NO333603B1 - Kjemiske forbindelser samt anvendelse og fremstilling derav og farmasoytisk sammensetning for behandling av cancer - Google Patents

Kjemiske forbindelser samt anvendelse og fremstilling derav og farmasoytisk sammensetning for behandling av cancer Download PDF

Info

Publication number: NO333603B1
Authority: NO; Norway
Prior art keywords: oph; nmr; mhz; group; mmol
Prior art date: 2003-07-21

Application number

NO20053993A

Other languages

English (en)

Norwegian (no)

Other versions

NO20053993D0 (no

NO20053993L (no

Inventor

Christopher Mcguigan

Original Assignee

Nucana Biomed Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-07-21

Filing date

2005-08-26

Publication date

2013-07-22

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27772362&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO333603(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2005-08-26 Application filed by Nucana Biomed Ltd filed Critical Nucana Biomed Ltd

2005-08-26 Publication of NO20053993D0 publication Critical patent/NO20053993D0/no

2005-11-02 Publication of NO20053993L publication Critical patent/NO20053993L/no

2013-07-22 Publication of NO333603B1 publication Critical patent/NO333603B1/no

Links

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229960001860 salicylate Drugs 0.000 description 1
229960001153 serine Drugs 0.000 description 1
231100000004 severe toxicity Toxicity 0.000 description 1
239000000741 silica gel Substances 0.000 description 1
229910002027 silica gel Inorganic materials 0.000 description 1
235000010413 sodium alginate Nutrition 0.000 description 1
URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 1
CDBYLPFSWZWCQE-UHFFFAOYSA-L sodium carbonate Substances [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 1
229910000029 sodium carbonate Inorganic materials 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
239000001488 sodium phosphate Substances 0.000 description 1
229910000162 sodium phosphate Inorganic materials 0.000 description 1
239000007921 spray Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000008107 starch Substances 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
238000003756 stirring Methods 0.000 description 1
238000006467 substitution reaction Methods 0.000 description 1
125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 description 1
150000003462 sulfoxides Chemical class 0.000 description 1
239000011593 sulfur Substances 0.000 description 1
239000000829 suppository Substances 0.000 description 1
239000000375 suspending agent Substances 0.000 description 1
239000003765 sweetening agent Substances 0.000 description 1
239000000454 talc Substances 0.000 description 1
235000012222 talc Nutrition 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
238000012360 testing method Methods 0.000 description 1
WHRNULOCNSKMGB-UHFFFAOYSA-N tetrahydrofuran thf Chemical compound C1CCOC1.C1CCOC1 WHRNULOCNSKMGB-UHFFFAOYSA-N 0.000 description 1
125000003718 tetrahydrofuranyl group Chemical group 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
125000000335 thiazolyl group Chemical group 0.000 description 1
125000001544 thienyl group Chemical group 0.000 description 1
150000003573 thiols Chemical group 0.000 description 1
229960002898 threonine Drugs 0.000 description 1
230000000699 topical effect Effects 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
231100000419 toxicity Toxicity 0.000 description 1
230000001988 toxicity Effects 0.000 description 1
FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
ILWRPSCZWQJDMK-UHFFFAOYSA-N triethylazanium;chloride Chemical compound Cl.CCN(CC)CC ILWRPSCZWQJDMK-UHFFFAOYSA-N 0.000 description 1
125000004953 trihalomethyl group Chemical group 0.000 description 1
210000004881 tumor cell Anatomy 0.000 description 1
229960004441 tyrosine Drugs 0.000 description 1
OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
210000003606 umbilical vein Anatomy 0.000 description 1
229960004295 valine Drugs 0.000 description 1
239000004474 valine Substances 0.000 description 1
238000010792 warming Methods 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

NO20053993A 2003-07-21 2005-08-26 Kjemiske forbindelser samt anvendelse og fremstilling derav og farmasoytisk sammensetning for behandling av cancer NO333603B1 (no)

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GBGB0317009.9A GB0317009D0 (en)	2003-07-21	2003-07-21	Chemical compounds
PCT/GB2004/003148 WO2005012327A2 (en)	2003-07-21	2004-07-20	Nucleotide phosphoramidates as anticancer agents

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US (2)	USRE47589E1 (es)
EP (5)	EP3904365B1 (es)
JP (1)	JP4923216B2 (es)
AU (1)	AU2004261455B2 (es)
CA (1)	CA2518115C (es)
CY (5)	CY1117960T1 (es)
DK (4)	DK2955190T3 (es)
ES (4)	ES2589738T3 (es)
FI (1)	FIC20230013I1 (es)
FR (1)	FR23C1014I2 (es)
GB (1)	GB0317009D0 (es)
HU (4)	HUE059970T2 (es)
MX (1)	MXPA05012606A (es)
NO (1)	NO333603B1 (es)
NZ (1)	NZ541974A (es)
PL (4)	PL1646639T3 (es)
PT (4)	PT1646639T (es)
SI (2)	SI2955190T1 (es)
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WO (1)	WO2005012327A2 (es)

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PL3904365T3 (pl)	2022-11-07
SI3040340T1 (sl)	2019-03-29
EP3904365A1 (en)	2021-11-03
PT3040340T (pt)	2019-02-06
MXPA05012606A (es)	2006-02-08
PL3040340T3 (pl)	2019-05-31
ES2708570T3 (es)	2019-04-10
FR23C1014I2 (fr)	2024-02-09
DK1646639T3 (en)	2016-09-12
CY1120202T1 (el)	2018-12-12
CA2518115A1 (en)	2005-02-10
EP1646639B8 (en)	2016-12-21
US7951787B2 (en)	2011-05-31
USRE47589E1 (en)	2019-09-03
AU2004261455A1 (en)	2005-02-10
WO2005012327A3 (en)	2005-04-21
NO20053993D0 (no)	2005-08-26
CY2023008I1 (el)	2024-02-16
EP2955190A2 (en)	2015-12-16
EP3904365B1 (en)	2022-09-07
HUE042282T2 (hu)	2019-06-28
NZ541974A (en)	2009-03-31
AU2004261455B2 (en)	2010-12-23
ES2928202T3 (es)	2022-11-16
PT3904365T (pt)	2022-10-13
GB0317009D0 (en)	2003-08-27
EP1646639B1 (en)	2016-08-17
HUE059970T2 (hu)	2023-01-28
CA2518115C (en)	2012-03-20
ES2589738T3 (es)	2016-11-16
CY1117960T1 (el)	2017-05-17
PT2955190T (pt)	2018-05-07
EP1646639A2 (en)	2006-04-19
DK2955190T3 (en)	2018-05-22
WO2005012327A2 (en)	2005-02-10
PT1646639T (pt)	2016-09-05
HUS2300012I1 (hu)	2023-03-28
FR23C1014I1 (fr)	2023-05-05
TR201901246T4 (tr)	2019-02-21
EP3486251A1 (en)	2019-05-22
JP2006528162A (ja)	2006-12-14
CY2023008I2 (el)	2024-02-16
JP4923216B2 (ja)	2012-04-25
FIC20230013I1 (fi)	2023-03-01
DK3040340T3 (en)	2019-02-25
PL1646639T3 (pl)	2016-12-30
SI2955190T1 (en)	2018-08-31
US20060142238A1 (en)	2006-06-29
PL2955190T3 (pl)	2018-09-28
NO20053993L (no)	2005-11-02
DK3904365T3 (da)	2022-10-17
ES2667698T3 (es)	2018-05-14
EP3040340B1 (en)	2018-11-14
EP2955190A3 (en)	2016-03-16
CY1125603T1 (el)	2023-06-09
EP2955190B1 (en)	2018-03-28
EP3040340A1 (en)	2016-07-06
HUE030374T2 (en)	2017-05-29
CY1121218T1 (el)	2020-05-29

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HK40059112B (en)	2022-12-23	Chemical compounds
HK40059112A (en)	2022-04-29	Chemical compounds
HK40002589A (en)	2020-03-27	Chemical compounds
HK1192758B (en)	2016-10-21	Phosphoramidate derivatives of 5-fluoro-2'-deoxyuridine for use in the treatment of cancer

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