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NO20061832L - Karboksamidderivat av amidtype - Google Patents

Karboksamidderivat av amidtype

Info

Publication number
NO20061832L
NO20061832L NO20061832A NO20061832A NO20061832L NO 20061832 L NO20061832 L NO 20061832L NO 20061832 A NO20061832 A NO 20061832A NO 20061832 A NO20061832 A NO 20061832A NO 20061832 L NO20061832 L NO 20061832L
Authority
NO
Norway
Prior art keywords
halogen
derivative
lower alkyl
amide type
salts
Prior art date
Application number
NO20061832A
Other languages
English (en)
Inventor
Takayuki Kawaguchi
Hidenori Akatsuka
Masamichi Morimoto
Tatsuya Watanabe
Toru Iijima
Jun Murakami
Original Assignee
Tanabe Seiyaku Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co filed Critical Tanabe Seiyaku Co
Publication of NO20061832L publication Critical patent/NO20061832L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/164—Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Karboksamidderivat av amidtype med generell formel [1]: hvor X er -N= eller -CH=; R1 er halogen, lavere alkyl etc; R2 har formel [2] Y1 og Y2 er like eller forskjellige og er halogen eller en gruppe valgt blant lavere alkyl, lavere alkoksy etc.; og ring A er fenyl etc. Det beskrives også farmakologisk akseptable salter av derivatet. Derivatet og saltene er anvendelige som medisin, særlig som en FXa-inhibitor. hvor X er -N= eller -CH=; R1 er halogen, lavere alkyl etc; R2 har formel [2] Y1 og Y2 er like eller forskjellige og er halogen eller en gruppe valgt blant lavere alkyl, lavere alkoksy etc.; og ring A er fenyl etc. Det beskrives også farmakologisk akseptable salter av derivatet. Derivatet og saltene er anvendelige som medisin, særlig som en FXa-inhibitor.
NO20061832A 2003-09-26 2006-04-25 Karboksamidderivat av amidtype NO20061832L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003334595 2003-09-26
PCT/JP2004/013892 WO2005030706A1 (ja) 2003-09-26 2004-09-24 アミド型カルボキサミド誘導体

Publications (1)

Publication Number Publication Date
NO20061832L true NO20061832L (no) 2006-04-25

Family

ID=34386034

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20061832A NO20061832L (no) 2003-09-26 2006-04-25 Karboksamidderivat av amidtype

Country Status (17)

Country Link
US (1) US7375119B2 (no)
EP (1) EP1666455A4 (no)
JP (1) JP4571075B2 (no)
KR (1) KR100740820B1 (no)
CN (1) CN100475777C (no)
AR (1) AR045816A1 (no)
AU (1) AU2004276128B2 (no)
BR (1) BRPI0414460A (no)
CA (1) CA2538072C (no)
IL (1) IL174188A0 (no)
MX (1) MXPA06003382A (no)
NO (1) NO20061832L (no)
NZ (1) NZ546160A (no)
RU (1) RU2307829C2 (no)
TW (1) TW200512181A (no)
WO (1) WO2005030706A1 (no)
ZA (1) ZA200602131B (no)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7875627B2 (en) 2004-12-07 2011-01-25 Abbott Laboratories Thienopyridyl compounds that inhibit vanilloid receptor subtype 1 (VR1) and uses thereof
TW200734304A (en) * 2005-11-08 2007-09-16 Astellas Pharma Inc Benzene derivative or salt thereof
EA201101492A1 (ru) 2006-11-15 2012-09-28 Вирокем Фарма Инк. Аналоги тиофена для лечения или предупреждения флавивирусных инфекций
CA2676670C (en) 2007-02-02 2012-03-13 Pfizer Products Inc. Tricyclic compounds, compositions, and methods
EP2070916A1 (de) 2007-12-10 2009-06-17 Bayer Schering Pharma Aktiengesellschaft 2-Aryl-thiazol-4-carbonsäureamid-Derivate, deren Herstellung und Verwendung als Arzneimittel
EP2070924A1 (de) 2007-12-10 2009-06-17 Bayer Schering Pharma Aktiengesellschaft Neue 2-Hetarylthiazol-4-carbonsäureamid-Derivative, deren Herstellung und Verwendung als Arzneimittel
EP2070925A1 (de) 2007-12-10 2009-06-17 Bayer Schering Pharma Aktiengesellschaft Neue 2-substituierte Tiazol-4-carbonsäureamid-Derivative deren Herstellung und Verwendung als Arzneimittel
US8178583B2 (en) * 2008-12-19 2012-05-15 Hoffmann-La Roche Inc. Compounds
WO2010132554A2 (en) * 2009-05-12 2010-11-18 Mallinckrodt Inc. Diaza heterocyclic compounds for phototherapy
EP2635559A2 (en) * 2010-11-01 2013-09-11 Neurotune AG Neurotrypsin inhibitors

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9306453D0 (en) * 1993-03-29 1993-05-19 Zeneca Ltd Heterocyclic derivatives
JP2002512633A (ja) * 1997-06-26 2002-04-23 イーライ・リリー・アンド・カンパニー 抗血栓剤
CN1143855C (zh) 1997-12-19 2004-03-31 舍林公开股份有限公司 作为抗凝剂的邻氨基苯甲酰胺衍生物
EP0937711A1 (de) * 1998-02-18 1999-08-25 Roche Diagnostics GmbH Neue Thiobenzamide, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel
US6956988B2 (en) 1998-08-21 2005-10-18 Avanex Corporation Optical interleaver
CA2361149A1 (en) * 1998-12-23 2000-07-06 Eli Lilly And Company Aromatic amides
DE60040676D1 (de) * 1999-09-17 2008-12-11 Millennium Pharm Inc BENZAMIDE UND ÄHNLICHE INHIBITOREN VON FAKTOR Xa
AU2001277731A1 (en) 2000-08-09 2002-02-18 Welfide Corporation Fused bicyclic amide compounds and medicinal use thereof
US7163938B2 (en) * 2000-11-28 2007-01-16 Eli Lilly And Company Substituted carboxamides
EP1373194B1 (en) 2001-03-30 2007-08-01 Millennium Pharmaceuticals, Inc. BENZAMIDE INHIBITORS OF FACTOR Xa
US7312235B2 (en) 2001-03-30 2007-12-25 Millennium Pharmaceuticals, Inc. Benzamide inhibitors of factor Xa
SI1427415T1 (sl) * 2001-09-21 2009-12-31 Bristol Myers Squibb Co Sestavine, ki vsebujejo laktame in njihovi derivati kot inhibitorji faktorja xa
WO2003048081A2 (en) * 2001-12-04 2003-06-12 Bristol-Myers Squibb Company Glycinamides as factor xa inhibitors
AU2003221178B2 (en) * 2002-03-28 2006-06-15 Tanabe Seiyaku Co., Ltd. Benzofuran derivative
JP2005104838A (ja) * 2003-01-09 2005-04-21 Tanabe Seiyaku Co Ltd 縮合フラン化合物

Also Published As

Publication number Publication date
CA2538072C (en) 2009-08-25
US20060287329A1 (en) 2006-12-21
EP1666455A1 (en) 2006-06-07
NZ546160A (en) 2008-09-26
JP4571075B2 (ja) 2010-10-27
IL174188A0 (en) 2006-08-01
CN1860097A (zh) 2006-11-08
AU2004276128B2 (en) 2007-11-29
KR20060095982A (ko) 2006-09-05
JPWO2005030706A1 (ja) 2006-12-07
ZA200602131B (en) 2007-02-28
BRPI0414460A (pt) 2006-11-14
RU2006114055A (ru) 2006-09-10
AR045816A1 (es) 2005-11-16
RU2307829C2 (ru) 2007-10-10
CA2538072A1 (en) 2005-04-07
EP1666455A4 (en) 2009-02-25
TW200512181A (en) 2005-04-01
CN100475777C (zh) 2009-04-08
MXPA06003382A (es) 2006-06-08
KR100740820B1 (ko) 2007-07-19
WO2005030706A1 (ja) 2005-04-07
AU2004276128A1 (en) 2005-04-07
US7375119B2 (en) 2008-05-20

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