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NO20075802L - Antistoff-noytraliserere av human granulocytmakrofagkoloni-stimulerende faktor - Google Patents

Antistoff-noytraliserere av human granulocytmakrofagkoloni-stimulerende faktor

Info

Publication number
NO20075802L
NO20075802L NO20075802A NO20075802A NO20075802L NO 20075802 L NO20075802 L NO 20075802L NO 20075802 A NO20075802 A NO 20075802A NO 20075802 A NO20075802 A NO 20075802A NO 20075802 L NO20075802 L NO 20075802L
Authority
NO
Norway
Prior art keywords
stimulating factor
macrophage colony
granulocyte macrophage
human granulocyte
antibody
Prior art date
Application number
NO20075802A
Other languages
English (en)
Other versions
NO344249B1 (no
Inventor
Tobias Raum
Julia Nee Henckel Hepp
Eva Krinner
Steven Zeman
Andreas Wolf
Sandra Bruckmaier
Silke Petsch
Original Assignee
Micromet Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Micromet Ag filed Critical Micromet Ag
Publication of NO20075802L publication Critical patent/NO20075802L/no
Publication of NO344249B1 publication Critical patent/NO344249B1/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/243—Colony Stimulating Factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
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  • Diabetes (AREA)
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Abstract

Sammendrag Den foreliggende oppfinnelsen vedrører et humant, monoklonalt antistoff eller fragment av det som spesifikt binder seg til og nøytraliserer primat GM-CSF.
NO20075802A 2005-04-18 2007-11-12 Humane monoklonale antistoffer som nøytraliserer human granulocyttmakrofagkolonistimulerende faktor NO344249B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05008410 2005-04-18
PCT/EP2006/003528 WO2006111353A2 (en) 2005-04-18 2006-04-18 Antibody neutralizers of human granulocyte macrophage colony stimulating factor

Publications (2)

Publication Number Publication Date
NO20075802L true NO20075802L (no) 2008-01-10
NO344249B1 NO344249B1 (no) 2019-10-21

Family

ID=37115507

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20075802A NO344249B1 (no) 2005-04-18 2007-11-12 Humane monoklonale antistoffer som nøytraliserer human granulocyttmakrofagkolonistimulerende faktor

Country Status (28)

Country Link
US (3) US8017748B2 (no)
EP (2) EP1874819B1 (no)
JP (1) JP5085533B2 (no)
KR (2) KR20150091193A (no)
CN (2) CN103342751B (no)
AU (1) AU2006237159B2 (no)
BR (1) BRPI0608281B8 (no)
CA (1) CA2605402C (no)
CY (1) CY1116632T1 (no)
DK (1) DK1874819T3 (no)
EA (2) EA017420B9 (no)
ES (1) ES2545769T3 (no)
HR (1) HRP20150773T1 (no)
HU (1) HUE025134T2 (no)
IL (2) IL186486A0 (no)
ME (1) ME02191B (no)
MX (1) MX2007012569A (no)
NO (1) NO344249B1 (no)
NZ (1) NZ562093A (no)
PL (1) PL1874819T3 (no)
PT (1) PT1874819E (no)
RS (1) RS54127B1 (no)
RU (2) RU2458071C2 (no)
SG (1) SG161292A1 (no)
SI (1) SI1874819T1 (no)
UA (1) UA94403C2 (no)
WO (1) WO2006111353A2 (no)
ZA (1) ZA200708201B (no)

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