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EA200800549A1 - Региоселективный способ получения бензимидазолтиофенов - Google Patents

Региоселективный способ получения бензимидазолтиофенов

Info

Publication number
EA200800549A1
EA200800549A1 EA200800549A EA200800549A EA200800549A1 EA 200800549 A1 EA200800549 A1 EA 200800549A1 EA 200800549 A EA200800549 A EA 200800549A EA 200800549 A EA200800549 A EA 200800549A EA 200800549 A1 EA200800549 A1 EA 200800549A1
Authority
EA
Eurasian Patent Office
Prior art keywords
benzimidazolthiophenes
obtaining
selective method
regional selective
regional
Prior art date
Application number
EA200800549A
Other languages
English (en)
Inventor
Кейт Хорнбергер
Муи Чеунг
Марк Эндрю Побанз
Кайл Аллен Эммитт
Кевин Уэйн Кунц
Дженнифер Гэбриэл Бэдьянг
Original Assignee
Смитклайн Бичем Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Смитклайн Бичем Корпорейшн filed Critical Смитклайн Бичем Корпорейшн
Publication of EA200800549A1 publication Critical patent/EA200800549A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D333/40—Thiophene-2-carboxylic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Настоящее изобретение относится к способу получения соединений бензимидазолтиофенов формулы I. Кроме того, предложены промежуточные соединения, используемые в этом способе.
EA200800549A 2005-09-06 2006-08-28 Региоселективный способ получения бензимидазолтиофенов EA200800549A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71430105P 2005-09-06 2005-09-06
PCT/US2006/033793 WO2007030366A1 (en) 2005-09-06 2006-08-28 Regioselective process for preparing benzimidazole thiophenes

Publications (1)

Publication Number Publication Date
EA200800549A1 true EA200800549A1 (ru) 2008-08-29

Family

ID=37605702

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200800549A EA200800549A1 (ru) 2005-09-06 2006-08-28 Региоселективный способ получения бензимидазолтиофенов

Country Status (18)

Country Link
US (1) US20080249301A1 (ru)
EP (1) EP1924572B1 (ru)
JP (1) JP2009507022A (ru)
KR (1) KR20080045266A (ru)
CN (1) CN101304986A (ru)
AT (1) ATE453634T1 (ru)
AU (1) AU2006287771A1 (ru)
BR (1) BRPI0615705A2 (ru)
CA (1) CA2621073A1 (ru)
DE (1) DE602006011482D1 (ru)
EA (1) EA200800549A1 (ru)
ES (1) ES2338590T3 (ru)
IL (1) IL189769A0 (ru)
MA (1) MA29781B1 (ru)
MX (1) MX2008003172A (ru)
NO (1) NO20081101L (ru)
WO (1) WO2007030366A1 (ru)
ZA (1) ZA200801950B (ru)

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DK1937671T3 (da) * 2005-09-06 2010-04-26 Glaxosmithkline Llc Benzimidazolthiophenforbindelser som PLK-inhibitorer
ATE459620T1 (de) * 2005-09-06 2010-03-15 Glaxosmithkline Llc Benzimidazolthiophenverbindungen als plk- modulatoren
EP2474546A1 (en) 2006-01-23 2012-07-11 Vertex Pharmaceuticals Inc. Thiophene-carboxamides useful as inhibitors of protein kinases
CA2648207A1 (en) 2006-04-13 2007-10-25 Vertex Pharmaceuticals Incorporated Thiophene-carboxamides useful as inhibitors of protein kinases
CN101495474A (zh) 2006-05-23 2009-07-29 沃泰克斯药物股份有限公司 可用作蛋白激酶抑制剂的噻吩-甲酰胺类
CN101484447A (zh) 2006-05-23 2009-07-15 沃泰克斯药物股份有限公司 可用作蛋白激酶抑制剂的噻吩-甲酰胺类
US7615643B2 (en) 2006-06-02 2009-11-10 Smithkline Beecham Corporation Benzimidazole thiophene compounds
EP2170871A2 (en) * 2007-06-26 2010-04-07 GlaxoSmithKline LLC Processes for preparing benzimidazole thiophenes
EP2100894A1 (en) 2008-03-12 2009-09-16 4Sc Ag Pyridopyrimidines used as Plk1 (polo-like kinase) inhibitors
ES2552166T3 (es) * 2010-04-12 2015-11-26 Supernus Pharmaceuticals, Inc. Métodos para producir sales de viloxazina y polimorfos novedosos de las mismas
WO2012003338A1 (en) 2010-07-01 2012-01-05 Takeda Pharmaceutical Company Limited COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET
WO2012088266A2 (en) * 2010-12-22 2012-06-28 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3
EP2565186A1 (en) 2011-09-02 2013-03-06 Hybrigenics S.A. Selective and reversible inhibitors of ubiquitin specific protease 7
WO2013154109A1 (ja) 2012-04-10 2013-10-17 大日本住友製薬株式会社 新規１位置換インダゾール誘導体
ES2984771T3 (es) 2012-06-13 2024-10-31 Incyte Holdings Corp Compuestos tricíclicos sustituidos como inhibidores de FGFR
WO2014026125A1 (en) 2012-08-10 2014-02-13 Incyte Corporation Pyrazine derivatives as fgfr inhibitors
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
EA035095B1 (ru) 2013-04-19 2020-04-27 Инсайт Холдингс Корпорейшн Бициклические гетероциклы в качестве ингибиторов fgfr
US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
US9580423B2 (en) 2015-02-20 2017-02-28 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
MA41551A (fr) 2015-02-20 2017-12-26 Incyte Corp Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
EA038045B1 (ru) 2015-02-20 2021-06-28 Инсайт Корпорейшн Бициклические гетероциклы в качестве ингибиторов fgfr
AR111960A1 (es) 2017-05-26 2019-09-04 Incyte Corp Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
JP7569688B2 (ja) 2017-12-22 2024-10-18 ハイバーセル，インコーポレイテッド ホスファチジルイノシトールリン酸キナーゼ阻害剤としてのアミノピリジン誘導体
US11174257B2 (en) 2018-05-04 2021-11-16 Incyte Corporation Salts of an FGFR inhibitor
RS66310B1 (sr) 2018-05-04 2025-01-31 Incyte Corp Čvrsti oblici inhibitora fgfr i procesi za njegovu pripremu
WO2020185532A1 (en) 2019-03-08 2020-09-17 Incyte Corporation Methods of treating cancer with an fgfr inhibitor
CN109988098A (zh) * 2019-05-23 2019-07-09 常州工程职业技术学院 一种(r)-n-叔丁氧羰基-3-羟甲基哌啶的合成方法
TW202112767A (zh) 2019-06-17 2021-04-01 美商佩特拉製藥公司 作為磷脂酸肌醇磷酸激酶抑制劑之胺基吡啶衍生物
WO2021007269A1 (en) 2019-07-09 2021-01-14 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
WO2021067374A1 (en) 2019-10-01 2021-04-08 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
PH12022550892A1 (en) 2019-10-14 2023-05-03 Incyte Corp Bicyclic heterocycles as fgfr inhibitors
US11566028B2 (en) 2019-10-16 2023-01-31 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
AU2020395185A1 (en) 2019-12-04 2022-06-02 Incyte Corporation Derivatives of an FGFR inhibitor
EP4069696A1 (en) 2019-12-04 2022-10-12 Incyte Corporation Tricyclic heterocycles as fgfr inhibitors
US12012409B2 (en) 2020-01-15 2024-06-18 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
JP2024513575A (ja) 2021-04-12 2024-03-26 インサイト・コーポレイション Ｆｇｆｒ阻害剤及びネクチン－４標的化剤を含む併用療法
WO2022261160A1 (en) 2021-06-09 2022-12-15 Incyte Corporation Tricyclic heterocycles as fgfr inhibitors
TW202313610A (zh) 2021-06-09 2023-04-01 美商英塞特公司 作為ｆｇｆｒ抑制劑之三環雜環

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US5990146A (en) * 1997-08-20 1999-11-23 Warner-Lambert Company Benzimidazoles for inhibiting protein tyrosine kinase mediated cellular proliferation
US6162804A (en) * 1997-09-26 2000-12-19 Merck & Co., Inc. Tyrosine kinase inhibitors
GB0005642D0 (en) * 2000-03-10 2000-05-03 Astrazeneca Uk Ltd Chemical compounds
EP1451173A4 (en) * 2001-11-01 2005-10-26 Icagen Inc PIPERIDINE
MXPA05001544A (es) * 2002-08-08 2005-04-19 Smithkline Beecham Corp Compuestos de tiofeno.
WO2004041777A2 (en) * 2002-10-30 2004-05-21 Merck & Co., Inc. Heteroarylpiperidine modulators of chemokine receptor activity
WO2005037827A1 (en) * 2003-10-16 2005-04-28 Smithkline Beecham Corporation Process for preparing benzimidazole thiophenes

Also Published As

Publication number Publication date
NO20081101L (no) 2008-04-04
AU2006287771A1 (en) 2007-03-15
ES2338590T3 (es) 2010-05-10
ATE453634T1 (de) 2010-01-15
ZA200801950B (en) 2009-09-30
MX2008003172A (es) 2008-03-18
WO2007030366A1 (en) 2007-03-15
CA2621073A1 (en) 2007-03-15
BRPI0615705A2 (pt) 2016-08-23
JP2009507022A (ja) 2009-02-19
CN101304986A (zh) 2008-11-12
EP1924572B1 (en) 2009-12-30
DE602006011482D1 (de) 2010-02-11
MA29781B1 (fr) 2008-09-01
KR20080045266A (ko) 2008-05-22
US20080249301A1 (en) 2008-10-09
IL189769A0 (en) 2008-08-07
EP1924572A1 (en) 2008-05-28

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