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NO20083520L - Tricykliske N-heteroaryl-karboksamidderivater inneholdende en benzimidazolenhet, fremgangsmate for fremstilling av samme og deres terapeutiske anvendelser - Google Patents

Tricykliske N-heteroaryl-karboksamidderivater inneholdende en benzimidazolenhet, fremgangsmate for fremstilling av samme og deres terapeutiske anvendelser

Info

Publication number
NO20083520L
NO20083520L NO20083520A NO20083520A NO20083520L NO 20083520 L NO20083520 L NO 20083520L NO 20083520 A NO20083520 A NO 20083520A NO 20083520 A NO20083520 A NO 20083520A NO 20083520 L NO20083520 L NO 20083520L
Authority
NO
Norway
Prior art keywords
tricyclic
preparation
derivatives containing
carboxamide derivatives
same
Prior art date
Application number
NO20083520A
Other languages
English (en)
Inventor
Laurent Dubois
Yannick Evanno
Luc Even
Catherine Gille
Andre Malanda
David Machnik
Nathalie Rakotoarisoa
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of NO20083520L publication Critical patent/NO20083520L/no

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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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Abstract

Foreliggende oppfinnelse angår tricykliske N-heteroaryl-karboksamidderivater som inneholder en benzimidazolenhet, med generell formel (I) hvori: A representerer, med C-N-bindingen til benzimidazolenheten til hvilken den er bundet, et 4 til 7-leddet monosyklisk heterocykel eller et monosyklisk heteroaryl som inneholder fra 1 til 3 heteroatomer valgt fra O, S eller N, som inkluderer nitrogenatomet til benzimidazolenheten; P representerer et 8-, 9-, 10- eller 11-leddet bicykel eller et bisyklisk heteroaryl, som innebefatter 1 til 6 heteroatomer valgt fra N, O eller S; Ri representerer fra 1 til 4 atomer eller grupper, identiske eller forskjellige; og Y representerer et oksygen- eller svovelatom; R2 representerer et hydrogenatom, et halogenatom, en Ci^alkyl, C3-7cykloalkyl, C3-7cykloalkylCi-3alkylen, Ci^fluoralkyl eller Ci_6alkoksygruppe; R3 representerer fra 1 til 3 atomer eller grupper, identisk eller forskjellige; i base eller syreaddisjonstilstand så vel som i hydrat- eller solvatform. Oppfinnelsen angår også en fremgangsmåte for fremstilling av forbindelsene og deres terapeutiske anvendelse.
NO20083520A 2006-02-03 2008-08-13 Tricykliske N-heteroaryl-karboksamidderivater inneholdende en benzimidazolenhet, fremgangsmate for fremstilling av samme og deres terapeutiske anvendelser NO20083520L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0601007A FR2897061B1 (fr) 2006-02-03 2006-02-03 Derives de n-heteroaryl-carboxamides tricycliques contenant un motif benzimidazole, leur preparation et leur application en therapeutique.
PCT/FR2007/000183 WO2007088277A1 (fr) 2006-02-03 2007-02-01 Dérivés de ν-heteroaryl-carboxamides tricycliques contenant un motif benzimidazole, leur préparation et leur application en thérapeutique

Publications (1)

Publication Number Publication Date
NO20083520L true NO20083520L (no) 2008-09-11

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NO20083520A NO20083520L (no) 2006-02-03 2008-08-13 Tricykliske N-heteroaryl-karboksamidderivater inneholdende en benzimidazolenhet, fremgangsmate for fremstilling av samme og deres terapeutiske anvendelser

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US (2) US8143248B2 (no)
EP (1) EP1987010B1 (no)
JP (1) JP5136938B2 (no)
KR (1) KR20080090495A (no)
CN (1) CN101379041B (no)
AR (1) AR059279A1 (no)
AT (1) ATE463484T1 (no)
AU (1) AU2007211399B2 (no)
BR (1) BRPI0710480A2 (no)
CA (1) CA2637333C (no)
CY (1) CY1110168T1 (no)
DE (1) DE602007005779D1 (no)
DK (1) DK1987010T3 (no)
DO (1) DOP2007000022A (no)
EA (1) EA014450B1 (no)
ES (1) ES2344087T3 (no)
FR (1) FR2897061B1 (no)
HR (1) HRP20100327T1 (no)
IL (1) IL192648A (no)
JO (1) JO2602B1 (no)
MA (1) MA30229B1 (no)
NO (1) NO20083520L (no)
NZ (1) NZ569669A (no)
PE (1) PE20071325A1 (no)
PL (1) PL1987010T3 (no)
PT (1) PT1987010E (no)
RS (1) RS51366B (no)
SI (1) SI1987010T1 (no)
TW (1) TWI401256B (no)
UY (1) UY30130A1 (no)
WO (1) WO2007088277A1 (no)
ZA (1) ZA200806139B (no)

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ATE463484T1 (de) 2010-04-15
JP5136938B2 (ja) 2013-02-06
MA30229B1 (fr) 2009-02-02
PE20071325A1 (es) 2008-02-21
EP1987010A1 (fr) 2008-11-05
WO2007088277A1 (fr) 2007-08-09
ZA200806139B (en) 2010-05-26
JO2602B1 (en) 2011-11-01
DOP2007000022A (es) 2007-09-15
CY1110168T1 (el) 2015-01-14
US20120122852A1 (en) 2012-05-17
AU2007211399B2 (en) 2012-09-20
BRPI0710480A2 (pt) 2012-08-14
EA014450B1 (ru) 2010-12-30
FR2897061A1 (fr) 2007-08-10
EP1987010B1 (fr) 2010-04-07
ES2344087T3 (es) 2010-08-17
CA2637333C (fr) 2015-12-29
PL1987010T3 (pl) 2010-09-30
FR2897061B1 (fr) 2010-09-03
JP2009525313A (ja) 2009-07-09
NZ569669A (en) 2011-05-27
US8288376B2 (en) 2012-10-16
HK1129670A1 (en) 2009-12-04
CN101379041A (zh) 2009-03-04
UY30130A1 (es) 2007-09-28
CN101379041B (zh) 2012-08-29
RS51366B (sr) 2011-02-28
US8143248B2 (en) 2012-03-27
AR059279A1 (es) 2008-03-19
EA200870226A1 (ru) 2009-02-27
SI1987010T1 (sl) 2010-07-30
DK1987010T3 (da) 2010-08-02
PT1987010E (pt) 2010-06-25
IL192648A0 (en) 2009-02-11
TW200738726A (en) 2007-10-16
US20090042873A1 (en) 2009-02-12
KR20080090495A (ko) 2008-10-08
HRP20100327T1 (hr) 2010-08-31
DE602007005779D1 (de) 2010-05-20
AU2007211399A1 (en) 2007-08-09
TWI401256B (zh) 2013-07-11
CA2637333A1 (fr) 2007-08-09
IL192648A (en) 2012-06-28

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