NO20055310L - Terapeutisk plaster med polysiloksanmatriks omfattende capsaicin - Google Patents
Terapeutisk plaster med polysiloksanmatriks omfattende capsaicinInfo
- Publication number
- NO20055310L NO20055310L NO20055310A NO20055310A NO20055310L NO 20055310 L NO20055310 L NO 20055310L NO 20055310 A NO20055310 A NO 20055310A NO 20055310 A NO20055310 A NO 20055310A NO 20055310 L NO20055310 L NO 20055310L
- Authority
- NO
- Norway
- Prior art keywords
- capsaicin
- therapeutic compound
- preparation
- disclosed
- therapeutic
- Prior art date
Links
- YKPUWZUDDOIDPM-SOFGYWHQSA-N capsaicin Chemical compound COC1=CC(CNC(=O)CCCC\C=C\C(C)C)=CC=C1O YKPUWZUDDOIDPM-SOFGYWHQSA-N 0.000 title abstract 9
- 230000001225 therapeutic effect Effects 0.000 title abstract 5
- 229960002504 capsaicin Drugs 0.000 title abstract 4
- 235000017663 capsaicin Nutrition 0.000 title abstract 4
- 239000011159 matrix material Substances 0.000 title abstract 3
- -1 polysiloxane Polymers 0.000 title abstract 2
- 229920001296 polysiloxane Polymers 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 2
- 230000000699 topical effect Effects 0.000 abstract 2
- 239000007788 liquid Substances 0.000 abstract 1
- 208000004296 neuralgia Diseases 0.000 abstract 1
- 208000021722 neuropathic pain Diseases 0.000 abstract 1
- 229920003023 plastic Polymers 0.000 abstract 1
- 239000004033 plastic Substances 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7092—Transdermal patches having multiple drug layers or reservoirs, e.g. for obtaining a specific release pattern, or for combining different drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T156/00—Adhesive bonding and miscellaneous chemical manufacture
- Y10T156/10—Methods of surface bonding and/or assembly therefor
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Materials Engineering (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Det beskrives et topisk plaster irmeholdende capsaicin eller en capsaicinanalog, fremgangsmåte for fremstilling derav, samt dets anvendelse. Det beskrives således et topisk plaster omfattende et ryggsjikt som er impermeabelt for terapeutisk forbindelse, en selvadherende matriks basert på polysiloksaner og irmeholdende capsaicin eller terapeutiske forbindelser analoge til capsaicin, og en beskyttende film som ^emes før bruk, hvori matriksen irmeholdende flytende reservoar basert på et amfifilisk oppløsningsmiddel, hvori den terapeutiske forbindelse er tilstede i fullstendig oppløst form og konsentrasjonen av den terapeutiske forbindelse i mikroreservoardråpene er under metningskonsenfrasjonen. Det beskrives videre en fremgangsmåte for fremstilling av slike plaster og deres bruk for behandling av neuropatisk smerte.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46263003P | 2003-04-14 | 2003-04-14 | |
| PCT/EP2003/012929 WO2004089361A1 (en) | 2003-04-14 | 2003-11-19 | Therapeutic patch with polysiloxane matrix comprising capsaicin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20055310L true NO20055310L (no) | 2005-11-10 |
| NO337896B1 NO337896B1 (no) | 2016-07-04 |
Family
ID=33159857
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20055310A NO337896B1 (no) | 2003-04-14 | 2005-11-10 | Terapeutisk plaster inneholdende en oppløst terapeutisk forbindelse, anvendelse derav samt fremgangsmåte for fremstilling av nevnte plaster |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US8821920B2 (no) |
| EP (1) | EP1613297B1 (no) |
| JP (1) | JP4943657B2 (no) |
| KR (1) | KR101050672B1 (no) |
| CN (2) | CN100512806C (no) |
| AT (1) | ATE363900T1 (no) |
| AU (1) | AU2003289710B2 (no) |
| BR (1) | BRPI0318250B8 (no) |
| CA (1) | CA2517493C (no) |
| CY (1) | CY1106744T1 (no) |
| DE (1) | DE60314298T2 (no) |
| DK (1) | DK1613297T3 (no) |
| ES (1) | ES2288222T3 (no) |
| IL (1) | IL171249A (no) |
| MX (1) | MXPA05011012A (no) |
| NO (1) | NO337896B1 (no) |
| NZ (1) | NZ541956A (no) |
| PL (1) | PL219512B1 (no) |
| PT (1) | PT1613297E (no) |
| RU (1) | RU2349315C9 (no) |
| UA (1) | UA81665C2 (no) |
| WO (1) | WO2004089361A1 (no) |
| ZA (1) | ZA200506462B (no) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA012599B1 (ru) | 2003-04-10 | 2009-10-30 | Ньюроджескс, Инк. | Способы и композиции для введения агонистов trpv1 |
| DE102004044578A1 (de) | 2004-09-13 | 2006-03-30 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System mit einer Haftschicht, Verfahren zum Silikonisieren einer Rückschicht des Systems und Verwendung der Rückschicht |
| JP2006206471A (ja) * | 2005-01-26 | 2006-08-10 | Nitto Denko Corp | テープ製剤 |
| BRPI0607461A2 (pt) * | 2005-02-14 | 2009-09-08 | Neurogesx Inc | dispositivo para liberação de agonistas de trpv1 |
| WO2006105481A1 (en) * | 2005-03-30 | 2006-10-05 | Neurogesx, Inc. | Low-concentration capsaicin patch and methods for treating neuropathic pain |
| JP4505644B2 (ja) * | 2006-02-17 | 2010-07-21 | フジコピアン株式会社 | 固定シート |
| JP4505645B2 (ja) * | 2006-02-17 | 2010-07-21 | フジコピアン株式会社 | 固定シートの貼付方法 |
| JP4505646B2 (ja) * | 2006-02-20 | 2010-07-21 | フジコピアン株式会社 | 固定シート |
| JP4505649B2 (ja) * | 2006-03-23 | 2010-07-21 | フジコピアン株式会社 | 固定シート |
| JP2007284370A (ja) * | 2006-04-14 | 2007-11-01 | Alcare Co Ltd | 体表面用貼付材 |
| US7943666B2 (en) * | 2006-07-24 | 2011-05-17 | Trinity Laboratories, Inc. | Esters of capsaicin for treating pain |
| EP2155175B1 (en) * | 2007-06-08 | 2014-03-12 | Samyang Biopharmaceuticals Corporation | Matrix-type transdermal drug delivery system and preparation method thereof |
| KR101857827B1 (ko) * | 2010-06-09 | 2018-05-14 | 카오카부시키가이샤 | 수증기 발생 온열구 |
| TW201431570A (zh) | 2012-11-22 | 2014-08-16 | Ucb Pharma Gmbh | 用於經皮投服羅替戈汀(Rotigotine)之多天式貼片 |
| HK1220384A1 (zh) * | 2013-03-14 | 2017-05-05 | Allergan, Inc. | 包含比马前列素的局部组合物和利用其刺激毛发生长的方法 |
| DK2810646T3 (en) * | 2013-06-04 | 2016-10-31 | Lts Lohmann Therapie Systeme Ag | A transdermal |
| US10046151B2 (en) | 2013-07-03 | 2018-08-14 | Lts Lohmann Therapie-Systeme, Ag | Transdermal therapeutic system with electronic component |
| CN104586818A (zh) * | 2013-11-01 | 2015-05-06 | 北京中卫神农慢性病医学研究院有限公司 | 辣椒碱微孔久释器材 |
| KR101574760B1 (ko) * | 2013-11-13 | 2015-12-04 | 주식회사 엘지생활건강 | 흡수속도를 개선한 마이크로니들 시스템 |
| ES2924899T3 (es) | 2014-05-20 | 2022-10-11 | Lts Lohmann Therapie Systeme Ag | Sistema de administración transdérmica que contiene rotigotina |
| CA2948221C (en) | 2014-05-20 | 2022-11-22 | Lts Lohmann Therapie-Systeme Ag | Transdermal delivery system including an interface mediator |
| CN106456567A (zh) | 2014-05-20 | 2017-02-22 | Lts勒曼治疗系统股份公司 | 在经皮递送系统中调节活性剂释放的方法 |
| MA40998A (fr) | 2014-11-21 | 2017-09-26 | Ophirex Inc | Thérapies contre une envenimation, ainsi que compositions, systèmes et kits pharmaceutiques associés |
| CN104546805A (zh) * | 2014-12-15 | 2015-04-29 | 刘闯 | 一种治疗皮肤色斑的药膏贴 |
| EP3266472A1 (en) * | 2016-07-08 | 2018-01-10 | Mölnlycke Health Care AB | A medical dressing comprising a carrier and a composite material |
| KR101880442B1 (ko) * | 2017-02-02 | 2018-07-23 | 대구한의대학교산학협력단 | 혈압 강하용 패치 조성물 |
| US12383509B2 (en) * | 2017-09-04 | 2025-08-12 | Lts Lohmann Therapie-Systeme Ag | Transdermal delivery system including an emulsifier |
| BR112022018608A2 (pt) | 2020-03-17 | 2022-11-08 | Gruenenthal Gmbh | Aplicação tópica repetida de emplastro de capsaicina para o tratamento de não-respondedores iniciais |
| KR20220164022A (ko) | 2020-04-03 | 2022-12-12 | 그뤼넨탈 게엠베하 | 캡사이신 패치의 반복된 국소 적용 요법 |
| TWI807338B (zh) * | 2020-06-26 | 2023-07-01 | 美商美國禮來大藥廠 | 結合TGF-α及表皮調節素(EPIREGULIN)之抗體於治療疼痛之用途 |
| US11234947B2 (en) * | 2020-06-30 | 2022-02-01 | Imperial College Innovations Limited | Treatment of peripheral neuropathy induced by cancer chemotherapy |
| JP7683009B2 (ja) * | 2020-12-30 | 2025-05-26 | エルケム・シリコーンズ・シャンハイ・カンパニー・リミテッド | カプサイシン含有シリコーンゲルでコーティングされたパッチ |
| CN120752028A (zh) * | 2023-03-15 | 2025-10-03 | Lts罗曼治疗系统股份公司 | 包含辣椒素的医用贴剂 |
| WO2024189213A1 (en) * | 2023-03-15 | 2024-09-19 | Lts Lohmann Therapie-Systeme Ag | Medical patch comprising skin irritating active agent |
| WO2025087915A1 (en) * | 2023-10-23 | 2025-05-01 | Lts Lohmann Therapie-Systeme Ag | Medical patch comprising capsaicin or a capsaicin analog |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US3946106A (en) | 1974-10-24 | 1976-03-23 | G. D. Searle & Co. | Microsealed pharmaceutical delivery device |
| US4053580A (en) | 1975-01-01 | 1977-10-11 | G. D. Searle & Co. | Microsealed pharmaceutical delivery device |
| DE3333240A1 (de) * | 1983-09-12 | 1985-03-28 | Schering AG, 1000 Berlin und 4709 Bergkamen | Mittel zur transdermalen applikation von arzneimittelwirkstoffen |
| US5145682A (en) | 1986-05-30 | 1992-09-08 | Rutgers, The State University Of New Jersey | Transdermal absorption dosage unit for postmenopausal syndrome treatment and process for administration |
| GB8704755D0 (en) | 1987-02-28 | 1987-04-01 | Dow Corning Ltd | Pharmaceutical delivery device |
| US5788983A (en) * | 1989-04-03 | 1998-08-04 | Rutgers, The State University Of New Jersey | Transdermal controlled delivery of pharmaceuticals at variable dosage rates and processes |
| US5494680A (en) * | 1993-12-08 | 1996-02-27 | Minnesota Mining And Manufacturing Company | Transdermal delivery device |
| CN1037242C (zh) * | 1994-04-22 | 1998-02-04 | 天津轻工业学院 | 以干红辣椒为原料制备辣椒碱的方法 |
| US5714162A (en) * | 1994-09-16 | 1998-02-03 | Lts Lohmann Therapie-Systeme Gmbh & Co. Kg | Scopolamine patch |
| US5762963A (en) | 1995-06-07 | 1998-06-09 | Emory University | Method and compositions for controlling oral and pharyngeal pain using capsaicinoids |
| US6248788B1 (en) | 1996-11-06 | 2001-06-19 | The Regents Of The University Of California | Therapeutic method with capsaicin and capasicin analogs |
| US6239180B1 (en) * | 1995-11-08 | 2001-05-29 | The Regents Of The University Of California | Transdermal therapeutic device and method with capsaicin and capsaicin analogs |
| RU2097057C1 (ru) * | 1995-11-15 | 1997-11-27 | Акционерное общество открытого типа "Нижегородский химико-фармацевтический завод" | Состав мази болеутоляющего и местнораздражающего действия с тепловым эффектом |
| GB2340751B (en) * | 1998-08-12 | 2003-11-05 | Edko Trading Representation | Pharmaceutical compositions |
| CA2267049A1 (en) * | 1999-02-05 | 2000-08-05 | Bioglan Laboratories Ltd. | Pharmaceutical compositions |
| DE19923427A1 (de) * | 1999-05-21 | 2000-11-23 | Lohmann Therapie Syst Lts | Vorrichtung und Verfahren zur Steigerung der transdermalen Permeation von Arzneistoffen |
| DE19958554C2 (de) * | 1999-07-02 | 2002-06-13 | Lohmann Therapie Syst Lts | Mikroreservoirsystem auf Basis von Polysiloxanen und ambiphilen Lösemitteln und ihre Herstellung |
| BR0012152A (pt) * | 1999-07-02 | 2002-03-12 | Lohmann Therapie Syst Lts | Sistema de microrreservatórios na base de polissiloxanos e solventes ambifìlicos |
| US6348501B1 (en) * | 1999-09-29 | 2002-02-19 | Medical Merchandising, Inc. | Lotion compositions utilizing capsaicin |
| DE10025971B4 (de) * | 2000-05-25 | 2004-09-02 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System in Plasterform mit verminderter Tendenz zur Wirkstoffkristallisation und seine Verwendung |
| DE10114382A1 (de) | 2001-03-23 | 2002-09-26 | Beiersdorf Ag | Feuchtigkeitsaufnehmende Matrix auf Silikonbasis insbesondere zur Wundversorgung und/oder pharmazeutisch/kosmetischen Hautbehandlung |
| JP3989188B2 (ja) * | 2001-04-27 | 2007-10-10 | クリストファー・エム・キム | 蜂針を用いない蜂毒療法 |
| CA2447302C (en) * | 2001-05-01 | 2008-07-29 | A.V. Topchiev Institute Of Petrochemical Synthesis | Two-phase, water-absorbent bioadhesive composition |
| DE10141651B4 (de) * | 2001-08-24 | 2007-02-15 | Lts Lohmann Therapie-Systeme Ag | Transdermales Therapeutisches System (TTS) mit dem Wirkstoff Fentanyl und Verfahren zu seiner Herstellung |
| WO2003015698A2 (en) * | 2001-08-13 | 2003-02-27 | University Of Pittsburgh | Application of lipid vehicles and use for drug delivery |
| US7247315B2 (en) * | 2001-08-17 | 2007-07-24 | Lavipharm Laboratories Inc. | Compositions and medical device for transdermal delivery of a drug and methods of making and using same |
| US8246979B2 (en) * | 2002-07-30 | 2012-08-21 | Ucb Pharma Gmbh | Transdermal delivery system for the administration of rotigotine |
-
2003
- 2003-11-19 EP EP03779987A patent/EP1613297B1/en not_active Expired - Lifetime
- 2003-11-19 CN CNB2003801101762A patent/CN100512806C/zh not_active Expired - Lifetime
- 2003-11-19 DE DE60314298T patent/DE60314298T2/de not_active Expired - Lifetime
- 2003-11-19 AT AT03779987T patent/ATE363900T1/de active
- 2003-11-19 MX MXPA05011012A patent/MXPA05011012A/es active IP Right Grant
- 2003-11-19 WO PCT/EP2003/012929 patent/WO2004089361A1/en not_active Ceased
- 2003-11-19 JP JP2004570482A patent/JP4943657B2/ja not_active Expired - Lifetime
- 2003-11-19 UA UAA200510752A patent/UA81665C2/ru unknown
- 2003-11-19 PL PL378806A patent/PL219512B1/pl unknown
- 2003-11-19 DK DK03779987T patent/DK1613297T3/da active
- 2003-11-19 AU AU2003289710A patent/AU2003289710B2/en not_active Expired
- 2003-11-19 RU RU2005134984/15A patent/RU2349315C9/ru active
- 2003-11-19 KR KR1020057019471A patent/KR101050672B1/ko not_active Expired - Lifetime
- 2003-11-19 PT PT03779987T patent/PT1613297E/pt unknown
- 2003-11-19 CN CN2009101505394A patent/CN101601664B/zh not_active Expired - Lifetime
- 2003-11-19 NZ NZ541956A patent/NZ541956A/en not_active IP Right Cessation
- 2003-11-19 CA CA2517493A patent/CA2517493C/en not_active Expired - Lifetime
- 2003-11-19 ES ES03779987T patent/ES2288222T3/es not_active Expired - Lifetime
- 2003-11-19 BR BRPI0318250A patent/BRPI0318250B8/pt active IP Right Grant
-
2004
- 2004-04-12 US US10/823,119 patent/US8821920B2/en active Active
-
2005
- 2005-08-12 ZA ZA200506462A patent/ZA200506462B/en unknown
- 2005-10-02 IL IL171249A patent/IL171249A/en active IP Right Grant
- 2005-11-10 NO NO20055310A patent/NO337896B1/no not_active IP Right Cessation
-
2007
- 2007-07-19 CY CY20071100962T patent/CY1106744T1/el unknown
-
2014
- 2014-07-23 US US14/338,932 patent/US20140335150A1/en not_active Abandoned
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