NO20071341L - Stabilt, pegylert interferonpreparat. - Google Patents
Stabilt, pegylert interferonpreparat.Info
- Publication number
- NO20071341L NO20071341L NO20071341A NO20071341A NO20071341L NO 20071341 L NO20071341 L NO 20071341L NO 20071341 A NO20071341 A NO 20071341A NO 20071341 A NO20071341 A NO 20071341A NO 20071341 L NO20071341 L NO 20071341L
- Authority
- NO
- Norway
- Prior art keywords
- pegylated interferon
- formulations
- stable
- interferon preparation
- preparation
- Prior art date
Links
- 102000014150 Interferons Human genes 0.000 title abstract 3
- 108010050904 Interferons Proteins 0.000 title abstract 3
- 229940079322 interferon Drugs 0.000 title abstract 3
- 238000009472 formulation Methods 0.000 abstract 4
- 239000000203 mixture Substances 0.000 abstract 4
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 abstract 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 abstract 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 abstract 1
- 239000002577 cryoprotective agent Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7012—Compounds having a free or esterified carboxyl group attached, directly or through a carbon chain, to a carbon atom of the saccharide radical, e.g. glucuronic acid, neuraminic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/212—IFN-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biochemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Virology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60084604P | 2004-08-12 | 2004-08-12 | |
| PCT/US2005/028441 WO2006020720A2 (fr) | 2004-08-12 | 2005-08-11 | Preparation stable d'interferon pegyle |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20071341L true NO20071341L (no) | 2007-03-12 |
Family
ID=35885766
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20071341A NO20071341L (no) | 2004-08-12 | 2007-03-12 | Stabilt, pegylert interferonpreparat. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7632491B2 (fr) |
| EP (1) | EP1796647B1 (fr) |
| JP (1) | JP4971160B2 (fr) |
| KR (1) | KR20070045244A (fr) |
| CN (1) | CN101039660B (fr) |
| AT (1) | ATE476967T1 (fr) |
| AU (1) | AU2005272862B2 (fr) |
| BR (1) | BRPI0513332A (fr) |
| CA (1) | CA2576549C (fr) |
| DE (1) | DE602005022895D1 (fr) |
| ES (1) | ES2349472T3 (fr) |
| MX (1) | MX2007001663A (fr) |
| NO (1) | NO20071341L (fr) |
| WO (1) | WO2006020720A2 (fr) |
| ZA (1) | ZA200701154B (fr) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2531988C (fr) | 2003-08-05 | 2016-06-28 | Novo Nordisk A/S | Nouveaux derives de l'insuline |
| JP4808785B2 (ja) | 2005-12-28 | 2011-11-02 | ノボ・ノルデイスク・エー／エス | インスリン組成物および組成物の製造方法 |
| EP2422770A1 (fr) * | 2006-11-24 | 2012-02-29 | Cadila Healthcare Limited | Formulations de conjugués d'interféron alpha PEG |
| EA019345B1 (ru) * | 2007-03-05 | 2014-03-31 | Кадила Хелзкэр Лимитед | Композиции, содержащие конъюгаты пэг-интерферон-альфа и рафинозу в качестве криопротектора |
| ES2744384T3 (es) | 2007-06-13 | 2020-02-24 | Novo Nordisk As | Formulación farmacéutica que comprende un derivado de insulina |
| US9138403B2 (en) * | 2007-12-20 | 2015-09-22 | Merck Serono Sa | PEG-interferon-beta formulations |
| WO2010017296A1 (fr) * | 2008-08-05 | 2010-02-11 | Wyeth | Lyophilisation au-dessus de la température d’effondrement |
| EP2352513B1 (fr) | 2008-10-30 | 2016-09-14 | Novo Nordisk A/S | Traitement du diabète à l'aide d'injections d'insuline avec une fréquence inférieure à une injection par jour |
| WO2010064258A2 (fr) * | 2008-12-01 | 2010-06-10 | Intas Biopharmaceuticals Limited | Formulations pharmaceutiques de conjugués d’interféron |
| HRP20191793T1 (hr) | 2010-10-27 | 2019-12-27 | Novo Nordisk A/S | Liječenje dijabetesa melitusa injekcijama inzulina koje se primijenjuje u različitim intervalima injiciranja |
| WO2012118687A1 (fr) * | 2011-02-28 | 2012-09-07 | Merck Sharp & Dohme Corp. | Injecteur actionné manuellement avec séquence d'injection limitée |
| MX345102B (es) | 2011-04-28 | 2017-01-16 | Oncopeptides Ab | Preparacion liofilizada de dipeptidos citotoxicos. |
| EP2911685A2 (fr) * | 2012-10-26 | 2015-09-02 | Lupin Limited | Composition pharmaceutique stable d'interféron pégylé alpha-2b |
| CA2897062A1 (fr) * | 2013-01-15 | 2014-07-24 | Teva Pharmaceutical Industries Ltd. | Procede de lyophilisation |
| CN103054818B (zh) * | 2013-01-28 | 2014-03-05 | 苏州二叶制药有限公司 | 一种优质高效的冷冻干燥技术 |
| EP2991672A1 (fr) | 2013-04-30 | 2016-03-09 | Novo Nordisk A/S | Schéma d'administration d'un nouveau type |
| GB201513010D0 (en) * | 2015-07-23 | 2015-09-09 | Glaxosmithkline Biolog Sa | Novel formulation |
| FI126979B (en) * | 2016-02-29 | 2017-09-15 | Faron Pharmaceuticals Oy | Lyophilized pharmaceutical formulation and its use |
| CN108379561B (zh) * | 2018-03-01 | 2021-11-26 | 修正生物医药（杭州）研究院有限公司 | 一种聚乙二醇化尿酸氧化酶冻干粉剂及其制备方法 |
| US10335464B1 (en) | 2018-06-26 | 2019-07-02 | Novo Nordisk A/S | Device for titrating basal insulin |
| KR102562968B1 (ko) * | 2018-11-01 | 2023-08-04 | 주식회사 셀비온 | 붕소 중성자 포획 치료용 파라-보로노페닐알라닌 조성물 및 이의 제조방법 |
| WO2021009027A1 (fr) | 2019-07-12 | 2021-01-21 | Novo Nordisk A/S | Formulation d'insuline à concentration élevée |
| CN112245570A (zh) * | 2019-07-22 | 2021-01-22 | 厦门特宝生物工程股份有限公司 | 一种基于干扰素的疾病治疗方法 |
| CN112807281A (zh) * | 2019-10-31 | 2021-05-18 | 南京海维医药科技有限公司 | 包含血管紧张素ii的稳定组合物及其制备方法、使用方法 |
| CA3194975A1 (fr) * | 2020-09-11 | 2022-03-17 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Procedes pour la preparation d'un hydrogel ou d'une suspension colloidale, sterilise(e) de maniere terminale, issu(e) d'une matrice extracellulaire et utilisations correspondantes |
| CN113797318B (zh) * | 2021-10-26 | 2023-06-30 | 深圳科兴药业有限公司 | 一种干扰素组合物及其制备方法和应用 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3262575D1 (en) * | 1981-12-23 | 1985-04-18 | Schering Corp | Stabilised interferon formulations and their preparation |
| CA2024046A1 (fr) | 1989-09-28 | 1991-03-29 | Alberto Ferro | Interferons stabilises |
| US5595732A (en) * | 1991-03-25 | 1997-01-21 | Hoffmann-La Roche Inc. | Polyethylene-protein conjugates |
| US5382657A (en) | 1992-08-26 | 1995-01-17 | Hoffmann-La Roche Inc. | Peg-interferon conjugates |
| HUT75533A (en) | 1993-11-10 | 1997-05-28 | Schering Corp | Improved interferon polymer conjugates |
| US5951974A (en) * | 1993-11-10 | 1999-09-14 | Enzon, Inc. | Interferon polymer conjugates |
| US5766582A (en) | 1994-10-11 | 1998-06-16 | Schering Corporation | Stable, aqueous alfa interferon solution formulations |
| US5738846A (en) | 1994-11-10 | 1998-04-14 | Enzon, Inc. | Interferon polymer conjugates and process for preparing the same |
| US5691298A (en) * | 1994-12-14 | 1997-11-25 | The Procter & Gamble Company | Ester oligomers suitable as soil release agents in detergent compositions |
| EP0820299B1 (fr) | 1995-02-06 | 2002-04-24 | Genetics Institute, Inc. | Formulations de preparation d'interleukine-12 |
| JP2758154B2 (ja) | 1995-04-06 | 1998-05-28 | エフ・ホフマン−ラ ロシユ アーゲー | インターフェロンを含む液体製剤 |
| US5908621A (en) | 1995-11-02 | 1999-06-01 | Schering Corporation | Polyethylene glycol modified interferon therapy |
| TW517067B (en) | 1996-05-31 | 2003-01-11 | Hoffmann La Roche | Interferon conjugates |
| KR100420642B1 (ko) * | 1998-03-26 | 2004-03-02 | 쉐링 코포레이션 | Ｐｅｇ-인터페론 알파 결합체의 보호에 사용되는 제형 |
| US6180096B1 (en) * | 1998-03-26 | 2001-01-30 | Schering Corporation | Formulations for protection of peg-interferon alpha conjugates |
| CN1368887A (zh) * | 1999-08-13 | 2002-09-11 | 弗·哈夫曼-拉罗切有限公司 | 与PEG－IFN－α结合的霉酚酸酯Mofetil |
| US6887462B2 (en) * | 2001-04-09 | 2005-05-03 | Chiron Corporation | HSA-free formulations of interferon-beta |
| EP1461067A1 (fr) | 2001-12-07 | 2004-09-29 | Intermune, Inc. | Compositions et procede de traitement de l'infection par le virus de l'hepatite |
-
2005
- 2005-08-11 MX MX2007001663A patent/MX2007001663A/es active IP Right Grant
- 2005-08-11 CA CA2576549A patent/CA2576549C/fr not_active Expired - Fee Related
- 2005-08-11 ES ES05785190T patent/ES2349472T3/es not_active Expired - Lifetime
- 2005-08-11 US US11/201,731 patent/US7632491B2/en active Active
- 2005-08-11 BR BRPI0513332-7A patent/BRPI0513332A/pt not_active IP Right Cessation
- 2005-08-11 EP EP05785190A patent/EP1796647B1/fr not_active Expired - Lifetime
- 2005-08-11 CN CN2005800348502A patent/CN101039660B/zh not_active Expired - Fee Related
- 2005-08-11 AU AU2005272862A patent/AU2005272862B2/en not_active Ceased
- 2005-08-11 KR KR1020077003190A patent/KR20070045244A/ko not_active Withdrawn
- 2005-08-11 JP JP2007525768A patent/JP4971160B2/ja not_active Expired - Fee Related
- 2005-08-11 DE DE602005022895T patent/DE602005022895D1/de not_active Expired - Lifetime
- 2005-08-11 WO PCT/US2005/028441 patent/WO2006020720A2/fr not_active Ceased
- 2005-08-11 AT AT05785190T patent/ATE476967T1/de not_active IP Right Cessation
-
2007
- 2007-02-08 ZA ZA200701154A patent/ZA200701154B/xx unknown
- 2007-03-12 NO NO20071341A patent/NO20071341L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN101039660A (zh) | 2007-09-19 |
| CN101039660B (zh) | 2010-10-06 |
| ZA200701154B (en) | 2008-08-27 |
| AU2005272862A1 (en) | 2006-02-23 |
| HK1103977A1 (en) | 2008-01-04 |
| KR20070045244A (ko) | 2007-05-02 |
| JP4971160B2 (ja) | 2012-07-11 |
| ATE476967T1 (de) | 2010-08-15 |
| AU2005272862B2 (en) | 2011-03-10 |
| CA2576549C (fr) | 2011-01-18 |
| ES2349472T3 (es) | 2011-01-03 |
| US7632491B2 (en) | 2009-12-15 |
| WO2006020720A2 (fr) | 2006-02-23 |
| EP1796647A2 (fr) | 2007-06-20 |
| BRPI0513332A (pt) | 2008-05-06 |
| US20060051320A1 (en) | 2006-03-09 |
| JP2008509919A (ja) | 2008-04-03 |
| EP1796647B1 (fr) | 2010-08-11 |
| WO2006020720A3 (fr) | 2006-06-01 |
| DE602005022895D1 (de) | 2010-09-23 |
| CA2576549A1 (fr) | 2006-02-23 |
| MX2007001663A (es) | 2007-04-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |