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WO2005028650A3 - Inhibition a mediation par interference arn de l'expression du gene du virus de l'hepatite c (vhc) au moyen d'acide nucleique interferent court (sina) - Google Patents

Inhibition a mediation par interference arn de l'expression du gene du virus de l'hepatite c (vhc) au moyen d'acide nucleique interferent court (sina) Download PDF

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Publication number
WO2005028650A3
WO2005028650A3 PCT/US2004/031012 US2004031012W WO2005028650A3 WO 2005028650 A3 WO2005028650 A3 WO 2005028650A3 US 2004031012 W US2004031012 W US 2004031012W WO 2005028650 A3 WO2005028650 A3 WO 2005028650A3
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WO
WIPO (PCT)
Prior art keywords
nucleic acid
expression
short interfering
sina
hcv
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2004/031012
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English (en)
Other versions
WO2005028650A2 (fr
Inventor
Vasant Jadhav
Karl Kossen
Shawn Zinnen
Narendra Vaish
James Mcswiggen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sirna Therapeutics Inc
Original Assignee
Sirna Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/667,271 external-priority patent/US20040209831A1/en
Priority claimed from US10/693,059 external-priority patent/US20080039414A1/en
Priority claimed from US10/720,448 external-priority patent/US8273866B2/en
Priority claimed from US10/727,780 external-priority patent/US20050233329A1/en
Priority claimed from US10/757,803 external-priority patent/US20050020525A1/en
Priority claimed from US10/780,447 external-priority patent/US7491805B2/en
Priority claimed from US10/826,966 external-priority patent/US20050032733A1/en
Priority claimed from PCT/US2004/013456 external-priority patent/WO2005041859A2/fr
Priority claimed from PCT/US2004/016390 external-priority patent/WO2005019453A2/fr
Priority to EP04816223A priority Critical patent/EP1670915A2/fr
Priority to JP2006526440A priority patent/JP2007505606A/ja
Application filed by Sirna Therapeutics Inc filed Critical Sirna Therapeutics Inc
Publication of WO2005028650A2 publication Critical patent/WO2005028650A2/fr
Publication of WO2005028650A3 publication Critical patent/WO2005028650A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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Abstract

L'invention concerne des composés, des compositions et des procédés utiles pour moduler l'expression du gène du VHC au moyen de molécules d'acide nucléique interférent court (siNA). L'invention concerne aussi des composés, des compositions et des procédés utiles pour moduler l'expression et l'activité d'autres gènes intervenant dans les trajets de l'expression et/ou de l'activité du gène de ce virus, par interférence ARN (RNAi), au moyen de petites molécules d'acide nucléique. On décrit en particulier de petites molécules d'acide nucléique, du type acide nucléique interférent court (siNA), ARN interférent court (siRNA), ARN double brin (dsRNA), micro-ARN (miRNA), et ARN court en épingle à cheveux (shRNA), ainsi que des procédés modulant l'expression du gène du VHC
PCT/US2004/031012 2003-09-16 2004-09-15 Inhibition a mediation par interference arn de l'expression du gene du virus de l'hepatite c (vhc) au moyen d'acide nucleique interferent court (sina) Ceased WO2005028650A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2006526440A JP2007505606A (ja) 2003-09-16 2004-09-15 低分子干渉核酸（ｓｉＮＡ）を使用したＣ型肝炎ウィルス（ＨＣＶ）発現のＲＮＡ干渉媒介性抑制
EP04816223A EP1670915A2 (fr) 2003-09-16 2004-09-15 INHIBITION A MEDIATION PAR INTERFERENCE ARN DE L'EXPRESSION DU GENE DU VIRUS DE L'HEPATITE C (VHC) AU MOYEN D'ACIDE NUCLEIQUE INTERFERENT COURT (siNA)

Applications Claiming Priority (20)

Application Number Priority Date Filing Date Title
US10/667,271 US20040209831A1 (en) 2002-02-20 2003-09-16 RNA interference mediated inhibition of hepatitis C virus (HCV) gene expression using short interfering nucleic acid (siNA)
US10/667,271 2003-09-16
US10/693,059 2003-10-23
US10/693,059 US20080039414A1 (en) 2002-02-20 2003-10-23 RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
US10/720,448 2003-11-24
US10/720,448 US8273866B2 (en) 2002-02-20 2003-11-24 RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SINA)
US10/727,780 2003-12-03
US10/727,780 US20050233329A1 (en) 2002-02-20 2003-12-03 Inhibition of gene expression using duplex forming oligonucleotides
US10/757,803 US20050020525A1 (en) 2002-02-20 2004-01-14 RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
US10/757,803 2004-01-14
US54348004P 2004-02-10 2004-02-10
US60/543,480 2004-02-10
US10/780,447 2004-02-13
US10/780,447 US7491805B2 (en) 2001-05-18 2004-02-13 Conjugates and compositions for cellular delivery
US10/826,966 US20050032733A1 (en) 2001-05-18 2004-04-16 RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SiNA)
US10/826,966 2004-04-16
USPCT/US04/13456 2004-04-30
PCT/US2004/013456 WO2005041859A2 (fr) 2003-04-30 2004-04-30 Conjugues et compositions
PCT/US2004/016390 WO2005019453A2 (fr) 2001-05-18 2004-05-24 Interference arn a mediation assuree par l'inhibition de genes au moyen de petit acide nucleique interferent (ansi) modifie chimiquement
USPCT/US04/16390 2004-05-24

Publications (2)

Publication Number Publication Date
WO2005028650A2 WO2005028650A2 (fr) 2005-03-31
WO2005028650A3 true WO2005028650A3 (fr) 2005-12-29

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Application Number Title Priority Date Filing Date
PCT/US2004/031012 Ceased WO2005028650A2 (fr) 2003-09-16 2004-09-15 Inhibition a mediation par interference arn de l'expression du gene du virus de l'hepatite c (vhc) au moyen d'acide nucleique interferent court (sina)

Country Status (3)

Country Link
EP (1) EP1670915A2 (fr)
JP (1) JP2007505606A (fr)
WO (1) WO2005028650A2 (fr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8202979B2 (en) 2002-02-20 2012-06-19 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid
US9994853B2 (en) 2001-05-18 2018-06-12 Sirna Therapeutics, Inc. Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference
US9657294B2 (en) 2002-02-20 2017-05-23 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
US9181551B2 (en) 2002-02-20 2015-11-10 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
US7935812B2 (en) 2002-02-20 2011-05-03 Merck Sharp & Dohme Corp. RNA interference mediated inhibition of hepatitis C virus (HCV) expression using short interfering nucleic acid (siNA)
US20080207542A1 (en) * 2002-03-26 2008-08-28 Sirna Therapeutics, Inc. RNA inteference mediated inhibition of hepatitis C virus (HVC) gene expression using short interfering nucleic acid (siNA)
US7923547B2 (en) 2002-09-05 2011-04-12 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
US10508277B2 (en) 2004-05-24 2019-12-17 Sirna Therapeutics, Inc. Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference
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