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NO20053624L - Tetrahydro-4H-pyrido [1,2-A] pyrimidiner og beslektede forbindelser som er anvendbare som HIV-integrase inhibitorer - Google Patents

Tetrahydro-4H-pyrido [1,2-A] pyrimidiner og beslektede forbindelser som er anvendbare som HIV-integrase inhibitorer

Info

Publication number
NO20053624L
NO20053624L NO20053624A NO20053624A NO20053624L NO 20053624 L NO20053624 L NO 20053624L NO 20053624 A NO20053624 A NO 20053624A NO 20053624 A NO20053624 A NO 20053624A NO 20053624 L NO20053624 L NO 20053624L
Authority
NO
Norway
Prior art keywords
compounds
pyrido
pyrimidines
tetrahydro
hiv
Prior art date
Application number
NO20053624A
Other languages
English (en)
Other versions
NO20053624D0 (no
Inventor
Benedetta Crescenzi
Ester Muraglia
Giovanna Pescatore
Michael Rowley
Vincenzo Summa
Olaf Kinzel
Frederica Orvieto
Original Assignee
Angeletti P Ist Richerche Bio
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Angeletti P Ist Richerche Bio filed Critical Angeletti P Ist Richerche Bio
Publication of NO20053624D0 publication Critical patent/NO20053624D0/no
Publication of NO20053624L publication Critical patent/NO20053624L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Tetrahydro-4H-pyrido[ 1,2-a]pyrimidiner og beslektede forbinder av Formel (I) er beskrevet som inhibitorer av HIV-integrase og inhibitorer av HIV-replikasjon, hvori n er et heltall lik 0, 1 eller 2, og R1, R3, R4, R12 og R14 er som her definert.
NO20053624A 2002-12-27 2005-07-26 Tetrahydro-4H-pyrido [1,2-A] pyrimidiner og beslektede forbindelser som er anvendbare som HIV-integrase inhibitorer NO20053624L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US43683002P 2002-12-27 2002-12-27
US52877603P 2003-12-12 2003-12-12
PCT/GB2003/005543 WO2004058757A1 (en) 2002-12-27 2003-12-18 Tetrahydro-4h-pyrido[1,2-a]pyrimidines and related compounds useful as hiv integrase inhibitors

Publications (2)

Publication Number Publication Date
NO20053624D0 NO20053624D0 (no) 2005-07-26
NO20053624L true NO20053624L (no) 2005-09-26

Family

ID=32685467

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20053624A NO20053624L (no) 2002-12-27 2005-07-26 Tetrahydro-4H-pyrido [1,2-A] pyrimidiner og beslektede forbindelser som er anvendbare som HIV-integrase inhibitorer

Country Status (20)

Country Link
US (2) US7414045B2 (no)
EP (1) EP1578748B1 (no)
JP (1) JP4733986B2 (no)
KR (1) KR20050087865A (no)
CN (1) CN100343253C (no)
AT (1) ATE481401T1 (no)
AU (2) AU2003292436B2 (no)
BR (1) BR0317749A (no)
CA (1) CA2509554C (no)
DE (1) DE60334248D1 (no)
EC (1) ECSP055890A (no)
HR (1) HRP20050593A2 (no)
IS (1) IS7892A (no)
MA (1) MA27583A1 (no)
MX (1) MXPA05007010A (no)
NO (1) NO20053624L (no)
NZ (1) NZ540729A (no)
PL (1) PL377354A1 (no)
RU (1) RU2329265C2 (no)
WO (2) WO2004058757A1 (no)

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US8039458B2 (en) * 2005-11-17 2011-10-18 Bristol-Myers Squibb Company HIV integrase inhibitors
WO2007064316A1 (en) * 2005-11-30 2007-06-07 Bristol-Myers Squibb Company Bicyclic heterocycles as hiv integrase inhibitors
US20070129379A1 (en) * 2005-12-01 2007-06-07 Bristol-Myers Squibb Company Hiv integrase inhibitors
US20090136570A1 (en) * 2006-01-20 2009-05-28 Bhagwant Rege Taste-Masked Tablets and Granules
WO2007143446A1 (en) * 2006-05-30 2007-12-13 Bristol-Myers Squibb Company Spiro-condensed heterotricyclic compounds as hiv integrase inhibitors
US7893055B2 (en) * 2006-06-28 2011-02-22 Bristol-Myers Squibb Company HIV integrase inhibitors
US7763630B2 (en) * 2007-06-06 2010-07-27 Bristol-Myers Squibb Company HIV integrase inhibitors
US8129398B2 (en) * 2008-03-19 2012-03-06 Bristol-Myers Squibb Company HIV integrase inhibitors
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WO2016187788A1 (en) 2015-05-25 2016-12-01 Merck Sharp & Dohme Corp. Fused tricyclic heterocyclic compounds useful for treating hiv infection
US10548910B2 (en) 2015-11-17 2020-02-04 Merck Sharp & Dohme Corp. Amido-substituted pyridotriazine derivatives useful as HIV integrase inhibitors
WO2017106071A1 (en) 2015-12-15 2017-06-22 Merck Sharp & Dohme Corp. Spirocyclic quinolizine derivatives useful as hiv integrase inhibitors
WO2017113288A1 (en) 2015-12-31 2017-07-06 Merck Sharp & Dohme Corp. Fused tricyclic heterocyclic compounds as hiv integrase inhibitors
JOP20190130A1 (ar) 2016-12-02 2019-06-02 Merck Sharp & Dohme مركبات حلقية غير متجانسة رباعية الحلقات مفيدة كمثبطات إنزيم مدمج لفيروس نقص المناعة البشرية (hiv)
EP3548031B1 (en) 2016-12-02 2023-07-19 Merck Sharp & Dohme LLC Tricyclic heterocycle compounds useful as hiv integrase inhibitors
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Also Published As

Publication number Publication date
PL377354A1 (pl) 2006-01-23
AU2003292436A1 (en) 2004-07-22
CA2509554C (en) 2011-02-01
MA27583A1 (fr) 2005-10-03
US20080176869A1 (en) 2008-07-24
IS7892A (is) 2005-06-13
MXPA05007010A (es) 2005-08-18
BR0317749A (pt) 2005-11-22
RU2005123807A (ru) 2006-01-20
US20060046985A1 (en) 2006-03-02
RU2329265C2 (ru) 2008-07-20
AU2003292436B2 (en) 2009-07-30
CN100343253C (zh) 2007-10-17
JP4733986B2 (ja) 2011-07-27
EP1578748B1 (en) 2010-09-15
US7968553B2 (en) 2011-06-28
CN1753892A (zh) 2006-03-29
ECSP055890A (es) 2005-09-20
HRP20050593A2 (en) 2006-03-31
US7414045B2 (en) 2008-08-19
AU2003292437A1 (en) 2004-07-22
KR20050087865A (ko) 2005-08-31
WO2004058756A1 (en) 2004-07-15
JP2006513200A (ja) 2006-04-20
NO20053624D0 (no) 2005-07-26
DE60334248D1 (de) 2010-10-28
EP1578748A1 (en) 2005-09-28
NZ540729A (en) 2008-03-28
WO2004058757A1 (en) 2004-07-15
ATE481401T1 (de) 2010-10-15
CA2509554A1 (en) 2004-07-15

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