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NO20060144L - Nye modifiserte corinmolekyler som har substituerte aktiveringssekvenser og anvendelser derav - Google Patents

Nye modifiserte corinmolekyler som har substituerte aktiveringssekvenser og anvendelser derav

Info

Publication number
NO20060144L
NO20060144L NO20060144A NO20060144A NO20060144L NO 20060144 L NO20060144 L NO 20060144L NO 20060144 A NO20060144 A NO 20060144A NO 20060144 A NO20060144 A NO 20060144A NO 20060144 L NO20060144 L NO 20060144L
Authority
NO
Norway
Prior art keywords
molecules
corin molecules
substituted
new modified
activation sequences
Prior art date
Application number
NO20060144A
Other languages
English (en)
Inventor
Qingyu Mu
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of NO20060144L publication Critical patent/NO20060144L/no

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)

Abstract

Denne oppfinnelsen vedrører nye modifiserte corinmolekyler, eller fiiagmenter eller derivater derav, som omfatter en substituert aktiveringssekvens. De modifiserte corinmolekylene blir kløyvet på den substituerte aktiveringssekvensen, for derved å generere aktiverte corinmolekyler, eller fragmenter eller derivater derav, som oppviser den fimksjonelle aktiviteten til naturlig forekommende villtype- corinmolekyler. De modifiserte corinmolekylene kan bli benyttet til å behandle en mengde sykdommer eller forstyrrelser, inkludert kongestiv hjertesvikt og akutt hjerteinfarkt.
NO20060144A 2003-06-11 2006-01-10 Nye modifiserte corinmolekyler som har substituerte aktiveringssekvenser og anvendelser derav NO20060144L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47768303P 2003-06-11 2003-06-11
PCT/US2004/018669 WO2004111225A1 (en) 2003-06-11 2004-06-09 Novel modified corin molecules having substitute activation sequences and uses thereof

Publications (1)

Publication Number Publication Date
NO20060144L true NO20060144L (no) 2006-01-10

Family

ID=33551745

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20060144A NO20060144L (no) 2003-06-11 2006-01-10 Nye modifiserte corinmolekyler som har substituerte aktiveringssekvenser og anvendelser derav

Country Status (15)

Country Link
US (1) US7176013B2 (no)
EP (1) EP1636356A1 (no)
JP (1) JP2007502132A (no)
KR (1) KR20060022683A (no)
CN (2) CN1836037A (no)
AU (1) AU2004248192A1 (no)
BR (1) BRPI0411353A (no)
CA (1) CA2527361A1 (no)
IL (1) IL172095A0 (no)
MX (1) MXPA05013321A (no)
NO (1) NO20060144L (no)
PL (1) PL379196A1 (no)
RU (1) RU2006100035A (no)
WO (1) WO2004111225A1 (no)
ZA (1) ZA200600224B (no)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050026255A1 (en) * 2002-06-25 2005-02-03 Morser John Michael Corin, a serine protease
TW200723151A (en) * 2005-12-07 2007-06-16 Era Digital Media Co Business website method
US20110160128A1 (en) * 2008-03-28 2011-06-30 Qingyu Wu Corin for Treating Obesity and Diabetes
WO2010096658A1 (en) 2009-02-19 2010-08-26 The Cleveland Clinic Foundation Corin as a marker for heart failure
US10314894B2 (en) * 2014-02-12 2019-06-11 The Cleveland Clinic Foundation Treatment of cardio-renal disease using PCSK6
SG10202001578RA (en) * 2016-02-29 2020-04-29 Regeneron Pharma Rodents having a humanized tmprss gene
CN105734070A (zh) * 2016-04-11 2016-07-06 苏州大学 Corin基因变异体及其用途
CN108066286B (zh) * 2016-11-10 2021-06-29 复旦大学 炔丙基半胱氨酸纳米粒长循环脂质体及其制备方法和用途
CN118530307B (zh) * 2024-06-14 2025-09-09 中国人民解放军军事科学院军事医学研究院 一种阻断pts途径的多肽及其应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK275788A (da) * 1987-05-22 1989-02-03 Zymogenetics Inc Fibrinolytiske proteiner
US5869637A (en) 1996-07-22 1999-02-09 Incyte Pharmaceuticals, Inc. Human Kallikrein
US5968782A (en) * 1996-12-04 1999-10-19 Brigham And Womens's Hospital, Inc. Mast cell protease that cleaves fibrinogen
WO1998036054A1 (en) 1997-02-13 1998-08-20 Amrad Operations Pty. Ltd. Novel molecules
AU9260598A (en) 1997-08-22 1999-03-16 Boehringer Mannheim Gmbh Zymogenic protease precursors that can be autocatalytically activated and their use
EP0927764B1 (de) * 1997-12-03 2004-05-26 Boehringer Mannheim Gmbh Chimäre Serinproteasen
ES2307338T3 (es) 1998-06-05 2008-11-16 Bayer Schering Pharma Aktiengesellschaft Corina, una serina proteasa.
US6420157B1 (en) * 1999-04-30 2002-07-16 Ortho-Mcneil Pharmaceutical, Inc. Zymogen activation system
EP1252300B1 (en) 2000-02-03 2011-01-19 Dendreon Corporation Nucleic acid molecules encoding transmembrane serine proteases, the encoded proteins and methods based thereon
EP1326882A2 (en) * 2000-06-19 2003-07-16 Dyax Corp. Enterokinase cleavage sequences and their use
HUP0203251A2 (hu) * 2000-09-04 2003-01-28 Hyo-Joon Kim Az apolipoprotein B-100 epitópját utánzó peptidek, ezeknek megfelelő konkatemér és módosított peptidek és ezeket tartalmazó vakcinakészítmények
FR2831170B1 (fr) * 2001-10-19 2004-03-19 Inst Nat Sante Rech Med Proteines c modifiees activables directement par la thrombine
WO2004033630A2 (en) * 2002-10-04 2004-04-22 Schering Aktiengesellschaft Modified hepsin molecules having a substitute activation sequence and uses thereof

Also Published As

Publication number Publication date
AU2004248192A1 (en) 2004-12-23
CN1836037A (zh) 2006-09-20
CN101109011A (zh) 2008-01-23
IL172095A0 (en) 2009-02-11
EP1636356A1 (en) 2006-03-22
KR20060022683A (ko) 2006-03-10
CA2527361A1 (en) 2004-12-23
RU2006100035A (ru) 2006-08-27
US20050003416A1 (en) 2005-01-06
WO2004111225A1 (en) 2004-12-23
US7176013B2 (en) 2007-02-13
ZA200600224B (en) 2007-04-25
JP2007502132A (ja) 2007-02-08
PL379196A1 (pl) 2006-07-24
BRPI0411353A (pt) 2006-07-11
MXPA05013321A (es) 2006-03-09
WO2004111225A8 (en) 2006-04-06

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