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PL2032575T3 - Nowa pochodna oksadiazolylu, 1,4-diaza-bicyklo[3.2.2]nonylu i jej medyczne zastosowanie - Google Patents

Nowa pochodna oksadiazolylu, 1,4-diaza-bicyklo[3.2.2]nonylu i jej medyczne zastosowanie

Info

Publication number
PL2032575T3
PL2032575T3 PL07729591T PL07729591T PL2032575T3 PL 2032575 T3 PL2032575 T3 PL 2032575T3 PL 07729591 T PL07729591 T PL 07729591T PL 07729591 T PL07729591 T PL 07729591T PL 2032575 T3 PL2032575 T3 PL 2032575T3
Authority
PL
Poland
Prior art keywords
diseases
disorders
diaza
bicyclo
novel
Prior art date
Application number
PL07729591T
Other languages
English (en)
Inventor
Dan Peters
Gunnar M Olsen
Elsebet Östergaard Nielsen
Daniel B Timmermann
Steven Charles Loechel
Original Assignee
Neurosearch As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch As filed Critical Neurosearch As
Publication of PL2032575T3 publication Critical patent/PL2032575T3/pl

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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PL07729591T 2006-05-30 2007-05-29 Nowa pochodna oksadiazolylu, 1,4-diaza-bicyklo[3.2.2]nonylu i jej medyczne zastosowanie PL2032575T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US80902406P 2006-05-30 2006-05-30
DKPA200600731 2006-05-30
PCT/EP2007/055169 WO2007138038A1 (en) 2006-05-30 2007-05-29 Novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their medical use
EP07729591A EP2032575B1 (en) 2006-05-30 2007-05-29 Novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivative and its medical use

Publications (1)

Publication Number Publication Date
PL2032575T3 true PL2032575T3 (pl) 2010-09-30

Family

ID=40616686

Family Applications (1)

Application Number Title Priority Date Filing Date
PL07729591T PL2032575T3 (pl) 2006-05-30 2007-05-29 Nowa pochodna oksadiazolylu, 1,4-diaza-bicyklo[3.2.2]nonylu i jej medyczne zastosowanie

Country Status (23)

Country Link
US (4) US8158619B2 (pl)
EP (3) EP2032575B1 (pl)
JP (2) JP5290964B2 (pl)
KR (1) KR101458194B1 (pl)
CN (2) CN101432286A (pl)
AT (3) ATE463497T1 (pl)
AU (2) AU2007267175A1 (pl)
BR (1) BRPI0708843A2 (pl)
CA (2) CA2653769A1 (pl)
DE (2) DE602007005802D1 (pl)
DK (2) DK2032575T3 (pl)
ES (1) ES2342334T3 (pl)
IL (1) IL193925A (pl)
MX (2) MX2008014887A (pl)
MY (1) MY147764A (pl)
NO (1) NO20085398L (pl)
NZ (1) NZ571288A (pl)
PL (1) PL2032575T3 (pl)
PT (1) PT2032575E (pl)
RU (1) RU2427581C2 (pl)
UA (1) UA95946C2 (pl)
WO (2) WO2007138037A1 (pl)
ZA (1) ZA200807756B (pl)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2032575T3 (pl) * 2006-05-30 2010-09-30 Neurosearch As Nowa pochodna oksadiazolylu, 1,4-diaza-bicyklo[3.2.2]nonylu i jej medyczne zastosowanie
EP2079734A1 (en) * 2006-10-25 2009-07-22 NeuroSearch A/S Oxadiazole and thiadiazole compounds and their use as nicotinic acetylcholine receptor modulators
WO2009024517A1 (en) 2007-08-17 2009-02-26 Neurosearch A/S Novel 1,4-diaza-bicyclo[3.2.2]nonyl heteroaryl derivatives useful as nicotinic acetylcholine receptor ligands
AU2009224737A1 (en) 2008-03-11 2009-09-17 Neurosearch A/S Novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives useful as modulator of nicotinic acetylcholine receptors
EP2288608A1 (en) * 2008-06-10 2011-03-02 NeuroSearch A/S Novel oxadiazolyl-diazabicyclononane derivatives and their medical use
US20110263577A1 (en) * 2008-10-13 2011-10-27 Neurosearch A/S Novel oxadiazolyl-diazabicyclononane derivatives and their medical use
US20110257161A1 (en) * 2008-12-04 2011-10-20 Neurosearch A/S Novel diaza-bicyclononyl-phenyl derivatives and their medical use
CN102300574A (zh) 2009-01-26 2011-12-28 神经研究公司 新的吲哚基-*二唑基-二氮杂二环壬烷衍生物及它们的医药和诊断用途
WO2010086279A1 (en) 2009-01-27 2010-08-05 Neurosearch A/S Novel dibenzofuranyl-oxadiazolyl-diazabicyclononane derivatives and their medical use
WO2010086280A1 (en) 2009-01-27 2010-08-05 Neurosearch A/S Novel n-oxides of furanyl-oxadiazolyl-diazabicyclononane derivatives and their medical use
US20120238553A1 (en) * 2009-01-27 2012-09-20 Neurosearch A/S Novel benzodioxolyl-oxadiazolyl-diazabicyclononane derivatives and their medical use
WO2010130768A1 (en) * 2009-05-14 2010-11-18 Neurosearch A/S Novel 1,4-diaza-bicyclo[3.2.1]octane derivatives useful as nicotinic acetylcholine receptor modulators
JO3250B1 (ar) 2009-09-22 2018-09-16 Novartis Ag إستعمال منشطات مستقبل نيكوتينيك أسيتيل كولين ألفا 7
US20120288443A1 (en) 2009-11-11 2012-11-15 Neurosearch A/S Labelled pyrrolyl-oxadiazolyl-diazabicyclononane derivatives and their use in diagnostic methods
WO2011073296A1 (en) 2009-12-18 2011-06-23 Neurosearch A/S Diazabicyclononyl oxadiazole compounds and their use as nicotinic acetylcholine receptor modulators
US8986654B2 (en) 2011-04-15 2015-03-24 Danpet Ab Labelled and un-labelled methyl-pyrrolyl-oxadiazolyl-diazabicyclononane derivatives and their medical use
RU2020105929A (ru) 2017-08-04 2021-09-06 Скайхоук Терапьютикс, Инк. Способы и композиции для модулирования сплайсинга
EA202092490A1 (ru) 2018-04-18 2020-12-23 Констеллейшен Фармасьютикалс, Инк. Модуляторы метилмодифицирующих ферментов, композиции и их применения
CN120097995A (zh) 2018-05-21 2025-06-06 星座制药公司 甲基修饰酶的调节剂、其组合物和用途
WO2020163323A1 (en) * 2019-02-04 2020-08-13 Skyhawk Therapeutics, Inc. Methods and compositions for modulating splicing
CN114007613A (zh) 2019-02-05 2022-02-01 斯基霍克疗法公司 用于调节剪接的方法和组合物
KR20210135507A (ko) 2019-02-06 2021-11-15 스카이호크 테라퓨틱스, 인코포레이티드 스플라이싱을 조절하는 방법 및 조성물

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US5672709A (en) * 1994-10-24 1997-09-30 Eli Lilly And Company Heterocyclic compounds and their preparation and use
FR2809732B1 (fr) 2000-05-31 2002-07-19 Sanofi Synthelabo DERIVES DE 4(-2-PHENYLTHIAZOL-5-yl)-1,4-DIAZABICYCLO-[3.2.2] NONANE, LEUR PREPARATION ET LEUR APPLICATION ENTHERAPEUTIQUE
FR2809731B1 (fr) 2000-05-31 2002-07-19 Sanofi Synthelabo Derives de 1,4-diazabicyclo-[3.2.2] nonane-pheylisoxazole, leur preparation et leur application en therapeutique
FR2832713B1 (fr) * 2001-11-23 2004-02-13 Sanofi Synthelabo Derives de 4-(1,3,4-thiadiazol-2-yl)-1,4-diazabicyclo[3.2.2] nonane, leur preparation et leur application en therapeutique
FR2832712B1 (fr) * 2001-11-23 2004-02-13 Sanofi Synthelabo Derives de 4-(oxadiazol-3-yl)-1,4-diazabicyclo[3.2.2]nonane, leur preparation et leur application en therapeutique
RU2323218C2 (ru) * 2002-09-30 2008-04-27 НьюроСёрч А/С Новые производные 1,4-диазабициклоалкана и фармацевтическая композиция на их основе
US7220741B2 (en) 2002-09-30 2007-05-22 Neurosearch A/S 1,4-diazabicycloalkane derivatives, their preparation and use
DE60309740T2 (de) * 2002-11-11 2007-03-29 Neurosearch A/S 1,4-dizabicyclo(3,2,2)nonane derivative, verfahren zu ihrer herstellung und therapeutical verwendung
US6996399B2 (en) * 2003-01-13 2006-02-07 Micrel, Inc. Wireless device and method using frequency hopping and sweep modes
EP1713487B1 (en) 2004-02-04 2009-12-02 Neurosearch A/S Diazabicyclic aryl derivatives as cholinergic receptor modulators
WO2006087306A2 (en) 2005-02-16 2006-08-24 Neurosearch A/S Diazabicyclic aryl derivatives and their use as cholinergic ligands at the nicotinic acetylcholine receptors
PL2032575T3 (pl) 2006-05-30 2010-09-30 Neurosearch As Nowa pochodna oksadiazolylu, 1,4-diaza-bicyklo[3.2.2]nonylu i jej medyczne zastosowanie

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