NO20084564L - Stramme "Constrained" forbindelser som CGRP-reseptor antagonister - Google Patents
Stramme "Constrained" forbindelser som CGRP-reseptor antagonisterInfo
- Publication number
- NO20084564L NO20084564L NO20084564A NO20084564A NO20084564L NO 20084564 L NO20084564 L NO 20084564L NO 20084564 A NO20084564 A NO 20084564A NO 20084564 A NO20084564 A NO 20084564A NO 20084564 L NO20084564 L NO 20084564L
- Authority
- NO
- Norway
- Prior art keywords
- receptor antagonists
- cgrp receptor
- constrained
- tight
- compounds
- Prior art date
Links
- 108010078311 Calcitonin Gene-Related Peptide Receptors Proteins 0.000 title abstract 3
- 102000008323 calcitonin gene-related peptide receptor activity proteins Human genes 0.000 title abstract 2
- 239000002464 receptor antagonist Substances 0.000 title abstract 2
- 229940044551 receptor antagonist Drugs 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- 102000014468 Calcitonin Gene-Related Peptide Receptors Human genes 0.000 abstract 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 abstract 1
- 206010019233 Headaches Diseases 0.000 abstract 1
- 208000019695 Migraine disease Diseases 0.000 abstract 1
- 208000007920 Neurogenic Inflammation Diseases 0.000 abstract 1
- 206010047141 Vasodilatation Diseases 0.000 abstract 1
- 208000027418 Wounds and injury Diseases 0.000 abstract 1
- 230000008485 antagonism Effects 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- 230000005796 circulatory shock Effects 0.000 abstract 1
- 230000006378 damage Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 231100000869 headache Toxicity 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 208000014674 injury Diseases 0.000 abstract 1
- 230000009245 menopause Effects 0.000 abstract 1
- 206010027599 migraine Diseases 0.000 abstract 1
- 230000001272 neurogenic effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000000241 respiratory effect Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 230000024883 vasodilation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Oppfinnelsen omfatter sterisk hindrede bicykliske og tricykliske CGRP-reseptorantagonister, metoder for å identifisere dem, farmasøytiske preparater omfattende dem og metoder for anvendelse av dem i terapi for behandling av migrene og andre hodepiner, nevrogen vasodilatasjon, nevrogen inflammasjon, termisk skade, kretsløpssjokk, rødming forbundet med menopause, luftveisinflammatoriske sykdommer, så som astma og kronisk obstruktiv lungesykdom (KOLS) og andre lidelser der behandlingen kan utføres ved antagonismen av CGRP-reseptorer. I II
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79740006P | 2006-05-03 | 2006-05-03 | |
| US11/742,626 US7470680B2 (en) | 2006-05-03 | 2007-05-01 | Constrained compounds as CGRP-receptor antagonists |
| PCT/US2007/067998 WO2007131020A2 (en) | 2006-05-03 | 2007-05-02 | Constrained compounds as cgrp-receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20084564L true NO20084564L (no) | 2008-12-02 |
Family
ID=38544174
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20084564A NO20084564L (no) | 2006-05-03 | 2008-10-30 | Stramme "Constrained" forbindelser som CGRP-reseptor antagonister |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7470680B2 (no) |
| EP (1) | EP2013214B1 (no) |
| JP (1) | JP2009535429A (no) |
| KR (1) | KR20090018930A (no) |
| AR (1) | AR060845A1 (no) |
| AU (1) | AU2007248038A1 (no) |
| BR (1) | BRPI0709759A2 (no) |
| CA (1) | CA2651033A1 (no) |
| IL (1) | IL195027A0 (no) |
| MX (1) | MX2008013760A (no) |
| NO (1) | NO20084564L (no) |
| PE (1) | PE20080232A1 (no) |
| TW (1) | TW200813063A (no) |
| WO (1) | WO2007131020A2 (no) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7384931B2 (en) * | 2004-11-03 | 2008-06-10 | Bristol-Myers Squibb Company | Constrained compounds as CGRP-receptor antagonists |
| WO2008085317A1 (en) * | 2006-12-20 | 2008-07-17 | Merck & Co., Inc. | Benzazepine compounds as cgrp receptor antagonists |
| CA2711367A1 (en) * | 2008-02-19 | 2009-08-27 | Merck Sharp & Dohme Corp. | Imidazobenzazepine cgrp receptor antagonists |
| EP2582668B1 (en) | 2010-06-16 | 2016-01-13 | Bristol-Myers Squibb Company | Carboline carboxamide compounds useful as kinase inhibitors |
| WO2017214269A1 (en) | 2016-06-08 | 2017-12-14 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| GB201707938D0 (en) | 2017-05-17 | 2017-06-28 | Univ Sheffield | Compounds |
| WO2024220626A1 (en) * | 2023-04-20 | 2024-10-24 | Azkarra Therapeutics, Inc. | Small molecule modulators of ogg1 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4584914B2 (ja) | 2003-03-14 | 2010-11-24 | メルク・シャープ・エンド・ドーム・コーポレイション | ベノジアゼピンスピロヒダントインｃｇｒｐ受容体拮抗物質 |
| US7288559B2 (en) | 2003-03-14 | 2007-10-30 | Merck + Co, Inc. | Carboxamide spirohydantoin CGRP receptor antagonists |
| DE602004027021D1 (de) | 2003-04-15 | 2010-06-17 | Merck Sharp & Dohme | Cgrp-rezeptorantagonisten |
| JO2355B1 (en) | 2003-04-15 | 2006-12-12 | ميرك شارب اند دوم كوربوريشن | Hereditary calcitonin polypeptide receptor antagonists |
| WO2005000807A2 (en) | 2003-06-26 | 2005-01-06 | Merck & Co., Inc. | Benzodiazepine cgrp receptor antagonists |
| EP1641423B1 (en) | 2003-06-26 | 2010-03-17 | Merck Sharp & Dohme Corp. | Benzodiazepine cgrp receptor antagonists |
| CN101124217A (zh) | 2004-01-29 | 2008-02-13 | 默克公司 | Cgrp受体拮抗剂 |
| US7390798B2 (en) | 2004-09-13 | 2008-06-24 | Merck & Co., Inc. | Carboxamide spirolactam CGRP receptor antagonists |
| JP2008515895A (ja) | 2004-10-07 | 2008-05-15 | メルク エンド カムパニー インコーポレーテッド | Ｃｇｒｐ受容体拮抗薬 |
| US8039460B2 (en) | 2004-10-13 | 2011-10-18 | Merck Sharp & Dohme Corp. | CGRP receptor antagonists |
| JP2008516957A (ja) | 2004-10-14 | 2008-05-22 | メルク エンド カムパニー インコーポレーテッド | Ｃｇｒｐ受容体拮抗薬 |
| WO2006047196A2 (en) | 2004-10-22 | 2006-05-04 | Merck & Co., Inc. | Cgrp receptor antagonists |
| US7384930B2 (en) | 2004-11-03 | 2008-06-10 | Bristol-Myers Squibb Company | Constrained compounds as CGRP-receptor antagonists |
| US7384931B2 (en) | 2004-11-03 | 2008-06-10 | Bristol-Myers Squibb Company | Constrained compounds as CGRP-receptor antagonists |
| JP2008526984A (ja) | 2005-01-18 | 2008-07-24 | メルク エンド カムパニー インコーポレーテッド | Ｃｇｒｐ受容体拮抗薬 |
| EP1861399B1 (en) | 2005-03-14 | 2011-12-14 | Merck Sharp & Dohme Corp. | Cgrp receptor antagonists |
| AU2006275981A1 (en) | 2005-07-29 | 2007-02-08 | Merck Sharp & Dohme Corp. | Heterocyclic benzodiazepine CGRP receptor antagonists |
| WO2008085317A1 (en) | 2006-12-20 | 2008-07-17 | Merck & Co., Inc. | Benzazepine compounds as cgrp receptor antagonists |
-
2007
- 2007-05-01 US US11/742,626 patent/US7470680B2/en active Active
- 2007-05-02 MX MX2008013760A patent/MX2008013760A/es not_active Application Discontinuation
- 2007-05-02 KR KR1020087029499A patent/KR20090018930A/ko not_active Withdrawn
- 2007-05-02 AU AU2007248038A patent/AU2007248038A1/en not_active Abandoned
- 2007-05-02 WO PCT/US2007/067998 patent/WO2007131020A2/en not_active Ceased
- 2007-05-02 PE PE2007000536A patent/PE20080232A1/es not_active Application Discontinuation
- 2007-05-02 CA CA002651033A patent/CA2651033A1/en not_active Abandoned
- 2007-05-02 EP EP07761726.4A patent/EP2013214B1/en active Active
- 2007-05-02 JP JP2009510047A patent/JP2009535429A/ja active Pending
- 2007-05-02 BR BRPI0709759-0A patent/BRPI0709759A2/pt not_active IP Right Cessation
- 2007-05-02 AR ARP070101906A patent/AR060845A1/es not_active Application Discontinuation
- 2007-05-03 TW TW096115732A patent/TW200813063A/zh unknown
-
2008
- 2008-10-30 IL IL195027A patent/IL195027A0/en unknown
- 2008-10-30 NO NO20084564A patent/NO20084564L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| US7470680B2 (en) | 2008-12-30 |
| WO2007131020A2 (en) | 2007-11-15 |
| CA2651033A1 (en) | 2007-11-15 |
| AU2007248038A1 (en) | 2007-11-15 |
| MX2008013760A (es) | 2008-11-14 |
| BRPI0709759A2 (pt) | 2011-10-25 |
| US20070259851A1 (en) | 2007-11-08 |
| IL195027A0 (en) | 2009-08-03 |
| WO2007131020A3 (en) | 2008-01-17 |
| TW200813063A (en) | 2008-03-16 |
| EP2013214B1 (en) | 2015-06-24 |
| AR060845A1 (es) | 2008-07-16 |
| PE20080232A1 (es) | 2008-04-11 |
| EP2013214A2 (en) | 2009-01-14 |
| KR20090018930A (ko) | 2009-02-24 |
| JP2009535429A (ja) | 2009-10-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |