-05-16 Analogous Process for Preparation of Therapeutically Active Indole Derivatives

Country Status (18)

Country Link
EP (1) EP0458207B1 (en)
JP (1) JPH0678307B2 (en)
KR (1) KR910019975A (en)
CN (1) CN1030701C (en)
AT (1) ATE150747T1 (en)
AU (1) AU645560B2 (en)
CA (1) CA2042905A1 (en)
DE (1) DE69125308T2 (en)
DK (1) DK0458207T3 (en)
FI (1) FI912375A7 (en)
GB (1) GB9011335D0 (en)
GR (1) GR3022953T3 (en)
HU (2) HUT60471A (en)
IE (1) IE911641A1 (en)
NO (1) NO175475C (en)
PT (1) PT97717B (en)
RU (1) RU2045518C1 (en)
ZA (1) ZA913457B (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2120942C1 (en) * 1991-06-17 1998-10-27 Фудзисава Фармасьютикал Ко., Лтд. INDOLIZINE DERIVATIVES, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION, METHOD OF INHIBITION OF ACTIVITY OF TESTOSTERONE-5α-REDUCTASE
US5334716A (en) * 1991-06-17 1994-08-02 Fujisawa Pharmaceutical Co., Ltd. Heterocyclic derivatives
GB9115951D0 (en) * 1991-07-24 1991-09-11 Pfizer Ltd Indoles
CA2118697A1 (en) * 1991-09-11 1993-03-18 Satoshi Okada Indole derivatives as 5-alpha-reductase inhibitor
GB9127531D0 (en) * 1991-12-31 1992-02-19 Fujisawa Pharmaceutical Co Heterocyclic compound
GB9204024D0 (en) * 1992-02-25 1992-04-08 Fujisawa Pharmaceutical Co Indole derivatives
GB9204365D0 (en) * 1992-02-28 1992-04-08 Pfizer Ltd Indoles
PL175591B1 (en) * 1992-05-21 1999-01-29 Endorecherche Inc Farmaceutic agent for inhibiting 5-alpha testosterone reductase
GB9302577D0 (en) * 1993-02-10 1993-03-24 Fujisawa Pharmaceutical Co Indole derivatives
WO1994022821A1 (en) * 1993-04-05 1994-10-13 Fujisawa Pharmaceutical Co., Ltd. Indole derivatives as testosterone 5 alpha-reductase inhibitors
GB9310092D0 (en) * 1993-05-17 1993-06-30 Fujisawa Pharmaceutical Co Indole derivatives
IL109728A0 (en) * 1993-05-28 1994-08-26 Pfizer Res & Dev Indoles
GB9317096D0 (en) * 1993-08-17 1993-09-29 Pfizer Ltd Indoles
CN1067985C (en) * 1994-03-30 2001-07-04 泽里新药工业株式会社 Indole derivative and medicine containing the same
GB9409583D0 (en) * 1994-05-13 1994-07-06 Pfizer Ltd Indoles
IL138711A0 (en) 1998-03-31 2001-10-31 Inst Pharmaceutical Discovery Substituted indolealkanoic acids
WO2003020311A1 (en) * 2001-08-28 2003-03-13 Fujisawa Pharmaceutical Co., Ltd. Remedies for skin diseases
WO2004099189A1 (en) 2003-05-09 2004-11-18 F. Hoffmann-La Roche Ag Methyl indoles and methyl pyrrolopyridines as alph-1 adrenergic agonists
TW201329025A (en) * 2011-11-01 2013-07-16 Astex Therapeutics Ltd Pharmaceutical compound
EP3774767B1 (en) * 2018-04-05 2025-10-29 Beth Israel Deaconess Medical Center, Inc. Aryl hydrocarbon receptor modulators and uses thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR7337M (en) * 1968-01-11 1969-10-13
PH23498A (en) * 1984-08-06 1989-08-16 Sterling Drug Inc 3-carbonyl-1-aminoalkyl-1h-indoles,composition and use thereof

Also Published As

Publication number Publication date
EP0458207A2 (en) 1991-11-27
KR910019975A (en) 1991-12-19
JPH0678307B2 (en) 1994-10-05
FI912375A0 (en) 1991-05-16
PT97717B (en) 1998-08-31
CA2042905A1 (en) 1991-11-22
DE69125308D1 (en) 1997-04-30
HU911681D0 (en) 1991-11-28
CN1056685A (en) 1991-12-04
AU7711691A (en) 1991-11-21
NO175475C (en) 1994-10-19
FI912375A7 (en) 1991-11-22
JPH04244061A (en) 1992-09-01
EP0458207A3 (en) 1992-03-25
IE911641A1 (en) 1991-12-04
DK0458207T3 (en) 1997-04-21
NO175475B (en) 1994-07-11
EP0458207B1 (en) 1997-03-26
NO911938D0 (en) 1991-05-16
RU2045518C1 (en) 1995-10-10
HU211637A9 (en) 1995-12-28
CN1030701C (en) 1996-01-17
AU645560B2 (en) 1994-01-20
PT97717A (en) 1992-02-28
GB9011335D0 (en) 1990-07-11
HUT60471A (en) 1992-09-28
GR3022953T3 (en) 1997-06-30
DE69125308T2 (en) 1997-07-10
ZA913457B (en) 1992-02-26
ATE150747T1 (en) 1997-04-15

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