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NO20081025L - Krystalliseringsprosess - Google Patents

Krystalliseringsprosess

Info

Publication number
NO20081025L
NO20081025L NO20081025A NO20081025A NO20081025L NO 20081025 L NO20081025 L NO 20081025L NO 20081025 A NO20081025 A NO 20081025A NO 20081025 A NO20081025 A NO 20081025A NO 20081025 L NO20081025 L NO 20081025L
Authority
NO
Norway
Prior art keywords
purification
solvent
carried out
continuous crystallization
crystallization
Prior art date
Application number
NO20081025A
Other languages
English (en)
Other versions
NO342096B1 (no
Inventor
Jan Cervenka
Khalid Hussain
Arne W Aabye
Original Assignee
Ge Healthcare As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare As filed Critical Ge Healthcare As
Priority to NO20081025A priority Critical patent/NO342096B1/no
Publication of NO20081025L publication Critical patent/NO20081025L/no
Publication of NO342096B1 publication Critical patent/NO342096B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C07C231/24—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B63/00—Purification; Separation; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/38—Separation; Purification; Stabilisation; Use of additives
    • C07C17/392—Separation; Purification; Stabilisation; Use of additives by crystallisation; Purification or separation of the crystals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C31/00—Saturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C31/18—Polyhydroxylic acyclic alcohols

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Oppfinnelsen beskriver en prosess for rensing av joderte arylforbindelser der rensingen utføres ved kontinuerlig krystallisering av et råprodukt i et løsemiddel med tilsatt antiløsemiddel. Den kontinuerlige krystalliseringsprosessen utføres i en eller flere krystallisatorer ved en temperatur som ligger opp til kokepunktet for innholdet av krystallisatoren.
NO20081025A 2005-07-29 2008-02-26 Kontinuerlig krystalliseringsprosess NO342096B1 (no)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NO20081025A NO342096B1 (no) 2005-07-29 2008-02-26 Kontinuerlig krystalliseringsprosess

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NO20053687A NO20053687D0 (no) 2005-07-29 2005-07-29 Crystallisation Process.
PCT/NO2006/000288 WO2007013815A1 (en) 2005-07-29 2006-07-28 Continuous crystallisation process of iodinated phenyl derivatives
NO20081025A NO342096B1 (no) 2005-07-29 2008-02-26 Kontinuerlig krystalliseringsprosess

Publications (2)

Publication Number Publication Date
NO20081025L true NO20081025L (no) 2008-02-26
NO342096B1 NO342096B1 (no) 2018-03-19

Family

ID=35295627

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20053687A NO20053687D0 (no) 2005-07-29 2005-07-29 Crystallisation Process.
NO20081025A NO342096B1 (no) 2005-07-29 2008-02-26 Kontinuerlig krystalliseringsprosess

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO20053687A NO20053687D0 (no) 2005-07-29 2005-07-29 Crystallisation Process.

Country Status (7)

Country Link
US (1) US8829241B2 (no)
EP (1) EP1924541A1 (no)
JP (1) JP5155164B2 (no)
KR (2) KR101409609B1 (no)
CN (2) CN101233092A (no)
NO (2) NO20053687D0 (no)
WO (1) WO2007013815A1 (no)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO20043305D0 (no) * 2004-08-09 2004-08-09 Amersham Health As Preparation of lodixanol
NO20053676D0 (no) * 2005-07-29 2005-07-29 Amersham Health As Crystallisation Process
EP1966110B1 (en) * 2005-12-19 2013-04-24 Ge Healthcare As Purification process of iodixanol
KR100976097B1 (ko) * 2008-12-05 2010-08-16 주식회사 대웅제약 이오프로마이드의 ｚ 이성체를 선택적으로 결정화하는 방법
US7999134B2 (en) * 2009-07-21 2011-08-16 Ge Healthcare As Crystallization of iodixanol using milling
US20110021822A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As continuous deacetylation and purification process in synthesis of non-ionic x-ray contrast agents
US20110021833A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As Crystallization of an intermediate for synthesizing non-ionic x-ray contrast agents
US7754918B1 (en) 2009-07-21 2010-07-13 Ge Healthcare As Crystallization of iodixanol in isopropanol and methanol
BR112012012497B1 (pt) * 2009-11-26 2021-09-08 Hovione China Holding Limited Método para preparar iodixanol
CN102079716B (zh) * 2009-11-26 2014-03-05 浙江台州海神制药有限公司 碘克沙醇的制备与纯化
MX354604B (es) * 2012-09-27 2018-03-07 Ge Healthcare As Preparacion de un compuesto intermediario de ioforminol.
WO2016096675A1 (en) 2014-12-16 2016-06-23 Koninklijke Philips N.V. Pulsed-light emitting marker device
PT108524B (pt) * 2015-06-02 2017-12-15 Hovione Farmaciência S A Processo para a preparação de intermediários úteis na preparação de agentes de contraste não-iónicos
KR20180077198A (ko) * 2015-11-04 2018-07-06 오츠카 세이야쿠 가부시키가이샤 이오시메놀의 혁신적인 제조 및 결정화
CN107698457B (zh) * 2016-08-08 2021-04-02 正大天晴药业集团股份有限公司 一种碘克沙醇的结晶纯化方法
CN111777525B (zh) * 2019-04-04 2021-08-27 成都西岭源药业有限公司 一种碘克沙醇的精制方法
CN117658849A (zh) * 2023-12-05 2024-03-08 成都倍特药业股份有限公司 一种碘比醇晶型ⅱ及其制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT101720A (pt) * 1995-06-08 1997-01-31 Hovione Sociedade Quimica S A Processo para a purificacao e cristalizacao de iopamidol
GB9618056D0 (en) * 1996-08-29 1996-10-09 Nycomed Imaging As Process
PT101919B (pt) * 1996-09-30 2000-01-31 Hovione Sociedade Quimica Sa Um processo para a purificacao de tohexol
DE69717156T2 (de) * 1997-02-11 2003-03-13 Bracco International B.V., Amsterdam Verfahren zur kritallisation von (s)-n-n'-bis [2-hydroxy-1-(hydroxymethyl) ethyl]-5-[(2-hydroxy-1-oxopropyl) amino]-2,4,6-triiodo-1,3-benzoldicarboxamid aus linearem oder verzweigtem (c5-c6) alkohol oder gemischen davon
GB9720969D0 (en) * 1997-10-02 1997-12-03 Nycomed Imaging As Process
GB9903109D0 (en) * 1999-02-11 1999-04-07 Nycomed Imaging As Process
ITMI20010773A1 (it) * 2001-04-11 2002-10-11 Chemi Spa Processo per la produzione di ioexolo ad elevata purezza
JP2004223451A (ja) 2003-01-24 2004-08-12 Sankio Chemical Co Ltd 有機化合物の分離精製方法及び分離精製装置
NO20033058D0 (no) * 2003-07-03 2003-07-03 Amersham Health As Prosess

Also Published As

Publication number Publication date
CN101233092A (zh) 2008-07-30
US8829241B2 (en) 2014-09-09
JP5155164B2 (ja) 2013-02-27
KR101409609B1 (ko) 2014-06-18
CN103922956A (zh) 2014-07-16
NO342096B1 (no) 2018-03-19
EP1924541A1 (en) 2008-05-28
NO20053687D0 (no) 2005-07-29
KR20080034901A (ko) 2008-04-22
CN103922956B (zh) 2016-08-17
US20080214867A1 (en) 2008-09-04
WO2007013815A1 (en) 2007-02-01
KR20140045599A (ko) 2014-04-16
JP2009502910A (ja) 2009-01-29
HK1203476A1 (en) 2015-10-30

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Legal Events

Date Code Title Description
CREP Change of representative

Representative=s name: ZACCO NORWAY AS, POSTBOKS 2003 VIKA