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NO20060494L - Regioselektiv syntese av CCI-779 - Google Patents

Regioselektiv syntese av CCI-779

Info

Publication number
NO20060494L
NO20060494L NO20060494A NO20060494A NO20060494L NO 20060494 L NO20060494 L NO 20060494L NO 20060494 A NO20060494 A NO 20060494A NO 20060494 A NO20060494 A NO 20060494A NO 20060494 L NO20060494 L NO 20060494L
Authority
NO
Norway
Prior art keywords
cci
regioselective synthesis
regioselective
synthesis
boronate
Prior art date
Application number
NO20060494A
Other languages
English (en)
Inventor
Warren Chew
Chia-Cheng Shaw
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of NO20060494L publication Critical patent/NO20060494L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C07F7/1872—Preparation; Treatments not provided for in C07F7/20
    • C07F7/1892—Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)

Abstract

Det er beskrevet en fremgangsmåte for regioselektiv syntese av CCI-779 basert på boronatkjemi. Det er videre beskrevet nye mellomprodukter som er nyttige i disse fremgangsmåtene.
NO20060494A 2003-08-07 2006-01-31 Regioselektiv syntese av CCI-779 NO20060494L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49324903P 2003-08-07 2003-08-07
PCT/US2004/022860 WO2005016935A2 (en) 2003-08-07 2004-07-15 Regioselective synthesis of cci-779

Publications (1)

Publication Number Publication Date
NO20060494L true NO20060494L (no) 2006-03-06

Family

ID=34193170

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20060494A NO20060494L (no) 2003-08-07 2006-01-31 Regioselektiv syntese av CCI-779

Country Status (26)

Country Link
US (1) US7153957B2 (no)
EP (1) EP1658295B1 (no)
JP (1) JP4227649B2 (no)
KR (1) KR20060057605A (no)
CN (1) CN1829722B (no)
AR (1) AR045217A1 (no)
AT (1) ATE365169T1 (no)
AU (1) AU2004265267A1 (no)
BR (1) BRPI0412667A (no)
CA (1) CA2532988A1 (no)
CO (1) CO5650251A2 (no)
CR (1) CR8189A (no)
DE (1) DE602004007145T2 (no)
DK (1) DK1658295T3 (no)
EC (1) ECSP066413A (no)
ES (1) ES2287772T3 (no)
IL (1) IL173134A0 (no)
MX (1) MXPA06000951A (no)
NO (1) NO20060494L (no)
PL (1) PL1658295T3 (no)
PT (1) PT1658295E (no)
RU (1) RU2339639C2 (no)
TW (1) TW200508241A (no)
UA (1) UA83245C2 (no)
WO (1) WO2005016935A2 (no)
ZA (1) ZA200601055B (no)

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DE60231868D1 (de) * 2001-04-24 2009-05-20 Purdue Research Foundation Folat-mimetika und deren folatrezeptorbindende konjugate
JP4814520B2 (ja) * 2002-05-15 2011-11-16 エンドサイト，インコーポレイテッド ビタミン−マイトマイシン結合体
AR040693A1 (es) 2002-07-30 2005-04-13 Wyeth Corp Formulaciones parenterales
EP2529758A3 (en) 2003-01-27 2013-01-02 Endocyte, Inc. Vitamin receptor binding drug delivery conjugates
CA2536775A1 (en) * 2003-09-03 2005-03-17 Wyeth Amorphous rapamycin 42-ester with 3-hydroxy-2-(hydroxymethyl)-2-methylpropionic acid and its pharmaceutical compositions containing the same
ES2298861T3 (es) * 2004-01-08 2008-05-16 Wyeth Composicion farmaceutica que puede obtenerse mediante compresion directa para la administracion oral de cci-779.
WO2005105811A1 (en) 2004-04-14 2005-11-10 Wyeth Regiospecific synthesis of rapamycin 42-ester derivatives
EP1735321B1 (en) * 2004-04-14 2008-10-08 Wyeth Process for preparing rapamycin 42-esters and fk-506 32-esters with dicarboxylic acid, precursors for rapamycin conjugates and antibodies
BRPI0509854A (pt) 2004-04-14 2007-10-23 Wyeth Corp composto, métodos para a preparação regio-especìfica de um 42-éster de rapamicina ou 42-éster de prolina-rapamicina e para a preparação de um 42-éster de prolina-rapamicina, composição, e, produto
MXPA06012404A (es) * 2004-04-27 2007-01-17 Wyeth Corp Marcado de rapamicina usando metilasas especificas de rapamicina.
EP1789391B1 (en) 2004-07-23 2017-06-28 Endocyte, Inc. Bivalent linkers and conjugates thereof
CA2577011A1 (en) 2004-08-10 2006-04-13 Wyeth Cci-779 derivatives and methods of making same
KR20070070184A (ko) 2004-10-28 2007-07-03 와이어쓰 자궁근종의 치료에 있어서 ｍＴＯＲ 억제제의 용도
BRPI0607932A2 (pt) 2005-02-09 2016-11-08 Wyeth Corp polimorfo cci-779, processo para preparar polimorfo cci-779, composição farmacêutica, kit, e método para preparar uma composição farmacêutica
BRPI0607390A2 (pt) 2005-03-02 2017-08-22 Wyeth Corp Processo para recuperar cci-779 de licores mâe
CA2599582A1 (en) * 2005-03-02 2006-09-08 Wyeth Purification of rapamycin
CN101175757B (zh) 2005-03-16 2012-11-14 恩多塞特公司 蝶酸及其缀合物的合成和纯化
JP5475992B2 (ja) 2005-08-19 2014-04-16 エンドサイト，インコーポレイテッド 多剤リガンド結合体
WO2007022493A2 (en) * 2005-08-19 2007-02-22 Endocyte, Inc. Ligand conjugates of vinca alkaloids, analogs, and derivatives
CN103110948A (zh) 2005-11-04 2013-05-22 惠氏公司 mTOR抑制剂、赫赛汀和/或HKI-272的抗肿瘤组合
WO2007056175A2 (en) * 2005-11-04 2007-05-18 Wyeth 41-methoxy isotope labeled rapamycin 42-ester
JP2009518412A (ja) * 2005-12-07 2009-05-07 ワイス ラパマイシン４２−エステルボロネートからラパマイシン４２−エステルを調製するためのスケーラブルな方法
WO2007067566A2 (en) * 2005-12-07 2007-06-14 Wyeth Methods for preparing crystalline rapamycin and for measuring crystallinity of rapamycin compounds using differential scanning calorimetry
TW200732342A (en) * 2005-12-07 2007-09-01 Wyeth Corp Process for the preparation of purified crystalline CCI-779
EP1962819A1 (en) * 2005-12-20 2008-09-03 Wyeth Control of cci-779 dosage form stability through control of drug substance impurities
US20070203169A1 (en) * 2006-02-28 2007-08-30 Zhao Jonathon Z Isomers and 42-epimers of rapamycin ester analogs, methods of making and using the same
TW200824713A (en) * 2006-10-18 2008-06-16 Wyeth Corp Processes for the synthesis of individual isomers of mono-PEG CCI-779
US9700704B2 (en) 2006-11-20 2017-07-11 Lutonix, Inc. Drug releasing coatings for balloon catheters
US8414909B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Drug releasing coatings for medical devices
US8414526B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids
US8425459B2 (en) 2006-11-20 2013-04-23 Lutonix, Inc. Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent
US9737640B2 (en) 2006-11-20 2017-08-22 Lutonix, Inc. Drug releasing coatings for medical devices
US8998846B2 (en) 2006-11-20 2015-04-07 Lutonix, Inc. Drug releasing coatings for balloon catheters
US8414525B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Drug releasing coatings for medical devices
US8414910B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Drug releasing coatings for medical devices
US20080276935A1 (en) 2006-11-20 2008-11-13 Lixiao Wang Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs
WO2008101231A2 (en) 2007-02-16 2008-08-21 Endocyte, Inc. Methods and compositions for treating and diagnosing kidney disease
CN101678124A (zh) * 2007-03-14 2010-03-24 恩多塞特公司 结合配体连接的微管溶素递药缀合物
TW200845960A (en) * 2007-04-05 2008-12-01 Wyeth Corp Wortmannin-rapalog conjugate and uses thereof
TW200901989A (en) 2007-04-10 2009-01-16 Wyeth Corp Anti-tumor activity of CCI-779 in papillary renal cell cancer
EP3569251A1 (en) 2007-06-25 2019-11-20 Endocyte, Inc. Conjugates containing hydrophilic spacer linkers
US9877965B2 (en) 2007-06-25 2018-01-30 Endocyte, Inc. Vitamin receptor drug delivery conjugates for treating inflammation
CN101909441B (zh) 2007-10-25 2015-05-13 恩多塞特公司 微管蛋白抑制剂及其制备方法
WO2010024898A2 (en) 2008-08-29 2010-03-04 Lutonix, Inc. Methods and apparatuses for coating balloon catheters
US8754207B2 (en) 2009-09-25 2014-06-17 Cadila Healthcare Limited Process for the preparation of rapamycin derivatives
EP2528906A2 (en) * 2010-01-28 2012-12-05 Fresenius Kabi Oncology Ltd Process for the preparation of temsirolimus and its intermediates
CN102020662B (zh) * 2011-01-07 2013-02-13 天津市炜杰科技有限公司 一种驮瑞塞尔制备方法
CN102020661B (zh) * 2011-01-07 2013-02-13 天津市炜杰科技有限公司 一种驮瑞塞尔合成方法
MX2013011412A (es) * 2011-04-01 2014-04-30 Sandoz Ag Acilacion regioselectiva de rapamicina en la posicion c-42.
WO2013126797A1 (en) 2012-02-24 2013-08-29 Purdue Research Foundation Cholecystokinin b receptor targeting for imaging and therapy
US20140080175A1 (en) 2012-03-29 2014-03-20 Endocyte, Inc. Processes for preparing tubulysin derivatives and conjugates thereof
KR20150070318A (ko) 2012-10-16 2015-06-24 엔도사이트, 인코포레이티드 비천연 아미노산을 함유하는 약물 전달 컨쥬게이트 및 사용 방법
CN104086564B (zh) * 2014-07-30 2019-02-05 江苏奥赛康药业股份有限公司 一种高纯度坦罗莫司的制备方法

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DE19857765A1 (de) 1998-12-15 2000-06-21 Clariant Gmbh Verfahren zur Herstellung von para-Oxadiazolyl-phenyl-boronsäuren
US6277983B1 (en) * 2000-09-27 2001-08-21 American Home Products Corporation Regioselective synthesis of rapamycin derivatives

Also Published As

Publication number Publication date
HK1085482A1 (en) 2006-08-25
AR045217A1 (es) 2005-10-19
US20050033046A1 (en) 2005-02-10
UA83245C2 (en) 2008-06-25
JP2007501783A (ja) 2007-02-01
BRPI0412667A (pt) 2006-09-26
AU2004265267A1 (en) 2005-02-24
RU2006106910A (ru) 2007-09-20
ATE365169T1 (de) 2007-07-15
PT1658295E (pt) 2007-09-25
PL1658295T3 (pl) 2007-11-30
RU2339639C2 (ru) 2008-11-27
KR20060057605A (ko) 2006-05-26
JP4227649B2 (ja) 2009-02-18
CO5650251A2 (es) 2006-06-30
CN1829722A (zh) 2006-09-06
CR8189A (es) 2006-10-04
MXPA06000951A (es) 2006-03-30
ECSP066413A (es) 2006-09-18
ZA200601055B (en) 2008-07-30
DE602004007145T2 (de) 2008-02-28
DK1658295T3 (da) 2007-09-24
DE602004007145D1 (de) 2007-08-02
CA2532988A1 (en) 2005-02-24
CN1829722B (zh) 2010-10-27
ES2287772T3 (es) 2007-12-16
EP1658295B1 (en) 2007-06-20
WO2005016935A3 (en) 2005-04-07
TW200508241A (en) 2005-03-01
EP1658295A2 (en) 2006-05-24
WO2005016935A2 (en) 2005-02-24
IL173134A0 (en) 2006-06-11
US7153957B2 (en) 2006-12-26

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