NO20080564L - Antitumorale biokonjugater av hyaluronsyre eller dens derivater oppnadd ved indirekte kjemisk konjugering, og deres anvendelse innen det farmasoytiske omradet - Google Patents
Antitumorale biokonjugater av hyaluronsyre eller dens derivater oppnadd ved indirekte kjemisk konjugering, og deres anvendelse innen det farmasoytiske omradetInfo
- Publication number
- NO20080564L NO20080564L NO20080564A NO20080564A NO20080564L NO 20080564 L NO20080564 L NO 20080564L NO 20080564 A NO20080564 A NO 20080564A NO 20080564 A NO20080564 A NO 20080564A NO 20080564 L NO20080564 L NO 20080564L
- Authority
- NO
- Norway
- Prior art keywords
- bioconjugates
- hyaluronic acid
- antitumoral
- pharmaceutical field
- chemical conjugation
- Prior art date
Links
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title abstract 2
- 230000000259 anti-tumor effect Effects 0.000 title abstract 2
- 229920002674 hyaluronan Polymers 0.000 title abstract 2
- 229960003160 hyaluronic acid Drugs 0.000 title abstract 2
- 230000021615 conjugation Effects 0.000 title 1
- 239000000126 substance Substances 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000000771 oncological effect Effects 0.000 abstract 1
- 125000006850 spacer group Chemical group 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 230000008685 targeting Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Inorganic Chemistry (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Den foreliggende beskrivelse beskriver en ny gruppe av biokonjugater som kan oppnås ved hjelp av indirekte syntese, via en molekylær spacer, mellom hyaluronsyre og/eller dens derivater og legemidler med en antitumoral aktivitet som tilhører forskjellige grupper, deres fremstillingsprosesser og anvendelser innen det onkologiske området. De nye derivatene, i forhold til typen av binding og substitusjonsgrad, har ulike fysisk-kjemiske egenskaper som forbedrer deres tolererbarhet og effektivitet og som tillater en mer nøyaktig modulering av doseringen, med utnyttelse av en aktiv målrettingsmekanisme.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT000242A ITPD20050242A1 (it) | 2005-08-03 | 2005-08-03 | Bioconiugati antitumorali dell'acido ialuronico o dei suoi derivati, ottenibili per coniugazione chimica diretta o indiretta, e loro impiego in campo farmaceutico |
| PCT/EP2006/007717 WO2007014784A2 (en) | 2005-08-03 | 2006-08-02 | Antitumoral bioconjugates of hyaluronic acid or its derivatives obtained by indirect chemical conjugation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20080564L true NO20080564L (no) | 2008-05-05 |
Family
ID=37038336
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20080564A NO20080564L (no) | 2005-08-03 | 2008-01-30 | Antitumorale biokonjugater av hyaluronsyre eller dens derivater oppnadd ved indirekte kjemisk konjugering, og deres anvendelse innen det farmasoytiske omradet |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US9687558B2 (no) |
| EP (4) | EP2537533B1 (no) |
| JP (2) | JP5457672B2 (no) |
| KR (1) | KR101614157B1 (no) |
| CN (2) | CN103041402A (no) |
| AU (1) | AU2006274992B2 (no) |
| BR (1) | BRPI0614536A2 (no) |
| CA (1) | CA2616957C (no) |
| DK (2) | DK2537533T3 (no) |
| ES (4) | ES2596877T3 (no) |
| IL (1) | IL189078A0 (no) |
| IT (1) | ITPD20050242A1 (no) |
| NO (1) | NO20080564L (no) |
| NZ (1) | NZ565504A (no) |
| PL (3) | PL2540319T3 (no) |
| RU (1) | RU2411958C2 (no) |
| SI (3) | SI2540319T1 (no) |
| WO (1) | WO2007014784A2 (no) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101217982B (zh) * | 2005-07-06 | 2012-10-10 | 生化学工业株式会社 | 药剂导入光交联透明质酸衍生物凝胶 |
| ITMI20071267A1 (it) * | 2007-06-22 | 2008-12-23 | Fidia Farmaceutici | Uso di coniugati dell'acido ialuronico nel trattamento locale di malattie cutanee iperproliferative |
| IE20070900A1 (en) * | 2007-12-12 | 2009-06-24 | Eurand Pharmaceuticals Ltd | New anticancer conjugates |
| US20120100218A1 (en) * | 2008-01-30 | 2012-04-26 | Laird Forrest | Intralymphatic Chemotherapy Drug Carriers |
| EP2242514B1 (en) * | 2008-01-30 | 2015-09-30 | University Of Kansas | Intralymphatic chemotherapy drug carriers |
| IT1391006B1 (it) * | 2008-10-08 | 2011-10-27 | Fidia Farmaceutici | Uso terapeutico di nuove preparazioni farmaceutiche contenenti farmaci antitumorali legati all'acido ialuronico nel trattamento delle neoplasie |
| RU2581972C2 (ru) * | 2008-04-22 | 2016-04-20 | Фидия Фармачеутичи С.П.А. | Терапевтическое применение новых фармацевтических препаратов, содержащих противоопухолевые лекарственные средства, связанные с гиалуроновой кислотой, в лечении неоплазий |
| KR20110032561A (ko) * | 2009-09-23 | 2011-03-30 | 포항공과대학교 산학협력단 | 약물 전달체의 표적 특이성 조절 방법, 표적 특이적 약물 전달체, 및 표적-비특이적 약효 장기 지속성 약물 전달체 |
| CN102399295B (zh) | 2010-09-09 | 2013-11-06 | 常州百瑞吉生物医药有限公司 | 低巯基化改性度生物相容高分子巯基化衍生物及其交联材料和用途 |
| CA2910325A1 (en) * | 2013-04-25 | 2014-10-30 | Aluron Biopharma Inc. | Crosslinked hyaluronic acid compositions |
| WO2015005459A1 (ja) * | 2013-07-10 | 2015-01-15 | 生化学工業株式会社 | 呼吸器投与用の医薬組成物 |
| CZ305153B6 (cs) * | 2014-03-11 | 2015-05-20 | Contipro Biotech S.R.O. | Konjugáty oligomeru kyseliny hyaluronové nebo její soli, způsob jejich přípravy a použití |
| CN104497167B (zh) * | 2014-11-24 | 2017-05-17 | 山东省药学科学院 | 透明质酸衍生物及其治疗药物 |
| CN105727305B (zh) * | 2016-02-24 | 2018-09-07 | 温州医科大学 | 一种Legumain响应释放阿霉素缓释纳米制剂及制备方法与作为制备载体药物的应用 |
| KR20210021361A (ko) | 2018-06-15 | 2021-02-25 | 크로마-파르마 게엠베하 | 가교된 폴리머를 포함하는 히드로겔 조성물 |
| JP7374133B2 (ja) | 2018-06-15 | 2023-11-06 | クロマ－ファーマ ゲゼルシャフト エム．ベー．ハー． | 安定化されたヒアルロン酸 |
| CN108912245B (zh) * | 2018-07-13 | 2020-04-28 | 吉林大学 | 一种具有靶向性和抗炎活性的氟化透明质酸衍生物及其制备方法和应用 |
| WO2020067507A1 (ja) * | 2018-09-28 | 2020-04-02 | 生化学工業株式会社 | 第１級アミン化合物又は第２級アミン化合物－酸性多糖コンジュゲートとその製造方法 |
| CA3157952A1 (en) | 2019-12-19 | 2021-06-24 | Ralph Hollaus | Thiol-modified hyaluronan and hydrogel comprising the crosslinked hyaluronan |
| US11643431B2 (en) * | 2020-06-08 | 2023-05-09 | Aihol Corporation | Uses of hyaluronan conjugate |
| CN111892668B (zh) * | 2020-07-03 | 2022-07-12 | 广东工业大学 | 一种化合物及其制备方法、荧光探针和抗肿瘤药物 |
| CN112089690A (zh) * | 2020-08-31 | 2020-12-18 | 厦门大学 | 一种透明质酸化青蒿琥酯、其纳米胶束制剂及其制备方法和用途 |
| CN112608397B (zh) * | 2020-11-30 | 2021-12-28 | 西安交通大学 | 一种铂类抗肿瘤药物-多糖聚合物纳米前药及制备方法和应用 |
| CA3204240A1 (en) * | 2021-06-18 | 2022-12-22 | Aihol Corporation | Uses of hyaluronan conjugate |
| WO2025174913A1 (en) * | 2024-02-12 | 2025-08-21 | Prolynx Llc | Locoregional therapies using slow-release conjugates |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO169637C (no) | 1983-10-11 | 1992-07-22 | Fidia Spa | Fremgangsmaate for fremstilling av terapeutisk aktive hyaluronsyre-fraksjoner |
| US4851521A (en) | 1985-07-08 | 1989-07-25 | Fidia, S.P.A. | Esters of hyaluronic acid |
| IT1219587B (it) | 1988-05-13 | 1990-05-18 | Fidia Farmaceutici | Polisaccaridi carbossiilici autoreticolati |
| EP0506976B1 (en) * | 1990-10-18 | 1997-04-09 | Shiseido Company Limited | Combination of hyaluronic acid with medicinal ingredient and production thereof |
| IT1247175B (it) | 1991-04-19 | 1994-12-12 | Fidia Spa | Procedimento per la purificazione di acido ialuronico e frazione di acido ialuronico puro per uso oftalmico. |
| WO1993024476A1 (en) | 1992-06-04 | 1993-12-09 | Clover Consolidated, Limited | Water-soluble polymeric carriers for drug delivery |
| DK0640622T3 (da) | 1993-02-26 | 2000-10-23 | Drug Delivery System Inst Ltd | Polysaccharidderivat og lægemiddelbærer |
| GB9320781D0 (en) * | 1993-10-08 | 1993-12-01 | Erba Carlo Spa | Polymer-bound camptothecin derivatives |
| US5616568A (en) | 1993-11-30 | 1997-04-01 | The Research Foundation Of State University Of New York | Functionalized derivatives of hyaluronic acid |
| ITPD940054A1 (it) | 1994-03-23 | 1995-09-23 | Fidia Advanced Biopolymers Srl | Polisaccaridi solfatati |
| CA2192725C (en) | 1995-12-28 | 2004-04-20 | Kenji Tsujihara | Camptothecin derivatives |
| AU735900B2 (en) | 1996-03-12 | 2001-07-19 | Pg-Txl Company, L.P. | Water soluble paclitaxel prodrugs |
| TW409058B (en) | 1996-06-06 | 2000-10-21 | Daiichi Seiyaku Co | Method for preparation of a drug complex |
| ITPD980169A1 (it) | 1998-07-06 | 2000-01-06 | Fidia Advanced Biopolymers Srl | Ammidi dell'acido ialuronico e dei suoi derivati e processo per la loro preparazione. |
| CA2402643A1 (en) * | 2000-03-17 | 2001-09-27 | Cell Therapeutics, Inc. | Polyglutamic acid-camptothecin conjugates and methods of preparation |
| GB0012718D0 (en) * | 2000-05-24 | 2000-07-19 | Angeletti P Ist Richerche Bio | Conjugates of aminodrugs |
| IT1317359B1 (it) | 2000-08-31 | 2003-06-16 | Fidia Advanced Biopolymers Srl | Polisaccaridi percarbossilati, quali l'acido ialuronico, processo perla loro preparazione e loro impiego in campo farmaceutico e |
| IT1317358B1 (it) | 2000-08-31 | 2003-06-16 | Fidia Advanced Biopolymers Srl | Derivati cross-linkati dell'acido ialuronico. |
| EP1610751A4 (en) | 2001-04-26 | 2006-05-24 | Univ Texas | THERAPEUTIC AGENT / LIGAND CONJUGATE COMPOSITIONS, ITS SYNTHESIS PROCESSES AND ITS APPLICATION |
| WO2002090390A1 (en) | 2001-05-04 | 2002-11-14 | University Of Utah Research Foundation | Hyaluronic acid containing bioconjugates : targeted delivery of anti-cancer drugs to cancer cells |
| US7034127B2 (en) * | 2002-07-02 | 2006-04-25 | Genzyme Corporation | Hydrophilic biopolymer-drug conjugates, their preparation and use |
| ITPD20020271A1 (it) * | 2002-10-18 | 2004-04-19 | Fidia Farmaceutici | Composti chimico-farmaceutici costituiti da derivati dei taxani legati covalentemente all'acido ialuronico o ai suoi derivati. |
-
2005
- 2005-08-03 IT IT000242A patent/ITPD20050242A1/it unknown
-
2006
- 2006-08-02 EP EP11159629.2A patent/EP2537533B1/en active Active
- 2006-08-02 EP EP11159649.0A patent/EP2540319B1/en active Active
- 2006-08-02 RU RU2008102878/05A patent/RU2411958C2/ru active
- 2006-08-02 US US11/989,716 patent/US9687558B2/en active Active
- 2006-08-02 SI SI200632187T patent/SI2540319T1/sl unknown
- 2006-08-02 NZ NZ565504A patent/NZ565504A/en unknown
- 2006-08-02 PL PL11159649T patent/PL2540319T3/pl unknown
- 2006-08-02 ES ES06762981.6T patent/ES2596877T3/es active Active
- 2006-08-02 CA CA2616957A patent/CA2616957C/en active Active
- 2006-08-02 BR BRPI0614536-1A patent/BRPI0614536A2/pt not_active IP Right Cessation
- 2006-08-02 ES ES11159629.2T patent/ES2633290T3/es active Active
- 2006-08-02 SI SI200632120A patent/SI1909843T1/sl unknown
- 2006-08-02 AU AU2006274992A patent/AU2006274992B2/en active Active
- 2006-08-02 EP EP11159664.9A patent/EP2548582B1/en active Active
- 2006-08-02 SI SI200632189T patent/SI2537533T1/sl unknown
- 2006-08-02 WO PCT/EP2006/007717 patent/WO2007014784A2/en not_active Ceased
- 2006-08-02 DK DK11159629.2T patent/DK2537533T3/da active
- 2006-08-02 KR KR1020087004522A patent/KR101614157B1/ko active Active
- 2006-08-02 CN CN201210568694XA patent/CN103041402A/zh active Pending
- 2006-08-02 CN CN200680034187.0A patent/CN101267840B/zh active Active
- 2006-08-02 PL PL11159629T patent/PL2537533T3/pl unknown
- 2006-08-02 EP EP06762981.6A patent/EP1909843B1/en active Active
- 2006-08-02 JP JP2008524445A patent/JP5457672B2/ja active Active
- 2006-08-02 PL PL06762981T patent/PL1909843T3/pl unknown
- 2006-08-02 ES ES11159664.9T patent/ES2692619T3/es active Active
- 2006-08-02 DK DK11159649.0T patent/DK2540319T3/en active
- 2006-08-02 ES ES11159649.0T patent/ES2633291T3/es active Active
-
2008
- 2008-01-28 IL IL189078A patent/IL189078A0/en active IP Right Grant
- 2008-01-30 NO NO20080564A patent/NO20080564L/no not_active Application Discontinuation
-
2013
- 2013-10-10 JP JP2013212756A patent/JP2014001249A/ja not_active Abandoned
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