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NO20081975L - Diarylamin-inneholdende forbindelser og sammensetninger, og deres anvendelse som modulatorer av C-kit-reseptorer - Google Patents

Diarylamin-inneholdende forbindelser og sammensetninger, og deres anvendelse som modulatorer av C-kit-reseptorer

Info

Publication number
NO20081975L
NO20081975L NO20081975A NO20081975A NO20081975L NO 20081975 L NO20081975 L NO 20081975L NO 20081975 A NO20081975 A NO 20081975A NO 20081975 A NO20081975 A NO 20081975A NO 20081975 L NO20081975 L NO 20081975L
Authority
NO
Norway
Prior art keywords
compounds
diarylamine
compositions
modulators
kit receptors
Prior art date
Application number
NO20081975A
Other languages
English (en)
Inventor
Pascal Furet
Vito Guagnano
Shifeng Pan
Yi Liu
Valentina Molteni
Xiaolin Li
Donatella Chianelli
Jon Loren
Donald S Karanewsky
Shuli You
Juliet Nabakka
Xiaodong Liu
Original Assignee
Irm Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Irm Llc filed Critical Irm Llc
Publication of NO20081975L publication Critical patent/NO20081975L/no

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    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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Abstract

Beskrevet heri er forbindelser som inkluderer et diarylamin strukturelt trekk. Også beskrevet heri er fremgangsmåter for fremstilling av slike forbindelser, fremgangsmåte for anvendelse av slike forbindelser forbindelser for å modulere aktiviteten til c-kit reseptorer og farmasøytiske sammensetninger og medikamenter som innbefatter slike forbindelser. Også beskrevet heri er fremgangsmåter for anvendelse av slike forbindelser, farmasøytiske sammensetninger og medikamenter for behandling og/eller hindring og/eller inhibering og/eller lindring av patologien og/eller symptomologien til sykdommer eller tilstander assosiert med aktiviteten til c-kit reseptorer.
NO20081975A 2005-09-27 2008-04-24 Diarylamin-inneholdende forbindelser og sammensetninger, og deres anvendelse som modulatorer av C-kit-reseptorer NO20081975L (no)

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Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101354114B1 (ko) * 2005-06-14 2014-01-24 타이젠 바이오테크놀러지 컴퍼니 리미티드 피리미딘 화합물
US8193206B2 (en) 2005-06-14 2012-06-05 Taigen Biotechnology Co., Ltd. Pyrimidine compounds
AU2006297089B2 (en) * 2005-09-27 2012-05-03 Irm Llc Diarylamine-containing compounds and compositions, and their use as modulators of c-kit receptors
SI2402317T1 (sl) * 2006-03-31 2013-10-30 Novartis Ag DGAT inhibitor
MX2009011950A (es) 2007-05-04 2009-12-11 Irm Llc Derivados de pirimidina y composiciones como inhibidores de cinasa c-kit y pdgfr.
WO2008145681A2 (en) 2007-05-31 2008-12-04 Boehringer Ingelheim International Gmbh Ccr2 receptor antagonists and uses thereof
PL2190825T3 (pl) * 2007-08-22 2014-09-30 Novartis Ag Związki 5-(4-(chlorowcoalkoksy)-fenylo)-pirymidyno-2-aminowe i kompozycje jako inhibitory kinazy
CN101784539A (zh) * 2007-08-22 2010-07-21 Irm责任有限公司 作为激酶抑制剂的2-杂芳基氨基嘧啶衍生物
US20090170842A1 (en) * 2007-11-14 2009-07-02 University Of Kansas Brca1-based breast or ovarian cancer prevention agents and methods of use
CL2009000400A1 (es) 2008-02-22 2010-09-10 Irm Llc Compuestos heterociclicos derivados de 3-fenil-1,6- naftiridin-2-ona; moduladores de la actividad cinasa; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como trastornos alergicos, trastornos autoinmunes, neoplasias, rechazo en trasplante de organos, entre otras.
SI2268635T1 (sl) 2008-04-21 2015-10-30 Taigen Biotechnology Co., Ltd. Heterociklične spojine
CN102256963B (zh) 2008-12-19 2014-06-11 贝林格尔.英格海姆国际有限公司 作为ccr2受体拮抗剂用于治疗炎症、哮喘和copd的环状嘧啶-4-甲酰胺
PL2513093T3 (pl) 2009-12-17 2015-03-31 Centrexion Therapeutics Corp Nowi antagoniści receptora CCR2 i ich zastosowanie
JP2013526507A (ja) 2010-05-12 2013-06-24 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規ｃｃｒ２受容体アンタゴニスト、その製造方法及び薬物としてのその使用
WO2011141477A1 (en) 2010-05-12 2011-11-17 Boehringer Ingelheim International Gmbh New ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments
JP5647339B2 (ja) 2010-05-17 2014-12-24 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｃｒ２アンタゴニスト及びこれらの使用
WO2011147772A1 (en) 2010-05-25 2011-12-01 Boehringer Ingelheim International Gmbh Ccr2 receptor antagonists
JP5721242B2 (ja) 2010-06-01 2015-05-20 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規ｃｃｒ２アンタゴニスト
GB201009603D0 (en) 2010-06-08 2010-07-21 Cambridge Entpr Ltd Anti-inflammatory agent
RU2436786C1 (ru) * 2010-07-23 2011-12-20 Александр Васильевич Иващенко Замещенные индолы, противовирусный активный компонент, способ получения и применения
EP2718288B1 (en) * 2011-06-09 2015-03-11 Boehringer Ingelheim International GmbH Substituted piperidines as gpr119 modulators for the treatment of metabolic disorders
EP2731941B1 (en) 2011-07-15 2019-05-08 Boehringer Ingelheim International GmbH Novel and selective ccr2 antagonists
WO2014164749A1 (en) 2013-03-13 2014-10-09 Forma Therapeutics, Inc. Novel compounds and compositions for inhibition of fasn
PT3071559T (pt) 2013-11-18 2018-02-05 Elanco Tiergesundheit Ag Novos compostos
EP3233077A4 (en) 2014-12-19 2018-08-08 The Broad Institute Inc. Dopamine d2 receptor ligands
EP3233799B1 (en) 2014-12-19 2021-05-19 The Broad Institute, Inc. Dopamine d2 receptor ligands
EP3317270B1 (en) 2015-07-02 2020-05-13 Centrexion Therapeutics Corporation (4-((3r,4r)-3-methoxytetrahydro-pyran-4-ylamino)piperidin-1-yl)(5-methyl-6-(((2r,6s)-6-(p-tolyl)tetrahydro-2h-pyran-2-yl)methylamino)pyrimidin-4yl)methanone citrate
CN109328018A (zh) 2016-12-15 2019-02-12 雀巢产品技术援助有限公司 调节伴侣动物体内的磷或酶的组合物和方法
TWI767148B (zh) 2018-10-10 2022-06-11 美商弗瑪治療公司 抑制脂肪酸合成酶(fasn)
US10793554B2 (en) 2018-10-29 2020-10-06 Forma Therapeutics, Inc. Solid forms of 4-(2-fluoro-4-(1-methyl-1H-benzo[d]imidazol-5-yl)benzoyl)piperazin-1-yl)(1-hydroxycyclopropyl)methanone
KR20210142154A (ko) 2019-03-21 2021-11-24 옹쎄오 암 치료를 위한 키나제 억제제와 조합된 dbait 분자
JP2023500906A (ja) 2019-11-08 2023-01-11 インサーム（インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシェ メディカル） キナーゼ阻害剤に対する獲得抵抗性を有するがんの処置方法
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
CN114763342A (zh) * 2021-01-09 2022-07-19 江苏天士力帝益药业有限公司 一种高纯度4-甲基哌嗪-1-甲酸酯的合成方法
UY39614A (es) * 2021-01-22 2022-07-29 Ildong Pharmaceutical Co Ltd Inhibidores de la proteína anoctamina 6 y usos de estos
WO2023283488A2 (en) * 2021-07-09 2023-01-12 Chan Zuckerberg Biohub, Inc. Cdk19-selective inhibitors, and methods of use thereof

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670537A1 (de) * 1966-11-09 1970-10-29 Degussa Verfahren zur Herstellung neuer substituierter Aminopyrimidine
DE1918073A1 (de) * 1969-04-09 1970-10-15 Boehringer Sohn Ingelheim Verfahren zur Herstellung neuer 5-Aryl-1H-1,5-benzodiazepin-2,4-dione
GB1534593A (en) * 1976-09-03 1978-12-06 Soc D Etudes Prod Chimique N-2,6-dichlorophenyl-2-aminopyrimidine and therapeutic compositions containing it
EP0164204A1 (en) 1984-05-12 1985-12-11 FISONS plc Novel pharmaceutically useful pyrimidines
AU671959B2 (en) * 1991-11-25 1996-09-19 Pfizer Inc. Indole derivatives
TW440563B (en) * 1996-05-23 2001-06-16 Hoffmann La Roche Aryl pyrimidine derivatives and a pharmaceutical composition thereof
KR100272471B1 (ko) * 1998-11-17 2000-11-15 김선진 신규의 피리미딘 유도체 및 그의 제조방법
ATE253915T1 (de) * 1999-06-30 2003-11-15 Merck & Co Inc Src-kinase hemmende verbindungen
GB0022438D0 (en) * 2000-09-13 2000-11-01 Novartis Ag Organic Compounds
US7129242B2 (en) * 2000-12-06 2006-10-31 Signal Pharmaceuticals, Llc Anilinopyrimidine derivatives as JNK pathway inhibitors and compositions and methods related thereto
HUP0402352A2 (hu) * 2001-06-19 2005-02-28 Bristol-Myers Squibb Co. Foszfodiészteráz (PDE) 7 inhibitorként alkalmazható pirimidinszármazékok és ezeket tartalmazó gyógyszerkészítmények
EP1401411A2 (en) * 2001-06-29 2004-03-31 AB Science Use of tyrosine kinase inhibitors for treating bone loss
WO2003011837A1 (en) * 2001-08-01 2003-02-13 Merck & Co., Inc. Tyrosine kinase inhibitors
EP1578722A4 (en) * 2001-10-12 2006-09-06 Irm Llc KINASEINHIBITOR SCAFFOLD AND METHOD FOR THE PRODUCTION THEREOF
US7232825B2 (en) * 2003-05-02 2007-06-19 Guoqing P Chen Phenylaminopyrimidine derivatives and methods of use
JP2007538063A (ja) * 2004-05-20 2007-12-27 スージェン， インク． チオフェンヘテロアリールアミン
CA2600531A1 (en) * 2005-03-16 2006-09-28 Targegen, Inc. Pyrimidine compounds and methods of use
JP2008543775A (ja) * 2005-06-08 2008-12-04 ターゲジェン インコーポレーティッド 眼の障害を治療するための方法および組成物
AU2006297089B2 (en) * 2005-09-27 2012-05-03 Irm Llc Diarylamine-containing compounds and compositions, and their use as modulators of c-kit receptors

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