NO20055826L - HIV-prodroger spaltbare ved CD26 - Google Patents
HIV-prodroger spaltbare ved CD26Info
- Publication number
- NO20055826L NO20055826L NO20055826A NO20055826A NO20055826L NO 20055826 L NO20055826 L NO 20055826L NO 20055826 A NO20055826 A NO 20055826A NO 20055826 A NO20055826 A NO 20055826A NO 20055826 L NO20055826 L NO 20055826L
- Authority
- NO
- Norway
- Prior art keywords
- prodrugs
- acid
- allyl
- present
- dipeptidyl
- Prior art date
Links
- 239000000651 prodrug Substances 0.000 title abstract 5
- 229940002612 prodrug Drugs 0.000 title abstract 5
- 102100025012 Dipeptidyl peptidase 4 Human genes 0.000 title abstract 3
- 101000908391 Homo sapiens Dipeptidyl peptidase 4 Proteins 0.000 title abstract 2
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 3
- IADUEWIQBXOCDZ-VKHMYHEASA-N (S)-azetidine-2-carboxylic acid Chemical group OC(=O)[C@@H]1CCN1 IADUEWIQBXOCDZ-VKHMYHEASA-N 0.000 abstract 2
- DZLNHFMRPBPULJ-VKHMYHEASA-N L-thioproline Chemical compound OC(=O)[C@@H]1CSCN1 DZLNHFMRPBPULJ-VKHMYHEASA-N 0.000 abstract 2
- FJLFXMJCHNQICR-RXMQYKEDSA-N (2r)-1,2-dihydroxypyrrolidine-2-carboxylic acid Chemical group ON1CCC[C@@]1(O)C(O)=O FJLFXMJCHNQICR-RXMQYKEDSA-N 0.000 abstract 1
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- OMGHIGVFLOPEHJ-UHFFFAOYSA-N 2,5-dihydro-1h-pyrrol-1-ium-2-carboxylate Chemical group OC(=O)C1NCC=C1 OMGHIGVFLOPEHJ-UHFFFAOYSA-N 0.000 abstract 1
- 108090000194 Dipeptidyl-peptidases and tripeptidyl-peptidases Proteins 0.000 abstract 1
- 102000003779 Dipeptidyl-peptidases and tripeptidyl-peptidases Human genes 0.000 abstract 1
- 101000684208 Homo sapiens Prolyl endopeptidase FAP Proteins 0.000 abstract 1
- PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical group O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 abstract 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical group C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 abstract 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 abstract 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 abstract 1
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 abstract 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 abstract 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 abstract 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 abstract 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 abstract 1
- 239000004473 Threonine Substances 0.000 abstract 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 abstract 1
- 235000004279 alanine Nutrition 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000005336 allyloxy group Chemical group 0.000 abstract 1
- 229940024606 amino acid Drugs 0.000 abstract 1
- 235000001014 amino acid Nutrition 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Chemical group OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000005553 heteroaryloxy group Chemical group 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 229960002591 hydroxyproline Drugs 0.000 abstract 1
- 229960000310 isoleucine Drugs 0.000 abstract 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 abstract 1
- DJIWKBNZEOPEAM-JEDNCBNOSA-N piperidine-2-carboxylic acid;(2s)-piperidine-2-carboxylic acid Chemical group OC(=O)C1CCCCN1.OC(=O)[C@@H]1CCCCN1 DJIWKBNZEOPEAM-JEDNCBNOSA-N 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229930195734 saturated hydrocarbon Natural products 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Chemical group ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 abstract 1
- 239000004474 valine Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/17—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
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- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
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- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
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- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
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- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
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- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
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- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
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- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
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- C07K9/003—Peptides being substituted by heterocyclic radicals, e.g. bleomycin, phleomycin
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Abstract
Foreliggende oppfinnelse tilveiebringer nye prodroger som er konjugater av en terapeutisk forbindelse og et peptid, hvori konjugatet kan spaltes ved dipeptidylpeptidaser, mer foretrukket ved CD26, også kjent som DPPIV (dipeptidyl aminodipeptidase IV). Foreliggende prodroger har formelen de stereoisomere formene og saltene derav, hvori n er 1 til 5, Y er prolin, alanin, hydroksyprolin, dihydroksyprolin, tiazolidinkarboksylsyre (tioprolin), dehydroprolin, pipecolinsyre (L-homoprolin), azetidinkarboksylsyre, aziridinkarboksylsyre, glysin, serin, valin, leucin, isoleucin og treonin, X velges fra enhver aminosyre i D- eller L-konfigurasjonen, X og Y i hver gjentagelse av [Y-X] velges uavhengig fra hverandre og uavhengig fra andre gjentagelser, Z er en direkte binding eller en bivalent rett eller forgrenet mettet hydrokarbongruppe med fra 1 til 4 karbonatomer. R' er et aryl, heteroaryl, aryloksy, heteroaryloksy, aryloksyCi.4alkyl, heterocykloalkyloksy, heterocykloalkylCMalkyloksy, heteroaryloksyCi. 4alkyl, heteroarylCi^allyloksy, R^ er arylCi^iallyl, R^ er Ci.ioallyl, ^.^alkei^l eller C3.7cykloalkylCi^allyl, R'' er hydrogen eller Ci^kyl. Foreliggende oppfinnelse tilveiebringer videre anvendelsen av prodrogene som medisin samt som en fremgangsmåte for å fremstille prodrogene.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0310593.9A GB0310593D0 (en) | 2003-05-08 | 2003-05-08 | Peptidic prodrugs |
| PCT/EP2004/050753 WO2004099135A2 (en) | 2003-05-08 | 2004-05-10 | Hiv prodrugs cleavable by cd26 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20055826D0 NO20055826D0 (no) | 2005-12-08 |
| NO20055826L true NO20055826L (no) | 2006-02-08 |
Family
ID=9957688
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20055826A NO20055826L (no) | 2003-05-08 | 2005-12-08 | HIV-prodroger spaltbare ved CD26 |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US20080214648A1 (no) |
| EP (2) | EP1620130A1 (no) |
| JP (2) | JP2007526872A (no) |
| KR (1) | KR20060008300A (no) |
| CN (1) | CN1784244A (no) |
| AP (1) | AP2005003465A0 (no) |
| AT (1) | ATE375172T1 (no) |
| AU (2) | AU2004236371B2 (no) |
| BR (1) | BRPI0410158A (no) |
| CA (2) | CA2525191A1 (no) |
| DE (1) | DE602004009435T2 (no) |
| DK (1) | DK1624897T3 (no) |
| EA (1) | EA009727B1 (no) |
| ES (1) | ES2295879T3 (no) |
| GB (1) | GB0310593D0 (no) |
| MX (1) | MXPA05012019A (no) |
| NO (1) | NO20055826L (no) |
| NZ (1) | NZ543946A (no) |
| PT (1) | PT1624897E (no) |
| UA (1) | UA82221C2 (no) |
| WO (2) | WO2004098644A1 (no) |
| ZA (1) | ZA200509940B (no) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101291683B (zh) | 2004-11-24 | 2011-08-17 | 纽普罗研究有限公司 | 治疗疾病的方法和组合物 |
| DK1831361T3 (da) | 2004-12-23 | 2012-05-14 | Campina Nederland Holding Bv | Proteinhydrolysat beriget med peptider, som inhiberer DPP-IV, og deres anvendelse |
| WO2007064208A1 (en) | 2005-11-30 | 2007-06-07 | Campina Nederland Holding B.V. | Use of a protein hydrolysate for enhancing activity of glucagon-like peptide-1 |
| CA2647835A1 (en) | 2006-03-28 | 2007-10-04 | Neopro Labs, Llc | Methods and compositions for treating conditions |
| US8217141B2 (en) | 2007-05-17 | 2012-07-10 | Neopro Labs, Llc | Crystalline and amorphous forms of peptide |
| AU2008318986B2 (en) * | 2007-10-30 | 2014-12-04 | Indiana University Research And Technology Corporation | Glucagon antagonists |
| JP2011511778A (ja) | 2008-01-30 | 2011-04-14 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーション | エステルに基づいたペプチドプロドラッグ |
| EP2276479B1 (en) * | 2008-04-15 | 2014-07-02 | SineVir Therapeutics LLC | Prodrugs of neuraminidase inhibitors |
| EP2343973B1 (en) * | 2008-09-12 | 2016-02-17 | Cadila Pharmaceuticals Ltd. | Prodrugs of Sitagliptin |
| WO2010053550A2 (en) | 2008-11-04 | 2010-05-14 | Anchor Therapeutics, Inc. | Cxcr4 receptor compounds |
| RU2411248C2 (ru) * | 2008-11-13 | 2011-02-10 | Учреждение Российской академии наук Институт молекулярной генетики РАН (ИМГ РАН) | Средство, обладающее антипсихотической активностью |
| CN102325539A (zh) | 2008-12-19 | 2012-01-18 | 印第安纳大学研究及科技有限公司 | 基于酰胺的胰高血糖素超家族肽前药 |
| CA2747195A1 (en) * | 2008-12-19 | 2010-07-15 | Indiana University Research And Technology Corporation | Dipeptide linked medicinal agents |
| WO2011061590A1 (en) | 2009-11-17 | 2011-05-26 | Hetero Research Foundation | Novel carboxamide derivatives as hiv inhibitors |
| WO2011106703A2 (en) * | 2010-02-26 | 2011-09-01 | Anchor Therapeutics, Inc. | Cxcr4 receptor compounds |
| US8946147B2 (en) | 2010-06-24 | 2015-02-03 | Indiana University Research And Technology Corporation | Amide-based insulin prodrugs |
| US10426740B1 (en) | 2010-08-18 | 2019-10-01 | Avm Biotechnology, Llc | Compositions and methods to inhibit stem cell and progenitor cell binding to lymphoid tissue and for regenerating germinal centers in lymphatic tissues |
| KR102336426B1 (ko) * | 2013-11-05 | 2021-12-08 | 아스트라제네카 아베 | Nmda 길항제 전구약물 |
| WO2016039403A1 (ja) * | 2014-09-11 | 2016-03-17 | 塩野義製薬株式会社 | 持続性ｈｉｖプロテアーゼ阻害剤 |
| ES2947409T3 (es) | 2014-09-24 | 2023-08-08 | Univ Indiana Res & Tech Corp | Profármacos de insulina a base de amida lipídica |
| KR102633963B1 (ko) * | 2015-05-29 | 2024-02-05 | 애로우헤드 파마슈티컬스 인코포레이티드 | 생물학적으로 절단가능한 테트라펩티드 연결제 |
| ES2954311T3 (es) | 2017-04-01 | 2023-11-21 | Avm Biotechnology Llc | Reemplazo de un preacondicionamiento citotóxico antes de una inmunoterapia celular |
| JP7046990B2 (ja) * | 2017-06-29 | 2022-04-04 | ユレカ・ソシエテ・ア・レスポンサビリテ・リミテ | 医薬的特性が改善されたプロドラッグペプチド |
| EP3488851A1 (en) | 2018-10-03 | 2019-05-29 | AVM Biotechnology, LLC | Immunoablative therapies |
| CN111233955B (zh) * | 2020-02-28 | 2022-06-10 | 南京缘聚医药科技有限公司 | 一类噻唑酮甲酰胞嘧啶衍生物及其药物用途 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL55431A (en) * | 1978-08-24 | 1982-07-30 | Yeda Res & Dev | Anthracycline type antibiotics,their preparation and pharmaceutical compositions comprising them |
| US4892939A (en) * | 1986-05-30 | 1990-01-09 | Fuji Kagaku Kogyo Kabushiki Kaisha | Oligopeptidyl-5-fluorouridine compounds and process for preparing the same |
| US5627035A (en) * | 1990-08-22 | 1997-05-06 | Syntello Vaccine Development Ab | Peptides that block human immunodeficiency virus and methods of use thereof |
| ES2123065T3 (es) * | 1992-08-25 | 1999-01-01 | Searle & Co | Hidroxietilamino-sulfonamidas utiles como inhibidores de proteasas retroviricas. |
| US6046190A (en) * | 1992-08-25 | 2000-04-04 | G.D. Searle & Co. | Hydroxyethylamino sulphonamides useful as retroviral protease inhibitors |
| US5968942A (en) * | 1992-08-25 | 1999-10-19 | G. D. Searle & Co. | α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
| US5830897A (en) * | 1992-08-27 | 1998-11-03 | G. D. Searle & Co. | α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
| DK0769967T3 (da) * | 1994-08-19 | 2008-03-31 | Wallone Region | Konjugater der omfatter et antitumormiddel, og anvendelse heraf |
| US5939550A (en) * | 1995-06-15 | 1999-08-17 | Pfizer Inc. | Process for preparing derivatives of azabicyclo naphthyridine carboxylic acid comprising a dipeptide |
| CZ389398A3 (cs) * | 1996-05-29 | 1999-07-14 | Prototek, Inc. | Proléčiva thalidomidu a jejich použití pro modulaci funkce T-buněk |
| US6177404B1 (en) * | 1996-10-15 | 2001-01-23 | Merck & Co., Inc. | Conjugates useful in the treatment of benign prostatic hyperplasia |
| US5783689A (en) * | 1996-11-12 | 1998-07-21 | University Of Notre Dame | Antibacterial and antifungal nucleosides |
| WO1999067254A2 (en) * | 1998-06-23 | 1999-12-29 | The United States Of America Represented By The Secretary, Department Of Health And Human Services | Multi-drug resistant retroviral protease inhibitors and use thereof |
| DE19828113A1 (de) * | 1998-06-24 | 2000-01-05 | Probiodrug Ges Fuer Arzneim | Prodrugs von Inhibitoren der Dipeptidyl Peptidase IV |
| US7425541B2 (en) * | 1998-12-11 | 2008-09-16 | Medarex, Inc. | Enzyme-cleavable prodrug compounds |
| US6613879B1 (en) * | 1999-05-14 | 2003-09-02 | Boehringer Ingelheim Pharma Kg | FAP-activated anti-tumour compounds |
| US8883856B2 (en) * | 2000-02-28 | 2014-11-11 | John Jackson | Compositions and methods for the treatment of inflammatory diseases using topoisomerase inhibitors |
| US7214663B2 (en) * | 2000-06-14 | 2007-05-08 | Medarex, Inc. | Tripeptide prodrug compounds |
| AU2001294196B2 (en) * | 2000-10-06 | 2005-11-17 | Tanabe Seiyaku Co., Ltd. | Nitrogenous five-membered ring compounds |
| UA74912C2 (en) * | 2001-07-06 | 2006-02-15 | Merck & Co Inc | Beta-aminotetrahydroimidazo-(1,2-a)-pyrazines and tetratriazolo-(4,3-a)-pyrazines as inhibitors of dipeptylpeptidase for the treatment or prevention of diabetes |
| AU2002360487A1 (en) * | 2001-12-04 | 2003-06-17 | Ashim K. Mitra | Acyclovir-peptide analogs |
| CA2508656A1 (en) * | 2002-12-10 | 2004-06-24 | F.Hoffmann-La Roche Ag | Antiviral nucleoside derivatives |
| WO2004073703A1 (en) * | 2003-02-21 | 2004-09-02 | Tripep Ab | Glycinamide derivative for inhibiting hiv replication |
-
2003
- 2003-05-08 GB GBGB0310593.9A patent/GB0310593D0/en not_active Ceased
-
2004
- 2004-05-10 CA CA002525191A patent/CA2525191A1/en not_active Abandoned
- 2004-05-10 US US10/555,712 patent/US20080214648A1/en not_active Abandoned
- 2004-05-10 MX MXPA05012019A patent/MXPA05012019A/es active IP Right Grant
- 2004-05-10 JP JP2006505596A patent/JP2007526872A/ja not_active Withdrawn
- 2004-05-10 WO PCT/BE2004/000069 patent/WO2004098644A1/en not_active Ceased
- 2004-05-10 EA EA200501768A patent/EA009727B1/ru not_active IP Right Cessation
- 2004-05-10 JP JP2006504046A patent/JP2006525235A/ja active Pending
- 2004-05-10 BR BRPI0410158-8A patent/BRPI0410158A/pt not_active IP Right Cessation
- 2004-05-10 DE DE602004009435T patent/DE602004009435T2/de not_active Expired - Fee Related
- 2004-05-10 PT PT04741542T patent/PT1624897E/pt unknown
- 2004-05-10 EP EP04731856A patent/EP1620130A1/en not_active Withdrawn
- 2004-05-10 NZ NZ543946A patent/NZ543946A/en unknown
- 2004-05-10 AU AU2004236371A patent/AU2004236371B2/en not_active Ceased
- 2004-05-10 ES ES04741542T patent/ES2295879T3/es not_active Expired - Lifetime
- 2004-05-10 WO PCT/EP2004/050753 patent/WO2004099135A2/en not_active Ceased
- 2004-05-10 CA CA002517338A patent/CA2517338A1/en not_active Abandoned
- 2004-05-10 AP AP2005003465A patent/AP2005003465A0/xx unknown
- 2004-05-10 AT AT04741542T patent/ATE375172T1/de not_active IP Right Cessation
- 2004-05-10 US US10/555,930 patent/US8236756B2/en not_active Expired - Fee Related
- 2004-05-10 CN CNA2004800122605A patent/CN1784244A/zh active Pending
- 2004-05-10 DK DK04741542T patent/DK1624897T3/da active
- 2004-05-10 AU AU2004235988A patent/AU2004235988A1/en not_active Abandoned
- 2004-05-10 KR KR1020057017724A patent/KR20060008300A/ko not_active Ceased
- 2004-05-10 EP EP04741542A patent/EP1624897B1/en not_active Expired - Lifetime
- 2004-10-05 UA UAA200508359A patent/UA82221C2/uk unknown
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2005
- 2005-12-07 ZA ZA200509940A patent/ZA200509940B/en unknown
- 2005-12-08 NO NO20055826A patent/NO20055826L/no not_active Application Discontinuation
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