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NO20080174L - Alkylquinolin- og alkylquinazolinkinasemodulatorer - Google Patents

Alkylquinolin- og alkylquinazolinkinasemodulatorer

Info

Publication number
NO20080174L
NO20080174L NO20080174A NO20080174A NO20080174L NO 20080174 L NO20080174 L NO 20080174L NO 20080174 A NO20080174 A NO 20080174A NO 20080174 A NO20080174 A NO 20080174A NO 20080174 L NO20080174 L NO 20080174L
Authority
NO
Norway
Prior art keywords
compounds
alkylquinazoline
trkb
flt3
kit
Prior art date
Application number
NO20080174A
Other languages
English (en)
Inventor
Robert W Tuman
Dana L Johnson
Nand Baindur
Michael David Gaul
Guozhang Xu
Christian Andrew Baumann
Kevin Douglas Kreutter
Alexander J Kim
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of NO20080174L publication Critical patent/NO20080174L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Foreliggende oppfinnelse angår alkylquinolin og alkylquinazolinforbindelser med formel I: hvori R1, R2, R3, B, Z, G, Q og X er som definert heri, anvendelsen av slike forbindelser som proteintyrosinkinasemodulatorer, særlig inhibitorer av FLT3 og/eller c-kit og/eller TrkB, anvendelsen av slike forbindelser for å redusere eller inhibere kinaseaktivitet til FLT3 og/eller c-kit og/eller TrkB i en celle eller hos et subjekt, og anvendelsen av slike forbindelser for å hindre eller behandle en en celleproliferativ forstyrrelse og/eller forstyrrelser relatert til FLT3 og/eller c-kit og/eller TrkB hos et subjekt. Foreliggende oppfinnelse angår videre farmasøytiske sammensetninger som innbefatter forbindelsene ifølge oppfinnelsen og fremgangsmåter for behandling av tilstander slik som kreft og andre celleproliferative forstyrrelser.
NO20080174A 2005-06-10 2008-01-10 Alkylquinolin- og alkylquinazolinkinasemodulatorer NO20080174L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US68938405P 2005-06-10 2005-06-10
US73091905P 2005-10-27 2005-10-27
PCT/US2006/022414 WO2006135721A1 (en) 2005-06-10 2006-06-07 Alkylquinoline and alkylquinazoline kinase modulators

Publications (1)

Publication Number Publication Date
NO20080174L true NO20080174L (no) 2008-02-19

Family

ID=37038081

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20080174A NO20080174L (no) 2005-06-10 2008-01-10 Alkylquinolin- og alkylquinazolinkinasemodulatorer

Country Status (18)

Country Link
US (1) US8071768B2 (no)
EP (1) EP1893598A1 (no)
JP (1) JP2009501135A (no)
KR (1) KR20080028912A (no)
AR (1) AR054386A1 (no)
AU (1) AU2006257945A1 (no)
BR (1) BRPI0611964A2 (no)
CA (1) CA2611242A1 (no)
CR (1) CR9652A (no)
EA (1) EA200800017A1 (no)
EC (1) ECSP077997A (no)
GT (1) GT200600251A (no)
IL (1) IL187692A0 (no)
NO (1) NO20080174L (no)
PE (1) PE20070014A1 (no)
TW (1) TW200716599A (no)
UY (1) UY29588A1 (no)
WO (1) WO2006135721A1 (no)

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WO2012041872A1 (en) 2010-09-29 2012-04-05 Intervet International B.V. N-heteroaryl compounds with cyclic bridging unit for the treatment of parasitic diseases
CA2840029C (en) 2011-07-27 2021-07-20 Ab Science Oxazole and thiazole derivatives as selective protein kinase inhibitors (c-kit)
AU2013348175B2 (en) * 2012-11-20 2016-11-17 Boehringer Ingelheim Animal Health USA Inc. Anthelmintic compounds and compositions and method of using thereof
BR112016008080B1 (pt) * 2013-10-16 2021-02-23 Fujifilm Corporation sal de ácido carboxílico ou um sal de ácido mineral, cristal de succinato, cristal de fumarato e composição farmacêutica
EP3083602A1 (en) * 2013-12-20 2016-10-26 Pfizer Limited N-acylpiperidine ether tropomyosin-related kinase inhibitors
WO2016073738A2 (en) 2014-11-05 2016-05-12 Flexus Biosciences, Inc. Immunoregulatory agents
UY36390A (es) * 2014-11-05 2016-06-01 Flexus Biosciences Inc Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido), sus métodos de síntesis y composiciones farmacéuticas que los contienen
JP6412471B2 (ja) * 2015-07-15 2018-10-24 富士フイルム株式会社 含窒素複素環化合物の製造方法およびその中間体
EP3858813A4 (en) * 2018-09-27 2022-06-22 Shenzhen Chipscreen Biosciences Co., Ltd. QUINOLONE DERIVATIVE WITH INDOLEAMINE-2,3-DIOXYGENASE INHIBITED ACTIVITY
EP3911330B1 (en) * 2018-12-21 2025-03-05 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Dna-pkcs inhibitors for increasing genome editing efficiency

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Also Published As

Publication number Publication date
US20060281772A1 (en) 2006-12-14
WO2006135721A1 (en) 2006-12-21
UY29588A1 (es) 2006-10-02
GT200600251A (es) 2007-01-12
ECSP077997A (es) 2008-01-23
IL187692A0 (en) 2008-08-07
TW200716599A (en) 2007-05-01
EP1893598A1 (en) 2008-03-05
PE20070014A1 (es) 2007-03-08
CA2611242A1 (en) 2006-12-21
AR054386A1 (es) 2007-06-20
US8071768B2 (en) 2011-12-06
BRPI0611964A2 (pt) 2009-01-27
JP2009501135A (ja) 2009-01-15
CR9652A (es) 2008-09-09
KR20080028912A (ko) 2008-04-02
AU2006257945A1 (en) 2006-12-21
EA200800017A1 (ru) 2008-08-29

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