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WO2003020311A1 - Remedies for skin diseases - Google Patents

Remedies for skin diseases Download PDF

Info

Publication number
WO2003020311A1
WO2003020311A1 PCT/JP2002/008235 JP0208235W WO03020311A1 WO 2003020311 A1 WO2003020311 A1 WO 2003020311A1 JP 0208235 W JP0208235 W JP 0208235W WO 03020311 A1 WO03020311 A1 WO 03020311A1
Authority
WO
WIPO (PCT)
Prior art keywords
testosterone
remedies
reductase inhibitor
skin diseases
effect
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2002/008235
Other languages
French (fr)
Japanese (ja)
Inventor
Shozo Sakuma
Yoshihiro Yokota
Shinichi Kishi
Hiroko Takeuchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of WO2003020311A1 publication Critical patent/WO2003020311A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

It is confirmed that a testosterone 5α-reductase inhibitor has an effect of inhibiting the proliferation of keratinocytes and, further, inhibits inflammatory responses and epidermal thickening in various animal models pathologically resembling to psoriasis. Namely, it is found out that the testosterone 5α-reductase inhibitor has a keratinocyte proliferation inhibitory effect as well as an antiinflammatory effect. Thus, remedies for skin diseases containing the testosterone 5α-reductase inhibitor as the active ingredient are provided.
PCT/JP2002/008235 2001-08-28 2002-08-12 Remedies for skin diseases Ceased WO2003020311A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001-257554 2001-08-28
JP2001257554 2001-08-28

Publications (1)

Publication Number Publication Date
WO2003020311A1 true WO2003020311A1 (en) 2003-03-13

Family

ID=19085194

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/008235 Ceased WO2003020311A1 (en) 2001-08-28 2002-08-12 Remedies for skin diseases

Country Status (1)

Country Link
WO (1) WO2003020311A1 (en)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0155096A2 (en) * 1984-02-27 1985-09-18 Merck & Co. Inc. 17 Beta-Substituted-4-aza-5-alpha-androstenones and their use as 5-alpha-reductase inhibitors
EP0291245A2 (en) * 1987-05-11 1988-11-17 Ono Pharmaceutical Co., Ltd. Benzoylaminophenoxybutanoic acid derivatives
EP0458207A2 (en) * 1990-05-21 1991-11-27 Fujisawa Pharmaceutical Co., Ltd. Indole derivatives
EP0519353A2 (en) * 1991-06-17 1992-12-23 Fujisawa Pharmaceutical Co., Ltd. Indolizin derivatives, process for their preparation and pharmaceutical composition containing them
EP0715852A1 (en) * 1994-12-05 1996-06-12 Denki Kagaku Kogyo Kabushiki Kaisha Use of hyaluronic acid or its salt to treat skin disease
WO2000006144A1 (en) * 1998-07-27 2000-02-10 Howard Murad Pharmaceutical compositions and methods for managing scalp conditions

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0155096A2 (en) * 1984-02-27 1985-09-18 Merck & Co. Inc. 17 Beta-Substituted-4-aza-5-alpha-androstenones and their use as 5-alpha-reductase inhibitors
EP0291245A2 (en) * 1987-05-11 1988-11-17 Ono Pharmaceutical Co., Ltd. Benzoylaminophenoxybutanoic acid derivatives
EP0458207A2 (en) * 1990-05-21 1991-11-27 Fujisawa Pharmaceutical Co., Ltd. Indole derivatives
EP0519353A2 (en) * 1991-06-17 1992-12-23 Fujisawa Pharmaceutical Co., Ltd. Indolizin derivatives, process for their preparation and pharmaceutical composition containing them
EP0715852A1 (en) * 1994-12-05 1996-06-12 Denki Kagaku Kogyo Kabushiki Kaisha Use of hyaluronic acid or its salt to treat skin disease
WO2000006144A1 (en) * 1998-07-27 2000-02-10 Howard Murad Pharmaceutical compositions and methods for managing scalp conditions

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
NAZZARO-PORRO M. ET AL.: "L'acido azelaico nella terapia dell'acne", GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA, vol. 124, no. 4, 1989, pages 175 - 184, XP002959852 *
PASSI S. ET AL.: "Meccanismo di azione dell'acido azelaico nell'acne", GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA, vol. 124, no. 10, 1989, pages 455 - 463, XP002081116 *

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