NO20091977L - Oksadiazol- og tiadiazolforbindelser og deres anvendelse som nikotinacetylkolinreseptormodulatorer - Google Patents
Oksadiazol- og tiadiazolforbindelser og deres anvendelse som nikotinacetylkolinreseptormodulatorerInfo
- Publication number
- NO20091977L NO20091977L NO20091977A NO20091977A NO20091977L NO 20091977 L NO20091977 L NO 20091977L NO 20091977 A NO20091977 A NO 20091977A NO 20091977 A NO20091977 A NO 20091977A NO 20091977 L NO20091977 L NO 20091977L
- Authority
- NO
- Norway
- Prior art keywords
- disorders
- diseases
- oxadiazole
- receptor modulators
- acetylcholine receptor
- Prior art date
Links
- 102000019315 Nicotinic acetylcholine receptors Human genes 0.000 title 1
- 108050006807 Nicotinic acetylcholine receptors Proteins 0.000 title 1
- WCPAKWJPBJAGKN-UHFFFAOYSA-N oxadiazole Chemical compound C1=CON=N1 WCPAKWJPBJAGKN-UHFFFAOYSA-N 0.000 title 1
- 150000004867 thiadiazoles Chemical class 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 7
- 208000035475 disorder Diseases 0.000 abstract 4
- 201000010099 disease Diseases 0.000 abstract 3
- 210000003169 central nervous system Anatomy 0.000 abstract 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
- 210000001428 peripheral nervous system Anatomy 0.000 abstract 2
- 208000017701 Endocrine disease Diseases 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 208000029578 Muscle disease Diseases 0.000 abstract 1
- 208000021642 Muscular disease Diseases 0.000 abstract 1
- 206010056677 Nerve degeneration Diseases 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 abstract 1
- 235000012000 cholesterol Nutrition 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000030172 endocrine system disease Diseases 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 125000001715 oxadiazolyl group Chemical group 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 210000002460 smooth muscle Anatomy 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 125000001113 thiadiazolyl group Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
- C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
- C07D285/135—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Psychology (AREA)
- Rheumatology (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Gynecology & Obstetrics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85407806P | 2006-10-25 | 2006-10-25 | |
| DKPA200601380 | 2006-10-25 | ||
| PCT/EP2007/061433 WO2008049864A1 (fr) | 2006-10-25 | 2007-10-24 | Composés de type oxadiazole et thiadiazole et leur utilisation comme modulateurs des récepteurs nicotiniques de l'acétylcholine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20091977L true NO20091977L (no) | 2009-05-20 |
Family
ID=38962931
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20091977A NO20091977L (no) | 2006-10-25 | 2009-05-20 | Oksadiazol- og tiadiazolforbindelser og deres anvendelse som nikotinacetylkolinreseptormodulatorer |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20100029685A1 (fr) |
| EP (1) | EP2079734A1 (fr) |
| JP (1) | JP2010507619A (fr) |
| AU (1) | AU2007310897A1 (fr) |
| CA (1) | CA2667545A1 (fr) |
| IL (1) | IL197397A0 (fr) |
| MX (1) | MX2009003892A (fr) |
| NO (1) | NO20091977L (fr) |
| WO (1) | WO2008049864A1 (fr) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101597665B1 (ko) | 2007-08-13 | 2016-02-24 | 몬산토 테크놀로지 엘엘씨 | 선충류 방제용 조성물 및 방법 |
| AU2013203849B2 (en) * | 2007-08-13 | 2016-01-14 | Monsanto Technology Llc | Compositions and methods for controlling nematodes |
| GB0723719D0 (en) * | 2007-12-04 | 2008-01-16 | Glaxo Group Ltd | Compounds |
| GB0723815D0 (en) * | 2007-12-05 | 2008-01-16 | Glaxo Group Ltd | Compounds |
| US8383658B2 (en) | 2008-06-04 | 2013-02-26 | Abbott Laboratories | Isoxazole based neuronal nicotinic receptor ligands and methods of use |
| EP2591674B1 (fr) | 2008-07-17 | 2016-01-13 | Bayer CropScience AG | Liaisons hétérocycliques en tant que moyen de lutte contre les parasites |
| AU2009289329A1 (en) * | 2008-09-02 | 2010-03-11 | Neurosearch A/S | Triazole derivatives and their use as nicotinic acetylcholine receptor modulators |
| ES2754503T3 (es) | 2009-02-10 | 2020-04-17 | Monsanto Technology Llc | Composiciones y procedimientos de lucha contra nematodos |
| US9095596B2 (en) | 2009-10-15 | 2015-08-04 | Southern Research Institute | Treatment of neurodegenerative diseases, causation of memory enhancement, and assay for screening compounds for such |
| WO2011073299A1 (fr) | 2009-12-18 | 2011-06-23 | Neurosearch A/S | Composés pyridinyloxadiazole et leur utilisation en tant que modulateurs des récepteurs nicotiniques de l'acétylcholine |
| AU2011252974A1 (en) * | 2010-05-12 | 2012-12-13 | Vanderbilt University | Heterocyclic sulfone mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
| JP5826848B2 (ja) | 2010-09-02 | 2015-12-02 | モンサント テクノロジー エルエルシー | 線虫を防除する新規組成物および方法 |
| JP5953308B2 (ja) * | 2010-10-22 | 2016-07-20 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ | 殺害虫剤としての新規ヘテロ環式化合物 |
| EP2967065A4 (fr) | 2013-03-15 | 2016-08-24 | Monsanto Technology Llc | Azoles n,c-disubstitués de lutte contre les nématodes nuisibles |
| CZ305680B6 (cs) * | 2013-04-04 | 2016-02-03 | Univerzita Karlova v Praze, Farmaceutická fakulta v Hradci Králové | Substituovaný diazol, jeho použití a farmaceutický přípravek ho obsahující |
| US10513110B2 (en) * | 2014-06-13 | 2019-12-24 | Electronics For Imaging, Inc. | Integration of a line-scan camera on a single pass inkjet printer |
| CN108697709A (zh) | 2015-12-10 | 2018-10-23 | Ptc医疗公司 | 用于治疗亨廷顿病的方法 |
| AU2018282154B2 (en) | 2017-06-05 | 2022-04-07 | Ptc Therapeutics, Inc. | Compounds for treating huntington's disease |
| CN111182898B (zh) | 2017-06-28 | 2024-04-16 | Ptc医疗公司 | 用于治疗亨廷顿氏病的方法 |
| WO2019005993A1 (fr) | 2017-06-28 | 2019-01-03 | Ptc Therapeutics, Inc. | Méthodes de traitement de la maladie de huntington |
| BR112020019373A2 (pt) | 2018-03-27 | 2020-12-29 | Ptc Therapeutics, Inc. | Compostos para o tratamento da doença de hutington |
| EP3814360B8 (fr) | 2018-06-27 | 2024-11-06 | PTC Therapeutics, Inc. | Composés hétéroaryl pour traiter la maladie de huntington |
| WO2020005877A1 (fr) | 2018-06-27 | 2020-01-02 | Ptc Therapeutics, Inc. | Composés hétéroaryles pour le traitement de la maladie de huntington |
| IL279688B2 (en) | 2018-06-27 | 2025-01-01 | Ptc Therapeutics Inc | Heterocyclic and heteroaryl compounds for the treatment of Huntington's disease |
| BR112022003959A2 (pt) * | 2019-09-05 | 2022-05-24 | Trevena Inc | Métodos para tratamento de epilepsia |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL261797A (fr) * | 1960-03-01 | |||
| CH411906A (de) * | 1960-03-01 | 1966-04-30 | Ciba Geigy | Verfahren zur Herstellung neuer 1,3,4-Thiadiazole |
| NL287227A (fr) * | 1961-12-28 | |||
| US3574842A (en) * | 1969-11-10 | 1971-04-13 | American Cyanamid Co | Compositions of 4-(1,2,4-oxadiazole-3 or 5-yl)pyridinium salts and method of lowering blood sugar levels with same |
| US3964896A (en) | 1971-08-09 | 1976-06-22 | Uniroyal, Inc. | Oxadiazole benzoic acid derivatives as herbicides |
| US3947263A (en) * | 1974-07-29 | 1976-03-30 | Uniroyal, Inc. | Plant growth regulants |
| EP0288432A1 (fr) * | 1987-04-09 | 1988-10-26 | Ciba-Geigy Ag | Biocides |
| FR2636628B1 (fr) * | 1988-08-25 | 1990-12-28 | Sanofi Sa | Derives du thiadiazole-1,3,4, leur procede d'obtention et compositions pharmaceutiques en contenant |
| JP2801269B2 (ja) * | 1989-07-10 | 1998-09-21 | キヤノン株式会社 | 化合物およびこれを含む液晶組成物およびこれを使用した液晶素子 |
| US5670526A (en) * | 1995-12-21 | 1997-09-23 | Otsuka Pharmaceutical Co., Ltd. | 1,3,4-oxadiazoles |
| PL334570A1 (en) * | 1997-01-14 | 2000-03-13 | Egyt Gyogyszervegyeszeti Gyar | Derivatives of 2-(1,2,4-triazol-1-yl)-1,3,4-thiadiazole acting on central nervous system and hearth |
| US6699853B2 (en) * | 1997-06-16 | 2004-03-02 | Hoechst Schering Agrevo Gmbh | 4-haloalkyl-3-heterocyclylpyridines, 4-haloalkyl-5-heterocyclyl-pyrimidines and 4-trifluoromethyl-3-oxadiazolylpyridines, processes for their preparation, compositions comprising them, and their use as pesticides |
| DE19725450A1 (de) | 1997-06-16 | 1998-12-17 | Hoechst Schering Agrevo Gmbh | 4-Haloalkyl-3-heterocyclylpyridine und 4-Haloalkyl-5-heterocyclylpyrimidine, Verfahren zu ihrer Herstellung, sie enthaltende Mittel und ihre Verwendung als Schädlingsbekämpfungsmittel |
| US6660753B2 (en) * | 1999-08-19 | 2003-12-09 | Nps Pharmaceuticals, Inc. | Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists |
| AR032653A1 (es) * | 2001-02-09 | 2003-11-19 | Telik Inc | Inhibidores heterociclicos del trasportador de glicina 2 composiciones farmaceuticas, uso y metodos. |
| PL369598A1 (en) * | 2001-02-21 | 2005-05-02 | Nps Pharmaceuticals, Inc. | Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists |
| CN1638776A (zh) * | 2001-06-08 | 2005-07-13 | 西托维亚公司 | 取代的3－芳基－5－芳基－[1,2,4]－噁二唑和类似物 |
| FR2832712B1 (fr) * | 2001-11-23 | 2004-02-13 | Sanofi Synthelabo | Derives de 4-(oxadiazol-3-yl)-1,4-diazabicyclo[3.2.2]nonane, leur preparation et leur application en therapeutique |
| FR2832713B1 (fr) * | 2001-11-23 | 2004-02-13 | Sanofi Synthelabo | Derives de 4-(1,3,4-thiadiazol-2-yl)-1,4-diazabicyclo[3.2.2] nonane, leur preparation et leur application en therapeutique |
| ATE450263T1 (de) * | 2004-02-04 | 2009-12-15 | Neurosearch As | Diazabicyclische aryl-derivate als cholinerge rezeptor-modulatoren |
| GB0403744D0 (en) * | 2004-02-20 | 2004-03-24 | Astrazeneca Ab | Chemical process |
| EP2336113A1 (fr) * | 2004-05-29 | 2011-06-22 | 7TM Pharma A/S | Ligands de récepteur CRTH2 à usage médical |
| MX2008014887A (es) * | 2006-05-30 | 2008-12-05 | Neurosearch As | Nuevos derivados de 1,4-diaza-biciclo[3.2.2]nonil oxadiazolilo y su uso medico. |
| US20080015193A1 (en) * | 2006-06-20 | 2008-01-17 | Mendoza Jose S | Certain azoles exhibiting ATP-utilizing enzyme inhibitory activity, compositions, and uses thereof |
| EP2044926B1 (fr) * | 2006-07-20 | 2018-01-10 | National University Corporation Okayama University | Composition orale pour applications dentaires |
| BRPI0815490A2 (pt) * | 2007-08-17 | 2017-03-21 | Astrazeneca Ab | composto, composição faramcêutica, método para tratar diabetes mellitus e/ou obesidade em um animal de sangue quente, e, processo para preparar um composto |
| HRP20110449T1 (hr) * | 2007-08-17 | 2011-07-31 | Actelion Pharmaceuticals Ltd. | Derivati piridina kao modulatori receptora s1p1/edg1 |
| MX2010006647A (es) * | 2007-12-26 | 2010-08-17 | Sanofi Aventis | Piridil-n-[1,3,4]-tiadiazol-2-il-bencenosulfonamidas ciclicas, procedimientos para su preparacion y su uso como productos farmaceuticos. |
| BRPI0914978A2 (pt) * | 2008-06-09 | 2015-10-27 | Sanofi Aventis | sulfonamidas n-heterocíclicas reforçadas com grupo principal de oxadiazolona, processos para sua preparação e seu uso como farmacêuticos |
| WO2010117662A1 (fr) * | 2009-03-30 | 2010-10-14 | Exelixis, Inc. | Modulateurs de s1p et procédés de réalisation et d'utilisation de ceux-ci |
| SA110310332B1 (ar) * | 2009-05-01 | 2013-12-10 | Astrazeneca Ab | مركبات ميثانون (3 استبدال -ازيتيدين -1-يل )(5- فينيل -1، 3، 4- أوكساديازول -2-يل ) |
| US8399451B2 (en) * | 2009-08-07 | 2013-03-19 | Bristol-Myers Squibb Company | Heterocyclic compounds |
-
2007
- 2007-10-24 JP JP2009533834A patent/JP2010507619A/ja not_active Abandoned
- 2007-10-24 WO PCT/EP2007/061433 patent/WO2008049864A1/fr not_active Ceased
- 2007-10-24 CA CA002667545A patent/CA2667545A1/fr not_active Abandoned
- 2007-10-24 EP EP07821796A patent/EP2079734A1/fr not_active Withdrawn
- 2007-10-24 US US12/447,205 patent/US20100029685A1/en not_active Abandoned
- 2007-10-24 MX MX2009003892A patent/MX2009003892A/es not_active Application Discontinuation
- 2007-10-24 AU AU2007310897A patent/AU2007310897A1/en not_active Abandoned
-
2009
- 2009-03-04 IL IL197397A patent/IL197397A0/en unknown
- 2009-05-20 NO NO20091977A patent/NO20091977L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2007310897A1 (en) | 2008-05-02 |
| MX2009003892A (es) | 2009-04-23 |
| IL197397A0 (en) | 2009-12-24 |
| JP2010507619A (ja) | 2010-03-11 |
| US20100029685A1 (en) | 2010-02-04 |
| CA2667545A1 (fr) | 2008-05-02 |
| WO2008049864A1 (fr) | 2008-05-02 |
| EP2079734A1 (fr) | 2009-07-22 |
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