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NO20081101L - Regioselektiv metode for fremstilling av benzimidazol-tiofener - Google Patents

Regioselektiv metode for fremstilling av benzimidazol-tiofener

Info

Publication number
NO20081101L
NO20081101L NO20081101A NO20081101A NO20081101L NO 20081101 L NO20081101 L NO 20081101L NO 20081101 A NO20081101 A NO 20081101A NO 20081101 A NO20081101 A NO 20081101A NO 20081101 L NO20081101 L NO 20081101L
Authority
NO
Norway
Prior art keywords
thiophenes
benzimidazole
preparation
regioselective method
regioselective
Prior art date
Application number
NO20081101A
Other languages
English (en)
Norwegian (no)
Inventor
Mui Cheung
Kyle Allen Emmitte
Kevin W Kuntz
Keith Hornberger
Mark Andrew Pobanz
Jennifer Gabriel Badiang
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of NO20081101L publication Critical patent/NO20081101L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D333/40—Thiophene-2-carboxylic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
NO20081101A 2005-09-06 2008-03-03 Regioselektiv metode for fremstilling av benzimidazol-tiofener NO20081101L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71430105P 2005-09-06 2005-09-06
PCT/US2006/033793 WO2007030366A1 (fr) 2005-09-06 2006-08-28 Procede regioselectif de preparation de benzimidazole thiophenes

Publications (1)

Publication Number Publication Date
NO20081101L true NO20081101L (no) 2008-04-04

Family

ID=37605702

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20081101A NO20081101L (no) 2005-09-06 2008-03-03 Regioselektiv metode for fremstilling av benzimidazol-tiofener

Country Status (18)

Country Link
US (1) US20080249301A1 (fr)
EP (1) EP1924572B1 (fr)
JP (1) JP2009507022A (fr)
KR (1) KR20080045266A (fr)
CN (1) CN101304986A (fr)
AT (1) ATE453634T1 (fr)
AU (1) AU2006287771A1 (fr)
BR (1) BRPI0615705A2 (fr)
CA (1) CA2621073A1 (fr)
DE (1) DE602006011482D1 (fr)
EA (1) EA200800549A1 (fr)
ES (1) ES2338590T3 (fr)
IL (1) IL189769A0 (fr)
MA (1) MA29781B1 (fr)
MX (1) MX2008003172A (fr)
NO (1) NO20081101L (fr)
WO (1) WO2007030366A1 (fr)
ZA (1) ZA200801950B (fr)

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Publication number Priority date Publication date Assignee Title
AR055616A1 (es) * 2005-09-06 2007-08-29 Smithkline Beecham Corp Compuestos de tiofeno bencimidazol
DE602006012694D1 (de) * 2005-09-06 2010-04-15 Glaxosmithkline Llc Benzimidazolthiophenverbindungen als plk-modulatoren
CN101400678A (zh) 2006-01-23 2009-04-01 沃泰克斯药物股份有限公司 可用作蛋白激酶抑制剂的噻吩酰胺
WO2007120760A2 (fr) 2006-04-13 2007-10-25 Vertex Pharmaceuticals Incorporated Thiophène-carboxamides servant d'inhibiteurs de protéines kinases
US7851495B2 (en) 2006-05-23 2010-12-14 Vertex Pharmaceuticals Incorporated Thiophene-carboxamides useful as inhibitors of protein kinases
EP2439206A1 (fr) 2006-05-23 2012-04-11 Vertex Pharmaceuticals Incorporated Tiophène-carboxamides utiles en tant qu'inhibiteurs de protéine kinases
US7615643B2 (en) 2006-06-02 2009-11-10 Smithkline Beecham Corporation Benzimidazole thiophene compounds
WO2009002916A2 (fr) * 2007-06-26 2008-12-31 Smithkline Beecham Corporation Procédés de préparation de thiophènes de benzimidazole
EP2100894A1 (fr) 2008-03-12 2009-09-16 4Sc Ag Pyridopyrimidinones utilisés comme inhibiteurs de la kinase de type Plk1 (polo-like kinase)
MX357614B (es) 2010-04-12 2018-07-17 Supernus Pharmaceuticals Inc Métodos para producir sales de viloxazina y polimorfos novedosos de las mismas.
WO2012003338A1 (fr) 2010-07-01 2012-01-05 Takeda Pharmaceutical Company Limited Combinaison d'un inhibiteur de cmet et d'un anticorps dirigé contre hgf et/ou cmet
WO2012088266A2 (fr) 2010-12-22 2012-06-28 Incyte Corporation Imidazopyridazines et benzimidazoles substitués en tant qu'inhibiteurs de fgfr3
EP2565186A1 (fr) 2011-09-02 2013-03-06 Hybrigenics S.A. Inhibiteurs sélectifs et réversibles de la protéase 7 spécifique de l'ubiquitine
JP6088491B2 (ja) 2012-04-10 2017-03-01 大日本住友製薬株式会社 新規１位置換インダゾール誘導体
UA125503C2 (uk) 2012-06-13 2022-04-13 Інсайт Холдинґс Корпорейшн Заміщені трициклічні сполуки як інгібітори fgfr
US9388185B2 (en) 2012-08-10 2016-07-12 Incyte Holdings Corporation Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
MY181497A (en) 2013-04-19 2020-12-23 Incyte Holdings Corp Bicyclic heterocycles as fgfr inhibitors
US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
US9580423B2 (en) 2015-02-20 2017-02-28 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
CR20170390A (es) 2015-02-20 2017-10-23 Incyte Holdings Corp Heterociclos biciclicos como inhibidores de fgfr
MA41551A (fr) 2015-02-20 2017-12-26 Incyte Corp Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
AR111960A1 (es) 2017-05-26 2019-09-04 Incyte Corp Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
MX2020006587A (es) 2017-12-22 2020-12-10 Ravenna Pharmaceuticals Inc Derivados de aminopiridina como inhibidores de fosfatidilinositol fosfato cinasa.
BR112020022392A2 (pt) 2018-05-04 2021-02-02 Incyte Corporation formas sólidas de um inibidor de fgfr e processos para preparação das mesmas
PE20210919A1 (es) 2018-05-04 2021-05-19 Incyte Corp Sales de un inhibidor de fgfr
US11628162B2 (en) 2019-03-08 2023-04-18 Incyte Corporation Methods of treating cancer with an FGFR inhibitor
CN109988098A (zh) * 2019-05-23 2019-07-09 常州工程职业技术学院 一种(r)-n-叔丁氧羰基-3-羟甲基哌啶的合成方法
TW202112767A (zh) 2019-06-17 2021-04-01 美商佩特拉製藥公司 作為磷脂酸肌醇磷酸激酶抑制劑之胺基吡啶衍生物
US11591329B2 (en) 2019-07-09 2023-02-28 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
US12122767B2 (en) 2019-10-01 2024-10-22 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
GEP20247679B (en) 2019-10-14 2024-10-10 Incyte Corp Bicyclic heterocycles as fgfr inhibitors
WO2021076728A1 (fr) 2019-10-16 2021-04-22 Incyte Corporation Hétérocycles bicycliques en tant qu'inhibiteurs de fgfr
JP7720840B2 (ja) 2019-12-04 2025-08-08 インサイト・コーポレイション Ｆｇｆｒ阻害剤としての三環式複素環
PE20221504A1 (es) 2019-12-04 2022-09-30 Incyte Corp Derivados de un inhibidor de fgfr
WO2021146424A1 (fr) 2020-01-15 2021-07-22 Incyte Corporation Hétérocycles bicycliques en tant qu'inhibiteurs de fgfr
TW202304459A (zh) 2021-04-12 2023-02-01 美商英塞特公司 包含ｆｇｆｒ抑制劑及ｎｅｃｔｉｎ－４靶向劑之組合療法
TW202313611A (zh) 2021-06-09 2023-04-01 美商英塞特公司 作為ｆｇｆｒ抑制劑之三環雜環
CA3220155A1 (fr) 2021-06-09 2022-12-15 Incyte Corporation Heterocycles tricycliques utiles en tant qu'inhibiteurs de fgfr

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5990146A (en) * 1997-08-20 1999-11-23 Warner-Lambert Company Benzimidazoles for inhibiting protein tyrosine kinase mediated cellular proliferation
US6162804A (en) * 1997-09-26 2000-12-19 Merck & Co., Inc. Tyrosine kinase inhibitors
GB0005642D0 (en) * 2000-03-10 2000-05-03 Astrazeneca Uk Ltd Chemical compounds
EP1451173A4 (fr) * 2001-11-01 2005-10-26 Icagen Inc Piperidines
RU2296758C2 (ru) * 2002-08-08 2007-04-10 Смитклайн Бичем Корпорейшн Производные тиофена
EP1558599A4 (fr) * 2002-10-30 2007-06-27 Merck & Co Inc Modulateurs d'heteroarylpiperidine de l'activite des recepteurs de la chimiokine
WO2005037827A1 (fr) * 2003-10-16 2005-04-28 Smithkline Beecham Corporation Procede de preparation de thiophenes de benzimidazole

Also Published As

Publication number Publication date
CA2621073A1 (fr) 2007-03-15
WO2007030366A1 (fr) 2007-03-15
ZA200801950B (en) 2009-09-30
MX2008003172A (es) 2008-03-18
DE602006011482D1 (de) 2010-02-11
US20080249301A1 (en) 2008-10-09
KR20080045266A (ko) 2008-05-22
IL189769A0 (en) 2008-08-07
CN101304986A (zh) 2008-11-12
EP1924572A1 (fr) 2008-05-28
AU2006287771A1 (en) 2007-03-15
EA200800549A1 (ru) 2008-08-29
JP2009507022A (ja) 2009-02-19
BRPI0615705A2 (pt) 2016-08-23
MA29781B1 (fr) 2008-09-01
ES2338590T3 (es) 2010-05-10
ATE453634T1 (de) 2010-01-15
EP1924572B1 (fr) 2009-12-30

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