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MX2008001612A - Metodos para preparar acidos boronicos heterociclicos y derivados de los mismos. - Google Patents

Metodos para preparar acidos boronicos heterociclicos y derivados de los mismos.

Info

Publication number
MX2008001612A
MX2008001612A MX2008001612A MX2008001612A MX2008001612A MX 2008001612 A MX2008001612 A MX 2008001612A MX 2008001612 A MX2008001612 A MX 2008001612A MX 2008001612 A MX2008001612 A MX 2008001612A MX 2008001612 A MX2008001612 A MX 2008001612A
Authority
MX
Mexico
Prior art keywords
derivatives
preparing
hetercyclic
methods
boronic acids
Prior art date
Application number
MX2008001612A
Other languages
English (en)
Inventor
David Alan Campbell
David T Winn
Original Assignee
Phenomix Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Phenomix Corp filed Critical Phenomix Corp
Publication of MX2008001612A publication Critical patent/MX2008001612A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyrrole Compounds (AREA)

Abstract

En el contexto para sintetizar compuestos del acido boronico heterociclico, una metodologia sintetica convergente es particularmente eficiente para preparar boropirrolidinas y derivados de boropirrolidinas.
MX2008001612A 2005-08-01 2006-07-27 Metodos para preparar acidos boronicos heterociclicos y derivados de los mismos. MX2008001612A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70438005P 2005-08-01 2005-08-01
PCT/US2006/029451 WO2007016356A1 (en) 2005-08-01 2006-07-27 Methods of preparing hetercyclic boronic acids and derivatives thereof

Publications (1)

Publication Number Publication Date
MX2008001612A true MX2008001612A (es) 2008-04-04

Family

ID=37708952

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2008001612A MX2008001612A (es) 2005-08-01 2006-07-27 Metodos para preparar acidos boronicos heterociclicos y derivados de los mismos.

Country Status (9)

Country Link
US (1) US7786312B2 (es)
EP (1) EP1919485A4 (es)
JP (1) JP2009503077A (es)
KR (1) KR20080036125A (es)
CN (1) CN101232890A (es)
AU (1) AU2006275697A1 (es)
CA (1) CA2617310A1 (es)
MX (1) MX2008001612A (es)
WO (1) WO2007016356A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100087658A1 (en) * 1996-08-06 2010-04-08 Phenomix Corporation Methods and intermediates for synthesis of selective dpp-iv inhibitors
WO2008109681A2 (en) * 2007-03-08 2008-09-12 Phenomix Corporation Methods and intermediates for synthesis of selective dpp-iv inhibitors
KR20080036125A (ko) 2005-08-01 2008-04-24 페노믹스 코포레이션 헤테로시클릭 보론산 및 그의 유도체의 제조 방법
CL2007002499A1 (es) 2006-08-30 2008-03-14 Phenomix Corp Sales citrato y tartrato de compuestos derivados de acido pirrolidinilaminoacetilpirrolidinboronico, inhibidores de dpp-iv; metodo de preparacion; forma solida; combinacion farmaceutica, util para el tratamiento de diabetes.
MX2010000501A (es) * 2007-07-12 2011-05-25 Phenomix Corp Un intermediario sintetico cristalino para la preparacion de un inhibidor de dpp-iv y metodo de purificacion del mismo.
US20100240611A1 (en) * 2009-03-17 2010-09-23 Matthew Ronsheim Methods for preparing dpp-iv inhibitor compounds
CN111537622B (zh) * 2019-11-29 2021-11-26 杭州华东医药集团新药研究院有限公司 一种度格列汀及其盐的杂质的检测方法
CN111533675B (zh) * 2019-11-29 2021-09-28 杭州华东医药集团新药研究院有限公司 杂环硼酸化合物的杂质及其控制方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008109681A2 (en) 2007-03-08 2008-09-12 Phenomix Corporation Methods and intermediates for synthesis of selective dpp-iv inhibitors
GB0312609D0 (en) * 2003-06-02 2003-07-09 Astrazeneca Ab Novel compounds
DK1689757T3 (en) * 2003-11-12 2014-12-08 Sino Med Internat Alliance Inc HETEROCYCLIC DRY ACID COMPOUNDS
US7576121B2 (en) * 2003-11-12 2009-08-18 Phenomix Corporation Pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV
US7317109B2 (en) * 2003-11-12 2008-01-08 Phenomix Corporation Pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV
CA2606785A1 (en) * 2005-05-19 2006-11-23 Genentech, Inc. Fibroblast activation protein inhibitor compounds and methods
KR20080036125A (ko) 2005-08-01 2008-04-24 페노믹스 코포레이션 헤테로시클릭 보론산 및 그의 유도체의 제조 방법

Also Published As

Publication number Publication date
US20080300413A1 (en) 2008-12-04
CN101232890A (zh) 2008-07-30
EP1919485A1 (en) 2008-05-14
CA2617310A1 (en) 2007-02-08
KR20080036125A (ko) 2008-04-24
US7786312B2 (en) 2010-08-31
AU2006275697A1 (en) 2007-02-08
WO2007016356A1 (en) 2007-02-08
EP1919485A4 (en) 2011-03-23
JP2009503077A (ja) 2009-01-29

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