[go: up one dir, main page]

NO20082907L - Fremgangsmate for anvendelse av IL6 antagonister med proteasom-inhibitorer - Google Patents

Fremgangsmate for anvendelse av IL6 antagonister med proteasom-inhibitorer

Info

Publication number
NO20082907L
NO20082907L NO20082907A NO20082907A NO20082907L NO 20082907 L NO20082907 L NO 20082907L NO 20082907 A NO20082907 A NO 20082907A NO 20082907 A NO20082907 A NO 20082907A NO 20082907 L NO20082907 L NO 20082907L
Authority
NO
Norway
Prior art keywords
antagonists
proteasome inhibitors
condition
disorder
antagonist
Prior art date
Application number
NO20082907A
Other languages
English (en)
Inventor
Mohamed Zaki
Jeffrey Nemeth
Robert Orlowski
Original Assignee
Centocor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centocor Inc filed Critical Centocor Inc
Publication of NO20082907L publication Critical patent/NO20082907L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/248—IL-6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Sammendrag Oppfinnelsen vedrører en fremgangsmåte for å behandle en cancerliknende lidelse eller tilstand eller en IL-6 relatert lidelse eller tilstand i et pattedyr som trenger slik behandling som omfatter ko-administrering av en proteasomhemmer i kombinasjon med en IL-6 antagonist.
NO20082907A 2005-12-09 2008-06-27 Fremgangsmate for anvendelse av IL6 antagonister med proteasom-inhibitorer NO20082907L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74915205P 2005-12-09 2005-12-09
PCT/US2006/061786 WO2007067976A2 (en) 2005-12-09 2006-12-08 Method of using il6 antagonists with proteasome inhibitors

Publications (1)

Publication Number Publication Date
NO20082907L true NO20082907L (no) 2008-08-26

Family

ID=38123650

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20082907A NO20082907L (no) 2005-12-09 2008-06-27 Fremgangsmate for anvendelse av IL6 antagonister med proteasom-inhibitorer

Country Status (15)

Country Link
US (1) US20090022726A1 (no)
EP (1) EP1954310A4 (no)
JP (1) JP2009518447A (no)
KR (1) KR20080072761A (no)
CN (1) CN101325969A (no)
AR (1) AR057227A1 (no)
AU (1) AU2006321610A1 (no)
BR (1) BRPI0619498A2 (no)
CA (1) CA2632732A1 (no)
EA (1) EA014675B1 (no)
IL (1) IL191694A0 (no)
NO (1) NO20082907L (no)
TW (1) TW200803895A (no)
WO (1) WO2007067976A2 (no)
ZA (1) ZA200805956B (no)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8198270B2 (en) 2004-04-15 2012-06-12 Onyx Therapeutics, Inc. Compounds for proteasome enzyme inhibition
CA2562411A1 (en) 2004-04-15 2005-11-10 Proteolix, Inc. Compounds for enzyme inhibition
SG185963A1 (en) 2004-05-10 2012-12-28 Onyx Therapeutics Inc Compounds for enzyme inhibition
BRPI0617664B8 (pt) 2005-10-21 2021-05-25 Chugai Pharmaceutical Co Ltd uso de um anticorpo que reconhece a il-6 para a produção de uma composição farmacêutica para tratar o enfarte do miocárdio ou suprimir a remodelagem ventricular esquerda depois do enfarte do miocárdio
US7687456B2 (en) 2005-11-09 2010-03-30 Proteolix, Inc. Compounds for enzyme inhibition
AR057582A1 (es) * 2005-11-15 2007-12-05 Nat Hospital Organization Agentes para suprimir la induccion de linfocitos t citotoxicos
AU2007208678B2 (en) * 2006-01-27 2013-01-10 Chugai Seiyaku Kabushiki Kaisha Therapeutic agents for diseases involving choroidal neovascularization
WO2007116962A1 (ja) 2006-04-07 2007-10-18 Osaka University 筋再生促進剤
EP2484688B1 (en) 2006-06-19 2016-06-08 Onyx Therapeutics, Inc. Peptide epoxyketones for proteasome inhibition
CN101646459B (zh) * 2007-01-23 2014-02-12 国立大学法人信州大学 慢性排斥反应抑制剂
JP5424330B2 (ja) * 2007-07-26 2014-02-26 国立大学法人大阪大学 インターロイキン６受容体阻害剤を有効成分とする眼炎症疾患治療剤
MX2010003732A (es) 2007-10-04 2010-08-09 Onyx Therapeutics Inc Inhibidores de peptido cetona epoxi de proteasa cristalina y la sintesis de ceto-epoxidos de aminoacido.
JP5544290B2 (ja) * 2008-06-05 2014-07-09 独立行政法人国立がん研究センター 神経浸潤抑制剤
EP2344165A4 (en) * 2008-10-01 2012-12-05 Reddys Lab Ltd Dr PHARMACEUTICAL COMPOSITIONS COMPRISING BORONIC ACID COMPOUNDS
PE20120059A1 (es) * 2008-10-21 2012-02-27 Onyx Therapeutics Inc Combinaciones farmaceuticas con epoxicetonas peptidicas
JP5794919B2 (ja) * 2008-11-13 2015-10-14 ギリアード カリストガ エルエルシー 血液学的な悪性疾患のための療法
US9492449B2 (en) 2008-11-13 2016-11-15 Gilead Calistoga Llc Therapies for hematologic malignancies
TWI504598B (zh) 2009-03-20 2015-10-21 Onyx Therapeutics Inc 結晶性三肽環氧酮蛋白酶抑制劑
EP2464666B1 (en) 2009-07-15 2018-03-21 Eva Kovacs-Benke Combination of a human interleukin-6 antagonist and a human interleukin-6 receptor antagonist in therapy of tumour diseases
MY161541A (en) * 2009-07-31 2017-04-28 Shin Maeda Cancer metastasis inhibitor
US8323883B1 (en) 2009-10-09 2012-12-04 Cold Spring Harbor Laboratory Methods of assessing therapeutic benefits of patients having cancers resistant to epidermal growth factor receptor kinase inhibitors
US7947653B1 (en) 2009-10-09 2011-05-24 Cold Spring Harbor Laboratory Methods for treating epidermal growth factor receptor tyrosine kinase inhibitor-resistant cancers
US8853147B2 (en) 2009-11-13 2014-10-07 Onyx Therapeutics, Inc. Use of peptide epoxyketones for metastasis suppression
US9359398B2 (en) 2010-03-01 2016-06-07 Onyx Therapeutics, Inc. Compounds for immunoproteasome inhibition
HUE060454T2 (hu) 2010-05-28 2023-03-28 Chugai Pharmaceutical Co Ltd Daganatellenes T-sejt-választ fokozó szer
US20140294854A1 (en) * 2011-03-10 2014-10-02 Albert Einstein College Of Medicine Of Yeshiva University Target directed to adipocytes, methods and assays for treatment of obesity
WO2013175276A1 (en) * 2012-05-23 2013-11-28 Argen-X B.V Il-6 binding molecules
US9309283B2 (en) 2012-07-09 2016-04-12 Onyx Therapeutics, Inc. Prodrugs of peptide epoxy ketone protease inhibitors
KR101643041B1 (ko) * 2014-04-25 2016-07-28 아주대학교산학협력단 프로테아좀 저해제 및 디히드로피리딘계 화합물을 유효성분으로 함유하는 암의 예방 또는 치료용 조성물
CN104922659B (zh) * 2015-07-03 2018-04-20 刘永庆 防治肿瘤和/或慢性结核病的Th2免疫反应抑制剂及其应用
US20190046497A1 (en) * 2016-02-14 2019-02-14 Yeda Research And Development Co., Ltd. Methods of modulating protein exocytosis and uses of same in therapy
JP7185884B2 (ja) 2017-05-02 2022-12-08 国立研究開発法人国立精神・神経医療研究センター Ｉｌ－６及び好中球の関連する疾患の治療効果の予測及び判定方法
US20200246488A1 (en) * 2017-07-17 2020-08-06 The Broad Institute, Inc. Compositions and methods for treating inflammatory bowel diseases
EP3698808B1 (en) 2017-10-20 2025-01-01 Hyogo College Of Medicine Anti-il-6 receptor antibody-containing medicinal composition for preventing post-surgical adhesion
US20200165608A1 (en) * 2018-11-23 2020-05-28 Florida State University Research Foundation, Inc. Inhibition of vascular endothelial cell-mediated phagocytic processes for treatment of demyelinating conditions

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5210075A (en) * 1990-02-16 1993-05-11 Tanabe Seiyaku Co., Ltd. Interleukin 6 antagonist peptides
US5340736A (en) * 1991-05-13 1994-08-23 The President & Fellows Of Harvard College ATP-dependent protease and use of inhibitors for same in the treatment of cachexia and muscle wasting
AU6808194A (en) * 1993-05-31 1994-12-20 Chugai Seiyaku Kabushiki Kaisha Reconstructed human antibody against human interleukin-6
US5888510A (en) * 1993-07-21 1999-03-30 Chugai Seiyaku Kabushiki Kaisha Chronic rheumatoid arthritis therapy containing IL-6 antagonist as effective component
US5693617A (en) * 1994-03-15 1997-12-02 Proscript, Inc. Inhibitors of the 26s proteolytic complex and the 20s proteasome contained therein
CA2347275C (en) * 1998-10-20 2010-03-09 Millennium Pharmaceuticals, Inc. Method for monitoring proteasome inhibitor drug action
MXPA04004671A (es) * 2001-11-14 2005-08-25 Johnson & Johnson Anticuerpos anti-interleucina-6, composiciones, metodos y usos.
EP1594897A4 (en) * 2003-02-04 2006-11-08 Centocor Inc USE OF IL-6 ANTAGONISTS IN COMBINATION WITH STEROIDS FOR INCREASED APOPTOSIS
JO3058B1 (ar) * 2005-04-29 2017-03-15 Applied Molecular Evolution Inc الاجسام المضادة لمضادات -اي ال-6,تركيباتها طرقها واستعمالاتها

Also Published As

Publication number Publication date
WO2007067976A3 (en) 2008-02-14
KR20080072761A (ko) 2008-08-06
EA014675B1 (ru) 2010-12-30
CN101325969A (zh) 2008-12-17
TW200803895A (en) 2008-01-16
IL191694A0 (en) 2008-12-29
EP1954310A2 (en) 2008-08-13
AR057227A1 (es) 2007-11-21
JP2009518447A (ja) 2009-05-07
US20090022726A1 (en) 2009-01-22
EP1954310A4 (en) 2009-04-22
EA200870029A1 (ru) 2008-10-30
ZA200805956B (en) 2009-10-28
WO2007067976A2 (en) 2007-06-14
CA2632732A1 (en) 2007-06-14
BRPI0619498A2 (pt) 2011-10-04
AU2006321610A1 (en) 2007-06-14

Similar Documents

Publication Publication Date Title
NO20082907L (no) Fremgangsmate for anvendelse av IL6 antagonister med proteasom-inhibitorer
MX2024009727A (es) Terapias de combinacion.
EA201270184A1 (ru) Лечение расстройств печени ингибиторами pi3k
EA200970932A1 (ru) Способы лечения с применением пиридопиримидиноновых ингибиторов pi3k альфа
MX348941B (es) Medios y metodos para trata y/o prevenir el cancer dependiente del ligando natural de receptor de aril-hidrocarburo.
EA200870409A1 (ru) Антагонисты киназы pi3
CL2008001038A1 (es) Uso de una composicion que comprende un antagonosta h1, y un compuesto anti-tnf alfa para tratar conjuntivitis alegica o rinitis alergiva en un sujeto humano
AR086955A1 (es) TERAPIAS COMBINADAS PARA EL TRATAMIENTO DE NEOPLASIAS MALIGNAS HEMATOLOGICAS UTILIZANDO INHIBIDORES DE PIRIDOPIRIMIDINONA DE PI3K/mTOR CON BENDAMUSTINA Y/O RITUXIMAB
NI200700320A (es) Inhibidores de la actividad akt
EA200900091A1 (ru) Новые показания к применению прямых ингибиторов тромбина в лечении сердечно-сосудистых заболеваний
EA201490194A1 (ru) Комбинированная терапия, включающая ингибитор cdk4/6 и ингибитор pi3k для применения в лечении рака
ECSP099376A (es) Inhibidores de la actividad de la akt
NO20065148L (no) Monocykliske heterocykler som kinase inhibitorer
CY1117678T1 (el) Ενωσεις αναστολεων μεταλλοενζυμου
MX2010010300A (es) Formas de sal de inhibidores del objetivo de rapamicina en mamiferos.
JO3003B1 (ar) مركب أيميدازو [4، 5 -c ] كينولين-2- واحد واستخدامه كمثبط كيناز PI3/mtor
NO20083202L (no) ANG2- og VEFG-inhibitorkombinasjoner
PL1660507T5 (pl) Inhibitory proteazomu oraz sposoby ich stosowania
MA32934B1 (fr) Combinaisons inhibitrices hsp90
ECSP067080A (es) DIFENILIMIDAZOPIRIMIDINA Y AMINAS IMIDAZOL COMO INHIBIDORES DE ß-SECRETASA
SV2009003299A (es) Derivados de dihidropiridina de utilidad como inhibidores de la proteina quinasa
AR054094A1 (es) Tratamientos de cancer
EA200800755A1 (ru) Ikk ингибиторы, предназначенные для лечения эндометриоза
GT200600145A (es) Combinacion para terapia en hiperplasia benigna de prostata
ATE531721T1 (de) Cyanoaminochinolone als gsk-3-inhibitoren

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application