NO20081435L - N-oksider som prodroger for piperazin- og piperidinderivater - Google Patents
N-oksider som prodroger for piperazin- og piperidinderivaterInfo
- Publication number
- NO20081435L NO20081435L NO20081435A NO20081435A NO20081435L NO 20081435 L NO20081435 L NO 20081435L NO 20081435 A NO20081435 A NO 20081435A NO 20081435 A NO20081435 A NO 20081435A NO 20081435 L NO20081435 L NO 20081435L
- Authority
- NO
- Norway
- Prior art keywords
- art
- relates
- disease
- manufacture
- disclosed
- Prior art date
Links
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title abstract 4
- 150000001204 N-oxides Chemical class 0.000 title abstract 2
- 150000003053 piperidines Chemical class 0.000 title abstract 2
- 229940002612 prodrug Drugs 0.000 title 1
- 239000000651 prodrug Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 239000003814 drug Substances 0.000 abstract 3
- 238000004519 manufacturing process Methods 0.000 abstract 3
- 230000009286 beneficial effect Effects 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 206010003805 Autism Diseases 0.000 abstract 1
- 208000020706 Autistic disease Diseases 0.000 abstract 1
- 206010012335 Dependence Diseases 0.000 abstract 1
- 208000011688 Generalised anxiety disease Diseases 0.000 abstract 1
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 208000020114 Schizophrenia and other psychotic disease Diseases 0.000 abstract 1
- 208000012886 Vertigo Diseases 0.000 abstract 1
- 230000016571 aggressive behavior Effects 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 230000019771 cognition Effects 0.000 abstract 1
- 235000019788 craving Nutrition 0.000 abstract 1
- 208000029364 generalized anxiety disease Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 208000019906 panic disease Diseases 0.000 abstract 1
- 231100000889 vertigo Toxicity 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/423—Oxazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/24—Oxygen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Otolaryngology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Det beskrives N-oksider av visse piperazin og piperidin derivater og metoder for fremstilling av disse forbindelser. Det beskrives videre anvendelse av forbindelser som beskrevet her for fremstilling av et medikament som gir en fordelaktig virkning der en fordelaktig virkning er beskrevet her eller åpenbar for fagmannen fra beskrivelse og den generelle kunnskap. Det beskrives videre anvendelse av en forbindelse ifølge oppfinnelsen for fremstilling av et medikament for terapi eller prevensjon av en sykdom eller tilstand. Mer spesielt beskrives det en ny anvendelse for behandling av en sykdom eller tilstand som beskrevet her eller som er åpenbar for fagmannen. I utførelsesformer av oppfinnelsen er spesifikke forbindelser som beskrevet her nyttige for fremstilling av et medikament som er nyttig ved terapi av CNS forstyrrelser og særlig terapi av angstforstyrrelser inkludert generaliserte angstforstyrrelser og panisk forstyrrelse, obsessiv kompulsiv forstyrrelse, aggresjon, addiksjon (inkludert behov), depresjon, autisme, vertigo, schizofreni og andre psykotiske forstyrrelser, Parkinsons sykdom og forstyrrelser i forbindelse med kognisjon og hukommelse. Forbindelsene har den generelle formel der symbolene har den betydning som er gitt i beskrivelsen.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70982105P | 2005-08-22 | 2005-08-22 | |
| EP05107671 | 2005-08-22 | ||
| PCT/EP2006/065477 WO2007023141A1 (en) | 2005-08-22 | 2006-08-21 | N-oxides as prodrugs of piperazine & piperidine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20081435L true NO20081435L (no) | 2008-05-16 |
Family
ID=39246895
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20081435A NO20081435L (no) | 2005-08-22 | 2008-03-19 | N-oksider som prodroger for piperazin- og piperidinderivater |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP1919883B1 (no) |
| JP (1) | JP2009504799A (no) |
| KR (1) | KR20080046205A (no) |
| AT (1) | ATE417834T1 (no) |
| AU (1) | AU2006283882B2 (no) |
| CA (1) | CA2621158A1 (no) |
| DE (1) | DE602006004363D1 (no) |
| DK (1) | DK1919883T3 (no) |
| ES (1) | ES2318783T3 (no) |
| HR (1) | HRP20090143T3 (no) |
| IL (1) | IL188903A0 (no) |
| NO (1) | NO20081435L (no) |
| PL (1) | PL1919883T3 (no) |
| PT (1) | PT1919883E (no) |
| RU (1) | RU2394821C2 (no) |
| SI (1) | SI1919883T1 (no) |
| WO (1) | WO2007023141A1 (no) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7964604B2 (en) | 2005-02-18 | 2011-06-21 | Solvay Pharmaceuticals B.V. | Bifeprunox mesylate maintenance dose compositions and methods for using the same |
| US7423040B2 (en) | 2005-02-18 | 2008-09-09 | Irene Eijgendaal | Stable crystalline form of bifeprunox mesylate, dosage forms thereof and methods for using same |
| EP2035002A1 (en) * | 2006-06-16 | 2009-03-18 | Solvay Pharmaceuticals B.V. | Combination preparations comprising slv308 and a l-dopa |
| US7786126B2 (en) | 2006-06-16 | 2010-08-31 | Solvay Pharmaceuticals B.V. | Combination preparations comprising SLV308 and a dopamine agonist |
| WO2008025781A1 (en) | 2006-08-31 | 2008-03-06 | Solvay Pharmaceuticals B.V. | Bifeprunox doses for treating schizophrenia |
| PT2146961E (pt) | 2007-04-12 | 2014-04-30 | Ivax Int Gmbh | Derivados de n-óxido e/ou di-n-óxido de estabilizadores / moduladores dos recetores da dopamina exibindo perfis de efeitos secundários cardiovasculares melhorados |
| CN101918382A (zh) * | 2008-01-15 | 2010-12-15 | 雅培卫生保健产品有限责任公司 | 联苯芦诺衍生物 |
| WO2011023796A1 (en) | 2009-08-31 | 2011-03-03 | Abbott Healthcare Products B.V. | Bifeprunox for treating addiction |
| US9012476B2 (en) | 2011-12-08 | 2015-04-21 | IVAX International GmbH | Hydrobromide salt of pridopidine |
| NZ630560A (en) | 2012-04-04 | 2016-11-25 | Teva Pharmaceuticals Int Gmbh | Pharmaceutical compositions for combination therapy |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE503170A (no) * | 1975-09-02 | |||
| RU2178414C2 (ru) * | 1996-03-29 | 2002-01-20 | Дюфар Интернэшнл Рисерч Б.В. | Производные пиперазина и пиперидина и способ их получения |
| UA71590C2 (en) * | 1998-11-13 | 2004-12-15 | Duphar Int Res | Piperazine and piperidine derivatives |
| IL152177A0 (en) * | 2000-05-12 | 2003-05-29 | Solvay Pharm Bv | Piperazine and piperidine compounds |
| NZ533041A (en) * | 2002-01-16 | 2006-04-28 | Janssen Pharmaceutica Nv | Prucalopride-N-oxide |
-
2006
- 2006-08-21 AT AT06778284T patent/ATE417834T1/de active
- 2006-08-21 KR KR1020087006996A patent/KR20080046205A/ko not_active Ceased
- 2006-08-21 SI SI200630214T patent/SI1919883T1/sl unknown
- 2006-08-21 RU RU2008110945/04A patent/RU2394821C2/ru not_active IP Right Cessation
- 2006-08-21 WO PCT/EP2006/065477 patent/WO2007023141A1/en not_active Ceased
- 2006-08-21 JP JP2008527453A patent/JP2009504799A/ja active Pending
- 2006-08-21 CA CA002621158A patent/CA2621158A1/en not_active Abandoned
- 2006-08-21 AU AU2006283882A patent/AU2006283882B2/en not_active Ceased
- 2006-08-21 ES ES06778284T patent/ES2318783T3/es active Active
- 2006-08-21 DE DE602006004363T patent/DE602006004363D1/de active Active
- 2006-08-21 EP EP06778284A patent/EP1919883B1/en active Active
- 2006-08-21 DK DK06778284T patent/DK1919883T3/da active
- 2006-08-21 PT PT06778284T patent/PT1919883E/pt unknown
- 2006-08-21 PL PL06778284T patent/PL1919883T3/pl unknown
- 2006-08-21 HR HR20090143T patent/HRP20090143T3/xx unknown
-
2008
- 2008-01-21 IL IL188903A patent/IL188903A0/en unknown
- 2008-03-19 NO NO20081435A patent/NO20081435L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DK1919883T3 (da) | 2009-04-14 |
| KR20080046205A (ko) | 2008-05-26 |
| ATE417834T1 (de) | 2009-01-15 |
| WO2007023141A1 (en) | 2007-03-01 |
| HRP20090143T3 (hr) | 2009-04-30 |
| RU2008110945A (ru) | 2009-09-27 |
| PT1919883E (pt) | 2009-03-26 |
| RU2394821C2 (ru) | 2010-07-20 |
| EP1919883A1 (en) | 2008-05-14 |
| CA2621158A1 (en) | 2007-03-01 |
| IL188903A0 (en) | 2008-04-13 |
| EP1919883B1 (en) | 2008-12-17 |
| PL1919883T3 (pl) | 2009-06-30 |
| JP2009504799A (ja) | 2009-02-05 |
| ES2318783T3 (es) | 2009-05-01 |
| AU2006283882B2 (en) | 2011-06-23 |
| SI1919883T1 (sl) | 2009-04-30 |
| AU2006283882A1 (en) | 2007-03-01 |
| DE602006004363D1 (de) | 2009-01-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO20081435L (no) | N-oksider som prodroger for piperazin- og piperidinderivater | |
| TW200505907A (en) | Piperidine-benzenesulfonamide derivatives | |
| NO20051826L (no) | Heterosyklisk substituerte piperaziner for behandling av schizofreni | |
| NO20060324L (no) | [1,8]Naftyridin-2-oner og relaterte forbindelser for behandling av Schizofreni | |
| NO20060768L (no) | 1-(2-amino-benzol)-piperazinderivater som glycinopptaks-inhibitorer for behandling av psykoser | |
| ATE493407T1 (de) | 3-(heteroaryloxy)-2-alkyl-1- azabicycloalkylderivate als alpha.7-nachr- liganden zur behandlung von zns-erkrankungen | |
| BRPI0709773B8 (pt) | derivados de malonamida, processo de produção do mesmo, medicamento, e seus usos como inibidores de gama-secretase no tratamento do mal de alzheimer | |
| DE502004005033D1 (de) | Substituierte 2-aminotetraline zur behandlung von depressionen | |
| UA85707C2 (ru) | Бензоксазины для лечения заболеваний дыхательных путей | |
| IL186777A0 (en) | (3,4-dihydro-quinazolin-2-yl) - (2-aryloxy-ethyl) - amines having an activity on the 5 - ht receptor | |
| NO20083349L (no) | Anvendelse av 2-imidazoler for behandling av CNS sykdommer | |
| NO20055632L (no) | Aromatiske oksyfenyl- og aromatiske sulfanylfenylderivater | |
| NO20075477L (no) | Tetrahydro-pyridoazepin-8-one og beslektede forbindelser for behandling av schizofreni | |
| NO20072972L (no) | Terapeutiske pyrazolo[3,4-B]pyridiner og indazoler | |
| GB0412314D0 (en) | Compounds | |
| ATE483679T1 (de) | Substituierte cyclohexylessigsäure-derivate | |
| CO5640133A2 (es) | Derivados de 4-(2-feniloxifenil)-piperidina o 1,2,3,6-tetrahidropiridina como inhibidores de la recaptacion de la serotonina | |
| TW200738656A (en) | N-oxides as prodrugs of piperazine and piperidine derivatives | |
| ATE496534T1 (de) | Difluorierte piperidine zur behandlung von morbus alzheimer und verwandten leiden | |
| EA200870492A1 (ru) | N-оксиды производных пиридилметилпиперазина и - пиперидина | |
| MXPA05010678A (es) | Derivados de 4-(2-fenilsulfanil-fenil)-1,2,3,6-tetrahidropiridina como inhibidores de recaptacion de serotonina. | |
| ATE334980T1 (de) | Verfahren zur herstellung von 2-methyl piperazine derivaten. | |
| IL188109A0 (en) | Chloro-substituted guanidines | |
| BRPI0514077A (pt) | derivados de benzilóxi como inibidores de maob | |
| TH91553A (th) | N-ออกไซด์ที่เป็นโพรดรักส์ของอนุพันธ์พิเพอราซีนและพิเพอริดีน |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |