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NO20090667L - Tartratsalt av (7S)-7-[(5-fluor-2-metyl-benzyl)oksy]-2-[(2R)-2-metylpiperazin-1-yl]-6,7-dihydro-5H-syklopenta[b] pyridin - Google Patents

Tartratsalt av (7S)-7-[(5-fluor-2-metyl-benzyl)oksy]-2-[(2R)-2-metylpiperazin-1-yl]-6,7-dihydro-5H-syklopenta[b] pyridin

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Publication number
NO20090667L
NO20090667L NO20090667A NO20090667A NO20090667L NO 20090667 L NO20090667 L NO 20090667L NO 20090667 A NO20090667 A NO 20090667A NO 20090667 A NO20090667 A NO 20090667A NO 20090667 L NO20090667 L NO 20090667L
Authority
NO
Norway
Prior art keywords
tartrate salt
cyclopenta
dihydro
oxy
fluoro
Prior art date
Application number
NO20090667A
Other languages
English (en)
Inventor
Kevin Kun-Chin Liu
Yuan Zeng
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of NO20090667L publication Critical patent/NO20090667L/no

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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
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  • Plural Heterocyclic Compounds (AREA)

Abstract

Foreliggende oppfinnelse tilveiebringer et tartratsalt med formel (I), formel I er også kjent som (7S)-7-[(5-fluor-2-metyl-benzyl)oksy]-2-[(2R)-2-metylpiperazin-1 -yl]-6,7-dihydro-5H-syklopenta[b]pyridin. Tartratsaltet er foretrukket krystallinsk.Tartratsaltet med formel I ifølge oppfinnelsen er anvendbart ved behandling av sykdommer koblet til aktivering av 5-HT2c reseptoren i dyr inkludert mennesker, feks. ved behandling av schizofreni, kognitiv deficit inkludert kognitiv deficit assosiert med schizofreni, angst, depresjon, tvangslidelse, epilepsi, fedme, seksuell dysfunksjon og urininkontinens, blant andre.
NO20090667A 2006-07-14 2009-02-11 Tartratsalt av (7S)-7-[(5-fluor-2-metyl-benzyl)oksy]-2-[(2R)-2-metylpiperazin-1-yl]-6,7-dihydro-5H-syklopenta[b] pyridin NO20090667L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83089006P 2006-07-14 2006-07-14
PCT/IB2007/002025 WO2008010073A1 (en) 2006-07-14 2007-07-09 Tartrate salt of (7s)-7-[(5-fluoro-2-methyl-benzyl)oxy]-2-[(2r)-2-methylpiperazin-1-yl]-6,7-dihydro-5h-cyclopenta[b]pyridine

Publications (1)

Publication Number Publication Date
NO20090667L true NO20090667L (no) 2009-02-11

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NO20090667A NO20090667L (no) 2006-07-14 2009-02-11 Tartratsalt av (7S)-7-[(5-fluor-2-metyl-benzyl)oksy]-2-[(2R)-2-metylpiperazin-1-yl]-6,7-dihydro-5H-syklopenta[b] pyridin

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US (1) US20100004259A1 (no)
EP (1) EP2044029B1 (no)
JP (1) JP4312243B2 (no)
KR (1) KR20090029299A (no)
CN (1) CN101506172A (no)
AR (1) AR062068A1 (no)
AT (1) ATE496894T1 (no)
AU (1) AU2007274710A1 (no)
CA (1) CA2657640A1 (no)
DE (1) DE602007012254D1 (no)
IL (1) IL196417A0 (no)
MX (1) MX2009000508A (no)
NO (1) NO20090667L (no)
TW (1) TW200821293A (no)
WO (1) WO2008010073A1 (no)
ZA (1) ZA200901051B (no)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5520051B2 (ja) 2007-11-15 2014-06-11 武田薬品工業株式会社 縮合ピリジン誘導体およびその用途
JP5124308B2 (ja) 2008-02-26 2013-01-23 株式会社リコー トナー、該トナーを用いた現像剤、トナー入り容器、プロセスカートリッジ、及び画像形成方法
WO2010079605A1 (ja) * 2009-01-09 2010-07-15 東レ・ファインケミカル株式会社 高純度１－ベンジル－３－アミノピロリジンの製造方法
JO3250B1 (ar) 2009-09-22 2018-09-16 Novartis Ag إستعمال منشطات مستقبل نيكوتينيك أسيتيل كولين ألفا 7
US20140206667A1 (en) 2012-11-14 2014-07-24 Michela Gallagher Methods and compositions for treating schizophrenia
US9993273B2 (en) 2013-01-16 2018-06-12 Mako Surgical Corp. Bone plate and tracking device using a bone plate for attaching to a patient's anatomy
JP6472757B2 (ja) 2013-01-16 2019-02-20 ストライカー・コーポレイション 見通し線エラーを示し、かつ低減させるためのナビゲーションシステムおよび方法
US10095785B2 (en) * 2013-09-30 2018-10-09 Sonos, Inc. Audio content search in a media playback system
WO2015066344A1 (en) 2013-11-01 2015-05-07 Arena Pharmaceuticals, Inc. 5-ht2c receptor agonists and compositions and methods of use
US10606822B2 (en) * 2014-11-01 2020-03-31 Hewlett Packard Enterprise Development Lp Dynamically updating metadata
US10537395B2 (en) 2016-05-26 2020-01-21 MAKO Surgical Group Navigation tracker with kinematic connector assembly
EP3338768B1 (en) 2016-12-20 2019-10-30 LTS Lohmann Therapie-Systeme AG Transdermal therapeutic system containing asenapine
CA3047354A1 (en) 2016-12-20 2018-06-28 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system containing asenapine and polysiloxane or polyisobutylene
ES2881783T3 (es) 2017-06-26 2021-11-30 Lts Lohmann Therapie Systeme Ag Sistema terapéutico transdérmico que contiene asenapina y polímero de acrílico y silicona
LT3652176T (lt) * 2017-07-11 2022-02-25 Boehringer Ingelheim International Gmbh Pakeisti ksantino dariniai
JP7502199B2 (ja) 2018-06-20 2024-06-18 エルテーエス ローマン テラピー－ジステーメ アーゲー アセナピンを含有する経皮治療システム
EP3810099A1 (en) 2018-06-20 2021-04-28 LTS Lohmann Therapie-Systeme AG Transdermal therapeutic system containing asenapine
US20210393621A1 (en) 2018-10-26 2021-12-23 The Research Foundation For The State University Of New York Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia
EP3669876A1 (en) * 2018-12-18 2020-06-24 Aelis Farma 3béta-(benzyloxy)-17alpha-methyl-pregn-5-en-20-one for use in the treatment of cognitive disorders
WO2023248222A1 (en) * 2022-06-21 2023-12-28 Technion Research & Development Foundation Limited 5-ht2c receptor modulating agents for the treatment of neurodegenerative, mental, cognitive and autoimmune cns disorders

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4985352A (en) * 1988-02-29 1991-01-15 The Trustees Of Columbia University In The City Of New York DNA encoding serotonin 1C (5HT1c) receptor, isolated 5HT1c receptor, mammalian cells expressing same and uses thereof
EP0361489A3 (en) * 1988-09-30 1991-06-12 Chugai Seiyaku Kabushiki Kaisha Novel 3,4-diaminoquinoline and pyridine compounds
DE4326151A1 (de) * 1993-08-04 1995-02-09 Hoechst Ag Aromatische Verbindungen und ihre Verwendung in flüssigkristallinen Mischungen
TW334423B (en) * 1993-10-22 1998-06-21 Hoffmann La Roche Tricyclic 1-aminoethylpyrrole-derivatives
TW270114B (no) * 1993-10-22 1996-02-11 Hoffmann La Roche
US5698766A (en) * 1995-04-05 1997-12-16 The Regents Of The University Of California Transgenic animal model for testing drugs for treating eating disorders and epilepsy
US6875769B2 (en) * 1996-05-23 2005-04-05 Pfizer Inc. Substituted6,6-hetero-bicyclicderivatives
US6040448A (en) * 1997-10-24 2000-03-21 Neurogen Corporation Certain 1-(2-naphthyl) and 1-(2-azanaphthyl)-4-(1-phenylmethyl) piperazines, dopamine receptor subtype specific ligands
RU2198873C2 (ru) * 1998-02-26 2003-02-20 Акцо Нобель Н.В. Производные азетидина и пирролидина
GB9819019D0 (en) * 1998-09-01 1998-10-28 Cerebrus Ltd Chemical compounds II
GB9819035D0 (en) * 1998-09-01 1998-10-28 Cerebrus Res Ltd Chemical compounds VII
GB9819033D0 (en) * 1998-09-01 1998-10-28 Cerebrus Ltd Chemical compounds VI
EP1109544A4 (en) * 1998-09-01 2004-10-27 Bristol Myers Squibb Co POTASSIUM CHANNEL INHIBITORS AND THEIR METHOD OF USE
US6465467B1 (en) * 1999-05-21 2002-10-15 Biovitrum Ab Certain aryl-aliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases
JP3600209B2 (ja) * 2000-01-25 2004-12-15 ケーニツヒ ウント バウエル アクチエンゲゼルシヤフト スクリーン印刷胴を備えた印刷ユニット
TW527590B (en) * 2000-04-25 2003-04-11 Matsushita Electric Industrial Co Ltd Compact disk, and the manufacturing method of the same, and the manufacturing device of compact disk
SE0004245D0 (sv) * 2000-11-20 2000-11-20 Pharmacia Ab Novel compounds and their use
US6716840B2 (en) * 2001-04-09 2004-04-06 Chiron Corporation Guanidino compounds
US6825198B2 (en) * 2001-06-21 2004-11-30 Pfizer Inc 5-HT receptor ligands and uses thereof
US6953787B2 (en) * 2002-04-12 2005-10-11 Arena Pharmaceuticals, Inc. 5HT2C receptor modulators
DK1557411T3 (da) * 2002-07-12 2012-11-05 Astellas Pharma Inc N-phenyl-(2r,5s)-dimethylpiperazin-derivat
EP1613322A4 (en) * 2003-04-11 2008-08-13 Taigen Biotechnology Co Ltd AMINOQUINOLINE COMPOUNDS
US7101881B2 (en) * 2003-06-11 2006-09-05 Pfizer Inc Tetrahydroquinolines
US20070015771A1 (en) * 2004-07-29 2007-01-18 Threshold Pharmaceuticals, Inc. Lonidamine analogs
KR100894006B1 (ko) * 2005-03-31 2009-04-17 화이자 프로덕츠 인코포레이티드 사이클로펜타피리딘 및 테트라하이드로퀴놀린 유도체

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CN101506172A (zh) 2009-08-12
EP2044029B1 (en) 2011-01-26
AR062068A1 (es) 2008-10-15
CA2657640A1 (en) 2008-01-24
TW200821293A (en) 2008-05-16
KR20090029299A (ko) 2009-03-20
AU2007274710A1 (en) 2008-01-24
JP2008044931A (ja) 2008-02-28
US20100004259A1 (en) 2010-01-07
ZA200901051B (en) 2010-01-27
JP4312243B2 (ja) 2009-08-12
MX2009000508A (es) 2009-01-27
DE602007012254D1 (de) 2011-03-10
ATE496894T1 (de) 2011-02-15
WO2008010073A1 (en) 2008-01-24
WO2008010073A8 (en) 2009-03-05
EP2044029A1 (en) 2009-04-08
IL196417A0 (en) 2009-09-22

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