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NO20070387L - Kvarternaere salt-CCR2-antagonister - Google Patents

Kvarternaere salt-CCR2-antagonister

Info

Publication number
NO20070387L
NO20070387L NO20070387A NO20070387A NO20070387L NO 20070387 L NO20070387 L NO 20070387L NO 20070387 A NO20070387 A NO 20070387A NO 20070387 A NO20070387 A NO 20070387A NO 20070387 L NO20070387 L NO 20070387L
Authority
NO
Norway
Prior art keywords
quarterly
ccr2 antagonists
salt
ccr2
antagonists
Prior art date
Application number
NO20070387A
Other languages
English (en)
Inventor
Bharat Lagu
Michael P Wachter
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of NO20070387L publication Critical patent/NO20070387L/no

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    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • C07C233/77—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/80—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
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    • C07C2602/00—Systems containing two condensed rings
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    • C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms

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Abstract

Kvarternære ammoniumsforbindelser med formel (I) eller farmasøytisk akseptable former derav, som er CCR2-antagonister og er anvendelige ved hindring, behandling eller lindring av CCR2-medierte inflammasjonssyndromer, forstyrrelser eller sykdommer hos et subjekt som trenger det.
NO20070387A 2004-06-25 2007-01-22 Kvarternaere salt-CCR2-antagonister NO20070387L (no)

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PCT/US2005/022034 WO2006012135A1 (en) 2004-06-24 2005-06-22 Quaternary salt ccr2 antagonists

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