NO20083208L - RNA-interferensmediert inhibering av hepatitt C-virus-genekspresjon ved anvendelse av korte interfererende nukleinsyrer (siNA) - Google Patents
RNA-interferensmediert inhibering av hepatitt C-virus-genekspresjon ved anvendelse av korte interfererende nukleinsyrer (siNA)Info
- Publication number
- NO20083208L NO20083208L NO20083208A NO20083208A NO20083208L NO 20083208 L NO20083208 L NO 20083208L NO 20083208 A NO20083208 A NO 20083208A NO 20083208 A NO20083208 A NO 20083208A NO 20083208 L NO20083208 L NO 20083208L
- Authority
- NO
- Norway
- Prior art keywords
- nucleic acid
- acid molecules
- rna
- gene expression
- small nucleic
- Prior art date
Links
- 108020004707 nucleic acids Proteins 0.000 title abstract 10
- 102000039446 nucleic acids Human genes 0.000 title abstract 10
- 150000007523 nucleic acids Chemical class 0.000 title abstract 10
- 230000014509 gene expression Effects 0.000 title abstract 7
- 238000012228 RNA interference-mediated gene silencing Methods 0.000 title abstract 3
- 230000009368 gene silencing by RNA Effects 0.000 title abstract 3
- 230000005764 inhibitory process Effects 0.000 title abstract 2
- 230000002452 interceptive effect Effects 0.000 title abstract 2
- 241000711549 Hepacivirus C Species 0.000 title 1
- 230000001404 mediated effect Effects 0.000 title 1
- 108091032973 (ribonucleotides)n+m Proteins 0.000 abstract 6
- 108020004459 Small interfering RNA Proteins 0.000 abstract 6
- 239000004055 small Interfering RNA Substances 0.000 abstract 6
- 108091070501 miRNA Proteins 0.000 abstract 5
- 239000002679 microRNA Substances 0.000 abstract 5
- 239000000203 mixture Substances 0.000 abstract 5
- 102000040650 (ribonucleotides)n+m Human genes 0.000 abstract 4
- 201000010099 disease Diseases 0.000 abstract 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 4
- 108090000623 proteins and genes Proteins 0.000 abstract 4
- 230000000694 effects Effects 0.000 abstract 3
- 239000003112 inhibitor Substances 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000006870 function Effects 0.000 abstract 2
- 150000002632 lipids Chemical class 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000002105 nanoparticle Substances 0.000 abstract 2
- -1 ( for example Substances 0.000 abstract 1
- 230000033077 cellular process Effects 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 238000012423 maintenance Methods 0.000 abstract 1
- 230000037361 pathway Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 230000009467 reduction Effects 0.000 abstract 1
- 230000009711 regulatory function Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
- A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/51—Physical structure in polymeric form, e.g. multimers, concatemers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Dispersion Chemistry (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/311,826 US20060211642A1 (en) | 2001-05-18 | 2005-12-19 | RNA inteference mediated inhibition of hepatitis C virus (HVC) gene expression using short interfering nucleic acid (siNA) |
| US11/510,872 US20080207542A1 (en) | 2002-03-26 | 2006-08-25 | RNA inteference mediated inhibition of hepatitis C virus (HVC) gene expression using short interfering nucleic acid (siNA) |
| PCT/US2006/062252 WO2007076328A2 (fr) | 2005-12-19 | 2006-12-18 | INHIBITION A MEDIATION PAR INTERFERENCE ARN DE L'EXPRESSION DU GENE DU VIRUS DE L'HEPATITE C (VHC) AU MOYEN D'ACIDE NUCLEIQUE INTERFERENT COURT (siNA) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20083208L true NO20083208L (no) | 2008-09-18 |
Family
ID=38121890
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20083208A NO20083208L (no) | 2005-12-19 | 2008-07-18 | RNA-interferensmediert inhibering av hepatitt C-virus-genekspresjon ved anvendelse av korte interfererende nukleinsyrer (siNA) |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20080207542A1 (fr) |
| EP (1) | EP1987145A2 (fr) |
| KR (1) | KR20080079329A (fr) |
| AU (1) | AU2006330660A1 (fr) |
| CA (1) | CA2633684A1 (fr) |
| NO (1) | NO20083208L (fr) |
| WO (1) | WO2007076328A2 (fr) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7935812B2 (en) | 2002-02-20 | 2011-05-03 | Merck Sharp & Dohme Corp. | RNA interference mediated inhibition of hepatitis C virus (HCV) expression using short interfering nucleic acid (siNA) |
| US8765704B1 (en) | 2008-02-28 | 2014-07-01 | Novartis Ag | Modified small interfering RNA molecules and methods of use |
| EP1796732B1 (fr) | 2004-10-01 | 2013-10-30 | Novartis Vaccines and Diagnostics, Inc. | Molecules de petits arn interferants modifiees et methodes d'utilisation de celles-ci |
| US7404969B2 (en) * | 2005-02-14 | 2008-07-29 | Sirna Therapeutics, Inc. | Lipid nanoparticle based compositions and methods for the delivery of biologically active molecules |
| WO2007086883A2 (fr) | 2005-02-14 | 2007-08-02 | Sirna Therapeutics, Inc. | Compositions à base de nanoparticules lipidiques et méthodes pour l'administration de molécules biologiquement actives |
| WO2007010853A1 (fr) * | 2005-07-15 | 2007-01-25 | National University Corporation Nagoya University | Procédé de commande d'un appareil d'électroporation |
| WO2009029681A2 (fr) | 2007-08-27 | 2009-03-05 | The Regents Of The University Of California | Micro-arn utilisés pour inhiber la réplication virale |
| WO2010014895A2 (fr) * | 2008-07-31 | 2010-02-04 | Enzon Pharmaceuticals, Inc. | Compositions de nanoparticules pour un système d'administration d'acides nucléiques |
| WO2010061881A1 (fr) | 2008-11-26 | 2010-06-03 | 中外製薬株式会社 | Ologoribonucléotide ou acide nucléique de peptide capable d'inhiber l'activité du virus de l'hépatite c |
| WO2010105372A1 (fr) * | 2009-03-20 | 2010-09-23 | Protiva Biotherapeutics, Inc. | Compositions et procedes d'inactivation de l'expression du virus de l'hepatite c |
| EP3721943A1 (fr) | 2009-12-23 | 2020-10-14 | Novartis AG | Lipides, compositions de lipides et leurs procédés d'utilisation |
| CA2810928A1 (fr) | 2010-09-22 | 2012-03-29 | Alios Biopharma, Inc. | Analogues nucleotidiques substitues |
| DK2638163T3 (en) | 2010-11-12 | 2017-07-24 | Massachusetts Gen Hospital | POLYCOMB-ASSOCIATED NON-CODING RNAs |
| US9920317B2 (en) | 2010-11-12 | 2018-03-20 | The General Hospital Corporation | Polycomb-associated non-coding RNAs |
| EP3533873A1 (fr) | 2011-09-14 | 2019-09-04 | Translate Bio MA, Inc. | Composés d'oligonucléotides multimères |
| CA2860234A1 (fr) | 2011-12-22 | 2013-06-27 | Alios Biopharma, Inc. | Analogues de nucleotide phosphorothioate substitue |
| HK1206362A1 (zh) | 2012-03-21 | 2016-01-08 | Alios Biopharma, Inc. | 硫代氨基磷酸酯核苷酸前藥的固體形式 |
| US9012427B2 (en) | 2012-03-22 | 2015-04-21 | Alios Biopharma, Inc. | Pharmaceutical combinations comprising a thionucleotide analog |
| US10837014B2 (en) | 2012-05-16 | 2020-11-17 | Translate Bio Ma, Inc. | Compositions and methods for modulating SMN gene family expression |
| JP2015518712A (ja) | 2012-05-16 | 2015-07-06 | ラナ セラピューティクス インコーポレイテッド | Ｍｅｃｐ２発現を調節するための組成物及び方法 |
| WO2013173638A1 (fr) | 2012-05-16 | 2013-11-21 | Rana Therapeutics, Inc. | Compositions et procédés de modulation de l'expression de la famille génique smn |
| WO2014043544A1 (fr) | 2012-09-14 | 2014-03-20 | Rana Therapeutics, Inc. | Composés oligonucléotidiques multimères |
| WO2016010840A1 (fr) | 2014-07-16 | 2016-01-21 | Novartis Ag | Procédé d'encapsulation d'un acide nucléique dans une nanoparticule lipidique hôte |
| US10858650B2 (en) | 2014-10-30 | 2020-12-08 | The General Hospital Corporation | Methods for modulating ATRX-dependent gene repression |
| WO2016149455A2 (fr) | 2015-03-17 | 2016-09-22 | The General Hospital Corporation | Interactome arn de complexe répressif polycomb 1 (prc1) |
| WO2020181144A1 (fr) * | 2019-03-06 | 2020-09-10 | Northwestern University | Acide nucléique sphérique conjugué à un oligonucléotide de type épingle à cheveux |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002087541A1 (fr) * | 2001-04-30 | 2002-11-07 | Protiva Biotherapeutics Inc. | Formulations a base de lipides pour transfert genique |
| EP1670915A2 (fr) * | 2003-09-16 | 2006-06-21 | Sirna Therapeutics, Inc. | INHIBITION A MEDIATION PAR INTERFERENCE ARN DE L'EXPRESSION DU GENE DU VIRUS DE L'HEPATITE C (VHC) AU MOYEN D'ACIDE NUCLEIQUE INTERFERENT COURT (siNA) |
| US7858769B2 (en) * | 2004-02-10 | 2010-12-28 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using multifunctional short interfering nucleic acid (multifunctional siNA) |
-
2006
- 2006-08-25 US US11/510,872 patent/US20080207542A1/en not_active Abandoned
- 2006-12-18 WO PCT/US2006/062252 patent/WO2007076328A2/fr not_active Ceased
- 2006-12-18 KR KR1020087017733A patent/KR20080079329A/ko not_active Withdrawn
- 2006-12-18 EP EP06846665A patent/EP1987145A2/fr not_active Withdrawn
- 2006-12-18 CA CA002633684A patent/CA2633684A1/fr not_active Abandoned
- 2006-12-18 AU AU2006330660A patent/AU2006330660A1/en not_active Abandoned
-
2008
- 2008-07-18 NO NO20083208A patent/NO20083208L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007076328A3 (fr) | 2008-08-14 |
| CA2633684A1 (fr) | 2007-07-05 |
| US20080207542A1 (en) | 2008-08-28 |
| AU2006330660A1 (en) | 2007-07-05 |
| WO2007076328A2 (fr) | 2007-07-05 |
| EP1987145A2 (fr) | 2008-11-05 |
| KR20080079329A (ko) | 2008-08-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |